#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P49418 uniprotkb:O43426 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 intact:EBI-2821539|uniprotkb:O43425|uniprotkb:O94984|uniprotkb:Q4KMR1|ensembl:ENSP00000501426 psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:synj1_human(display_long)|uniprotkb:SYNJ1(gene name)|psi-mi:SYNJ1(display_short)|uniprotkb:KIAA0910(gene name synonym)|uniprotkb:Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7121552|mint:MINT-16056 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-376294(identity) refseq:NP_001153774.1|refseq:NP_001153778.1|refseq:NP_003886.3|refseq:NP_982271.2|refseq:XP_016883989.1|ensembl:ENSG00000159082(gene)|ensembl:ENST00000674308(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0005874"(microtubule)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014015"(positive regulation of gliogenesis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0034595"(phosphatidylinositol phosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043812"(phosphatidylinositol-4-phosphate phosphatase activity)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0061024"(membrane organization)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:1904980"(positive regulation of endosome organization)|go:"GO:1990175"(EH domain binding)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002013(Synaptojanin, N-terminal)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR015047(Region of unknown function DUF1866)|interpro:IPR034971|interpro:IPR034972|interpro:IPR035979|interpro:IPR036691|mint:O43426|rcsb pdb:1W80|rcsb pdb:2DNR|rcsb pdb:2VJ0|rcsb pdb:7A0V|reactome:R-HSA-1660499|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-8856828|mint:MINT-376287(identity) - function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 rogid:RA73eMbCn6F7MD0ItxF/V7QbjqM9606 intact-crc:F4234557A3B54840|rigid:n+UcEH4PPLkFnIyvBiXrLefK/xU false binding-associated region:626-695(MINT-376295) binding-associated region:1063-1070(MINT-376288) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P49418 intact:EBI-7121639 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 intact:MINT-8094608 psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:vrparrvlw(display_short)|psi-mi:EBI-7121639(display_long) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7121634|mint:MINT-8094596 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8094601(identity) mint:MINT-8094610(identity) - function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms comment:mint|no-uniprot-update: figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 rogid:lPy6gBhpgvyGSYgOqeHbjcqBtMQ-2 intact-crc:880913D9000BF26E|rigid:iRObbQsaUeX0PxuKeQwZ73s8iKU false binding-associated region:626-695(MINT-8094602) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:P49418 intact:EBI-7121654 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 intact:MINT-8094645 psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:hrpvrraap(display_short)|psi-mi:EBI-7121654(display_long) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7121659|mint:MINT-8094627 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8094629(identity) mint:MINT-8094647(identity) - function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms comment:mint|no-uniprot-update: figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 rogid:GsDnsVmAo8ZZoKTZ4/uDb2x+h3c-2 intact-crc:B68245E1F0508124|rigid:SlinPP5vIczFOGZjelrO+IXJq1s false binding-associated region:626-695(MINT-8094630) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:P49418 intact:EBI-7121715 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 intact:MINT-8094663 psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:vrptraada(display_short)|psi-mi:EBI-7121715(display_long) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7121710|mint:MINT-8094651 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8094653(identity) mint:MINT-8094665(identity) - function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms comment:mint|no-uniprot-update: figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 rogid:M+f6GE3SQXrMBiIVttW1MKhz3M0-2 intact-crc:8F7F46DF027DF34E|rigid:uiWbDe6gaj1XcnJXNxuLLq2l/m4 false binding-associated region:626-695(MINT-8094654) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0083"(peptide synthesis) intact:EBI-7121765 uniprotkb:P49418 intact:MINT-8094691 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 psi-mi:xrprrghal(display_short)|psi-mi:EBI-7121765(display_long) psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7121760|mint:MINT-8094677 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8094693(identity) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8094679(identity) - comment:mint|no-uniprot-update: function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:cilZXZ3YLDI1s7n8WNRyUE6EnJQ-2 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 intact-crc:2EF43A66D9B2D428|rigid:/ki1zA46M4Q+rHcjCcxNhhk+5Xw false - binding-associated region:626-695(MINT-8094680) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P49418 intact:EBI-7121785 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 intact:MINT-8094718 psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:hrptrskla(display_short)|psi-mi:EBI-7121785(display_long) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7121780|mint:MINT-8094706 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8094708(identity) mint:MINT-8094720(identity) - function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms comment:mint|no-uniprot-update: figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 rogid:Q9S7HY0OYKNz5U6ndWhu91PBN5Q-2 intact-crc:84BF0FF8155AE7F8|rigid:XLOVWM25uJw3qiUhKe6tGNH97NE false binding-associated region:626-695(MINT-8094709) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0083"(peptide synthesis) intact:EBI-7121821 uniprotkb:P49418 intact:MINT-8094732 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 psi-mi:krpprdgtl(display_short)|psi-mi:EBI-7121821(display_long) psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7121816|mint:MINT-8094722 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8094734(identity) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8094724(identity) - comment:mint|no-uniprot-update: function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:EBbNcr0zagot59cukEv+Me2oOy4-2 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 intact-crc:830DCFFA177D7718|rigid:JRSHO660pb1Xran2F9HWsNTty4E false - binding-associated region:626-695(MINT-8094725) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P49418 intact:EBI-7121875 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 intact:MINT-8094747 psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:qrplrrprm(display_short)|psi-mi:EBI-7121875(display_long) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7121870|mint:MINT-8094737 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8094739(identity) mint:MINT-8094749(identity) - function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms comment:mint|no-uniprot-update: figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 rogid:+PG7mBSIIqI0Qjrscg1Dca7xq4E-2 intact-crc:EBBB881A8816BA19|rigid:WzBj7stdRfHpLxVuhfndNR9eonc false binding-associated region:626-695(MINT-8094740) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0083"(peptide synthesis) intact:EBI-7121931 uniprotkb:P49418 intact:MINT-8094812 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 psi-mi:rrprrslpe(display_short)|psi-mi:EBI-7121931(display_long) psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7121926|mint:MINT-8094793 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8094814(identity) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8094795(identity) - comment:mint|no-uniprot-update: function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:mzrTgOnke4NRW+G9BPdWpU6Lhec-2 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 intact-crc:DC0C4486AEA6B83F|rigid:GTdqKccRaAT8WnHgZCAJQsSmYsE false - binding-associated region:626-695(MINT-8094796) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0078"(nucleotide sequence identification) intact:EBI-7121906 uniprotkb:P49418 intact:MINT-8094788 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 psi-mi:tpkrppril(display_short)|psi-mi:EBI-7121906(display_long) psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7121911|mint:MINT-8094755 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8094790(identity) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8094757(identity) - comment:mint|no-uniprot-update: function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:Sbd4rq4/EaxV04gaweZHEWSw2hI-2 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 intact-crc:D4B9F42A78EEEAD3|rigid:FkC6ZpD/4st+D9Zvy2EdtJeUXxA false - binding-associated region:626-695(MINT-8094758) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0078"(nucleotide sequence identification) intact:EBI-7121980 uniprotkb:P49418 intact:MINT-8094827 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 psi-mi:trpyrpthp(display_short)|psi-mi:EBI-7121980(display_long) psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7121975|mint:MINT-8094817 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8094829(identity) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8094819(identity) - comment:mint|no-uniprot-update: function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:z5kmeBeQFdIWiMbfWp4C8qwBR/g-2 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 intact-crc:F90FC627259D7360|rigid:Dn38B6RW6zAQ6vn6vF8lrkq8Ypc false - binding-associated region:626-695(MINT-8094820) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P49418 intact:EBI-7121996 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 intact:MINT-8094844 psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:grpprnarv(display_short)|psi-mi:EBI-7121996(display_long) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122020|mint:MINT-8094831 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8094833(identity) mint:MINT-8094846(identity) - function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms comment:mint|no-uniprot-update: figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 rogid:CUPbbOQuYo9PR7+v9aJSt+qUb2Y-2 intact-crc:45F3110987E7CEB3|rigid:N2G/wU8GCeEEgG4PzmvUQpi1FpU false binding-associated region:626-695(MINT-8094834) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0083"(peptide synthesis) intact:EBI-7122051 uniprotkb:P49418 intact:MINT-8094869 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 psi-mi:hrpwrrwre(display_short)|psi-mi:EBI-7122051(display_long) psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122056|mint:MINT-8094848 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8094871(identity) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8094850(identity) - comment:mint|no-uniprot-update: function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:41u0kCbfV659KDz2F+QN9d85IxI-2 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 intact-crc:101760D0E9C4B888|rigid:Z5H24OGEfo3joc/0HHsCufoU/+E false - binding-associated region:626-695(MINT-8094851) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0078"(nucleotide sequence identification) intact:EBI-7122090 uniprotkb:Q99962 intact:MINT-8094904 intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618 psi-mi:srpkrpphw(display_short)|psi-mi:EBI-7122090(display_long) psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122085|mint:MINT-8094877 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8094906(identity) go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N|mint:MINT-8094879(identity) - comment:mint|no-uniprot-update: - figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:9Bpv4P6fWQDaJzVhTiGxEukSnfI-2 rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606 intact-crc:65FAE4E98205F436|rigid:2/aEtKLb1xVQ3PIjcWTeXHgQR10 false - binding-associated region:293-348(MINT-8094880) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0078"(nucleotide sequence identification) intact:EBI-7122141 uniprotkb:Q99962 intact:MINT-8095438 intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618 psi-mi:fprrpprprl(display_short)|psi-mi:EBI-7122141(display_long) psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122146|mint:MINT-8094963 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8095440(identity) go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N|mint:MINT-8094965(identity) - comment:mint|no-uniprot-update: - figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:isEr+aNcUE/HqAuDIjFfbX7x+p4-2 rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606 intact-crc:F118DC765F1AB51B|rigid:8+nV5FGipP1cu0OlZ6gT1ec1Vr4 false - binding-associated region:293-348(MINT-8094966) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0078"(nucleotide sequence identification) intact:EBI-7122121 uniprotkb:Q99962 intact:MINT-8095434 intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618 psi-mi:fkprrppppg(display_short)|psi-mi:EBI-7122121(display_long) psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122126|mint:MINT-8094923 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8095436(identity) go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N|mint:MINT-8094925(identity) - comment:mint|no-uniprot-update: - figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:gT9qSj9NHe7sZDXaattBFBdf2MQ-2 rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606 intact-crc:CF571F4AAF105791|rigid:sbYiGV2/Jtn0HePCkqfC0BDFRB0 false - binding-associated region:293-348(MINT-8094926) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0078"(nucleotide sequence identification) intact:EBI-7122234 uniprotkb:Q99961 intact:MINT-8095505 intact:EBI-697911|uniprotkb:Q99668|uniprotkb:B4DRA1|uniprotkb:E7EVZ4|uniprotkb:M0QZV5|ensembl:ENSP00000269886 psi-mi:fsrpkrpphw(display_short)|psi-mi:EBI-7122234(display_long) psi-mi:sh3g1_human(display_long)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122229|mint:MINT-8095495 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8095507(identity) refseq:NP_001186872.1|refseq:NP_003016.1|refseq:NP_001186873.1|dip:DIP-29452N|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR035824|interpro:IPR036028|mint:Q99961|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|mint:MINT-8095498(identity) - comment:mint|no-uniprot-update: crc64:6E5BE978BC955077 figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:cVzCn2rsHIZrs7ajEHNKjTvuQmY-2 rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606 intact-crc:205C72FC7A917D5B|rigid:QhjTbMnWbfiav4e9GLkGxZwNDYM false - binding-associated region:309-364(MINT-8095499) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7122210 uniprotkb:Q99961 intact:MINT-8095452 intact:EBI-697911|uniprotkb:Q99668|uniprotkb:B4DRA1|uniprotkb:E7EVZ4|uniprotkb:M0QZV5|ensembl:ENSP00000269886 psi-mi:fpkrpplprs(display_short)|psi-mi:EBI-7122210(display_long) psi-mi:sh3g1_human(display_long)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122215|mint:MINT-8095442 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8095454(identity) refseq:NP_001186872.1|refseq:NP_003016.1|refseq:NP_001186873.1|dip:DIP-29452N|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR035824|interpro:IPR036028|mint:Q99961|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|mint:MINT-8095458(identity) - comment:mint|no-uniprot-update: crc64:6E5BE978BC955077 figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:mGiR0QhsaPf70vpf43lm6LmuhAU-2 rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606 intact-crc:33091A4717948848|rigid:6UfUuqtlcOHvVnxBeyVepAWDIdw false - binding-associated region:309-364(MINT-8095460) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7122298 uniprotkb:Q99961 intact:MINT-8095519 intact:EBI-697911|uniprotkb:Q99668|uniprotkb:B4DRA1|uniprotkb:E7EVZ4|uniprotkb:M0QZV5|ensembl:ENSP00000269886 psi-mi:fprrpppprm(display_short)|psi-mi:EBI-7122298(display_long) psi-mi:sh3g1_human(display_long)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122293|mint:MINT-8095509 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8095521(identity) refseq:NP_001186872.1|refseq:NP_003016.1|refseq:NP_001186873.1|dip:DIP-29452N|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR035824|interpro:IPR036028|mint:Q99961|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|mint:MINT-8095511(identity) - comment:mint|no-uniprot-update: crc64:6E5BE978BC955077 figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:2xrz71zHTYdhIf6vKs6qD6tJBqk-2 rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606 intact-crc:D57EC090CF8F9E46|rigid:44D/1nzbsBckXChGc/veG7spuUg false - binding-associated region:309-364(MINT-8095512) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7122348 uniprotkb:Q99963 intact:MINT-8095534 intact:EBI-473910|uniprotkb:O43553|uniprotkb:O43554|ensembl:ENSP00000391372 psi-mi:fpprppgpya(display_short)|psi-mi:EBI-7122348(display_long) psi-mi:sh3g3_human(display_long)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122353|mint:MINT-8095523 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8095536(identity) refseq:NP_001288037.1|refseq:NP_001288038.1|ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0006897"(endocytosis)|rcsb pdb:2Z0V|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9031628|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0098793"(presynapse)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0031901"(early endosome membrane)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR032469|interpro:IPR035824|interpro:IPR036028|mint:Q99963|rcsb pdb:2EW3|refseq:NP_003018.3|refseq:XP_011520191.1|refseq:NP_001311112.1|refseq:NP_001311114.1|refseq:NP_001311116.1|refseq:XP_016877975.1|dip:DIP-34766N|mint:MINT-8095525(identity) - comment:mint|no-uniprot-update: - figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:plGO7end964HzkQoF/6GSQcSHU0-2 rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606 intact-crc:F62A31A1BE6F62D6|rigid:LzS7kv/627Y3ajokkD33BflTejY false - binding-associated region:?-?(MINT-8095526) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7122141 uniprotkb:Q99963 intact:MINT-8095438 intact:EBI-473910|uniprotkb:O43553|uniprotkb:O43554|ensembl:ENSP00000391372 psi-mi:fprrpprprl(display_short)|psi-mi:EBI-7122141(display_long) psi-mi:sh3g3_human(display_long)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122383|mint:MINT-8095538 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8095560(identity) refseq:NP_001288037.1|refseq:NP_001288038.1|ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0006897"(endocytosis)|rcsb pdb:2Z0V|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9031628|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0098793"(presynapse)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0031901"(early endosome membrane)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR032469|interpro:IPR035824|interpro:IPR036028|mint:Q99963|rcsb pdb:2EW3|refseq:NP_003018.3|refseq:XP_011520191.1|refseq:NP_001311112.1|refseq:NP_001311114.1|refseq:NP_001311116.1|refseq:XP_016877975.1|dip:DIP-34766N|mint:MINT-8095540(identity) - comment:mint|no-uniprot-update: - figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:isEr+aNcUE/HqAuDIjFfbX7x+p4-2 rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606 intact-crc:A30AD57CD01D852D|rigid:9XQhHS3fCdbX0NPfiTKstD2p1Rg false - binding-associated region:?-?(MINT-8095541) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7122420 uniprotkb:Q99963 intact:MINT-8095583 intact:EBI-473910|uniprotkb:O43553|uniprotkb:O43554|ensembl:ENSP00000391372 psi-mi:fqkpsrpkpw(display_short)|psi-mi:EBI-7122420(display_long) psi-mi:sh3g3_human(display_long)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122415|mint:MINT-8095566 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8095585(identity) refseq:NP_001288037.1|refseq:NP_001288038.1|ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0006897"(endocytosis)|rcsb pdb:2Z0V|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9031628|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0098793"(presynapse)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0031901"(early endosome membrane)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR032469|interpro:IPR035824|interpro:IPR036028|mint:Q99963|rcsb pdb:2EW3|refseq:NP_003018.3|refseq:XP_011520191.1|refseq:NP_001311112.1|refseq:NP_001311114.1|refseq:NP_001311116.1|refseq:XP_016877975.1|dip:DIP-34766N|mint:MINT-8095568(identity) - comment:mint|no-uniprot-update: - figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:NhhmyN2aYZYxC1iRrF2vEJ2sq4E-2 rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606 intact-crc:D2A0990835F78A09|rigid:o2wBc1toZP4SBw/O9976YXEiV6k false - binding-associated region:?-?(MINT-8095569) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7122528 uniprotkb:Q99963 intact:MINT-8095652 intact:EBI-473910|uniprotkb:O43553|uniprotkb:O43554|ensembl:ENSP00000391372 psi-mi:fqkpqrpprw(display_short)|psi-mi:EBI-7122528(display_long) psi-mi:sh3g3_human(display_long)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122523|mint:MINT-8095636 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8095654(identity) refseq:NP_001288037.1|refseq:NP_001288038.1|ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0006897"(endocytosis)|rcsb pdb:2Z0V|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9031628|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0098793"(presynapse)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0031901"(early endosome membrane)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR032469|interpro:IPR035824|interpro:IPR036028|mint:Q99963|rcsb pdb:2EW3|refseq:NP_003018.3|refseq:XP_011520191.1|refseq:NP_001311112.1|refseq:NP_001311114.1|refseq:NP_001311116.1|refseq:XP_016877975.1|dip:DIP-34766N|mint:MINT-8095639(identity) - comment:mint|no-uniprot-update: - figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:9dwRflYreu5F7e5pExMfjKjC1jo-2 rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606 intact-crc:7A0F404DA8DD2AE0|rigid:lCV4ws0+NrxKawmrqkE9hWT2g0c false - binding-associated region:?-?(MINT-8095640) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7122482 uniprotkb:Q99963 intact:MINT-8095629 intact:EBI-473910|uniprotkb:O43553|uniprotkb:O43554|ensembl:ENSP00000391372 psi-mi:fpprppapyw(display_short)|psi-mi:EBI-7122482(display_long) psi-mi:sh3g3_human(display_long)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122487|mint:MINT-8095612 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8095631(identity) refseq:NP_001288037.1|refseq:NP_001288038.1|ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0006897"(endocytosis)|rcsb pdb:2Z0V|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9031628|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0098793"(presynapse)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0031901"(early endosome membrane)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR032469|interpro:IPR035824|interpro:IPR036028|mint:Q99963|rcsb pdb:2EW3|refseq:NP_003018.3|refseq:XP_011520191.1|refseq:NP_001311112.1|refseq:NP_001311114.1|refseq:NP_001311116.1|refseq:XP_016877975.1|dip:DIP-34766N|mint:MINT-8095614(identity) - comment:mint|no-uniprot-update: - figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:A1RmpSYZqCEsPY4PCn1r6RIFm8w-2 rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606 intact-crc:B614641BEFBF2A57|rigid:vOhxrMj6Hs5jwP1h8kyZPn9sfD0 false - binding-associated region:?-?(MINT-8095615) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7122234 uniprotkb:Q99963 intact:MINT-8095505 intact:EBI-473910|uniprotkb:O43553|uniprotkb:O43554|ensembl:ENSP00000391372 psi-mi:fsrpkrpphw(display_short)|psi-mi:EBI-7122234(display_long) psi-mi:sh3g3_human(display_long)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122436|mint:MINT-8095591 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8095605(identity) refseq:NP_001288037.1|refseq:NP_001288038.1|ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0006897"(endocytosis)|rcsb pdb:2Z0V|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9031628|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0098793"(presynapse)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0031901"(early endosome membrane)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR032469|interpro:IPR035824|interpro:IPR036028|mint:Q99963|rcsb pdb:2EW3|refseq:NP_003018.3|refseq:XP_011520191.1|refseq:NP_001311112.1|refseq:NP_001311114.1|refseq:NP_001311116.1|refseq:XP_016877975.1|dip:DIP-34766N|mint:MINT-8095593(identity) - comment:mint|no-uniprot-update: - figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:cVzCn2rsHIZrs7ajEHNKjTvuQmY-2 rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606 intact-crc:B1A6A419ED98BAB7|rigid:yd5PtUqICeenFWdReENh9A3cBGM false - binding-associated region:?-?(MINT-8095594) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7122560 uniprotkb:Q99963 intact:MINT-8095672 intact:EBI-473910|uniprotkb:O43553|uniprotkb:O43554|ensembl:ENSP00000391372 psi-mi:fpprpkpprm(display_short)|psi-mi:EBI-7122560(display_long) psi-mi:sh3g3_human(display_long)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122565|mint:MINT-8095661 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8095674(identity) refseq:NP_001288037.1|refseq:NP_001288038.1|ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0006897"(endocytosis)|rcsb pdb:2Z0V|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9031628|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0098793"(presynapse)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0031901"(early endosome membrane)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR032469|interpro:IPR035824|interpro:IPR036028|mint:Q99963|rcsb pdb:2EW3|refseq:NP_003018.3|refseq:XP_011520191.1|refseq:NP_001311112.1|refseq:NP_001311114.1|refseq:NP_001311116.1|refseq:XP_016877975.1|dip:DIP-34766N|mint:MINT-8095663(identity) - comment:mint|no-uniprot-update: - figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:adyGJBO27g5iBlmAi0NQgmU1Iaw-2 rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606 intact-crc:5CD5A2ED22F529CF|rigid:hdO/cbFW++C29oxZm3BoL4uYehI false - binding-associated region:?-?(MINT-8095664) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7122210 uniprotkb:Q99963 intact:MINT-8095452 intact:EBI-473910|uniprotkb:O43553|uniprotkb:O43554|ensembl:ENSP00000391372 psi-mi:fpkrpplprs(display_short)|psi-mi:EBI-7122210(display_long) psi-mi:sh3g3_human(display_long)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122610|mint:MINT-8095679 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8095701(identity) refseq:NP_001288037.1|refseq:NP_001288038.1|ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0006897"(endocytosis)|rcsb pdb:2Z0V|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9031628|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0098793"(presynapse)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0031901"(early endosome membrane)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR032469|interpro:IPR035824|interpro:IPR036028|mint:Q99963|rcsb pdb:2EW3|refseq:NP_003018.3|refseq:XP_011520191.1|refseq:NP_001311112.1|refseq:NP_001311114.1|refseq:NP_001311116.1|refseq:XP_016877975.1|dip:DIP-34766N|mint:MINT-8095681(identity) - comment:mint|no-uniprot-update: - figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:mGiR0QhsaPf70vpf43lm6LmuhAU-2 rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606 intact-crc:C0C87D6908232453|rigid:d+cYb+gCgx0CjbHxJO2Bd7574c0 false - binding-associated region:?-?(MINT-8095682) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7122631 uniprotkb:Q99963 intact:MINT-8095737 intact:EBI-473910|uniprotkb:O43553|uniprotkb:O43554|ensembl:ENSP00000391372 psi-mi:frpprpplpa(display_short)|psi-mi:EBI-7122631(display_long) psi-mi:sh3g3_human(display_long)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym) psi-mi:"MI:0084"(phage display) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122626|mint:MINT-8095708 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-8095739(identity) refseq:NP_001288037.1|refseq:NP_001288038.1|ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0006897"(endocytosis)|rcsb pdb:2Z0V|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9031628|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0098793"(presynapse)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0031901"(early endosome membrane)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR032469|interpro:IPR035824|interpro:IPR036028|mint:Q99963|rcsb pdb:2EW3|refseq:NP_003018.3|refseq:XP_011520191.1|refseq:NP_001311112.1|refseq:NP_001311114.1|refseq:NP_001311116.1|refseq:XP_016877975.1|dip:DIP-34766N|mint:MINT-8095710(identity) - comment:mint|no-uniprot-update: - figure legend:F1 F2|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:8Kr/LLyvobSyFulMmHM1cicQkNw-2 rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606 intact-crc:1E0F1B8C22E7F277|rigid:Eje2lSi+tjQOW2tHSA8XISVoA3s false - binding-associated region:?-?(MINT-8095711) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P49418 uniprotkb:O43426 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 intact:EBI-2821539|uniprotkb:O43425|uniprotkb:O94984|uniprotkb:Q4KMR1|ensembl:ENSP00000501426 psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:synj1_human(display_long)|uniprotkb:SYNJ1(gene name)|psi-mi:SYNJ1(display_short)|uniprotkb:KIAA0910(gene name synonym)|uniprotkb:Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1(gene name synonym) psi-mi:"MI:0081"(peptide array) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122684|mint:MINT-8095825 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8095828(identity) refseq:NP_001153774.1|refseq:NP_001153778.1|refseq:NP_003886.3|refseq:NP_982271.2|refseq:XP_016883989.1|ensembl:ENSG00000159082(gene)|ensembl:ENST00000674308(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0005874"(microtubule)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014015"(positive regulation of gliogenesis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0034595"(phosphatidylinositol phosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043812"(phosphatidylinositol-4-phosphate phosphatase activity)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0061024"(membrane organization)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:1904980"(positive regulation of endosome organization)|go:"GO:1990175"(EH domain binding)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002013(Synaptojanin, N-terminal)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR015047(Region of unknown function DUF1866)|interpro:IPR034971|interpro:IPR034972|interpro:IPR035979|interpro:IPR036691|mint:O43426|rcsb pdb:1W80|rcsb pdb:2DNR|rcsb pdb:2VJ0|rcsb pdb:7A0V|reactome:R-HSA-1660499|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-8856828|mint:MINT-8095827(identity) - function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms - figure legend:f5|comment:homomint|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 rogid:RA73eMbCn6F7MD0ItxF/V7QbjqM9606 intact-crc:1B3C495D257C1999|rigid:n+UcEH4PPLkFnIyvBiXrLefK/xU false glutathione s tranferase tag:?-?(MINT-8095915)|binding-associated region:620-695(MINT-8095918) binding-associated region:1060-1076(MINT-8095871) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:P49418 uniprotkb:O43426 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 intact:EBI-2821539|uniprotkb:O43425|uniprotkb:O94984|uniprotkb:Q4KMR1|ensembl:ENSP00000501426 psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:synj1_human(display_long)|uniprotkb:SYNJ1(gene name)|psi-mi:SYNJ1(display_short)|uniprotkb:KIAA0910(gene name synonym)|uniprotkb:Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1(gene name synonym) psi-mi:"MI:0081"(peptide array) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122727|mint:MINT-8095924 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8095930(identity) refseq:NP_001153774.1|refseq:NP_001153778.1|refseq:NP_003886.3|refseq:NP_982271.2|refseq:XP_016883989.1|ensembl:ENSG00000159082(gene)|ensembl:ENST00000674308(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0005874"(microtubule)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014015"(positive regulation of gliogenesis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0034595"(phosphatidylinositol phosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043812"(phosphatidylinositol-4-phosphate phosphatase activity)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0061024"(membrane organization)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:1904980"(positive regulation of endosome organization)|go:"GO:1990175"(EH domain binding)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002013(Synaptojanin, N-terminal)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR015047(Region of unknown function DUF1866)|interpro:IPR034971|interpro:IPR034972|interpro:IPR035979|interpro:IPR036691|mint:O43426|rcsb pdb:1W80|rcsb pdb:2DNR|rcsb pdb:2VJ0|rcsb pdb:7A0V|reactome:R-HSA-1660499|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-8856828|mint:MINT-8095926(identity) - function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms - figure legend:f5|comment:homomint|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 rogid:RA73eMbCn6F7MD0ItxF/V7QbjqM9606 intact-crc:3B294E9363BBEBF0|rigid:n+UcEH4PPLkFnIyvBiXrLefK/xU false binding-associated region:620-695(MINT-8095931)|glutathione s tranferase tag:?-?(MINT-8095934) binding-associated region:1191-1206(MINT-8095927) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:P49418 uniprotkb:O43426 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 intact:EBI-2821539|uniprotkb:O43425|uniprotkb:O94984|uniprotkb:Q4KMR1|ensembl:ENSP00000501426 psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:synj1_human(display_long)|uniprotkb:SYNJ1(gene name)|psi-mi:SYNJ1(display_short)|uniprotkb:KIAA0910(gene name synonym)|uniprotkb:Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1(gene name synonym) psi-mi:"MI:0081"(peptide array) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122766|mint:MINT-8095961 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8095967(identity) refseq:NP_001153774.1|refseq:NP_001153778.1|refseq:NP_003886.3|refseq:NP_982271.2|refseq:XP_016883989.1|ensembl:ENSG00000159082(gene)|ensembl:ENST00000674308(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0005874"(microtubule)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014015"(positive regulation of gliogenesis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0034595"(phosphatidylinositol phosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043812"(phosphatidylinositol-4-phosphate phosphatase activity)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0061024"(membrane organization)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:1904980"(positive regulation of endosome organization)|go:"GO:1990175"(EH domain binding)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002013(Synaptojanin, N-terminal)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR015047(Region of unknown function DUF1866)|interpro:IPR034971|interpro:IPR034972|interpro:IPR035979|interpro:IPR036691|mint:O43426|rcsb pdb:1W80|rcsb pdb:2DNR|rcsb pdb:2VJ0|rcsb pdb:7A0V|reactome:R-HSA-1660499|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-8856828|mint:MINT-8095963(identity) - function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms - figure legend:f5|comment:homomint|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 rogid:RA73eMbCn6F7MD0ItxF/V7QbjqM9606 intact-crc:17D53C44727F66B6|rigid:n+UcEH4PPLkFnIyvBiXrLefK/xU false binding-associated region:620-695(MINT-8095970)|glutathione s tranferase tag:?-?(MINT-8095968) binding-associated region:1280-1295(MINT-8095964) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:Q99961 uniprotkb:O43426 intact:EBI-697911|uniprotkb:Q99668|uniprotkb:B4DRA1|uniprotkb:E7EVZ4|uniprotkb:M0QZV5|ensembl:ENSP00000269886 intact:EBI-2821539|uniprotkb:O43425|uniprotkb:O94984|uniprotkb:Q4KMR1|ensembl:ENSP00000501426 psi-mi:sh3g1_human(display_long)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym) psi-mi:synj1_human(display_long)|uniprotkb:SYNJ1(gene name)|psi-mi:SYNJ1(display_short)|uniprotkb:KIAA0910(gene name synonym)|uniprotkb:Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1(gene name synonym) psi-mi:"MI:0081"(peptide array) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122802|mint:MINT-8096027 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186872.1|refseq:NP_003016.1|refseq:NP_001186873.1|dip:DIP-29452N|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR035824|interpro:IPR036028|mint:Q99961|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|mint:MINT-8096030(identity) refseq:NP_001153774.1|refseq:NP_001153778.1|refseq:NP_003886.3|refseq:NP_982271.2|refseq:XP_016883989.1|ensembl:ENSG00000159082(gene)|ensembl:ENST00000674308(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0005874"(microtubule)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014015"(positive regulation of gliogenesis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0034595"(phosphatidylinositol phosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043812"(phosphatidylinositol-4-phosphate phosphatase activity)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0061024"(membrane organization)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:1904980"(positive regulation of endosome organization)|go:"GO:1990175"(EH domain binding)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002013(Synaptojanin, N-terminal)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR015047(Region of unknown function DUF1866)|interpro:IPR034971|interpro:IPR034972|interpro:IPR035979|interpro:IPR036691|mint:O43426|rcsb pdb:1W80|rcsb pdb:2DNR|rcsb pdb:2VJ0|rcsb pdb:7A0V|reactome:R-HSA-1660499|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-8856828|mint:MINT-8096029(identity) - crc64:6E5BE978BC955077 - figure legend:f5|comment:homomint|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606 rogid:RA73eMbCn6F7MD0ItxF/V7QbjqM9606 intact-crc:0308D6DE536C0DF4|rigid:fxkuzNe+wQW8plOKp435NGHLMgA false glutathione s tranferase tag:?-?(MINT-8096039)|binding-associated region:286-352(MINT-8096042) binding-associated region:1060-1076(MINT-8096050) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:O43426 uniprotkb:Q99961 intact:EBI-2821539|uniprotkb:O43425|uniprotkb:O94984|uniprotkb:Q4KMR1|ensembl:ENSP00000501426 intact:EBI-697911|uniprotkb:Q99668|uniprotkb:B4DRA1|uniprotkb:E7EVZ4|uniprotkb:M0QZV5|ensembl:ENSP00000269886 psi-mi:synj1_human(display_long)|uniprotkb:SYNJ1(gene name)|psi-mi:SYNJ1(display_short)|uniprotkb:KIAA0910(gene name synonym)|uniprotkb:Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1(gene name synonym) psi-mi:sh3g1_human(display_long)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym) psi-mi:"MI:0081"(peptide array) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122861|mint:MINT-8096061 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001153774.1|refseq:NP_001153778.1|refseq:NP_003886.3|refseq:NP_982271.2|refseq:XP_016883989.1|ensembl:ENSG00000159082(gene)|ensembl:ENST00000674308(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0005874"(microtubule)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014015"(positive regulation of gliogenesis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0034595"(phosphatidylinositol phosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043812"(phosphatidylinositol-4-phosphate phosphatase activity)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0061024"(membrane organization)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:1904980"(positive regulation of endosome organization)|go:"GO:1990175"(EH domain binding)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002013(Synaptojanin, N-terminal)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR015047(Region of unknown function DUF1866)|interpro:IPR034971|interpro:IPR034972|interpro:IPR035979|interpro:IPR036691|mint:O43426|rcsb pdb:1W80|rcsb pdb:2DNR|rcsb pdb:2VJ0|rcsb pdb:7A0V|reactome:R-HSA-1660499|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-8856828|mint:MINT-8096063(identity) refseq:NP_001186872.1|refseq:NP_003016.1|refseq:NP_001186873.1|dip:DIP-29452N|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR035824|interpro:IPR036028|mint:Q99961|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|mint:MINT-8096067(identity) - - crc64:6E5BE978BC955077 figure legend:f5|comment:homomint|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:RA73eMbCn6F7MD0ItxF/V7QbjqM9606 rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606 intact-crc:7BD9741298C90AC3|rigid:fxkuzNe+wQW8plOKp435NGHLMgA false binding-associated region:1102-1132(MINT-8096064) glutathione s tranferase tag:?-?(MINT-8096071)|binding-associated region:286-352(MINT-8096068) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:O43426 uniprotkb:Q99961 intact:EBI-2821539|uniprotkb:O43425|uniprotkb:O94984|uniprotkb:Q4KMR1|ensembl:ENSP00000501426 intact:EBI-697911|uniprotkb:Q99668|uniprotkb:B4DRA1|uniprotkb:E7EVZ4|uniprotkb:M0QZV5|ensembl:ENSP00000269886 psi-mi:synj1_human(display_long)|uniprotkb:SYNJ1(gene name)|psi-mi:SYNJ1(display_short)|uniprotkb:KIAA0910(gene name synonym)|uniprotkb:Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1(gene name synonym) psi-mi:sh3g1_human(display_long)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym) psi-mi:"MI:0081"(peptide array) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122913|mint:MINT-8096099 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001153774.1|refseq:NP_001153778.1|refseq:NP_003886.3|refseq:NP_982271.2|refseq:XP_016883989.1|ensembl:ENSG00000159082(gene)|ensembl:ENST00000674308(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0005874"(microtubule)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014015"(positive regulation of gliogenesis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0034595"(phosphatidylinositol phosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043812"(phosphatidylinositol-4-phosphate phosphatase activity)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0061024"(membrane organization)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:1904980"(positive regulation of endosome organization)|go:"GO:1990175"(EH domain binding)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002013(Synaptojanin, N-terminal)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR015047(Region of unknown function DUF1866)|interpro:IPR034971|interpro:IPR034972|interpro:IPR035979|interpro:IPR036691|mint:O43426|rcsb pdb:1W80|rcsb pdb:2DNR|rcsb pdb:2VJ0|rcsb pdb:7A0V|reactome:R-HSA-1660499|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-8856828|mint:MINT-8096101(identity) refseq:NP_001186872.1|refseq:NP_003016.1|refseq:NP_001186873.1|dip:DIP-29452N|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR035824|interpro:IPR036028|mint:Q99961|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|mint:MINT-8096105(identity) - - crc64:6E5BE978BC955077 figure legend:f5|comment:homomint|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:RA73eMbCn6F7MD0ItxF/V7QbjqM9606 rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606 intact-crc:21D5657F19E31AB2|rigid:fxkuzNe+wQW8plOKp435NGHLMgA false binding-associated region:1280-1296(MINT-8096102) glutathione s tranferase tag:?-?(MINT-8096106)|binding-associated region:286-352(MINT-8096108) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P49418 uniprotkb:Q05193 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 intact:EBI-713135|uniprotkb:A6NLM6|uniprotkb:Q5SYX0|uniprotkb:Q5SYX2|uniprotkb:Q6P3T6|uniprotkb:Q86VD2|ensembl:ENSP00000362014 psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:dyn1_human(display_long)|uniprotkb:DNM1(gene name)|psi-mi:DNM1(display_short)|uniprotkb:DNM(gene name synonym) psi-mi:"MI:0081"(peptide array) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122936|mint:MINT-8096278 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8096281(identity) refseq:NP_001005336.1|refseq:NP_004399.2|refseq:NP_001275666.1|refseq:NP_001275667.1|refseq:NP_001275668.1|refseq:XP_005251825.1|refseq:XP_005251826.1|refseq:XP_016869860.1|dip:DIP-36242N|ensembl:ENSG00000106976(gene)|ensembl:ENST00000372923(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1904645"(response to amyloid-beta)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:Q05193|rcsb pdb:1DYN|rcsb pdb:2DYN|rcsb pdb:2X2E|rcsb pdb:2X2F|rcsb pdb:3SNH|rcsb pdb:3ZYC|rcsb pdb:3ZYS|rcsb pdb:4UUD|rcsb pdb:4UUK|rcsb pdb:5D3Q|rcsb pdb:6DLU|rcsb pdb:6DLV|rcsb pdb:6S9A|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-437239|reactome:R-HSA-8856828|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|mint:MINT-8096280(identity) - function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms - comment:homomint|figure legend:f7|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 rogid:uiP8CXhKWQaP2GIAZULJTLqwGLs9606 intact-crc:7C77F300E0144459|rigid:7jddVD3vx7GswRanVkLUi+ELNFk false glutathione s tranferase tag:?-?(MINT-8096286)|binding-associated region:620-695(MINT-8096289) binding-associated region:778-788(MINT-8096321) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:P49418 uniprotkb:Q05193 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 intact:EBI-713135|uniprotkb:A6NLM6|uniprotkb:Q5SYX0|uniprotkb:Q5SYX2|uniprotkb:Q6P3T6|uniprotkb:Q86VD2|ensembl:ENSP00000362014 psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:dyn1_human(display_long)|uniprotkb:DNM1(gene name)|psi-mi:DNM1(display_short)|uniprotkb:DNM(gene name synonym) psi-mi:"MI:0081"(peptide array) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7123032|mint:MINT-8096359 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8096365(identity) refseq:NP_001005336.1|refseq:NP_004399.2|refseq:NP_001275666.1|refseq:NP_001275667.1|refseq:NP_001275668.1|refseq:XP_005251825.1|refseq:XP_005251826.1|refseq:XP_016869860.1|dip:DIP-36242N|ensembl:ENSG00000106976(gene)|ensembl:ENST00000372923(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1904645"(response to amyloid-beta)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:Q05193|rcsb pdb:1DYN|rcsb pdb:2DYN|rcsb pdb:2X2E|rcsb pdb:2X2F|rcsb pdb:3SNH|rcsb pdb:3ZYC|rcsb pdb:3ZYS|rcsb pdb:4UUD|rcsb pdb:4UUK|rcsb pdb:5D3Q|rcsb pdb:6DLU|rcsb pdb:6DLV|rcsb pdb:6S9A|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-437239|reactome:R-HSA-8856828|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|mint:MINT-8096361(identity) - function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms - comment:homomint|figure legend:f7|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 rogid:uiP8CXhKWQaP2GIAZULJTLqwGLs9606 intact-crc:9B8598164037DFE4|rigid:7jddVD3vx7GswRanVkLUi+ELNFk false glutathione s tranferase tag:?-?(MINT-8096369)|binding-associated region:620-695(MINT-8096366) binding-associated region:813-823(MINT-8096362) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:Q99961 uniprotkb:Q05193 intact:EBI-697911|uniprotkb:Q99668|uniprotkb:B4DRA1|uniprotkb:E7EVZ4|uniprotkb:M0QZV5|ensembl:ENSP00000269886 intact:EBI-713135|uniprotkb:A6NLM6|uniprotkb:Q5SYX0|uniprotkb:Q5SYX2|uniprotkb:Q6P3T6|uniprotkb:Q86VD2|ensembl:ENSP00000362014 psi-mi:sh3g1_human(display_long)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym) psi-mi:dyn1_human(display_long)|uniprotkb:DNM1(gene name)|psi-mi:DNM1(display_short)|uniprotkb:DNM(gene name synonym) psi-mi:"MI:0081"(peptide array) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7122975|mint:MINT-8096329 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186872.1|refseq:NP_003016.1|refseq:NP_001186873.1|dip:DIP-29452N|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR035824|interpro:IPR036028|mint:Q99961|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|mint:MINT-8096335(identity) refseq:NP_001005336.1|refseq:NP_004399.2|refseq:NP_001275666.1|refseq:NP_001275667.1|refseq:NP_001275668.1|refseq:XP_005251825.1|refseq:XP_005251826.1|refseq:XP_016869860.1|dip:DIP-36242N|ensembl:ENSG00000106976(gene)|ensembl:ENST00000372923(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1904645"(response to amyloid-beta)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:Q05193|rcsb pdb:1DYN|rcsb pdb:2DYN|rcsb pdb:2X2E|rcsb pdb:2X2F|rcsb pdb:3SNH|rcsb pdb:3ZYC|rcsb pdb:3ZYS|rcsb pdb:4UUD|rcsb pdb:4UUK|rcsb pdb:5D3Q|rcsb pdb:6DLU|rcsb pdb:6DLV|rcsb pdb:6S9A|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-437239|reactome:R-HSA-8856828|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|mint:MINT-8096331(identity) - crc64:6E5BE978BC955077 - comment:homomint|figure legend:f7|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606 rogid:uiP8CXhKWQaP2GIAZULJTLqwGLs9606 intact-crc:5D8B99EF074DE5DB|rigid:zTtK2vcPxcBxqu+J7QSVFJXPhYI false binding-associated region:286-352(MINT-8096336)|glutathione s tranferase tag:?-?(MINT-8096339) binding-associated region:778-788(MINT-8096332) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:Q99961 uniprotkb:Q05193 intact:EBI-697911|uniprotkb:Q99668|uniprotkb:B4DRA1|uniprotkb:E7EVZ4|uniprotkb:M0QZV5|ensembl:ENSP00000269886 intact:EBI-713135|uniprotkb:A6NLM6|uniprotkb:Q5SYX0|uniprotkb:Q5SYX2|uniprotkb:Q6P3T6|uniprotkb:Q86VD2|ensembl:ENSP00000362014 psi-mi:sh3g1_human(display_long)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym) psi-mi:dyn1_human(display_long)|uniprotkb:DNM1(gene name)|psi-mi:DNM1(display_short)|uniprotkb:DNM(gene name synonym) psi-mi:"MI:0081"(peptide array) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7123110|mint:MINT-8096409 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186872.1|refseq:NP_003016.1|refseq:NP_001186873.1|dip:DIP-29452N|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR035824|interpro:IPR036028|mint:Q99961|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|mint:MINT-8096415(identity) refseq:NP_001005336.1|refseq:NP_004399.2|refseq:NP_001275666.1|refseq:NP_001275667.1|refseq:NP_001275668.1|refseq:XP_005251825.1|refseq:XP_005251826.1|refseq:XP_016869860.1|dip:DIP-36242N|ensembl:ENSG00000106976(gene)|ensembl:ENST00000372923(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1904645"(response to amyloid-beta)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:Q05193|rcsb pdb:1DYN|rcsb pdb:2DYN|rcsb pdb:2X2E|rcsb pdb:2X2F|rcsb pdb:3SNH|rcsb pdb:3ZYC|rcsb pdb:3ZYS|rcsb pdb:4UUD|rcsb pdb:4UUK|rcsb pdb:5D3Q|rcsb pdb:6DLU|rcsb pdb:6DLV|rcsb pdb:6S9A|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-437239|reactome:R-HSA-8856828|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|mint:MINT-8096411(identity) - crc64:6E5BE978BC955077 - comment:homomint|figure legend:f7|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606 rogid:uiP8CXhKWQaP2GIAZULJTLqwGLs9606 intact-crc:BDB45F122A54B95B|rigid:zTtK2vcPxcBxqu+J7QSVFJXPhYI false glutathione s tranferase tag:?-?(MINT-8096419)|binding-associated region:286-352(MINT-8096416) binding-associated region:833-841(MINT-8096412) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:P49418 uniprotkb:Q05193 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 intact:EBI-713135|uniprotkb:A6NLM6|uniprotkb:Q5SYX0|uniprotkb:Q5SYX2|uniprotkb:Q6P3T6|uniprotkb:Q86VD2|ensembl:ENSP00000362014 psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:dyn1_human(display_long)|uniprotkb:DNM1(gene name)|psi-mi:DNM1(display_short)|uniprotkb:DNM(gene name synonym) psi-mi:"MI:0081"(peptide array) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7123071|mint:MINT-8096384 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8096391(identity) refseq:NP_001005336.1|refseq:NP_004399.2|refseq:NP_001275666.1|refseq:NP_001275667.1|refseq:NP_001275668.1|refseq:XP_005251825.1|refseq:XP_005251826.1|refseq:XP_016869860.1|dip:DIP-36242N|ensembl:ENSG00000106976(gene)|ensembl:ENST00000372923(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1904645"(response to amyloid-beta)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:Q05193|rcsb pdb:1DYN|rcsb pdb:2DYN|rcsb pdb:2X2E|rcsb pdb:2X2F|rcsb pdb:3SNH|rcsb pdb:3ZYC|rcsb pdb:3ZYS|rcsb pdb:4UUD|rcsb pdb:4UUK|rcsb pdb:5D3Q|rcsb pdb:6DLU|rcsb pdb:6DLV|rcsb pdb:6S9A|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-437239|reactome:R-HSA-8856828|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|mint:MINT-8096387(identity) - function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms - comment:homomint|figure legend:f7|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 rogid:uiP8CXhKWQaP2GIAZULJTLqwGLs9606 intact-crc:9C4835FDCD0D18D9|rigid:7jddVD3vx7GswRanVkLUi+ELNFk false glutathione s tranferase tag:?-?(MINT-8096392)|binding-associated region:620-695(MINT-8096394) binding-associated region:833-841(MINT-8096388) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:P50570 uniprotkb:Q99961 intact:EBI-346547|uniprotkb:Q7Z5S3|uniprotkb:Q5I0Y0|uniprotkb:Q9UPH4|intact:EBI-3959204|uniprotkb:A8K1B6|uniprotkb:E7EV30|uniprotkb:K7ESI9|intact:EBI-5912046|uniprotkb:E9PEQ4|ensembl:ENSP00000347890 intact:EBI-697911|uniprotkb:Q99668|uniprotkb:B4DRA1|uniprotkb:E7EVZ4|uniprotkb:M0QZV5|ensembl:ENSP00000269886 psi-mi:dyn2_human(display_long)|uniprotkb:DNM2(gene name)|psi-mi:DNM2(display_short)|uniprotkb:DYN2(gene name synonym) psi-mi:sh3g1_human(display_long)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym) psi-mi:"MI:0081"(peptide array) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7123147|mint:MINT-8096445 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004936.2|refseq:NP_001005360.1|refseq:NP_001005361.1|refseq:NP_001005362.1|refseq:NP_001177645.1|dip:DIP-31244N|reactome:R-HSA-203641|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-8856828|reactome:R-HSA-9031628|reactome:R-HSA-196025|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071245"(cellular response to carbon monoxide)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P50570|rcsb pdb:2YS1|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-190873|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000079805(gene)|ensembl:ENST00000355667(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|mint:MINT-8096447(identity) refseq:NP_001186872.1|refseq:NP_003016.1|refseq:NP_001186873.1|dip:DIP-29452N|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR035824|interpro:IPR036028|mint:Q99961|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|mint:MINT-8096448(identity) - - crc64:6E5BE978BC955077 comment:homomint|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:BAUEy6Iju72PTot46Xhz75cQTQs9606 rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606 intact-crc:74E2DF71B74BF257|rigid:OjgY/Y1czQjGF6XxEKVj1Bu48No false binding-associated region:831-840(MINT-8096463) glutathione s tranferase tag:?-?(MINT-8096449)|binding-associated region:286-352(MINT-8096452) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P49418 uniprotkb:P50570 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 intact:EBI-346547|uniprotkb:Q7Z5S3|uniprotkb:Q5I0Y0|uniprotkb:Q9UPH4|intact:EBI-3959204|uniprotkb:A8K1B6|uniprotkb:E7EV30|uniprotkb:K7ESI9|intact:EBI-5912046|uniprotkb:E9PEQ4|ensembl:ENSP00000347890 psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:dyn2_human(display_long)|uniprotkb:DNM2(gene name)|psi-mi:DNM2(display_short)|uniprotkb:DYN2(gene name synonym) psi-mi:"MI:0081"(peptide array) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7123205|mint:MINT-8096469 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8096475(identity) refseq:NP_004936.2|refseq:NP_001005360.1|refseq:NP_001005361.1|refseq:NP_001005362.1|refseq:NP_001177645.1|dip:DIP-31244N|reactome:R-HSA-203641|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-8856828|reactome:R-HSA-9031628|reactome:R-HSA-196025|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071245"(cellular response to carbon monoxide)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P50570|rcsb pdb:2YS1|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-190873|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000079805(gene)|ensembl:ENST00000355667(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|mint:MINT-8096471(identity) - function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms - comment:homomint|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 rogid:BAUEy6Iju72PTot46Xhz75cQTQs9606 intact-crc:4D6725B98E8F4B80|rigid:AICabMj5X/Kirl2FK8w0SzAhC6o false binding-associated region:620-695(MINT-8096476)|glutathione s tranferase tag:?-?(MINT-8096479) binding-associated region:831-840(MINT-8096472) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:Q9UQ16 uniprotkb:P49418 intact:EBI-1111783|uniprotkb:A9Z1Y1|uniprotkb:O14982|uniprotkb:O95555|uniprotkb:Q1MTM8|uniprotkb:Q5W129|uniprotkb:Q9H0P3|uniprotkb:Q9H548|uniprotkb:Q9NQ68|uniprotkb:Q9NQN6|uniprotkb:Q6P2G1|ensembl:ENSP00000347457 intact:EBI-7121510|ensembl:ENSP00000348602|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 psi-mi:dyn3_human(display_long)|uniprotkb:KIAA0820(gene name synonym)|uniprotkb:DNM3(gene name)|psi-mi:DNM3(display_short)|uniprotkb:Dynamin, testicular(gene name synonym)|uniprotkb:T-dynamin(gene name synonym) psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) psi-mi:"MI:0081"(peptide array) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7123241|mint:MINT-8096497 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265181.1|refseq:NP_001129599.1|refseq:NP_056384.2|refseq:XP_005245136.1|refseq:XP_005245137.1|ensembl:ENSG00000197959(gene)|ensembl:ENST00000355305(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006897"(endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061829"(basal tubulobulbar complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|rcsb pdb:3L43|rcsb pdb:5A3F|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-2132295|go:"GO:0050803"(regulation of synapse structure or activity)|reactome:R-HSA-8856828|reactome:R-HSA-437239|dip:DIP-36244N|mint:MINT-8096499(identity) ensembl:ENSG00000078053(gene)|ensembl:ENST00000356264(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|mint:P49418|rcsb pdb:1KY7|rcsb pdb:1UTC|rcsb pdb:3SOG|rcsb pdb:4ATM|rcsb pdb:5M5S|rcsb pdb:5M61|reactome:R-HSA-8856828|refseq:NP_001626.1|refseq:NP_647477.1|dip:DIP-40729N|mint:MINT-8096503(identity) - - function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms comment:homomint|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:t1g0cjVLI4Bf0hbMJvoM4zKkVYk9606 rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 intact-crc:7E310E00CA5A5CA2|rigid:iiQFUsTuP3Fkcdp827rckqgo4N8 false binding-associated region:846-854(MINT-8096500) binding-associated region:620-695(MINT-8096506)|glutathione s tranferase tag:?-?(MINT-8096504) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:Q9UQ16 uniprotkb:Q99961 intact:EBI-1111783|uniprotkb:A9Z1Y1|uniprotkb:O14982|uniprotkb:O95555|uniprotkb:Q1MTM8|uniprotkb:Q5W129|uniprotkb:Q9H0P3|uniprotkb:Q9H548|uniprotkb:Q9NQ68|uniprotkb:Q9NQN6|uniprotkb:Q6P2G1|ensembl:ENSP00000347457 intact:EBI-697911|uniprotkb:Q99668|uniprotkb:B4DRA1|uniprotkb:E7EVZ4|uniprotkb:M0QZV5|ensembl:ENSP00000269886 psi-mi:dyn3_human(display_long)|uniprotkb:KIAA0820(gene name synonym)|uniprotkb:DNM3(gene name)|psi-mi:DNM3(display_short)|uniprotkb:Dynamin, testicular(gene name synonym)|uniprotkb:T-dynamin(gene name synonym) psi-mi:sh3g1_human(display_long)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym) psi-mi:"MI:0081"(peptide array) Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7123279|mint:MINT-8096522 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265181.1|refseq:NP_001129599.1|refseq:NP_056384.2|refseq:XP_005245136.1|refseq:XP_005245137.1|ensembl:ENSG00000197959(gene)|ensembl:ENST00000355305(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006897"(endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061829"(basal tubulobulbar complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|rcsb pdb:3L43|rcsb pdb:5A3F|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-2132295|go:"GO:0050803"(regulation of synapse structure or activity)|reactome:R-HSA-8856828|reactome:R-HSA-437239|dip:DIP-36244N|mint:MINT-8096531(identity) refseq:NP_001186872.1|refseq:NP_003016.1|refseq:NP_001186873.1|dip:DIP-29452N|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR035824|interpro:IPR036028|mint:Q99961|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|mint:MINT-8096524(identity) - - crc64:6E5BE978BC955077 comment:homomint|comment:domino|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2001/01/10 2014/10/16 rogid:t1g0cjVLI4Bf0hbMJvoM4zKkVYk9606 rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606 intact-crc:ABCBC6390EE38B89|rigid:Jz29gGH0FY8GskIkVnw6dQ6g998 false binding-associated region:846-854(MINT-8096532) binding-associated region:286-352(MINT-8096525)|glutathione s tranferase tag:?-?(MINT-8096528) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0411"(enzyme linked immunosorbent assay)