RPS6KB1
STK14A
UniProt:P23443 RPS6KB1
PPM1A
PPPM1A
UniProt:P35813 PPM1A
Phosphorylation of TSC2 by PKB
Phosphorylation of complexed TSC2 by PKB
GTP loading by Rheb
Formation of active mTORC1 complex
Activation of S6K1
Phosphorylation of Ribosomal protein S6 by activated S6K1
Phosphorylation and inactivation of eEF2K by activated S6K1
Phosphorylation and activation of eIF4G by activated S6K1
Phosphorylation and activation of eIF4B by activated S6K1
Phosphorylation of 4E-BP1 by activated mTORC1
Dissociation of phosphorylated 4EBP1 from eIF4E
LKB1 forms a trimeric complex with STRAD and MO25
Activation of cytosolic AMPK by phosphorylation
AMPK is dephosphorylated
Phosphorylated AMPK binds AMP
AMPK phosphorylates Raptor
p-AMPK phosphorylates TSC2
TSC2 activates intrinsic GTPase activity of Rheb
mTOR signalling
Inhibition of TSC complex formation by PKB
mTORC1-mediated signalling
S6K1-mediated signalling
S6K1 signalling
Release of eIF4E
Energy dependent regulation of mTOR by LKB1-AMPK
Regulation of AMPK activity via LKB1
Regulation of Rheb GTPase activity by AMPK