#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q7K105 uniprotkb:P08953 intact:EBI-129988|ensemblmetazoa:FBpp0087679|ensemblmetazoa:FBpp0305215|ensemblmetazoa:FBpp0311274 intact:EBI-143610|uniprotkb:A4V3G7|uniprotkb:A8WHK7|uniprotkb:Q8MRF3|uniprotkb:Q9VBB8|ensemblmetazoa:FBpp0084431|ensemblmetazoa:FBpp0303188 psi-mi:q7k105_drome(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)|uniprotkb:DMMYD88(gene name synonym)|uniprotkb:DmMyD88(gene name synonym)|uniprotkb:DmMyd88(gene name synonym)|uniprotkb:Dmel\CG2078(gene name synonym)|uniprotkb:"EP(2)2535"(gene name synonym)|uniprotkb:Kra(gene name synonym)|uniprotkb:LD20892(gene name synonym)|uniprotkb:MYD88(gene name synonym)|uniprotkb:MyD88(gene name synonym)|uniprotkb:Myd88F(gene name synonym)|uniprotkb:dMYd88(gene name synonym)|uniprotkb:dMyD88(gene name synonym)|uniprotkb:dMyd88(gene name synonym)|uniprotkb:kra(gene name synonym)|uniprotkb:myd88(gene name synonym)|uniprotkb:CG2078(orf name)|uniprotkb:Dmel_CG2078(orf name) psi-mi:toll_drome(display_long)|uniprotkb:Tl(gene name)|psi-mi:Tl(display_short)|uniprotkb:CG5490(orf name) psi-mi:"MI:0019"(coimmunoprecipitation) Horng et al. (2001) pubmed:11606776|mint:MINT-5214706 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-524696 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_610479.1|flybase:FBgn0033402|refseq:NP_001286246.1|ensemblmetazoa:FBgn0033402(gene)|ensemblmetazoa:FBtr0088598(transcript)|ensemblmetazoa:FBtr0333000(transcript)|ensemblmetazoa:FBtr0345024(transcript)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0002347"(response to tumor cell)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002804"(positive regulation of antifungal peptide production)|go:"GO:0005121"(Toll binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050832"(defense response to fungus)|go:"GO:0070976"(TIR domain binding)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR035897|reactome:R-DME-1810476|reactome:R-DME-209442|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214862|reactome:R-DME-214863|reactome:R-DME-214869|reactome:R-DME-214874|reactome:R-DME-3134963|interpro:IPR000157(Toll-Interleukin receptor)|refseq:NP_001260821.1 refseq:NP_524518.1|refseq:NP_733166.1|flybase:FBgn0262473|dip:DIP-34358N|ensemblmetazoa:FBgn0262473(gene)|ensemblmetazoa:FBtr0085059(transcript)|ensemblmetazoa:FBtr0330155(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0002229"(defense response to oomycetes)|go:"GO:0002347"(response to tumor cell)|go:"GO:0002804"(positive regulation of antifungal peptide production)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0007526"(larval somatic muscle development)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009597"(detection of virus)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009986"(cell surface)|go:"GO:0016201"(synaptic target inhibition)|go:"GO:0019955"(cytokine binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035208"(positive regulation of hemocyte proliferation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046790"(virion binding)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070976"(TIR domain binding)|go:"GO:1902875"(regulation of embryonic pattern specification)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR026906|interpro:IPR032675|interpro:IPR035897|rcsb pdb:4ARN|rcsb pdb:4ARR|rcsb pdb:4BV4|rcsb pdb:4LXR|rcsb pdb:4LXS|reactome:R-DME-209442|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214862|reactome:R-DME-214863|reactome:R-DME-214869|reactome:R-DME-214874 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:7227(drome-salivary_gland)|taxid:7227(Drosophila melanogaster Salivary gland) - 2001/12/19 2014/10/16 rogid:ylgI2zl+aLG3S8D2ER2DrTRUpI47227 rogid:6nIbDMNS71rQ+CzvUkspyPjTd707227 intact-crc:54B41399B32F5A39|rigid:AKh/WPe9ypB1yl7O1uagx3xcllo false v5 tag:?-?|binding-associated region:176-537(IPR000157) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P08953 uniprotkb:Q7K105 intact:EBI-143610|uniprotkb:A4V3G7|uniprotkb:A8WHK7|uniprotkb:Q8MRF3|uniprotkb:Q9VBB8|ensemblmetazoa:FBpp0084431|ensemblmetazoa:FBpp0303188 intact:EBI-129988|ensemblmetazoa:FBpp0087679|ensemblmetazoa:FBpp0305215|ensemblmetazoa:FBpp0311274 psi-mi:toll_drome(display_long)|uniprotkb:Tl(gene name)|psi-mi:Tl(display_short)|uniprotkb:CG5490(orf name) psi-mi:q7k105_drome(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)|uniprotkb:DMMYD88(gene name synonym)|uniprotkb:DmMyD88(gene name synonym)|uniprotkb:DmMyd88(gene name synonym)|uniprotkb:Dmel\CG2078(gene name synonym)|uniprotkb:"EP(2)2535"(gene name synonym)|uniprotkb:Kra(gene name synonym)|uniprotkb:LD20892(gene name synonym)|uniprotkb:MYD88(gene name synonym)|uniprotkb:MyD88(gene name synonym)|uniprotkb:Myd88F(gene name synonym)|uniprotkb:dMYd88(gene name synonym)|uniprotkb:dMyD88(gene name synonym)|uniprotkb:dMyd88(gene name synonym)|uniprotkb:kra(gene name synonym)|uniprotkb:myd88(gene name synonym)|uniprotkb:CG2078(orf name)|uniprotkb:Dmel_CG2078(orf name) psi-mi:"MI:0019"(coimmunoprecipitation) Horng et al. (2001) pubmed:11606776|mint:MINT-5214706 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-524704 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524518.1|refseq:NP_733166.1|flybase:FBgn0262473|dip:DIP-34358N|ensemblmetazoa:FBgn0262473(gene)|ensemblmetazoa:FBtr0085059(transcript)|ensemblmetazoa:FBtr0330155(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0002229"(defense response to oomycetes)|go:"GO:0002347"(response to tumor cell)|go:"GO:0002804"(positive regulation of antifungal peptide production)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0007526"(larval somatic muscle development)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009597"(detection of virus)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009986"(cell surface)|go:"GO:0016201"(synaptic target inhibition)|go:"GO:0019955"(cytokine binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035208"(positive regulation of hemocyte proliferation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046790"(virion binding)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070976"(TIR domain binding)|go:"GO:1902875"(regulation of embryonic pattern specification)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR026906|interpro:IPR032675|interpro:IPR035897|rcsb pdb:4ARN|rcsb pdb:4ARR|rcsb pdb:4BV4|rcsb pdb:4LXR|rcsb pdb:4LXS|reactome:R-DME-209442|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214862|reactome:R-DME-214863|reactome:R-DME-214869|reactome:R-DME-214874 refseq:NP_610479.1|flybase:FBgn0033402|refseq:NP_001286246.1|ensemblmetazoa:FBgn0033402(gene)|ensemblmetazoa:FBtr0088598(transcript)|ensemblmetazoa:FBtr0333000(transcript)|ensemblmetazoa:FBtr0345024(transcript)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0002347"(response to tumor cell)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002804"(positive regulation of antifungal peptide production)|go:"GO:0005121"(Toll binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050832"(defense response to fungus)|go:"GO:0070976"(TIR domain binding)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR035897|reactome:R-DME-1810476|reactome:R-DME-209442|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214862|reactome:R-DME-214863|reactome:R-DME-214869|reactome:R-DME-214874|reactome:R-DME-3134963|interpro:IPR000157(Toll-Interleukin receptor)|refseq:NP_001260821.1 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:7227(drome-salivary_gland)|taxid:7227(Drosophila melanogaster Salivary gland) - 2001/12/19 2014/10/16 rogid:6nIbDMNS71rQ+CzvUkspyPjTd707227 rogid:ylgI2zl+aLG3S8D2ER2DrTRUpI47227 intact-crc:6E86439FE2A24F50|rigid:AKh/WPe9ypB1yl7O1uagx3xcllo false - v5 tag:?-?|binding-associated region:1-237 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q7K105 uniprotkb:Q9V3B4 intact:EBI-129988|ensemblmetazoa:FBpp0087679|ensemblmetazoa:FBpp0305215|ensemblmetazoa:FBpp0311274 intact:EBI-104309|intact:EBI-1631809|uniprotkb:A4V9R6|uniprotkb:A4V9R7|uniprotkb:A4V9R5|ensemblmetazoa:FBpp0083574 psi-mi:q7k105_drome(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)|uniprotkb:DMMYD88(gene name synonym)|uniprotkb:DmMyD88(gene name synonym)|uniprotkb:DmMyd88(gene name synonym)|uniprotkb:Dmel\CG2078(gene name synonym)|uniprotkb:"EP(2)2535"(gene name synonym)|uniprotkb:Kra(gene name synonym)|uniprotkb:LD20892(gene name synonym)|uniprotkb:MYD88(gene name synonym)|uniprotkb:MyD88(gene name synonym)|uniprotkb:Myd88F(gene name synonym)|uniprotkb:dMYd88(gene name synonym)|uniprotkb:dMyD88(gene name synonym)|uniprotkb:dMyd88(gene name synonym)|uniprotkb:kra(gene name synonym)|uniprotkb:myd88(gene name synonym)|uniprotkb:CG2078(orf name)|uniprotkb:Dmel_CG2078(orf name) psi-mi:fadd_drome(display_long)|uniprotkb:Fadd(gene name)|psi-mi:Fadd(display_short)|uniprotkb:BG4(gene name synonym)|uniprotkb:Death domain-containing adapter protein BG4(gene name synonym)|uniprotkb:FAS-associating death domain-containing protein(gene name synonym)|uniprotkb:CG12297(orf name) psi-mi:"MI:0019"(coimmunoprecipitation) Horng et al. (2001) pubmed:11606776|mint:MINT-5214706 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-524712 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_610479.1|flybase:FBgn0033402|refseq:NP_001286246.1|ensemblmetazoa:FBgn0033402(gene)|ensemblmetazoa:FBtr0088598(transcript)|ensemblmetazoa:FBtr0333000(transcript)|ensemblmetazoa:FBtr0345024(transcript)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0002347"(response to tumor cell)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002804"(positive regulation of antifungal peptide production)|go:"GO:0005121"(Toll binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050832"(defense response to fungus)|go:"GO:0070976"(TIR domain binding)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR035897|reactome:R-DME-1810476|reactome:R-DME-209442|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214862|reactome:R-DME-214863|reactome:R-DME-214869|reactome:R-DME-214874|reactome:R-DME-3134963|interpro:IPR000157(Toll-Interleukin receptor)|refseq:NP_001260821.1 refseq:NP_651006.1|flybase:FBgn0038928|ensemblmetazoa:FBgn0038928(gene)|ensemblmetazoa:FBtr0084176(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006963"(positive regulation of antibacterial peptide biosynthetic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0061057"(peptidoglycan recognition protein signaling pathway)|go:"GO:0089720"(caspase binding)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|reactome:R-DME-214397|reactome:R-DME-214399|reactome:R-DME-214411|reactome:R-DME-214416|dip:DIP-18912N - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:7227(drome-salivary_gland)|taxid:7227(Drosophila melanogaster Salivary gland) - 2001/12/19 2014/10/16 rogid:ylgI2zl+aLG3S8D2ER2DrTRUpI47227 rogid:TD97aEJUqLIypZRYRBB7gttIcaU7227 intact-crc:713EB2B603E5FD92|rigid:h3PtClo3F61QzTynbCQWpAogCNc false binding-associated region:1-237|v5 tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q7K105 uniprotkb:Q8IRY7 intact:EBI-129988|ensemblmetazoa:FBpp0087679|ensemblmetazoa:FBpp0305215|ensemblmetazoa:FBpp0311274 intact:EBI-442182|ensemblmetazoa:FBpp0113052|uniprotkb:O02433|uniprotkb:O76797|uniprotkb:O76798|uniprotkb:Q95T94|uniprotkb:Q9UB42|uniprotkb:Q9W5E3 psi-mi:q7k105_drome(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)|uniprotkb:DMMYD88(gene name synonym)|uniprotkb:DmMyD88(gene name synonym)|uniprotkb:DmMyd88(gene name synonym)|uniprotkb:Dmel\CG2078(gene name synonym)|uniprotkb:"EP(2)2535"(gene name synonym)|uniprotkb:Kra(gene name synonym)|uniprotkb:LD20892(gene name synonym)|uniprotkb:MYD88(gene name synonym)|uniprotkb:MyD88(gene name synonym)|uniprotkb:Myd88F(gene name synonym)|uniprotkb:dMYd88(gene name synonym)|uniprotkb:dMyD88(gene name synonym)|uniprotkb:dMyd88(gene name synonym)|uniprotkb:kra(gene name synonym)|uniprotkb:myd88(gene name synonym)|uniprotkb:CG2078(orf name)|uniprotkb:Dmel_CG2078(orf name) psi-mi:casp8_drome(display_long)|uniprotkb:Death-related ced-3/NEDD2-like protein(gene name synonym)|uniprotkb:Dredd(gene name)|psi-mi:Dredd(display_short)|uniprotkb:DCP2(gene name synonym)|uniprotkb:CG7486(orf name) psi-mi:"MI:0019"(coimmunoprecipitation) Horng et al. (2001) pubmed:11606776|mint:MINT-5214706 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-524729 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_610479.1|flybase:FBgn0033402|refseq:NP_001286246.1|ensemblmetazoa:FBgn0033402(gene)|ensemblmetazoa:FBtr0088598(transcript)|ensemblmetazoa:FBtr0333000(transcript)|ensemblmetazoa:FBtr0345024(transcript)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0002347"(response to tumor cell)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002804"(positive regulation of antifungal peptide production)|go:"GO:0005121"(Toll binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050832"(defense response to fungus)|go:"GO:0070976"(TIR domain binding)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR035897|reactome:R-DME-1810476|reactome:R-DME-209442|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214862|reactome:R-DME-214863|reactome:R-DME-214869|reactome:R-DME-214874|reactome:R-DME-3134963|interpro:IPR000157(Toll-Interleukin receptor)|refseq:NP_001260821.1 ensemblmetazoa:FBgn0020381(gene)|ensemblmetazoa:FBtr0114560(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0006963"(positive regulation of antibacterial peptide biosynthetic process)|go:"GO:0006964"(positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria)|go:"GO:0007291"(sperm individualization)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|reactome:R-DME-198323|reactome:R-DME-214397|reactome:R-DME-214399|reactome:R-DME-214411|reactome:R-DME-214416|reactome:R-DME-448706|go:"GO:0061057"(peptidoglycan recognition protein signaling pathway)|flybase:FBgn0020381|refseq:NP_477249.3|refseq:NP_477250.3|refseq:NP_477251.3 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:7227(drome-salivary_gland)|taxid:7227(Drosophila melanogaster Salivary gland) - 2001/12/19 2014/10/16 rogid:ylgI2zl+aLG3S8D2ER2DrTRUpI47227 rogid:8VF2wS5q6ZXJbm/BlLH8aUFz9bw7227 intact-crc:10620FC2316D0AD1|rigid:njUEqxOY+GekyL4yLBQO7OGoRsU false v5 tag:?-? flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)