#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q14118	uniprotkb:P62994	intact:EBI-1755945|uniprotkb:A8K6M7|uniprotkb:Q969J9|ensembl:ENSP00000312435|ensembl:ENSP00000438421|ensembl:ENSP00000439334|ensembl:ENSP00000440590|ensembl:ENSP00000440705|ensembl:ENSP00000442600|ensembl:ENSP00000501140	intact:EBI-401775|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q5BKA7|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSRNOP00000005347	psi-mi:dag1_human(display_long)|uniprotkb:DAG1(gene name)|psi-mi:DAG1(display_short)|uniprotkb:Dystrophin-associated glycoprotein 1(gene name synonym)|uniprotkb:Dystroglycan(gene name synonym)	psi-mi:grb2_rat(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Ash(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Russo et al. (2000)	pubmed:10903901|mint:MINT-5212801	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7351553|mint:MINT-19267	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159400.2|refseq:NP_001171105.1|refseq:NP_001171106.1|refseq:NP_001171107.1|refseq:NP_001171108.1|refseq:NP_001171109.1|refseq:NP_001171110.1|refseq:NP_001171111.1|refseq:NP_001171112.1|refseq:NP_001171113.1|refseq:NP_001171114.1|refseq:NP_001171115.1|refseq:NP_004384.4|ensembl:ENSP00000312435|ensembl:ENSP00000440705|ensembl:ENSP00000438421|ensembl:ENSP00000439334|ensembl:ENSP00000440590|ensembl:ENSP00000442600|ensembl:ENSP00000501140|dip:DIP-40928N|ensembl:ENSG00000173402(gene)|ensembl:ENST00000308775(transcript)|ensembl:ENST00000515359(transcript)|ensembl:ENST00000538711(transcript)|ensembl:ENST00000539901(transcript)|ensembl:ENST00000541308(transcript)|ensembl:ENST00000545947(transcript)|ensembl:ENST00000673708(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007411"(axon guidance)|go:"GO:0007568"(aging)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016011"(dystroglycan complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016203"(muscle attachment)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0017166"(vinculin binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0021675"(nerve development)|go:"GO:0021682"(nerve maturation)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031103"(axon regeneration)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0033268"(node of Ranvier)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043236"(laminin binding)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070938"(contractile ring)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0071711"(basement membrane organization)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|interpro:IPR006644(Dystroglycan-type cadherin-like)|interpro:IPR008465(Dystroglycan)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015919(Cadherin-like)|interpro:IPR027468|interpro:IPR030398|interpro:IPR041631|rcsb pdb:1EG4|rcsb pdb:2MK7|rcsb pdb:5GGP|rcsb pdb:5LLK|rcsb pdb:6JJY|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-5083628|reactome:R-HSA-5083629|reactome:R-HSA-5083633|reactome:R-HSA-5173105|reactome:R-HSA-9010553|reactome:R-HSA-9619665|mint:MINT-428030(identity)	rgd:619758|refseq:NP_110473.2|ensembl:ENSRNOG00000003990(gene)|ensembl:ENSRNOT00000005347(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62994|reactome:R-RNO-109704|reactome:R-RNO-112412|reactome:R-RNO-1250347|reactome:R-RNO-1257604|reactome:R-RNO-1295596|reactome:R-RNO-1433557|reactome:R-RNO-1433559|reactome:R-RNO-167044|reactome:R-RNO-179812|reactome:R-RNO-180292|reactome:R-RNO-180336|reactome:R-RNO-182971|reactome:R-RNO-186763|reactome:R-RNO-1963640|reactome:R-RNO-1963642|reactome:R-RNO-2029482|reactome:R-RNO-210993|reactome:R-RNO-2179392|reactome:R-RNO-2424491|reactome:R-RNO-2428933|reactome:R-RNO-2730905|reactome:R-RNO-2871796|reactome:R-RNO-2871809|reactome:R-RNO-354194|reactome:R-RNO-375165|reactome:R-RNO-388841|reactome:R-RNO-389359|reactome:R-RNO-391160|reactome:R-RNO-5654688|reactome:R-RNO-5654689|reactome:R-RNO-5654693|reactome:R-RNO-5654695|reactome:R-RNO-5654699|reactome:R-RNO-5654700|reactome:R-RNO-5654704|reactome:R-RNO-5654706|reactome:R-RNO-5654710|reactome:R-RNO-5654712|reactome:R-RNO-5654719|reactome:R-RNO-5654720|reactome:R-RNO-5654726|reactome:R-RNO-5654727|reactome:R-RNO-5654732|reactome:R-RNO-5654733|reactome:R-RNO-5663213|reactome:R-RNO-5673001|reactome:R-RNO-6807004|reactome:R-RNO-6811558|reactome:R-RNO-74749|reactome:R-RNO-74751|reactome:R-RNO-8851805|reactome:R-RNO-8851907|reactome:R-RNO-8853659|reactome:R-RNO-8856828|reactome:R-RNO-8865999|reactome:R-RNO-8875555|reactome:R-RNO-8875656|reactome:R-RNO-8983432|reactome:R-RNO-9027284|reactome:R-RNO-9028731|reactome:R-RNO-912526|reactome:R-RNO-912631|reactome:R-RNO-9607240|reactome:R-RNO-9674555|reactome:R-RNO-983695|reactome:R-RNO-8856825|mint:MINT-428024(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:Both the SH3 domains of Grb2 binds the destroglycan, but the N-terminal binds more strongly.|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2001/03/30	2014/10/16	rogid:q+98wmc5ueyzkpOCrold06eukRg9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA410116	intact-crc:7026A8488922B9FE|rigid:tBQAWtQOzroycrB/grBkN3mz7Qk	false	binding-associated region:821-895(MINT-428031)	binding-associated region:1-57(MINT-428025)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)