LPP1
label: PPAP2A
label: UniProt:O14494 PPAP2A

DEGS1
label: DES1
label: MIG15
label: MLD
label: UniProt:O15121 DEGS1

KIAA1252
label: SGPL1
label: UniProt:O95470 SGPL1

CK1G2
label: CSNK1G2
label: UniProt:P78368 CSNK1G2

FVT1
label: KDSR
label: UniProt:Q06136 KDSR

PKD
label: PKD1
label: PRKCM
label: PRKD1
label: UniProt:Q15139 PRKD1

ACER2
label: ASAH3L
label: PP11646
label: UniProt:Q5QJU3 ACER2

C14orf66
label: DEGS2
label: UniProt:Q6QHC5 DEGS2

MOB
label: SGMS1
label: SMS1
label: TMEM23
label: UniProt:Q86VZ5 SGMS1

SGMS2
label: SMS2
label: UniProt:Q8NHU3 SGMS2

ACER1
label: ASAH3
label: UniProt:Q8TDN7 ACER1

ACER3
label: APHC
label: PHCA
label: UniProt:Q9NUN7 ACER3

3-ketosphinganine + NADPH + H+ => sphinganine + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: FVT1
type: GO_0047560
BFO_0000050: Sphingolipid de novo biosynthesis

CERT + ATP => monophospho-CERT + ADP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PKD
type: GO_0004674
BFO_0000050: Sphingolipid de novo biosynthesis

CERT [ER] + ceramide [ER] => CERT:ceramide [ER]
type: GO_0003674
BFO_0000050: Sphingolipid de novo biosynthesis
label: âCERTâ protein binds ceramide associated with the endoplasmic reticulum membrane

CERT:PPM1L:VAPA/B [ER] => CERT [cytosol] + PPM1L:VAPA/B [ER]
type: GO_0003674
BFO_0000050: Sphingolipid de novo biosynthesis
label: âCERTâ dissociates from the endoplasmic reticulum

CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER]
type: GO_0003674
BFO_0000050: Sphingolipid de novo biosynthesis
directly activates: BiochemicalReaction5311
directly activates: Catalysis2554
label: âCERTâ protein releases its bound ceramide into the membrane of the Golgi apparatus

ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]
type: Restriction
  on property: enabled by
  some values from: ACER1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0017040
BFO_0000050: Sphingolipid de novo biosynthesis

ceramide + H2O => stearate + sphingosine [Golgi]
type: Restriction
  on property: enabled by
  some values from: ACER2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0017040
BFO_0000050: Sphingolipid de novo biosynthesis

dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O
type: Restriction
  on property: enabled by
  some values from: DEGS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0042284
BFO_0000050: Sphingolipid de novo biosynthesis

dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O
type: Restriction
  on property: enabled by
  some values from: C14orf66
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0000170
BFO_0000050: Sphingolipid de novo biosynthesis

monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP
type: Restriction
  on property: enabled by
  some values from: CK1G2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Sphingolipid de novo biosynthesis

multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B
type: GO_0003674
BFO_0000050: Sphingolipid de novo biosynthesis

multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004722
BFO_0000050: Sphingolipid de novo biosynthesis
directly activates: CERT:PPM1L:VAPA/B [ER] => CERT [cytosol] + PPM1L:VAPA/B [ER]

palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004758
BFO_0000050: Sphingolipid de novo biosynthesis

phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: MOB
type: GO_0033188
BFO_0000050: Sphingolipid de novo biosynthesis

phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: SGMS2
type: GO_0033188
BFO_0000050: Sphingolipid de novo biosynthesis

phytoceramide + H2O => stearate + phytosphingosine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACER3
type: GO_0070774
BFO_0000050: Sphingolipid de novo biosynthesis

sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008481
BFO_0000050: Sphingolipid de novo biosynthesis

sphinganine + stearyl-CoA => dihydroceramide + CoASH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0050291
BFO_0000050: Sphingolipid de novo biosynthesis

sphinganine 1-phosphate + H2O => sphinganine + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0070780
BFO_0000050: Sphingolipid de novo biosynthesis
directly activates: sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP
directly activates: Catalysis2524

sphinganine 1-phosphate => phosphoethanolamine + hexadecanal
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: KIAA1252
type: GO_0008117
BFO_0000050: Sphingolipid de novo biosynthesis

sphingosine +ATP => sphingosine 1-phosphate + ADP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0017050
BFO_0000050: Sphingolipid de novo biosynthesis

sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0042392
BFO_0000050: Sphingolipid de novo biosynthesis
directly activates: sphingosine +ATP => sphingosine 1-phosphate + ADP
directly activates: Catalysis2528

sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0042392
BFO_0000050: Sphingolipid de novo biosynthesis

sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: LPP1
type: GO_0042392
BFO_0000050: Sphingolipid de novo biosynthesis

sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: KIAA1252
type: GO_0008117
BFO_0000050: Sphingolipid de novo biosynthesis

Sphingolipid de novo biosynthesis
type: GO_0008150