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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>MINT</shortLabel>
        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
        <alias type="synonym" typeAc="MI:1041">MINT</alias>
      </names>
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      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it/mint</attribute>
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        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2.</fullName>
        </names>
        <bibref>
          <xref>
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          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2.</attribute>
            <attribute name="journal" nameAc="MI:0885">Blood (0006-4971)</attribute>
            <attribute name="publication year" nameAc="MI:0886">1997</attribute>
            <attribute name="author-list" nameAc="MI:0636">Kupfer GM., Yamashita T., Naf D., Suliman A., Asano S., D'Andrea AD.</attribute>
            <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
            <attribute name="uniprot-dr-export">no</attribute>
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        </bibref>
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        <hostOrganismList>
          <hostOrganism ncbiTaxId="-1">
            <names>
              <shortLabel>in vitro</shortLabel>
              <fullName>In vitro</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>pull down</shortLabel>
            <fullName>pull down</fullName>
          </names>
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        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
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        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Kupfer GM., Yamashita T., Naf D., Suliman A., Asano S., D'Andrea AD.</attribute>
          <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
          <attribute name="uniprot-dr-export">no</attribute>
          <attribute name="journal" nameAc="MI:0885">Blood (0006-4971)</attribute>
          <attribute name="publication year" nameAc="MI:0886">1997</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>cdk1_human</shortLabel>
          <fullName>Cyclin-dependent kinase 1</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">p34 protein kinase</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cell division protein kinase 1</alias>
          <alias type="gene name" typeAc="MI:0301">CDK1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">CDC2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cell division control protein 2 homolog</alias>
          <alias type="gene name synonym" typeAc="MI:0302">CDC28A</alias>
          <alias type="gene name synonym" typeAc="MI:0302">CDKN1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">P34CDC2</alias>
        </names>
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          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005270360.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001307847.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-35N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
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        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P06493 original sequence version: 185</attribute>
          <attribute name="remark-internal">DIP protein P06493 original sequence version: 162</attribute>
          <attribute name="remark-internal">DIP protein P06493 original sequence version: 184</attribute>
          <attribute name="remark-internal">DIP protein P06493 original sequence version: 97</attribute>
          <attribute name="remark-internal">DIP protein P06493 original sequence version: 192</attribute>
          <attribute name="crc64">942D79448EFE490A</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>fancc_human</shortLabel>
          <fullName>Fanconi anemia group C protein</fullName>
          <alias type="gene name" typeAc="MI:0301">FANCC</alias>
          <alias type="gene name synonym" typeAc="MI:0302">FAC</alias>
          <alias type="gene name synonym" typeAc="MI:0302">FACC</alias>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002262" version="SP_191"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_191"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" version="SP_191"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_191"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_191"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006281" version="SP_191"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006289" version="SP_191"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007281" version="SP_191"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019430" version="SP_191"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0034599" version="SP_191"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0036297" version="SP_191"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043240" version="SP_191"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048854" version="SP_191"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0065003" version="SP_191"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097150" version="SP_191"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000686" version="SP_191"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="Q00597" version="SP_191"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000158169" version="SP_191" refType="gene"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7KZP" version="SP_191"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7KZQ" version="SP_191"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7KZR" version="SP_191"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7KZS" version="SP_191"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7KZT" version="SP_191"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7KZV" version="SP_191"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6783310" version="SP_191"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6796648" version="SP_191"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011516667.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001230672.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-32846N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MAQDSVDLSCDYQFWMQKLSVWDQASTLETQQDTCLHVAQFQEFLRKMYEALKEMDSNTVIERFPTIGQLLAKACWNPFILAYDESQKILIWCLCCLINKEPQNSGQSKLNSWIQGVLSHILSALRFDKEVALFTQGLGYAPIDYYPGLLKNMVLSLASELRENHLNGFNTQRRMAPERVASLSRVCVPLITLTDVDPLVEALLICHGREPQEILQPEFFEAVNEAILLKKISLPMSAVVCLWLRHLPSLEKAMLHLFEKLISSERNCLRRIECFIKDSSLPQAACHPAIFRVVDEMFRCALLETDGALEIIATIQVFTQCFVEALEKASKQLRFALKTYFPYTSPSLAMVLLQDPQDIPRGHWLQTLKHISELLREAVEDQTHGSCGGPFESWFLFIHFGGWAEMVAEQLLMSAAEPPTALLWLLAFYYGPRDGRQQRAQTMVQVKAVLGHLLAMSRSSSLSAQDLQTVAGQGTDTDLRAPAQQLIRHLLLNFLLWAPGGHTIAWDVITLMAHTAEITHEIIGFLDQTLYRWNRLGIESPRSEKLARELLKELRTQV</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q00597 original sequence version: 110</attribute>
          <attribute name="crc64">C9DDFFAC725D050C</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>fancc-cdk1</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-19437" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8610395" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-1526577" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>purified</shortLabel>
                  <fullName>purified</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <attributeList>
              <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
            </attributeList>
          </participant>
          <participant id="6">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-1526569" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>purified</shortLabel>
                  <fullName>purified</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <featureList>
              <feature id="7">
                <names>
                  <shortLabel>binding site</shortLabel>
                </names>
                <xref>
                  <primaryRef db="mint" dbAc="MI:0471" id="MINT-1526570" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8610406" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>binding region</shortLabel>
                    <fullName>binding-associated region</fullName>
                    <alias type="synonym" typeAc="MI:1041">binding region</alias>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <begin position="550"/>
                    <endStatus>
                      <names>
                        <shortLabel>c-terminal</shortLabel>
                        <fullName>c-terminal position</fullName>
                        <alias type="go synonym" typeAc="MI:0303">c-term</alias>
                        <alias type="go synonym" typeAc="MI:0303">carboxy-terminus</alias>
                        <alias type="go synonym" typeAc="MI:0303">c-terminus</alias>
                        <alias type="synonym" typeAc="MI:1041">c-term</alias>
                        <alias type="synonym" typeAc="MI:1041">c-terminus</alias>
                        <alias type="synonym" typeAc="MI:1041">carboxy-terminus</alias>
                        <alias type="synonym" typeAc="MI:1041">c-terminal</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0334" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448301" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                    <end position="558"/>
                  </featureRange>
                </featureRangeList>
                <attributeList>
                  <attribute name="remark-internal">range MINT-1526571: original sequence: 550-558 : SPRSEKLARELLKELRTQ</attribute>
                </attributeList>
              </feature>
              <feature id="8">
                <names>
                  <shortLabel>tagged molecule</shortLabel>
                </names>
                <xref>
                  <primaryRef db="mint" dbAc="MI:0471" id="MINT-1526573" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8610410" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>tag</shortLabel>
                    <fullName>tag</fullName>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0507" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456738" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>undetermined</shortLabel>
                        <fullName>undetermined sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">undetermined</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <endStatus>
                      <names>
                        <shortLabel>undetermined</shortLabel>
                        <fullName>undetermined sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">undetermined</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                  </featureRange>
                </featureRangeList>
              </feature>
            </featureList>
            <attributeList>
              <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
            </attributeList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">homomint</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>