#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O14924 uniprotkb:Q02294 intact:EBI-7358493|intact:MINT-154790|uniprotkb:B1AQ31|uniprotkb:O14923|uniprotkb:B1AQ32|uniprotkb:O14922|uniprotkb:O75338|uniprotkb:O43510|uniprotkb:B1AQ30|uniprotkb:E7EMN9|uniprotkb:Q147X0|uniprotkb:Q8WX95|ensembl:ENSP00000338509|ensembl:ENSP00000339381|uniprotkb:B7Z764 intact:EBI-540038 psi-mi:rgs12_human(display_long)|uniprotkb:RGS12(gene name)|psi-mi:RGS12(display_short) psi-mi:cac1b_rat(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide isoform 5(gene name synonym)|uniprotkb:Brain calcium channel III(gene name synonym)|uniprotkb:Cacna1b(gene name)|psi-mi:Cacna1b(display_short)|uniprotkb:Cach5(gene name synonym)|uniprotkb:Cacnl1a5(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Schiff et al. (2000) pubmed:11130074|mint:MINT-5213349 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7469196|mint:MINT-14859 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011511845.1|refseq:NP_002917.1|refseq:NP_937872.1|refseq:NP_937870.1|refseq:XP_016864018.1|refseq:XP_016864020.1|refseq:XP_016864021.1|refseq:XP_016864022.1|ensembl:ENSG00000159788(gene)|ensembl:ENST00000336727(transcript)|ensembl:ENST00000344733(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045202"(synapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003109(GoLoco)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR036034|interpro:IPR036305|interpro:IPR037880|rcsb pdb:2EBZ|rcsb pdb:2KV8|reactome:R-HSA-418594|refseq:XP_006713968.1|refseq:XP_006713969.1|refseq:XP_006713970.1|mint:MINT-442940(identity) rgd:628852|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR005447(Voltage-dependent calcium channel, N-type, alpha-1 subunit)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0045471"(response to ethanol)|go:"GO:0048265"(response to pain)|interpro:IPR031649|interpro:IPR043203|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:0050804"(modulation of chemical synaptic transmission)|rcsb pdb:4DEX|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR027359|reactome:R-RNO-112308|mint:MINT-442946(identity) - function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form|comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2001/02/08 2014/10/16 rogid:86ann2gpd8ZhURj5bP5EhPwz9Fo9606 rogid:hpV4gZ1tOmB6Pqvsry18/tzzxhU10116 intact-crc:94D2BE16AD0A443C|rigid:hvXzlnZnJ/tQJdnlnmoKS7fIoqk false binding-associated region:228-340(MINT-442941) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)