ATM
UniProt:Q13315 ATM
COP1
RFWD2
RNF200
UniProt:Q8NHY2 RFWD2
Phosphorylation of p53 at ser-15 by ATM kinase
Phosphorylation of MDM2 at serine-395 by ATM kinase
Phosphorylation of COP1 at Ser-387 by ATM
Dissociation of the COP1-p53 complex
Translocation of COP1 from the nucleus to the cytoplasm
Autoubiquitination of phospho-COP1(Ser-387 )
Proteasome mediated degradation of COP1
Stabilization of p53
Autodegradation of the E3 ubiquitin ligase COP1