LPP1
PPAP2A
UniProt:O14494 PPAP2A
DEGS1
DES1
MIG15
MLD
UniProt:O15121 DEGS1
KIAA1252
SGPL1
UniProt:O95470 SGPL1
CK1G2
CSNK1G2
UniProt:P78368 CSNK1G2
FVT1
KDSR
UniProt:Q06136 KDSR
PKD
PKD1
PRKCM
PRKD1
UniProt:Q15139 PRKD1
ACER2
ASAH3L
UniProt:Q5QJU3 ACER2
C14orf66
DEGS2
UniProt:Q6QHC5 DEGS2
MOB
SGMS1
SMS1
TMEM23
UniProt:Q86VZ5 SGMS1
SGMS2
SMS2
UniProt:Q8NHU3 SGMS2
ACER1
ASAH3
UniProt:Q8TDN7 ACER1
ACER3
APHC
PHCA
UniProt:Q9NUN7 ACER3
3-ketosphinganine + NADPH + H+ => sphinganine + NADP+
CERT + ATP => monophospho-CERT + ADP
CERT [ER] + ceramide [ER] => CERT:ceramide [ER]
âCERTâ protein binds ceramide associated with the endoplasmic reticulum membrane
CERT:PPM1L:VAPA/B [ER] => CERT [cytosol] + PPM1L:VAPA/B [ER]
âCERTâ dissociates from the endoplasmic reticulum
CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER]
âCERTâ protein releases its bound ceramide into the membrane of the Golgi apparatus
ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]
ceramide + H2O => stearate + sphingosine [Golgi]
dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O
dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O
monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP
multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B
multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate
palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2
phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]
phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]
phytoceramide + H2O => stearate + phytosphingosine
sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP
sphinganine + stearyl-CoA => dihydroceramide + CoASH
sphinganine 1-phosphate + H2O => sphinganine + orthophosphate
sphinganine 1-phosphate => phosphoethanolamine + hexadecanal
sphingosine +ATP => sphingosine 1-phosphate + ADP
sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]
sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]
sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal
Sphingolipid de novo biosynthesis