#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P22216	uniprotkb:P32325	intact:EBI-17843|uniprotkb:D6W3L5|uniprotkb:Q6B1S1|ensemblfungi:YPL153C	intact:EBI-5575|uniprotkb:P32355|uniprotkb:D6VS39|ensemblfungi:YDR052C	psi-mi:rad53_yeast(display_long)|uniprotkb:RAD53(gene name)|psi-mi:RAD53(display_short)|uniprotkb:MEC2(gene name synonym)|uniprotkb:SAD1(gene name synonym)|uniprotkb:Serine-protein kinase 1(gene name synonym)|uniprotkb:SPK1(gene name synonym)|uniprotkb:P2588(orf name)|uniprotkb:YPL153C(locus name)|uniprotkb:CHEK2 homolog(gene name synonym)	psi-mi:dbf4_yeast(display_long)|uniprotkb:DBF4(gene name)|psi-mi:DBF4(display_short)|uniprotkb:DNA52(gene name synonym)|uniprotkb:YDR052C(locus name)|uniprotkb:YD9609.07C(orf name)|uniprotkb:D4205(orf name)|uniprotkb:Dumbbell forming protein 4(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Dohrmann et al. (1999)	pubmed:10049915|mint:MINT-5211190|imex:IM-27290	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6948673|mint:MINT-18818|imex:IM-27290-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015172.1|sgd:S000006074|ensemblfungi:YPL153C(gene)|ensemblfungi:YPL153C_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008104"(protein localization)|go:"GO:0009202"(deoxyribonucleoside triphosphate biosynthetic process)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR000253(Forkhead-associated)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016256(Serine/threonine-protein kinase RAD53)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1DMZ|rcsb pdb:1FHQ|rcsb pdb:1FHR|rcsb pdb:1G3G|rcsb pdb:1G6G|rcsb pdb:1J4K|rcsb pdb:1J4L|rcsb pdb:1J4O|rcsb pdb:1J4P|rcsb pdb:1J4Q|rcsb pdb:1K2M|rcsb pdb:1K2N|rcsb pdb:1K3J|rcsb pdb:1K3N|rcsb pdb:1K3Q|rcsb pdb:1QU5|rcsb pdb:2A0T|rcsb pdb:2JQI|rcsb pdb:2JQL|rcsb pdb:2YGV|rcsb pdb:4PDP|rcsb pdb:4PDS|rcsb pdb:5T2F|rcsb pdb:5T2S|rcsb pdb:5XZV|rcsb pdb:5XZW|rcsb pdb:6C4U|dip:DIP-2322N|mint:P22216|mint:MINT-364152(identity)	sgd:S000002459|refseq:NP_010337.3|dip:DIP-2290N|mint:P32325|ensemblfungi:YDR052C(gene)|ensemblfungi:YDR052C_mRNA(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006279"(premeiotic DNA replication)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|go:"GO:0031431"(Dbf4-dependent protein kinase complex)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0060903"(positive regulation of meiosis I)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1903468"(positive regulation of DNA replication initiation)|interpro:IPR006572(Zinc finger, DBF-type)|interpro:IPR013939(Regulatory subunit Dfp1/Him1, central region)|interpro:IPR036420|interpro:IPR038545|rcsb pdb:3OQ0|rcsb pdb:3OQ4|rcsb pdb:3QBZ|rcsb pdb:5T2F|rcsb pdb:5T2S|rcsb pdb:6MF6|reactome:R-SCE-68962|mint:MINT-364158(identity)	-	crc64:84A9612229CA72D1|comment:"Stoichiometry: 1.0"	crc64:BDB93E72EF2ABC0B|comment:"Stoichiometry: 1.0"	comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2001/11/23	2019/08/22	rogid:OU8gjvSvTtvDvk+en1y8hyEjFhI559292	rogid:xwzOvmKEBwZILrUX1ss3l9K7ZnU559292	intact-crc:F62372A81EE0895F|rigid:+dFOnIRMsrzX7fkPTy0XYqC8wT0	false	tag:?-?(MINT-364153)|sufficient binding region:50-821	tag:?-?(MINT-364159)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06243	uniprotkb:P32325	intact:EBI-4451|uniprotkb:D6VRX3|ensemblfungi:YDL017W	intact:EBI-5575|uniprotkb:P32355|uniprotkb:D6VS39|ensemblfungi:YDR052C	psi-mi:cdc7_yeast(display_long)|uniprotkb:CDC7(gene name)|psi-mi:CDC7(display_short)|uniprotkb:OAF2(gene name synonym)|uniprotkb:YDL017W(locus name)|uniprotkb:D2855(orf name)	psi-mi:dbf4_yeast(display_long)|uniprotkb:DBF4(gene name)|psi-mi:DBF4(display_short)|uniprotkb:DNA52(gene name synonym)|uniprotkb:YDR052C(locus name)|uniprotkb:YD9609.07C(orf name)|uniprotkb:D4205(orf name)|uniprotkb:Dumbbell forming protein 4(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Dohrmann et al. (1999)	pubmed:10049915|mint:MINT-5211190|imex:IM-27290	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10918893|imex:IM-27290-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002175|mint:P06243|refseq:NP_010267.3|dip:DIP-1235N|ensemblfungi:YDL017W(gene)|ensemblfungi:YDL017W_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006279"(premeiotic DNA replication)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031431"(Dbf4-dependent protein kinase complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0034629"|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0060903"(positive regulation of meiosis I)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|go:"GO:1904968"(positive regulation of monopolar spindle attachment to meiosis I kinetochore)|go:"GO:1905263"(positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:5T2S|reactome:R-SCE-68962|mint:MINT-364152(identity)	sgd:S000002459|refseq:NP_010337.3|dip:DIP-2290N|mint:P32325|ensemblfungi:YDR052C(gene)|ensemblfungi:YDR052C_mRNA(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006279"(premeiotic DNA replication)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|go:"GO:0031431"(Dbf4-dependent protein kinase complex)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0060903"(positive regulation of meiosis I)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1903468"(positive regulation of DNA replication initiation)|interpro:IPR006572(Zinc finger, DBF-type)|interpro:IPR013939(Regulatory subunit Dfp1/Him1, central region)|interpro:IPR036420|interpro:IPR038545|rcsb pdb:3OQ0|rcsb pdb:3OQ4|rcsb pdb:3QBZ|rcsb pdb:5T2F|rcsb pdb:5T2S|rcsb pdb:6MF6|reactome:R-SCE-68962|mint:MINT-364158(identity)	-	crc64:B74BA9144D0EC39F|comment:"Stoichiometry: 1.0"	crc64:BDB93E72EF2ABC0B|comment:"Stoichiometry: 1.0"	comment:mint|figure legend:Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2001/11/23	2015/07/22	rogid:DDbpXCtfnaBaEZTzMGOfNGNmfrk559292	rogid:xwzOvmKEBwZILrUX1ss3l9K7ZnU559292	rigid:uz38czBxPbWta73J4lIbRi2P674	false	tag:?-?(MINT-364153)	tag:?-?(MINT-364159)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P32325	uniprotkb:P32325	intact:EBI-5575|uniprotkb:P32355|uniprotkb:D6VS39|ensemblfungi:YDR052C	intact:EBI-5575|uniprotkb:P32355|uniprotkb:D6VS39|ensemblfungi:YDR052C	psi-mi:dbf4_yeast(display_long)|uniprotkb:DBF4(gene name)|psi-mi:DBF4(display_short)|uniprotkb:DNA52(gene name synonym)|uniprotkb:YDR052C(locus name)|uniprotkb:YD9609.07C(orf name)|uniprotkb:D4205(orf name)|uniprotkb:Dumbbell forming protein 4(gene name synonym)	psi-mi:dbf4_yeast(display_long)|uniprotkb:DBF4(gene name)|psi-mi:DBF4(display_short)|uniprotkb:DNA52(gene name synonym)|uniprotkb:YDR052C(locus name)|uniprotkb:YD9609.07C(orf name)|uniprotkb:D4205(orf name)|uniprotkb:Dumbbell forming protein 4(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Dohrmann et al. (1999)	pubmed:10049915|mint:MINT-5211190|imex:IM-27290	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10918910|imex:IM-27290-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002459|refseq:NP_010337.3|dip:DIP-2290N|mint:P32325|ensemblfungi:YDR052C(gene)|ensemblfungi:YDR052C_mRNA(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006279"(premeiotic DNA replication)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|go:"GO:0031431"(Dbf4-dependent protein kinase complex)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0060903"(positive regulation of meiosis I)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1903468"(positive regulation of DNA replication initiation)|interpro:IPR006572(Zinc finger, DBF-type)|interpro:IPR013939(Regulatory subunit Dfp1/Him1, central region)|interpro:IPR036420|interpro:IPR038545|rcsb pdb:3OQ0|rcsb pdb:3OQ4|rcsb pdb:3QBZ|rcsb pdb:5T2F|rcsb pdb:5T2S|rcsb pdb:6MF6|reactome:R-SCE-68962|mint:MINT-364152(identity)	sgd:S000002459|refseq:NP_010337.3|dip:DIP-2290N|mint:P32325|ensemblfungi:YDR052C(gene)|ensemblfungi:YDR052C_mRNA(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006279"(premeiotic DNA replication)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|go:"GO:0031431"(Dbf4-dependent protein kinase complex)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0060903"(positive regulation of meiosis I)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1903468"(positive regulation of DNA replication initiation)|interpro:IPR006572(Zinc finger, DBF-type)|interpro:IPR013939(Regulatory subunit Dfp1/Him1, central region)|interpro:IPR036420|interpro:IPR038545|rcsb pdb:3OQ0|rcsb pdb:3OQ4|rcsb pdb:3QBZ|rcsb pdb:5T2F|rcsb pdb:5T2S|rcsb pdb:6MF6|reactome:R-SCE-68962|mint:MINT-364158(identity)	-	crc64:BDB93E72EF2ABC0B|comment:"Stoichiometry: 1.0"	crc64:BDB93E72EF2ABC0B|comment:"Stoichiometry: 1.0"	comment:mint|figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2001/11/23	2015/07/22	rogid:xwzOvmKEBwZILrUX1ss3l9K7ZnU559292	rogid:xwzOvmKEBwZILrUX1ss3l9K7ZnU559292	rigid:CjnbZBicllE3hmcBp/9KarIK3Is	false	tag:?-?(MINT-364153)	tag:?-?(MINT-364159)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)