#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49810	uniprotkb:P30626	intact:EBI-2010251|uniprotkb:Q96P32|uniprotkb:B1AP21|uniprotkb:A8K8D4|ensembl:ENSP00000355746|ensembl:ENSP00000355747|ensembl:ENSP00000429036|ensembl:ENSP00000486498|ensembl:ENSP00000503116|ensembl:ENSP00000504303|ensembl:ENSP00000504727|ensembl:ENSP00000504728	intact:EBI-750459|uniprotkb:D6W5Q0|intact:EBI-2623494|uniprotkb:A8MTH6|uniprotkb:B4DKK2|ensembl:ENSP00000265729	psi-mi:psn2_human(display_long)|uniprotkb:PSEN2(gene name)|psi-mi:PSEN2(display_short)|uniprotkb:AD4(gene name synonym)|uniprotkb:PS2(gene name synonym)|uniprotkb:PSNL2(gene name synonym)|uniprotkb:STM2(gene name synonym)|uniprotkb:STM-2(gene name synonym)|uniprotkb:E5-1(gene name synonym)|uniprotkb:AD3LP(gene name synonym)|uniprotkb:AD5(gene name synonym)	psi-mi:sorcn_human(display_long)|uniprotkb:22 kDa protein(gene name synonym)|uniprotkb:CP-22(gene name synonym)|uniprotkb:V19(gene name synonym)|uniprotkb:SRI(gene name)|psi-mi:SRI(display_short)	psi-mi:"MI:0049"(filter binding)	Pack-Chung et al. (2000)	pubmed:10748169|mint:MINT-5212422	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7255001|mint:MINT-17115	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016857324.1|refseq:XP_016857325.1|refseq:NP_000438.2|refseq:NP_036618.2|refseq:XP_005273256.1|ensembl:ENSG00000143801(gene)|ensembl:ENST00000366782(transcript)|ensembl:ENST00000366783(transcript)|ensembl:ENST00000524196(transcript)|ensembl:ENST00000626989(transcript)|ensembl:ENST00000677414(transcript)|ensembl:ENST00000678233(transcript)|ensembl:ENST00000679088(transcript)|ensembl:ENST00000679098(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030018"(Z disc)|go:"GO:0030426"(growth cone)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0110097"(regulation of calcium import into the mitochondrion)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR001493(Peptidase A22A, presenilin 2)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|reactome:R-HSA-1251985|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|mint:MINT-415296(identity)	refseq:NP_944490.1|refseq:NP_003121.1|refseq:NP_001243820.1|refseq:NP_001243821.1|dip:DIP-40970N|ensembl:ENSG00000075142(gene)|ensembl:ENST00000265729(transcript)|go:"GO:0001508"(action potential)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006880"(intracellular sequestering of iron ion)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0030315"(T-tubule)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901077"(regulation of relaxation of muscle)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030018"(Z disc)|rcsb pdb:2JC2|rcsb pdb:4U8D|rcsb pdb:4UPG|rcsb pdb:4USL|rcsb pdb:5MRA|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P30626|rcsb pdb:1JUO|mint:MINT-415293(identity)	-	comment:"Stoichiometry: 1.0"	crc64:A4829C7650A5E3FA|comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Cardiac - Interactions involving cardiac related proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2001/03/05	2014/10/16	rogid:+oNBP2O73tVWWMT6va284jSOmoc9606	rogid:upE31IMimaotkgnYa7HYr7EYAxc9606	intact-crc:F705CA665121FE27|rigid:AQ8lV9NEu4xKcI+vMzO9ZYAR6zk	false	binding-associated region:319-347(MINT-415297)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P30626	uniprotkb:P49810	intact:EBI-750459|uniprotkb:D6W5Q0|intact:EBI-2623494|uniprotkb:A8MTH6|uniprotkb:B4DKK2|ensembl:ENSP00000265729	intact:EBI-2010251|uniprotkb:Q96P32|uniprotkb:B1AP21|uniprotkb:A8K8D4|ensembl:ENSP00000355746|ensembl:ENSP00000355747|ensembl:ENSP00000429036|ensembl:ENSP00000486498|ensembl:ENSP00000503116|ensembl:ENSP00000504303|ensembl:ENSP00000504727|ensembl:ENSP00000504728	psi-mi:sorcn_human(display_long)|uniprotkb:22 kDa protein(gene name synonym)|uniprotkb:CP-22(gene name synonym)|uniprotkb:V19(gene name synonym)|uniprotkb:SRI(gene name)|psi-mi:SRI(display_short)	psi-mi:psn2_human(display_long)|uniprotkb:PSEN2(gene name)|psi-mi:PSEN2(display_short)|uniprotkb:AD4(gene name synonym)|uniprotkb:PS2(gene name synonym)|uniprotkb:PSNL2(gene name synonym)|uniprotkb:STM2(gene name synonym)|uniprotkb:STM-2(gene name synonym)|uniprotkb:E5-1(gene name synonym)|uniprotkb:AD3LP(gene name synonym)|uniprotkb:AD5(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Pack-Chung et al. (2000)	pubmed:10748169|mint:MINT-5212422	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7255040|mint:MINT-17116	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_944490.1|refseq:NP_003121.1|refseq:NP_001243820.1|refseq:NP_001243821.1|dip:DIP-40970N|ensembl:ENSG00000075142(gene)|ensembl:ENST00000265729(transcript)|go:"GO:0001508"(action potential)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006880"(intracellular sequestering of iron ion)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0030315"(T-tubule)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901077"(regulation of relaxation of muscle)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030018"(Z disc)|rcsb pdb:2JC2|rcsb pdb:4U8D|rcsb pdb:4UPG|rcsb pdb:4USL|rcsb pdb:5MRA|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P30626|rcsb pdb:1JUO|mint:MINT-415305(identity)	refseq:XP_016857324.1|refseq:XP_016857325.1|refseq:NP_000438.2|refseq:NP_036618.2|refseq:XP_005273256.1|ensembl:ENSG00000143801(gene)|ensembl:ENST00000366782(transcript)|ensembl:ENST00000366783(transcript)|ensembl:ENST00000524196(transcript)|ensembl:ENST00000626989(transcript)|ensembl:ENST00000677414(transcript)|ensembl:ENST00000678233(transcript)|ensembl:ENST00000679088(transcript)|ensembl:ENST00000679098(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030018"(Z disc)|go:"GO:0030426"(growth cone)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0110097"(regulation of calcium import into the mitochondrion)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR001493(Peptidase A22A, presenilin 2)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|reactome:R-HSA-1251985|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|mint:MINT-415308(identity)	-	crc64:A4829C7650A5E3FA|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Cardiac - Interactions involving cardiac related proteins	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/03/05	2014/10/16	rogid:upE31IMimaotkgnYa7HYr7EYAxc9606	rogid:+oNBP2O73tVWWMT6va284jSOmoc9606	intact-crc:5994083D3C19D8F9|rigid:AQ8lV9NEu4xKcI+vMzO9ZYAR6zk	false	-	binding-associated region:319-347(MINT-415309)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)