Phosphorylation of STK3 (MST2) and SAV1 by STK3
Phosphorylation of STK4 (MST1) and SAV1 by STK4
Cleavage of p-STK3 (p-MST2) by caspase 3
Cleavage of p-STK4 (p-MST1) by caspase 3
KIBRA (WWC1) binds LATS proteins
NPHP4 protein binds LATS proteins
Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)
Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N
Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)
Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N
Phosphorylation of MOB1A and B by p-STK3 (p-MST2)
Phosphorylation of MOB1A and B by p-STK3(MST2)/N
Phosphorylation of MOB1A and B by p-STK4 (p-MST1)
Phosphorylation of MOB1A and B by p-STK4(MST1)/N
Phosphorylated MOB1A proteins associate with LATS proteins
Translocation of YAP1 to the nucleus
YAP1 binds ZO-2 (TJP2)
Translocation of YAP1:ZO-2 (TJP2) to the nucleus
AMOT proteins bind YAP1
Phosphorylation of YAP by LATS1
Phosphorylation of YAP by LATS2
YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1
Translocation of WWTR1 (TAZ) to the nucleus
WWTR1 (TAZ) binds ZO-1 (TJP1)
WWTR1 (TAZ) binds ZO-2 (TJP2)
AMOT proteins bind WWTR1 (TAZ)
Phosphorylation of WWTR1 (TAZ) by LATS1
Phosphorylation of WWTR1 (TAZ) by LATS2
DVL2 binds phosphorylated WWTR1 (TAZ)
YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ)
Hippo signaling cascade
Signaling by Hippo