Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4
type: GO_0003674
BFO_0000050: Signaling by NODAL
directly activates: The SMAD2/3:SMAD4 complex transfers to the nucleus
directly activates: BiochemicalReaction325

The SMAD2/3:SMAD4 complex transfers to the nucleus
type: GO_0003674
BFO_0000050: Signaling by NODAL
directly activates: BiochemicalReaction324
directly activates: BiochemicalReaction331
directly activates: BiochemicalReaction333
directly activates: BiochemicalReaction335
directly activates: BiochemicalReaction336
directly activates: BiochemicalReaction337
directly activates: BiochemicalReaction340
directly activates: BiochemicalReaction349
directly activates: BiochemicalReaction350
directly activates: BiochemicalReaction352
directly activates: Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXH1 Binds Activin Response Element
directly activates: Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 Binds FoxO3a-binding Elements
directly activates: Catalysis115
directly activates: Catalysis123
directly activates: Control22
directly activates: Control356
directly activates: Degradation4

Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXH1 Binds Activin Response Element
type: GO_0003674
BFO_0000050: Signaling by NODAL

Cleavage of NODAL Proprotein
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Signaling by NODAL
directly activates: The NODAL Receptor Binds NODAL Ligands
directly activates: CERBERUS Binds NODAL
directly activates: LEFTY Binds NODAL
directly activates: Control500
directly activates: Control501
directly activates: Control502

The NODAL Receptor Binds NODAL Ligands
type: GO_0003674
BFO_0000050: Signaling by NODAL
directly activates: Type II Activin Receptor (ActRII/ACVR2) Phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in Response to NODAL
directly activates: Type II Activin Receptor (ActRIIB/ACVR2B) Phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in Response to NODAL
directly activates: Catalysis3216
directly activates: Catalysis3217

Type II Activin Receptor (ActRII/ACVR2) Phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in Response to NODAL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Signaling by NODAL
directly activates: Phosphorylation of R-SMAD2/3 by NODAL Receptor
directly activates: Catalysis3218

Type II Activin Receptor (ActRIIB/ACVR2B) Phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in Response to NODAL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Signaling by NODAL
directly activates: Phosphorylation of R-SMAD2/3 by NODAL Receptor
directly activates: Catalysis3218

Phosphorylation of R-SMAD2/3 by NODAL Receptor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Signaling by NODAL
directly activates: Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4

Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 Binds FoxO3a-binding Elements
type: GO_0003674
BFO_0000050: Signaling by NODAL

CERBERUS Binds NODAL
type: GO_0003674
BFO_0000050: Regulation of Signaling by NODAL

LEFTY Binds NODAL
type: GO_0003674
BFO_0000050: Regulation of Signaling by NODAL

LEFTY Binds the EGF-CFC Coreceptor in the NODAL Receptor
type: GO_0003674
BFO_0000050: Regulation of Signaling by NODAL

Signaling by NODAL
type: GO_0008150

Regulation of Signaling by NODAL
type: GO_0008150
BFO_0000050: Signaling by NODAL