DAPAT
DHAPAT
GNPAT
UniProt:O15228 GNPAT
AGPAT6
GPAT4
UniProt:Q86UL3 AGPAT6
AGPAT5
UniProt:Q9NUQ2 AGPAT5
Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate
DHAP is converted to G3P by GPD1/GPD1L
Conversion of glycerol-3-phosphate to lysophosphatidic acid
G3P is acylated to 1-acyl LPA by AGPAT6
glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated]
1-acyl LPA is acylated to PA by AGPAT (LPAAT)
1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH
lysophosphatidic acid + fatty acyl CoA => phosphatidic acid + CoA (1)
DHAP is converted to 1-acyl GO3P by GNPAT
PA is hydrolysed to 1-acyl LPA by PLA2[1]
PA is hydrolysed to 1-acyl LPA by PLA2G2A
G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)
1-acyl LPA is acylated to PA by AGPAT5 (OM)
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)
PC is hydrolyzed to PA and choline by PLD1/2
PA is hydrolyzed to 1-acyl LPA by PLA2[15]
Synthesis of PA