ATM
label: UniProt:Q13315 ATM

COP1
label: RFWD2
label: RNF200
label: UniProt:Q8NHY2 RFWD2

Phosphorylation of p53 at ser-15 by ATM kinase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: GO_0016301
BFO_0000050: Stabilization of p53
directly activates: TemplateReaction149
directly activates: TemplateReaction151
directly activates: TemplateReactionRegulation173
directly activates: TemplateReactionRegulation175

Phosphorylation of MDM2 at serine-395 by ATM kinase
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Stabilization of p53

Phosphorylation of COP1 at Ser-387 by ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Autodegradation of the E3 ubiquitin ligase COP1
directly activates: Dissociation of the COP1-p53 complex
directly activates: Translocation of COP1 from the nucleus to the cytoplasm

Dissociation of the COP1-p53 complex
type: GO_0003674
BFO_0000050: Autodegradation of the E3 ubiquitin ligase COP1

Translocation of COP1 from the nucleus to the cytoplasm
type: GO_0003674
BFO_0000050: Autodegradation of the E3 ubiquitin ligase COP1
directly activates: Autoubiquitination of phospho-COP1(Ser-387 )
directly activates: Catalysis806

Autoubiquitination of phospho-COP1(Ser-387 )
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Autodegradation of the E3 ubiquitin ligase COP1
directly activates: Proteasome mediated degradation of COP1
directly activates: Catalysis807

Proteasome mediated degradation of COP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Autodegradation of the E3 ubiquitin ligase COP1

Stabilization of p53
type: GO_0008150

Autodegradation of the E3 ubiquitin ligase COP1
type: GO_0008150
BFO_0000050: Stabilization of p53