#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P84024	uniprotkb:Q9WVQ1	intact:EBI-7201631|ensembl:ENSSSCP00000005327|ensembl:ENSSSCP00005035375|ensembl:ENSSSCP00015024943|ensembl:ENSSSCP00030029587|ensembl:ENSSSCP00035031189|ensembl:ENSSSCP00025018565|ensembl:ENSSSCP00040017352|ensembl:ENSSSCP00045012692|ensembl:ENSSSCP00050001837|ensembl:ENSSSCP00055048056|ensembl:ENSSSCP00060039794|ensembl:ENSSSCP00070012342|uniprotkb:Q9GKR4|uniprotkb:O35273|uniprotkb:O14510|intact:MINT-122157|uniprotkb:Q93002|uniprotkb:O09144|uniprotkb:O09064|uniprotkb:Q92940	intact:EBI-297151|uniprotkb:Q3UH81|uniprotkb:Q6GT88|ensembl:ENSMUSP00000085872|uniprotkb:Q8BYT1|uniprotkb:Q8CA85	psi-mi:smad3_pig(display_long)|uniprotkb:SMAD3(gene name)|psi-mi:SMAD3(display_short)|uniprotkb:MADH3(gene name synonym)|uniprotkb:SMAD family member 3(gene name synonym)	psi-mi:magi2_mouse(display_long)|uniprotkb:Magi2(gene name)|psi-mi:Magi2(display_short)|uniprotkb:Acvrinp1(gene name synonym)|uniprotkb:Arip1(gene name synonym)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Activin receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Shoji et al. (2000)	pubmed:10681527|mint:MINT-5212255	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7201628|mint:MINT-16328	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSSSCG00000004952(gene)|ensembl:ENSSSCG00005035367(gene)|ensembl:ENSSSCG00015045925(gene)|ensembl:ENSSSCG00025032064(gene)|ensembl:ENSSSCG00030046321(gene)|ensembl:ENSSSCG00035057061(gene)|ensembl:ENSSSCG00040030551(gene)|ensembl:ENSSSCG00045010800(gene)|ensembl:ENSSSCG00050003377(gene)|ensembl:ENSSSCG00055030102(gene)|ensembl:ENSSSCG00060067444(gene)|ensembl:ENSSSCG00070007681(gene)|ensembl:ENSSSCT00000005464(transcript)|ensembl:ENSSSCT00005057440(transcript)|ensembl:ENSSSCT00015062164(transcript)|ensembl:ENSSSCT00025043673(transcript)|ensembl:ENSSSCT00030064740(transcript)|ensembl:ENSSSCT00035076339(transcript)|ensembl:ENSSSCT00040041424(transcript)|ensembl:ENSSSCT00045018396(transcript)|ensembl:ENSSSCT00050004607(transcript)|ensembl:ENSSSCT00055059976(transcript)|ensembl:ENSSSCT00060092092(transcript)|ensembl:ENSSSCT00070014919(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|refseq:NP_999302.1|mint:MINT-383310(identity)	ensembl:ENSMUSG00000040003(gene)|ensembl:ENSMUST00000088516(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030036|interpro:IPR036020|interpro:IPR036034|rcsb pdb:6JJZ|rcsb pdb:6KKG|rcsb pdb:7D6F|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|refseq:NP_001164216.1|refseq:NP_001164217.1|refseq:NP_056638.1|mint:MINT-383304(identity)	-	function:"Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor-regulated SMAD (R-SMAD)"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/03/05	2014/10/16	rogid:47/62Iz3MOJAyDNCYtisL+unRDg9823	rogid:Dj0efnLWnVFm5op5RjDEVBl1NF810090	intact-crc:4570863E19AA25EB|rigid:DRrlICv92jM/kYzC6Se5FNJ/aTk	false	-	binding-associated region:139-217(MINT-383305)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27037	uniprotkb:Q9WVQ1	intact:EBI-296189|intact:EBI-1383627|uniprotkb:Q92474|ensembl:ENSP00000241416|ensembl:ENSP00000384338|uniprotkb:Q53TH4|uniprotkb:Q6NWV2|uniprotkb:B2RAB8|uniprotkb:B4DWQ2|uniprotkb:D3DP85	intact:EBI-297151|uniprotkb:Q3UH81|uniprotkb:Q6GT88|ensembl:ENSMUSP00000085872|uniprotkb:Q8BYT1|uniprotkb:Q8CA85	psi-mi:avr2a_human(display_long)|uniprotkb:ACVR2A(gene name)|psi-mi:ACVR2A(display_short)|uniprotkb:ACVR2(gene name synonym)|uniprotkb:Activin receptor type IIA(gene name synonym)	psi-mi:magi2_mouse(display_long)|uniprotkb:Magi2(gene name)|psi-mi:Magi2(display_short)|uniprotkb:Acvrinp1(gene name synonym)|uniprotkb:Arip1(gene name synonym)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Activin receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Shoji et al. (2000)	pubmed:10681527|mint:MINT-5212255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7201693|mint:MINT-16224	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|ensembl:ENST00000404590(transcript)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0007498"(mesoderm development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0005737"(cytoplasm)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0034673"(inhibin-betaglycan-ActRII complex)|go:"GO:0034711"(inhibin binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0060011"(Sertoli cell proliferation)|ensembl:ENSG00000121989(gene)|ensembl:ENST00000241416(transcript)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098821"(BMP receptor activity)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:3Q4T|rcsb pdb:3SOC|rcsb pdb:4ASX|rcsb pdb:5NH3|reactome:R-HSA-1181150|reactome:R-HSA-1433617|reactome:R-HSA-1502540|reactome:R-HSA-201451|refseq:NP_001607.1|refseq:NP_001265508.1|refseq:NP_001265509.1|dip:DIP-520N|mint:MINT-383380(identity)	ensembl:ENSMUSG00000040003(gene)|ensembl:ENSMUST00000088516(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030036|interpro:IPR036020|interpro:IPR036034|rcsb pdb:6JJZ|rcsb pdb:6KKG|rcsb pdb:7D6F|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|refseq:NP_001164216.1|refseq:NP_001164217.1|refseq:NP_056638.1|mint:MINT-383374(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/03/05	2014/10/16	rogid:JWP9gi/caaa3Tpin8YoeVC7K1nM9606	rogid:Dj0efnLWnVFm5op5RjDEVBl1NF810090	intact-crc:BAD683BA2708EA55|rigid:j/ffRzvrWLTtMae0TP/5oGaQQZY	false	binding-associated region:510-513(MINT-383381)	binding-associated region:984-1058(MINT-383375)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P84024	uniprotkb:Q9WVQ1	intact:EBI-7201631|ensembl:ENSSSCP00000005327|ensembl:ENSSSCP00005035375|ensembl:ENSSSCP00015024943|ensembl:ENSSSCP00030029587|ensembl:ENSSSCP00035031189|ensembl:ENSSSCP00025018565|ensembl:ENSSSCP00040017352|ensembl:ENSSSCP00045012692|ensembl:ENSSSCP00050001837|ensembl:ENSSSCP00055048056|ensembl:ENSSSCP00060039794|ensembl:ENSSSCP00070012342|uniprotkb:Q9GKR4|uniprotkb:O35273|uniprotkb:O14510|intact:MINT-122157|uniprotkb:Q93002|uniprotkb:O09144|uniprotkb:O09064|uniprotkb:Q92940	intact:EBI-297151|uniprotkb:Q3UH81|uniprotkb:Q6GT88|ensembl:ENSMUSP00000085872|uniprotkb:Q8BYT1|uniprotkb:Q8CA85	psi-mi:smad3_pig(display_long)|uniprotkb:SMAD3(gene name)|psi-mi:SMAD3(display_short)|uniprotkb:MADH3(gene name synonym)|uniprotkb:SMAD family member 3(gene name synonym)	psi-mi:magi2_mouse(display_long)|uniprotkb:Magi2(gene name)|psi-mi:Magi2(display_short)|uniprotkb:Acvrinp1(gene name synonym)|uniprotkb:Arip1(gene name synonym)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Activin receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0011"(beta lactamase complementation)	Shoji et al. (2000)	pubmed:10681527|mint:MINT-5212255	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7201720|mint:MINT-16327	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSSSCG00000004952(gene)|ensembl:ENSSSCG00005035367(gene)|ensembl:ENSSSCG00015045925(gene)|ensembl:ENSSSCG00025032064(gene)|ensembl:ENSSSCG00030046321(gene)|ensembl:ENSSSCG00035057061(gene)|ensembl:ENSSSCG00040030551(gene)|ensembl:ENSSSCG00045010800(gene)|ensembl:ENSSSCG00050003377(gene)|ensembl:ENSSSCG00055030102(gene)|ensembl:ENSSSCG00060067444(gene)|ensembl:ENSSSCG00070007681(gene)|ensembl:ENSSSCT00000005464(transcript)|ensembl:ENSSSCT00005057440(transcript)|ensembl:ENSSSCT00015062164(transcript)|ensembl:ENSSSCT00025043673(transcript)|ensembl:ENSSSCT00030064740(transcript)|ensembl:ENSSSCT00035076339(transcript)|ensembl:ENSSSCT00040041424(transcript)|ensembl:ENSSSCT00045018396(transcript)|ensembl:ENSSSCT00050004607(transcript)|ensembl:ENSSSCT00055059976(transcript)|ensembl:ENSSSCT00060092092(transcript)|ensembl:ENSSSCT00070014919(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|refseq:NP_999302.1|mint:MINT-383326(identity)	ensembl:ENSMUSG00000040003(gene)|ensembl:ENSMUST00000088516(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030036|interpro:IPR036020|interpro:IPR036034|rcsb pdb:6JJZ|rcsb pdb:6KKG|rcsb pdb:7D6F|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|refseq:NP_001164216.1|refseq:NP_001164217.1|refseq:NP_056638.1|mint:MINT-383317(identity)	-	function:"Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor-regulated SMAD (R-SMAD)"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/03/05	2014/10/16	rogid:47/62Iz3MOJAyDNCYtisL+unRDg9823	rogid:Dj0efnLWnVFm5op5RjDEVBl1NF810090	intact-crc:984E999C5603E2C8|rigid:DRrlICv92jM/kYzC6Se5FNJ/aTk	false	tag:?-?(MINT-383327)	tag:?-?(MINT-383321)|binding-associated region:139-217(MINT-383318)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P27037	uniprotkb:Q9WVQ1	intact:EBI-296189|intact:EBI-1383627|uniprotkb:Q92474|ensembl:ENSP00000241416|ensembl:ENSP00000384338|uniprotkb:Q53TH4|uniprotkb:Q6NWV2|uniprotkb:B2RAB8|uniprotkb:B4DWQ2|uniprotkb:D3DP85	intact:EBI-297151|uniprotkb:Q3UH81|uniprotkb:Q6GT88|ensembl:ENSMUSP00000085872|uniprotkb:Q8BYT1|uniprotkb:Q8CA85	psi-mi:avr2a_human(display_long)|uniprotkb:ACVR2A(gene name)|psi-mi:ACVR2A(display_short)|uniprotkb:ACVR2(gene name synonym)|uniprotkb:Activin receptor type IIA(gene name synonym)	psi-mi:magi2_mouse(display_long)|uniprotkb:Magi2(gene name)|psi-mi:Magi2(display_short)|uniprotkb:Acvrinp1(gene name synonym)|uniprotkb:Arip1(gene name synonym)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Activin receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Shoji et al. (2000)	pubmed:10681527|mint:MINT-5212255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7201792|mint:MINT-16223	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|ensembl:ENST00000404590(transcript)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0007498"(mesoderm development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0005737"(cytoplasm)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0034673"(inhibin-betaglycan-ActRII complex)|go:"GO:0034711"(inhibin binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0060011"(Sertoli cell proliferation)|ensembl:ENSG00000121989(gene)|ensembl:ENST00000241416(transcript)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098821"(BMP receptor activity)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:3Q4T|rcsb pdb:3SOC|rcsb pdb:4ASX|rcsb pdb:5NH3|reactome:R-HSA-1181150|reactome:R-HSA-1433617|reactome:R-HSA-1502540|reactome:R-HSA-201451|refseq:NP_001607.1|refseq:NP_001265508.1|refseq:NP_001265509.1|dip:DIP-520N|mint:MINT-383345(identity)	ensembl:ENSMUSG00000040003(gene)|ensembl:ENSMUST00000088516(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030036|interpro:IPR036020|interpro:IPR036034|rcsb pdb:6JJZ|rcsb pdb:6KKG|rcsb pdb:7D6F|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|refseq:NP_001164216.1|refseq:NP_001164217.1|refseq:NP_056638.1|mint:MINT-383336(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/03/05	2014/10/16	rogid:JWP9gi/caaa3Tpin8YoeVC7K1nM9606	rogid:Dj0efnLWnVFm5op5RjDEVBl1NF810090	intact-crc:7C9065DF0E95797D|rigid:j/ffRzvrWLTtMae0TP/5oGaQQZY	false	binding-associated region:510-513(MINT-383346)|tag:?-?(MINT-383348)	tag:?-?(MINT-383340)|binding-associated region:984-1058(MINT-383337)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P38444	uniprotkb:O88382	intact:EBI-7201825|intact:MINT-263218	intact:EBI-696179|uniprotkb:Q9R271	psi-mi:avr2a_rat(display_long)|uniprotkb:Acvr2a(gene name)|psi-mi:Acvr2a(display_short)|uniprotkb:Actrii(gene name synonym)|uniprotkb:Acvr2(gene name synonym)|uniprotkb:Activin receptor type IIA(gene name synonym)	psi-mi:magi2_rat(display_long)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Synaptic-scaffolding molecule(gene name synonym)|uniprotkb:Sscam(gene name synonym)|uniprotkb:Magi2(gene name)|psi-mi:Magi2(display_short)|uniprotkb:Acvrinp1(gene name synonym)|uniprotkb:Aip1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Shoji et al. (2000)	pubmed:10681527|mint:MINT-5212255	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7201962|mint:MINT-16225	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0005737"(cytoplasm)|go:"GO:0007498"(mesoderm development)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009986"(cell surface)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0034673"(inhibin-betaglycan-ActRII complex)|go:"GO:0034711"(inhibin binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0060011"(Sertoli cell proliferation)|rcsb pdb:1NYS|rgd:70911|rcsb pdb:1NYU|refseq:NP_113759.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-RNO-1502540|reactome:R-RNO-201451|mint:MINT-383365(identity)	rgd:621855|refseq:NP_446073.1|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR030036|interpro:IPR027417|mint:O88382|interpro:IPR036020|interpro:IPR036034|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003094"(glomerular filtration)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|mint:MINT-383357(identity)	-	comment:mint|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F6|comment:homomint|comment:mint	taxid:10116(rat-hippocampus_neuron)|taxid:10116(Rattus norvegicus)	-	2001/03/05	2014/10/16	rogid:hwJxA1D+bSJ/ji5jxqSF2Pz4Ozs10116	rogid:aZhWv5f2U8vKQoE9oFMfsQ8rgvQ10116	intact-crc:617EDFE56210C4FD|rigid:yiGYt+3v3nhLl+LAa5isBFmju+M	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P38444	uniprotkb:P84025	intact:EBI-7201825|intact:MINT-263218	intact:EBI-7201857|ensembl:ENSRNOP00000037346|uniprotkb:Q9GKR4|uniprotkb:O14510|intact:MINT-2739536|uniprotkb:O09064|uniprotkb:O35273|uniprotkb:Q92940|uniprotkb:Q93002|uniprotkb:O09144	psi-mi:avr2a_rat(display_long)|uniprotkb:Acvr2a(gene name)|psi-mi:Acvr2a(display_short)|uniprotkb:Actrii(gene name synonym)|uniprotkb:Acvr2(gene name synonym)|uniprotkb:Activin receptor type IIA(gene name synonym)	psi-mi:smad3_rat(display_long)|uniprotkb:Smad3(gene name)|psi-mi:Smad3(display_short)|uniprotkb:Madh3(gene name synonym)|uniprotkb:SMAD family member 3(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Shoji et al. (2000)	pubmed:10681527|mint:MINT-5212255	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7201962|mint:MINT-16225	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0005737"(cytoplasm)|go:"GO:0007498"(mesoderm development)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009986"(cell surface)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0034673"(inhibin-betaglycan-ActRII complex)|go:"GO:0034711"(inhibin binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0060011"(Sertoli cell proliferation)|rcsb pdb:1NYS|rgd:70911|rcsb pdb:1NYU|refseq:NP_113759.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-RNO-1502540|reactome:R-RNO-201451|mint:MINT-383365(identity)	go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031962"(mineralocorticoid receptor binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0001756"(somitogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002076"(osteoblast development)|go:"GO:0002520"(immune system development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007369"(gastrulation)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P84025|reactome:R-RNO-1181150|reactome:R-RNO-1502540|reactome:R-RNO-2173788|reactome:R-RNO-2173789|reactome:R-RNO-2173795|reactome:R-RNO-2173796|reactome:R-RNO-5689880|reactome:R-RNO-8941855|reactome:R-RNO-9617828|ensembl:ENSRNOG00000008620(gene)|ensembl:ENSRNOT00000039730(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060039"(pericardium development)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061767"(negative regulation of lung blood pressure)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|rgd:3032|refseq:NP_037227.1|mint:MINT-5206912(identity)	-	comment:mint|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A|comment:"Stoichiometry: 1.0"	function:"Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor-regulated SMAD (R-SMAD)"|comment:mint	figure legend:F6|comment:homomint|comment:mint	taxid:10116(rat-hippocampus_neuron)|taxid:10116(Rattus norvegicus)	-	2001/03/05	2014/10/16	rogid:hwJxA1D+bSJ/ji5jxqSF2Pz4Ozs10116	rogid:47/62Iz3MOJAyDNCYtisL+unRDg10116	intact-crc:617EDFE56210C4FD|rigid:yiGYt+3v3nhLl+LAa5isBFmju+M	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)