#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O43639	uniprotkb:Q14185	intact:EBI-713635|uniprotkb:Q9BWN9|uniprotkb:Q9UIC3|ensembl:ENSP00000233154|ensembl:ENSP00000377018|uniprotkb:D3DVK1	intact:EBI-446740|uniprotkb:A9Z1Z5|ensembl:ENSP00000280333	psi-mi:nck2_human(display_long)|uniprotkb:NCK adaptor protein 2(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-beta(gene name synonym)|uniprotkb:NCK2(gene name)|psi-mi:NCK2(display_short)|uniprotkb:GRB4(gene name synonym)|uniprotkb:Growth factor receptor-bound protein 4(gene name synonym)	psi-mi:dock1_human(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:DOCK1(gene name)|psi-mi:DOCK1(display_short)	psi-mi:"MI:0018"(two hybrid)	Tu et al. (2001)	pubmed:11240126|mint:MINT-5213677	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7791508|mint:MINT-14290	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006712860.1|refseq:NP_001004720.1|refseq:NP_003572.2|ensembl:ENSG00000071051(gene)|ensembl:ENST00000233154(transcript)|ensembl:ENST00000393349(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0060996"(dendritic spine development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028524|interpro:IPR035559|interpro:IPR035560|interpro:IPR035561|interpro:IPR035883|interpro:IPR036028|interpro:IPR036860|mint:O43639|rcsb pdb:1U5S|rcsb pdb:1WX6|rcsb pdb:1Z3K|rcsb pdb:2B86|rcsb pdb:2CIA|rcsb pdb:2FRW|rcsb pdb:2FRY|rcsb pdb:2JXB|rcsb pdb:4E6R|reactome:R-HSA-186763|reactome:R-HSA-373753|reactome:R-HSA-3928664|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-8985801|reactome:R-HSA-9013420|reactome:R-HSA-9013424|refseq:XP_016860592.1|refseq:XP_016860593.1|refseq:XP_016860594.1|refseq:XP_011510293.1|mint:MINT-469718(identity)	ensembl:ENSP00000280333|dip:DIP-29391N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000150760(gene)|ensembl:ENST00000280333(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|mint:Q14185|rcsb pdb:3L4C|reactome:R-HSA-2029482|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|reactome:R-HSA-983231|interpro:IPR043162|refseq:NP_001371.1|mint:MINT-469727(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:domino|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/03/19	2014/10/16	rogid:WV9nJ78Im/ga5KQlRuSN2ODzWpQ9606	rogid:SsN4jN+OIbDOnPEthCF7ZdEJrdc9606	intact-crc:FCBCFB21FDF41A97|rigid:nrjKLXPPABYLNgXR0rvrf7vxS7o	false	binding-associated region:196-258(MINT-469719)|tag:?-?(MINT-469722)	tag:?-?(MINT-469730)|binding-associated region:1819-1836(MINT-469728)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q14185	uniprotkb:O43639	intact:EBI-446740|uniprotkb:A9Z1Z5|ensembl:ENSP00000280333	intact:EBI-713635|uniprotkb:Q9BWN9|uniprotkb:Q9UIC3|ensembl:ENSP00000233154|ensembl:ENSP00000377018|uniprotkb:D3DVK1	psi-mi:dock1_human(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:DOCK1(gene name)|psi-mi:DOCK1(display_short)	psi-mi:nck2_human(display_long)|uniprotkb:NCK adaptor protein 2(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-beta(gene name synonym)|uniprotkb:NCK2(gene name)|psi-mi:NCK2(display_short)|uniprotkb:GRB4(gene name synonym)|uniprotkb:Growth factor receptor-bound protein 4(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Tu et al. (2001)	pubmed:11240126|mint:MINT-5213677	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7791560|mint:MINT-14292	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000280333|dip:DIP-29391N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000150760(gene)|ensembl:ENST00000280333(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|mint:Q14185|rcsb pdb:3L4C|reactome:R-HSA-2029482|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|reactome:R-HSA-983231|interpro:IPR043162|refseq:NP_001371.1|mint:MINT-469696(identity)	refseq:XP_006712860.1|refseq:NP_001004720.1|refseq:NP_003572.2|ensembl:ENSG00000071051(gene)|ensembl:ENST00000233154(transcript)|ensembl:ENST00000393349(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0060996"(dendritic spine development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028524|interpro:IPR035559|interpro:IPR035560|interpro:IPR035561|interpro:IPR035883|interpro:IPR036028|interpro:IPR036860|mint:O43639|rcsb pdb:1U5S|rcsb pdb:1WX6|rcsb pdb:1Z3K|rcsb pdb:2B86|rcsb pdb:2CIA|rcsb pdb:2FRW|rcsb pdb:2FRY|rcsb pdb:2JXB|rcsb pdb:4E6R|reactome:R-HSA-186763|reactome:R-HSA-373753|reactome:R-HSA-3928664|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-8985801|reactome:R-HSA-9013420|reactome:R-HSA-9013424|refseq:XP_016860592.1|refseq:XP_016860593.1|refseq:XP_016860594.1|refseq:XP_011510293.1|mint:MINT-469690(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:domino|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/03/19	2014/10/16	rogid:SsN4jN+OIbDOnPEthCF7ZdEJrdc9606	rogid:WV9nJ78Im/ga5KQlRuSN2ODzWpQ9606	intact-crc:FEC81450ECD06CB2|rigid:nrjKLXPPABYLNgXR0rvrf7vxS7o	false	binding-associated region:1819-1836(MINT-469697)	binding-associated region:196-258(MINT-469691)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43639	uniprotkb:Q14185	intact:EBI-713635|uniprotkb:Q9BWN9|uniprotkb:Q9UIC3|ensembl:ENSP00000233154|ensembl:ENSP00000377018|uniprotkb:D3DVK1	intact:EBI-446740|uniprotkb:A9Z1Z5|ensembl:ENSP00000280333	psi-mi:nck2_human(display_long)|uniprotkb:NCK adaptor protein 2(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-beta(gene name synonym)|uniprotkb:NCK2(gene name)|psi-mi:NCK2(display_short)|uniprotkb:GRB4(gene name synonym)|uniprotkb:Growth factor receptor-bound protein 4(gene name synonym)	psi-mi:dock1_human(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:DOCK1(gene name)|psi-mi:DOCK1(display_short)	psi-mi:"MI:0096"(pull down)	Tu et al. (2001)	pubmed:11240126|mint:MINT-5213677	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7791589|mint:MINT-14291	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006712860.1|refseq:NP_001004720.1|refseq:NP_003572.2|ensembl:ENSG00000071051(gene)|ensembl:ENST00000233154(transcript)|ensembl:ENST00000393349(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0060996"(dendritic spine development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028524|interpro:IPR035559|interpro:IPR035560|interpro:IPR035561|interpro:IPR035883|interpro:IPR036028|interpro:IPR036860|mint:O43639|rcsb pdb:1U5S|rcsb pdb:1WX6|rcsb pdb:1Z3K|rcsb pdb:2B86|rcsb pdb:2CIA|rcsb pdb:2FRW|rcsb pdb:2FRY|rcsb pdb:2JXB|rcsb pdb:4E6R|reactome:R-HSA-186763|reactome:R-HSA-373753|reactome:R-HSA-3928664|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-8985801|reactome:R-HSA-9013420|reactome:R-HSA-9013424|refseq:XP_016860592.1|refseq:XP_016860593.1|refseq:XP_016860594.1|refseq:XP_011510293.1|mint:MINT-469705(identity)	ensembl:ENSP00000280333|dip:DIP-29391N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000150760(gene)|ensembl:ENST00000280333(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|mint:Q14185|rcsb pdb:3L4C|reactome:R-HSA-2029482|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|reactome:R-HSA-983231|interpro:IPR043162|refseq:NP_001371.1|mint:MINT-469711(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:domino|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2001/03/19	2014/10/16	rogid:WV9nJ78Im/ga5KQlRuSN2ODzWpQ9606	rogid:SsN4jN+OIbDOnPEthCF7ZdEJrdc9606	intact-crc:5F6E69B77FB3923A|rigid:nrjKLXPPABYLNgXR0rvrf7vxS7o	false	binding-associated region:196-258(MINT-469706)	binding-associated region:1819-1836(MINT-469712)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)