#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y2G2	uniprotkb:Q9Y6K9	intact:EBI-2808370|ensembl:ENSP00000375767|ensembl:ENSP00000428883|ensembl:ENSP00000499211|uniprotkb:Q96P82|uniprotkb:Q6PGP8|uniprotkb:B7Z496|uniprotkb:B7Z4A2|uniprotkb:G3XAM9|uniprotkb:B5KVR6|uniprotkb:E9PEM7|uniprotkb:B5KVR8|uniprotkb:E5RFV9	intact:EBI-81279|intact:EBI-356130|uniprotkb:Q7LBY6|uniprotkb:Q7Z7F1|ensembl:ENSP00000471166|ensembl:ENSP00000479662	psi-mi:card8_human(display_long)|uniprotkb:CARD8(gene name)|psi-mi:CARD8(display_short)|uniprotkb:KIAA0955(gene name synonym)|uniprotkb:NDPP1(gene name synonym)|uniprotkb:CARD-inhibitor of NF-kappa-B-activating ligand(gene name synonym)|uniprotkb:DACAR(gene name synonym)|uniprotkb:Tumor up-regulated CARD-containing antagonist of CASP9(gene name synonym)	psi-mi:nemo_human(display_long)|uniprotkb:IKBKG(gene name)|psi-mi:IKBKG(display_short)|uniprotkb:FIP3(gene name synonym)|uniprotkb:NEMO(gene name synonym)|uniprotkb:NF-kappa-B essential modifier(gene name synonym)|uniprotkb:Inhibitor of nuclear factor kappa-B kinase subunit gamma(gene name synonym)|uniprotkb:IkB kinase-associated protein 1(gene name synonym)|uniprotkb:FIP-3(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Bouchier-Hayes et al. (2001)	pubmed:11551959|mint:MINT-5214513	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7968341|mint:MINT-17746	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105483(gene)|ensembl:ENST00000391898(transcript)|ensembl:ENST00000519940(transcript)|ensembl:ENST00000651546(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008233"(peptidase activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032089"(NACHT domain binding)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061702"(inflammasome complex)|go:"GO:0070269"(pyroptosis)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097264"(self proteolysis)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140608"(cysteine-type endopeptidase activator activity)|go:"GO:0140633"(CARD8 inflammasome complex assembly)|go:"GO:0140634"(CARD8 inflammasome complex)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR025307|rcsb pdb:4IKM|rcsb pdb:6K9F|rcsb pdb:6XKJ|rcsb pdb:7JKQ|rcsb pdb:7JN7|reactome:R-HSA-111458|reactome:R-HSA-9627069|refseq:XP_011524943.1|refseq:XP_011524944.1|refseq:XP_011524945.1|refseq:XP_011524946.1|refseq:XP_011524952.1|refseq:NP_001171833.1|refseq:XP_006723173.1|refseq:NP_001171829.1|refseq:NP_001171830.1|refseq:NP_001171831.1|refseq:NP_001171832.1|refseq:NP_055774.2|refseq:XP_016881972.1|refseq:XP_016881979.1|refseq:XP_016881987.1|refseq:XP_006723154.1|refseq:XP_006723155.1|refseq:XP_006723156.1|refseq:XP_006723158.1|refseq:XP_006723159.1|refseq:XP_006723160.1|refseq:XP_006723167.1|refseq:XP_006723169.1|refseq:XP_006723172.1|mint:MINT-586690(identity)	refseq:NP_001308325.1|refseq:NP_001308326.1|refseq:NP_001093326.2|refseq:NP_001093327.1|refseq:NP_001138727.1|refseq:NP_003630.1|dip:DIP-27528N|ensembl:ENSG00000269335(gene)|ensembl:ENST00000594239(transcript)|ensembl:ENST00000611071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990450"(linear polyubiquitin binding)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR021063|interpro:IPR032419|interpro:IPR034735|mint:Q9Y6K9|rcsb pdb:2JVX|rcsb pdb:2JVY|rcsb pdb:3BRT|rcsb pdb:3BRV|rcsb pdb:3CL3|rcsb pdb:3FX0|rcsb pdb:4BWN|rcsb pdb:5AAY|rcsb pdb:5LDE|rcsb pdb:6MI3|rcsb pdb:6MI4|rcsb pdb:6YEK|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-4755510|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5684264|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|mint:MINT-586693(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/11/17	2021/06/18	rogid:WCpalGD3/kZFOTQQNc42fKReKAA9606	rogid:9OeZIMeJvNtDEMoiLaKwVEpxSSM9606	intact-crc:1EEA3486D918785D|rigid:5zn3E6F3PqGowiNgQguxl8H6LDw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)