#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99828	uniprotkb:P49810	intact:EBI-372594|uniprotkb:B5BU40|uniprotkb:O00693|uniprotkb:O00735|uniprotkb:Q6IB49|uniprotkb:Q96J54|uniprotkb:Q99971|uniprotkb:H6WJF3|ensembl:ENSP00000333873	intact:EBI-2010251|uniprotkb:Q96P32|uniprotkb:B1AP21|uniprotkb:A8K8D4|ensembl:ENSP00000355746|ensembl:ENSP00000355747|ensembl:ENSP00000429036|ensembl:ENSP00000486498|ensembl:ENSP00000503116|ensembl:ENSP00000504303|ensembl:ENSP00000504727|ensembl:ENSP00000504728	psi-mi:cib1_human(display_long)|uniprotkb:Calmyrin(gene name synonym)|uniprotkb:DNA-PKcs-interacting protein(gene name synonym)|uniprotkb:Kinase-interacting protein(gene name synonym)|uniprotkb:SNK-interacting protein 2-28(gene name synonym)|uniprotkb:CIB1(gene name)|psi-mi:CIB1(display_short)|uniprotkb:CIB(gene name synonym)|uniprotkb:KIP(gene name synonym)|uniprotkb:PRKDCIP(gene name synonym)|uniprotkb:Calcium- and integrin-binding protein(gene name synonym)	psi-mi:psn2_human(display_long)|uniprotkb:PSEN2(gene name)|psi-mi:PSEN2(display_short)|uniprotkb:AD4(gene name synonym)|uniprotkb:PS2(gene name synonym)|uniprotkb:PSNL2(gene name synonym)|uniprotkb:STM2(gene name synonym)|uniprotkb:STM-2(gene name synonym)|uniprotkb:E5-1(gene name synonym)|uniprotkb:AD3LP(gene name synonym)|uniprotkb:AD5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Stabler et al. (1999)	pubmed:10366599|mint:MINT-5211550	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7017541|mint:MINT-15562	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006375.2|go:"GO:0002931"(response to ischemia)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007113"(endomitotic cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007286"(spermatid development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008427"(calcium-dependent protein kinase inhibitor activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030220"(platelet formation)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032433"(filopodium tip)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0038163"(thrombopoietin-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051301"(cell division)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|ensembl:ENSG00000185043(gene)|ensembl:ENST00000328649(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000256"(positive regulation of male germ cell proliferation)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q99828|rcsb pdb:1DGU|rcsb pdb:1DGV|rcsb pdb:1XO5|rcsb pdb:1Y1A|rcsb pdb:2L4H|rcsb pdb:2L4I|rcsb pdb:6OCX|rcsb pdb:6OD0|rcsb pdb:2LM5|refseq:NP_001264693.1|dip:DIP-31260N|mint:MINT-368849(identity)	refseq:XP_016857324.1|refseq:XP_016857325.1|refseq:NP_000438.2|refseq:NP_036618.2|refseq:XP_005273256.1|ensembl:ENSG00000143801(gene)|ensembl:ENST00000366782(transcript)|ensembl:ENST00000366783(transcript)|ensembl:ENST00000524196(transcript)|ensembl:ENST00000626989(transcript)|ensembl:ENST00000677414(transcript)|ensembl:ENST00000678233(transcript)|ensembl:ENST00000679088(transcript)|ensembl:ENST00000679098(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030018"(Z disc)|go:"GO:0030426"(growth cone)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0110097"(regulation of calcium import into the mitochondrion)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR001493(Peptidase A22A, presenilin 2)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|reactome:R-HSA-1251985|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|mint:MINT-368844(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2001/03/09	2014/10/16	rogid:6nPuuJSN/emL6jukTGtT2ab+jNU9606	rogid:+oNBP2O73tVWWMT6va284jSOmoc9606	intact-crc:49A90EE0F2C583E0|rigid:wm63ho+Ath/+iCFSMdLHB4oqQ+0	false	-	binding-associated region:270-320(MINT-368845)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49810	uniprotkb:Q99828	intact:EBI-2010251|uniprotkb:Q96P32|uniprotkb:B1AP21|uniprotkb:A8K8D4|ensembl:ENSP00000355746|ensembl:ENSP00000355747|ensembl:ENSP00000429036|ensembl:ENSP00000486498|ensembl:ENSP00000503116|ensembl:ENSP00000504303|ensembl:ENSP00000504727|ensembl:ENSP00000504728	intact:EBI-372594|uniprotkb:B5BU40|uniprotkb:O00693|uniprotkb:O00735|uniprotkb:Q6IB49|uniprotkb:Q96J54|uniprotkb:Q99971|uniprotkb:H6WJF3|ensembl:ENSP00000333873	psi-mi:psn2_human(display_long)|uniprotkb:PSEN2(gene name)|psi-mi:PSEN2(display_short)|uniprotkb:AD4(gene name synonym)|uniprotkb:PS2(gene name synonym)|uniprotkb:PSNL2(gene name synonym)|uniprotkb:STM2(gene name synonym)|uniprotkb:STM-2(gene name synonym)|uniprotkb:E5-1(gene name synonym)|uniprotkb:AD3LP(gene name synonym)|uniprotkb:AD5(gene name synonym)	psi-mi:cib1_human(display_long)|uniprotkb:Calmyrin(gene name synonym)|uniprotkb:DNA-PKcs-interacting protein(gene name synonym)|uniprotkb:Kinase-interacting protein(gene name synonym)|uniprotkb:SNK-interacting protein 2-28(gene name synonym)|uniprotkb:CIB1(gene name)|psi-mi:CIB1(display_short)|uniprotkb:CIB(gene name synonym)|uniprotkb:KIP(gene name synonym)|uniprotkb:PRKDCIP(gene name synonym)|uniprotkb:Calcium- and integrin-binding protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Stabler et al. (1999)	pubmed:10366599|mint:MINT-5211550	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7017629|mint:MINT-15560	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016857324.1|refseq:XP_016857325.1|refseq:NP_000438.2|refseq:NP_036618.2|refseq:XP_005273256.1|ensembl:ENSG00000143801(gene)|ensembl:ENST00000366782(transcript)|ensembl:ENST00000366783(transcript)|ensembl:ENST00000524196(transcript)|ensembl:ENST00000626989(transcript)|ensembl:ENST00000677414(transcript)|ensembl:ENST00000678233(transcript)|ensembl:ENST00000679088(transcript)|ensembl:ENST00000679098(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030018"(Z disc)|go:"GO:0030426"(growth cone)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0110097"(regulation of calcium import into the mitochondrion)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR001493(Peptidase A22A, presenilin 2)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|reactome:R-HSA-1251985|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|mint:MINT-368874(identity)	refseq:NP_006375.2|go:"GO:0002931"(response to ischemia)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007113"(endomitotic cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007286"(spermatid development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008427"(calcium-dependent protein kinase inhibitor activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030220"(platelet formation)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032433"(filopodium tip)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0038163"(thrombopoietin-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051301"(cell division)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|ensembl:ENSG00000185043(gene)|ensembl:ENST00000328649(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000256"(positive regulation of male germ cell proliferation)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q99828|rcsb pdb:1DGU|rcsb pdb:1DGV|rcsb pdb:1XO5|rcsb pdb:1Y1A|rcsb pdb:2L4H|rcsb pdb:2L4I|rcsb pdb:6OCX|rcsb pdb:6OD0|rcsb pdb:2LM5|refseq:NP_001264693.1|dip:DIP-31260N|mint:MINT-368882(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/03/09	2014/10/16	rogid:+oNBP2O73tVWWMT6va284jSOmoc9606	rogid:6nPuuJSN/emL6jukTGtT2ab+jNU9606	intact-crc:9A82FA3C47B12CD5|rigid:wm63ho+Ath/+iCFSMdLHB4oqQ+0	false	tag:?-?(MINT-368877)|binding-associated region:270-320(MINT-368875)	tag:?-?(MINT-368883)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99828	uniprotkb:P49810	intact:EBI-372594|uniprotkb:B5BU40|uniprotkb:O00693|uniprotkb:O00735|uniprotkb:Q6IB49|uniprotkb:Q96J54|uniprotkb:Q99971|uniprotkb:H6WJF3|ensembl:ENSP00000333873	intact:EBI-2010251|uniprotkb:Q96P32|uniprotkb:B1AP21|uniprotkb:A8K8D4|ensembl:ENSP00000355746|ensembl:ENSP00000355747|ensembl:ENSP00000429036|ensembl:ENSP00000486498|ensembl:ENSP00000503116|ensembl:ENSP00000504303|ensembl:ENSP00000504727|ensembl:ENSP00000504728	psi-mi:cib1_human(display_long)|uniprotkb:Calmyrin(gene name synonym)|uniprotkb:DNA-PKcs-interacting protein(gene name synonym)|uniprotkb:Kinase-interacting protein(gene name synonym)|uniprotkb:SNK-interacting protein 2-28(gene name synonym)|uniprotkb:CIB1(gene name)|psi-mi:CIB1(display_short)|uniprotkb:CIB(gene name synonym)|uniprotkb:KIP(gene name synonym)|uniprotkb:PRKDCIP(gene name synonym)|uniprotkb:Calcium- and integrin-binding protein(gene name synonym)	psi-mi:psn2_human(display_long)|uniprotkb:PSEN2(gene name)|psi-mi:PSEN2(display_short)|uniprotkb:AD4(gene name synonym)|uniprotkb:PS2(gene name synonym)|uniprotkb:PSNL2(gene name synonym)|uniprotkb:STM2(gene name synonym)|uniprotkb:STM-2(gene name synonym)|uniprotkb:E5-1(gene name synonym)|uniprotkb:AD3LP(gene name synonym)|uniprotkb:AD5(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Stabler et al. (1999)	pubmed:10366599|mint:MINT-5211550	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7017881|mint:MINT-15561	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006375.2|go:"GO:0002931"(response to ischemia)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007113"(endomitotic cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007286"(spermatid development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008427"(calcium-dependent protein kinase inhibitor activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030220"(platelet formation)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032433"(filopodium tip)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0038163"(thrombopoietin-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051301"(cell division)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|ensembl:ENSG00000185043(gene)|ensembl:ENST00000328649(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000256"(positive regulation of male germ cell proliferation)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q99828|rcsb pdb:1DGU|rcsb pdb:1DGV|rcsb pdb:1XO5|rcsb pdb:1Y1A|rcsb pdb:2L4H|rcsb pdb:2L4I|rcsb pdb:6OCX|rcsb pdb:6OD0|rcsb pdb:2LM5|refseq:NP_001264693.1|dip:DIP-31260N|mint:MINT-368865(identity)	refseq:XP_016857324.1|refseq:XP_016857325.1|refseq:NP_000438.2|refseq:NP_036618.2|refseq:XP_005273256.1|ensembl:ENSG00000143801(gene)|ensembl:ENST00000366782(transcript)|ensembl:ENST00000366783(transcript)|ensembl:ENST00000524196(transcript)|ensembl:ENST00000626989(transcript)|ensembl:ENST00000677414(transcript)|ensembl:ENST00000678233(transcript)|ensembl:ENST00000679088(transcript)|ensembl:ENST00000679098(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030018"(Z disc)|go:"GO:0030426"(growth cone)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0110097"(regulation of calcium import into the mitochondrion)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR001493(Peptidase A22A, presenilin 2)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|reactome:R-HSA-1251985|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|mint:MINT-368856(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F6|comment:homomint|comment:mint	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2001/03/09	2014/10/16	rogid:6nPuuJSN/emL6jukTGtT2ab+jNU9606	rogid:+oNBP2O73tVWWMT6va284jSOmoc9606	intact-crc:70015B4CBE08277F|rigid:wm63ho+Ath/+iCFSMdLHB4oqQ+0	false	-	binding-associated region:270-320(MINT-368857)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)