DAPAT
label: DHAPAT
label: GNPAT
label: UniProt:O15228 GNPAT

AGPAT6
label: GPAT4
label: UNQ551/PRO1108
label: UniProt:Q86UL3 AGPAT6

AGPAT5
label: UniProt:Q9NUQ2 AGPAT5

Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004367
BFO_0000050: Synthesis of PA
directly activates: Conversion of glycerol-3-phosphate to lysophosphatidic acid
directly activates: BiochemicalReaction4759
directly activates: G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)
directly activates: Catalysis2114
directly activates: Catalysis2115
directly activates: Catalysis2301
label: DHAP is converted to G3P by GPD1/GPD1L

Conversion of glycerol-3-phosphate to lysophosphatidic acid
type: Restriction
  on property: enabled by
  some values from: AGPAT6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004366
BFO_0000050: Synthesis of PA
directly activates: 1-acyl LPA is acylated to PA by AGPAT (LPAAT)
directly activates: Catalysis2116
label: G3P is acylated to 1-acyl LPA by AGPAT6
label: glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated]

1-acyl LPA is acylated to PA by AGPAT (LPAAT)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003841
BFO_0000050: Synthesis of PA
directly activates: BiochemicalReaction4761
directly activates: PA is hydrolysed to 1-acyl LPA by PLA2[1]
directly activates: PA is hydrolysed to 1-acyl LPA by PLA2G2A
directly activates: BiochemicalReaction5029
directly activates: BiochemicalReaction5075
directly activates: Catalysis2117
directly activates: Catalysis2299
directly activates: Catalysis2300
directly activates: Catalysis2315
directly activates: Catalysis2355
label: 1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH
label: lysophosphatidic acid + fatty acyl CoA => phosphatidic acid + CoA (1)

DHAP is converted to 1-acyl GO3P by GNPAT
type: Restriction
  on property: enabled by
  some values from: DAPAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: GO_0016287
BFO_0000050: Synthesis of PA

PA is hydrolysed to 1-acyl LPA by PLA2[1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Synthesis of PA
directly activates: 1-acyl LPA is acylated to PA by AGPAT (LPAAT)
directly activates: Catalysis2116

PA is hydrolysed to 1-acyl LPA by PLA2G2A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004623
BFO_0000050: Synthesis of PA
directly activates: 1-acyl LPA is acylated to PA by AGPAT (LPAAT)
directly activates: Catalysis2116

G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0004366
BFO_0000050: Synthesis of PA
directly activates: 1-acyl LPA is acylated to PA by AGPAT5 (OM)
directly activates: Catalysis2302

1-acyl LPA is acylated to PA by AGPAT5 (OM)
type: Restriction
  on property: enabled by
  some values from: AGPAT5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0003841
BFO_0000050: Synthesis of PA
directly activates: PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)
directly activates: BiochemicalReaction5084
directly activates: Catalysis2303

PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Synthesis of PA
directly activates: 1-acyl LPA is acylated to PA by AGPAT5 (OM)
directly activates: Catalysis2302

PC is hydrolyzed to PA and choline by PLD1/2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004630
BFO_0000050: Synthesis of PA
directly activates: BiochemicalReaction3696
directly activates: PA is hydrolysed to 1-acyl LPA by PLA2[1]
directly activates: PA is hydrolysed to 1-acyl LPA by PLA2G2A
directly activates: BiochemicalReaction5029
directly activates: BiochemicalReaction5045
directly activates: BiochemicalReaction5075
directly activates: Catalysis1652
directly activates: Catalysis2299
directly activates: Catalysis2300
directly activates: Catalysis2315
directly activates: Catalysis2329
directly activates: Catalysis2355

PA is hydrolyzed to 1-acyl LPA by PLA2[15]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004623
BFO_0000050: Synthesis of PA

Synthesis of PA
type: GO_0008150