#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q22038	uniprotkb:Q28021	intact:EBI-2418951|ensemblmetazoa:Y51H4A.3a.1	intact:EBI-3862767	psi-mi:rho1_caeel(display_long)|uniprotkb:rho-1(gene name)|psi-mi:rho-1(display_short)|uniprotkb:rhoa(gene name synonym)|uniprotkb:Y51H4A.3(orf name)	psi-mi:rock2_bovin(display_long)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase II(gene name synonym)|uniprotkb:ROCK2(gene name)|psi-mi:ROCK2(display_short)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 2(gene name synonym)|uniprotkb:p164 ROCK-2(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Matsui et al. (1996)	mint:MINT-5221030|pubmed:8641286|imex:IM-14011	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8680059|mint:MINT-19050|imex:IM-14011-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR027417|refseq:NP_502959.1|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase)|reactome:R-CEL-3928662|reactome:R-CEL-5625740|wormbase:Y51H4A.3a|reactome:R-CEL-114604|reactome:R-CEL-198203|reactome:R-CEL-392451|reactome:R-CEL-416482|reactome:R-CEL-416572|reactome:R-CEL-4420097|reactome:R-CEL-5627117|reactome:R-CEL-5663220|reactome:R-CEL-5666185|interpro:IPR003578(Ras small GTPase, Rho type)|reactome:R-CEL-5689896|reactome:R-CEL-6798695|reactome:R-CEL-193634|reactome:R-CEL-4086400|reactome:R-CEL-8980692|reactome:R-CEL-9013405|reactome:R-CEL-9035034|reactome:R-CEL-6785631|reactome:R-CEL-3928663|reactome:R-CEL-416550|reactome:R-CEL-8849471|ensemblmetazoa:WBGene00004357(gene)|ensemblmetazoa:Y51H4A.3a.1(transcript)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031034"(myosin filament assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0040017"(positive regulation of locomotion)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|mint:MINT-1517406(identity)	refseq:NP_776877.1|dip:DIP-29038N|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010825"(positive regulation of centrosome duplication)|interpro:IPR000719(Protein kinase, core)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|go:"GO:0031032"(actomyosin structure organization)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|interpro:IPR011009(Protein kinase-like)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0046872"(metal ion binding)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015008(Rho Binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR037311|go:"GO:0048511"(rhythmic process)|rcsb pdb:1UIX|rcsb pdb:2F2U|rcsb pdb:2H9V|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901888"(regulation of cell junction assembly)|mint:MINT-1517412(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/12/30	2014/10/16	rogid:akQc6UxFj7YDkz0O/gzsmt81uw46239	rogid:vSVhN90yaqgBtW3Vf6aUZ0mm4V89913	intact-crc:FD7DF7D2C317CC98|rigid:Ch/q5p1Rz+W1edFQGnKlsWrrGxg	false	binding-associated region:34-42(MINT-1517407)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q22038	uniprotkb:Q28021	intact:EBI-2418951|ensemblmetazoa:Y51H4A.3a.1	intact:EBI-3862767	psi-mi:rho1_caeel(display_long)|uniprotkb:rho-1(gene name)|psi-mi:rho-1(display_short)|uniprotkb:rhoa(gene name synonym)|uniprotkb:Y51H4A.3(orf name)	psi-mi:rock2_bovin(display_long)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase II(gene name synonym)|uniprotkb:ROCK2(gene name)|psi-mi:ROCK2(display_short)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 2(gene name synonym)|uniprotkb:p164 ROCK-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Matsui et al. (1996)	mint:MINT-5221030|pubmed:8641286|imex:IM-14011	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8680082|mint:MINT-19051|imex:IM-14011-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR027417|refseq:NP_502959.1|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase)|reactome:R-CEL-3928662|reactome:R-CEL-5625740|wormbase:Y51H4A.3a|reactome:R-CEL-114604|reactome:R-CEL-198203|reactome:R-CEL-392451|reactome:R-CEL-416482|reactome:R-CEL-416572|reactome:R-CEL-4420097|reactome:R-CEL-5627117|reactome:R-CEL-5663220|reactome:R-CEL-5666185|interpro:IPR003578(Ras small GTPase, Rho type)|reactome:R-CEL-5689896|reactome:R-CEL-6798695|reactome:R-CEL-193634|reactome:R-CEL-4086400|reactome:R-CEL-8980692|reactome:R-CEL-9013405|reactome:R-CEL-9035034|reactome:R-CEL-6785631|reactome:R-CEL-3928663|reactome:R-CEL-416550|reactome:R-CEL-8849471|ensemblmetazoa:WBGene00004357(gene)|ensemblmetazoa:Y51H4A.3a.1(transcript)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031034"(myosin filament assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0040017"(positive regulation of locomotion)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|mint:MINT-1517420(identity)	refseq:NP_776877.1|dip:DIP-29038N|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010825"(positive regulation of centrosome duplication)|interpro:IPR000719(Protein kinase, core)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|go:"GO:0031032"(actomyosin structure organization)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|interpro:IPR011009(Protein kinase-like)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0046872"(metal ion binding)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015008(Rho Binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR037311|go:"GO:0048511"(rhythmic process)|rcsb pdb:1UIX|rcsb pdb:2F2U|rcsb pdb:2H9V|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901888"(regulation of cell junction assembly)|mint:MINT-1517426(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2001/12/30	2014/10/16	rogid:akQc6UxFj7YDkz0O/gzsmt81uw46239	rogid:vSVhN90yaqgBtW3Vf6aUZ0mm4V89913	intact-crc:1B97BC3FAC0A61BB|rigid:Ch/q5p1Rz+W1edFQGnKlsWrrGxg	false	binding-associated region:34-42(MINT-1517421)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)