Phosphorylation of STK3 (MST2) and SAV1 by STK3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Hippo signaling cascade
directly activates: Cleavage of p-STK3 (p-MST2) by caspase 3
directly activates: Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)
directly activates: Phosphorylation of MOB1A and B by p-STK3 (p-MST2)
directly activates: Catalysis1924
directly activates: Catalysis1926
directly activates: Catalysis1930

Phosphorylation of STK4 (MST1) and SAV1 by STK4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Hippo signaling cascade
directly activates: Cleavage of p-STK4 (p-MST1) by caspase 3
directly activates: Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)
directly activates: Phosphorylation of MOB1A and B by p-STK4 (p-MST1)
directly activates: Catalysis1925
directly activates: Catalysis1928
directly activates: Catalysis1932

Cleavage of p-STK3 (p-MST2) by caspase 3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Hippo signaling cascade
directly activates: Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N
directly activates: Phosphorylation of MOB1A and B by p-STK3(MST2)/N
directly activates: Catalysis1927
directly activates: Catalysis1931

Cleavage of p-STK4 (p-MST1) by caspase 3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Hippo signaling cascade
directly activates: Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N
directly activates: Phosphorylation of MOB1A and B by p-STK4(MST1)/N
directly activates: Catalysis1929
directly activates: Catalysis1933

KIBRA (WWC1) binds LATS proteins
type: GO_0003674
BFO_0000050: Hippo signaling cascade

NPHP4 protein binds LATS proteins
type: GO_0003674
BFO_0000050: Hippo signaling cascade

Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Hippo signaling cascade
directly activates: Phosphorylation of YAP by LATS1
directly activates: Phosphorylation of YAP by LATS2
directly activates: Phosphorylation of WWTR1 (TAZ) by LATS1
directly activates: Phosphorylation of WWTR1 (TAZ) by LATS2
directly activates: Catalysis1934
directly activates: Catalysis1935
directly activates: Catalysis1936
directly activates: Catalysis1937
directly activates: Control353
directly activates: Control355

Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Hippo signaling cascade
directly activates: Phosphorylation of YAP by LATS1
directly activates: Phosphorylation of YAP by LATS2
directly activates: Catalysis1934
directly activates: Catalysis1935
directly activates: Control353

Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Hippo signaling cascade
directly activates: Phosphorylation of YAP by LATS1
directly activates: Phosphorylation of YAP by LATS2
directly activates: Phosphorylation of WWTR1 (TAZ) by LATS1
directly activates: Phosphorylation of WWTR1 (TAZ) by LATS2
directly activates: Catalysis1934
directly activates: Catalysis1935
directly activates: Catalysis1936
directly activates: Catalysis1937
directly activates: Control353
directly activates: Control355

Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Hippo signaling cascade
directly activates: Phosphorylation of YAP by LATS1
directly activates: Phosphorylation of YAP by LATS2
directly activates: Catalysis1934
directly activates: Catalysis1935
directly activates: Control353

Phosphorylation of MOB1A and B by p-STK3 (p-MST2)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Hippo signaling cascade
directly activates: Phosphorylated MOB1A proteins associate with LATS proteins

Phosphorylation of MOB1A and B by p-STK3(MST2)/N
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Hippo signaling cascade

Phosphorylation of MOB1A and B by p-STK4 (p-MST1)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Hippo signaling cascade
directly activates: Phosphorylated MOB1A proteins associate with LATS proteins

Phosphorylation of MOB1A and B by p-STK4(MST1)/N
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Hippo signaling cascade

Phosphorylated MOB1A proteins associate with LATS proteins
type: GO_0003674
BFO_0000050: Hippo signaling cascade
directly activates: Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)
directly activates: Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N
directly activates: Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)
directly activates: Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N
directly activates: Catalysis1926
directly activates: Catalysis1927
directly activates: Catalysis1928
directly activates: Catalysis1929

Translocation of YAP1 to the nucleus
type: GO_0003674
BFO_0000050: Hippo signaling cascade
directly activates: BiochemicalReaction319

YAP1 binds ZO-2 (TJP2)
type: GO_0003674
BFO_0000050: Hippo signaling cascade
directly activates: Translocation of YAP1:ZO-2 (TJP2) to the nucleus

Translocation of YAP1:ZO-2 (TJP2) to the nucleus
type: GO_0003674
BFO_0000050: Hippo signaling cascade

AMOT proteins bind YAP1
type: GO_0003674
BFO_0000050: Hippo signaling cascade

Phosphorylation of YAP by LATS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Hippo signaling cascade
directly activates: YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1

Phosphorylation of YAP by LATS2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Hippo signaling cascade
directly activates: YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1

YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1
type: GO_0003674
BFO_0000050: Hippo signaling cascade

Translocation of WWTR1 (TAZ) to the nucleus
type: GO_0003674
BFO_0000050: Hippo signaling cascade
directly activates: BiochemicalReaction318
directly activates: BiochemicalReaction320

WWTR1 (TAZ) binds ZO-1 (TJP1)
type: GO_0003674
BFO_0000050: Hippo signaling cascade

WWTR1 (TAZ) binds ZO-2 (TJP2)
type: GO_0003674
BFO_0000050: Hippo signaling cascade

AMOT proteins bind WWTR1 (TAZ)
type: GO_0003674
BFO_0000050: Hippo signaling cascade

Phosphorylation of WWTR1 (TAZ) by LATS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Hippo signaling cascade
directly activates: DVL2 binds phosphorylated WWTR1 (TAZ)

Phosphorylation of WWTR1 (TAZ) by LATS2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Hippo signaling cascade
directly activates: DVL2 binds phosphorylated WWTR1 (TAZ)
directly activates: YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ)

DVL2 binds phosphorylated WWTR1 (TAZ)
type: GO_0003674
BFO_0000050: Hippo signaling cascade

YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ)
type: GO_0003674
BFO_0000050: Hippo signaling cascade

Hippo signaling cascade
type: GO_0008150
label: Signaling by Hippo