#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q92851	uniprotkb:Q13158	intact:EBI-495095|uniprotkb:Q8WYQ8|uniprotkb:Q99845|uniprotkb:Q9Y2U6|uniprotkb:Q9Y2U7|uniprotkb:Q6KF62|uniprotkb:Q6KF63|uniprotkb:Q8IUP5|uniprotkb:Q68HC0|ensembl:ENSP00000272879	intact:EBI-494804|uniprotkb:Q14866|uniprotkb:Q6IBR4|ensembl:ENSP00000301838	psi-mi:caspa_human(display_long)|uniprotkb:ICE-like apoptotic protease 4(gene name synonym)|uniprotkb:Apoptotic protease Mch-4(gene name synonym)|uniprotkb:FAS-associated death domain protein interleukin-1B-converting enzyme 2(gene name synonym)|uniprotkb:CASP10(gene name)|psi-mi:CASP10(display_short)|uniprotkb:MCH4(gene name synonym)	psi-mi:fadd_human(display_long)|uniprotkb:FAS-associating death domain-containing protein(gene name synonym)|uniprotkb:Mediator of receptor induced toxicity(gene name synonym)|uniprotkb:FADD(gene name)|psi-mi:FADD(display_short)|uniprotkb:MORT1(gene name synonym)|uniprotkb:GIG3(orf name)|uniprotkb:Growth-inhibiting gene 3 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vincenz et al. (1997)	mint:MINT-5221350|pubmed:9045686	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8674631|mint:MINT-16276	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116756.2|refseq:NP_116758.1|refseq:NP_116759.2|refseq:NP_001193453.1|refseq:NP_001193471.1|refseq:NP_001221.2|refseq:NP_001293012.1|ensembl:ENSG00000003400(gene)|ensembl:ENST00000272879(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097342"(ripoptosome)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR035701|mint:Q92851|reactome:R-HSA-6803207|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-933543|mint:MINT-1521962(identity)	refseq:NP_003815.1|dip:DIP-286N|ensembl:ENSG00000168040(gene)|ensembl:ENST00000301838(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002020"(protease binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043278"(response to morphine)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0089720"(caspase binding)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097342"(ripoptosome)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:2000454"(positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR016729(FADD)|mint:Q13158|rcsb pdb:1A1W|rcsb pdb:1A1Z|rcsb pdb:1E3Y|rcsb pdb:1E41|rcsb pdb:2GF5|rcsb pdb:3EZQ|rcsb pdb:3OQ9|rcsb pdb:6ACI|reactome:R-HSA-140534|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9693928|mint:MINT-1521956(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2001/12/11	2014/10/16	rogid:3m6JTo82z7pldV6eFKO1BjrWwP09606	rogid:DzaWyJjHDsNt8nMWLbv6GYa0Ri49606	intact-crc:A6C3782F54289F7F|rigid:z6sst5z/nOjSBQ78PKfjCg20m0g	false	binding-associated region:1-219(MINT-1521963)	binding-associated region:1-18(MINT-1521957)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13158	uniprotkb:Q92851	intact:EBI-494804|uniprotkb:Q14866|uniprotkb:Q6IBR4|ensembl:ENSP00000301838	intact:EBI-495095|uniprotkb:Q8WYQ8|uniprotkb:Q99845|uniprotkb:Q9Y2U6|uniprotkb:Q9Y2U7|uniprotkb:Q6KF62|uniprotkb:Q6KF63|uniprotkb:Q8IUP5|uniprotkb:Q68HC0|ensembl:ENSP00000272879	psi-mi:fadd_human(display_long)|uniprotkb:FAS-associating death domain-containing protein(gene name synonym)|uniprotkb:Mediator of receptor induced toxicity(gene name synonym)|uniprotkb:FADD(gene name)|psi-mi:FADD(display_short)|uniprotkb:MORT1(gene name synonym)|uniprotkb:GIG3(orf name)|uniprotkb:Growth-inhibiting gene 3 protein(gene name synonym)	psi-mi:caspa_human(display_long)|uniprotkb:ICE-like apoptotic protease 4(gene name synonym)|uniprotkb:Apoptotic protease Mch-4(gene name synonym)|uniprotkb:FAS-associated death domain protein interleukin-1B-converting enzyme 2(gene name synonym)|uniprotkb:CASP10(gene name)|psi-mi:CASP10(display_short)|uniprotkb:MCH4(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Vincenz et al. (1997)	mint:MINT-5221350|pubmed:9045686	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8674660|mint:MINT-16275	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003815.1|dip:DIP-286N|ensembl:ENSG00000168040(gene)|ensembl:ENST00000301838(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002020"(protease binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043278"(response to morphine)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0089720"(caspase binding)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097342"(ripoptosome)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:2000454"(positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR016729(FADD)|mint:Q13158|rcsb pdb:1A1W|rcsb pdb:1A1Z|rcsb pdb:1E3Y|rcsb pdb:1E41|rcsb pdb:2GF5|rcsb pdb:3EZQ|rcsb pdb:3OQ9|rcsb pdb:6ACI|reactome:R-HSA-140534|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9693928|mint:MINT-1521972(identity)	refseq:NP_116756.2|refseq:NP_116758.1|refseq:NP_116759.2|refseq:NP_001193453.1|refseq:NP_001193471.1|refseq:NP_001221.2|refseq:NP_001293012.1|ensembl:ENSG00000003400(gene)|ensembl:ENST00000272879(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097342"(ripoptosome)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR035701|mint:Q92851|reactome:R-HSA-6803207|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-933543|mint:MINT-1521978(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/12/11	2014/10/16	rogid:DzaWyJjHDsNt8nMWLbv6GYa0Ri49606	rogid:3m6JTo82z7pldV6eFKO1BjrWwP09606	intact-crc:FDB771F097307891|rigid:z6sst5z/nOjSBQ78PKfjCg20m0g	false	binding-associated region:1-18(MINT-1521973)	binding-associated region:1-219(MINT-1521979)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)