TPIP
label: TPTE2
label: UniProt:Q6XPS3 TPTE2

KIAA0851
label: SACM1L
label: UniProt:Q9NTJ5 SACM1L

PI:PITPNB is transported from the ER membrane to the Golgi membrane
type: GO_0003674
BFO_0000050: PI and PC transport between ER and Golgi membranes
directly activates: PI is exchanged with PC by PITPNB

PI is exchanged with PC by PITPNB
type: GO_0003674
BFO_0000050: PI and PC transport between ER and Golgi membranes
directly activates: PC:PITPNB is transported from the Golgi membrane to the ER membrane
directly activates: PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane
directly activates: PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
directly activates: PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane
directly activates: Catalysis2389
directly activates: Catalysis2390
directly activates: Catalysis2392

PC:PITPNB is transported from the Golgi membrane to the ER membrane
type: GO_0003674
BFO_0000050: PI and PC transport between ER and Golgi membranes
directly activates: PC is exchanged with PI by PITPNB

PC is exchanged with PI by PITPNB
type: GO_0003674
BFO_0000050: PI and PC transport between ER and Golgi membranes
directly activates: BiochemicalReaction5018
directly activates: PI:PITPNB is transported from the ER membrane to the Golgi membrane
directly activates: BiochemicalReaction5054
directly activates: BiochemicalReaction5055
directly activates: BiochemicalReaction5057
directly activates: BiochemicalReaction5058
directly activates: BiochemicalReaction5067
directly activates: BiochemicalReaction5083
directly activates: Catalysis2304
directly activates: Catalysis2334
directly activates: Catalysis2335
directly activates: Catalysis2337
directly activates: Catalysis2338
directly activates: Catalysis2347
directly activates: Catalysis2363

PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004430
BFO_0000050: Synthesis of PIPs at the ER membrane
directly activates: PI4P is dephosphorylated to PI by SACM1L at the ER membrane
directly activates: Catalysis2388

PI4P is dephosphorylated to PI by SACM1L at the ER membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: GO_0034596
BFO_0000050: Synthesis of PIPs at the ER membrane
directly activates: PC is exchanged with PI by PITPNB
directly activates: BiochemicalReaction5077
directly activates: BiochemicalReaction5078
directly activates: BiochemicalReaction5080
directly activates: PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
directly activates: Catalysis2357
directly activates: Catalysis2358
directly activates: Catalysis2360
directly activates: Catalysis2387

PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004430
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
directly activates: PI4P transports from the Golgi membrane to the plasma membrane
directly activates: Catalysis2391
directly activates: Catalysis2396

PI4KB binds to ARF1/3:GTP at the Golgi membrane
type: GO_0003674
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
directly activates: Catalysis2390

PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0004430
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
directly activates: PI4P transports from the Golgi membrane to the plasma membrane
directly activates: Catalysis2391
directly activates: Catalysis2396

PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: GO_0034596
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane
directly activates: PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
directly activates: PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane
directly activates: Catalysis2389
directly activates: Catalysis2390
directly activates: Catalysis2392

PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016303
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
directly activates: Catalysis2393
directly activates: Catalysis2394

PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: GO_0004438
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane
directly activates: PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
directly activates: PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane
directly activates: Catalysis2389
directly activates: Catalysis2390
directly activates: Catalysis2392

PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0000285
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
directly activates: Catalysis2395

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0043813
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
directly activates: Catalysis2393
directly activates: Catalysis2394

PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0035005
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane
directly activates: Catalysis2397

PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: TPIP
type: Restriction
  on property: enabled by
  some values from: TPIP
type: GO_0051800
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
directly activates: PI4P transports from the Golgi membrane to the plasma membrane
directly activates: Catalysis2391
directly activates: Catalysis2396

PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004439
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
directly activates: PI4P transports from the Golgi membrane to the plasma membrane
directly activates: Catalysis2391
directly activates: Catalysis2396

PI4P transports from the Golgi membrane to the plasma membrane
type: GO_0003674
BFO_0000050: PIPs transport between Golgi and plasma membranes
directly activates: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
directly activates: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
directly activates: Catalysis2399
directly activates: Catalysis2405
directly activates: Catalysis2416

PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016308
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: BiochemicalReaction4609
directly activates: BiochemicalReaction4610
directly activates: PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
directly activates: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
directly activates: BiochemicalReaction979
directly activates: Catalysis2022
directly activates: Catalysis2023
directly activates: Catalysis2400
directly activates: Catalysis2401

PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004439
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
directly activates: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
directly activates: Catalysis2399
directly activates: Catalysis2405
directly activates: Catalysis2416

PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0046934
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane
directly activates: PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
directly activates: Catalysis2402
directly activates: Catalysis2404

PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016314
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: BiochemicalReaction4609
directly activates: BiochemicalReaction4610
directly activates: PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
directly activates: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
directly activates: Catalysis2022
directly activates: Catalysis2023
directly activates: Catalysis2400
directly activates: Catalysis2401

PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052812
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane
directly activates: PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
directly activates: Catalysis2402
directly activates: Catalysis2404

PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0034485
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
directly activates: PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane
directly activates: Catalysis2403
directly activates: Catalysis2406
directly activates: Catalysis2408

PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0035005
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
directly activates: PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane
directly activates: Catalysis2403
directly activates: Catalysis2406
directly activates: Catalysis2408

PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0051800
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
directly activates: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
directly activates: Catalysis2399
directly activates: Catalysis2405
directly activates: Catalysis2416

PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052811
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
directly activates: PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane
directly activates: Catalysis2403
directly activates: Catalysis2406
directly activates: Catalysis2408

PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016316
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
directly activates: PI3P is dephosphorylated to PI by SYNJ/MTM[1] at the plasma membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane
directly activates: Catalysis2407
directly activates: Catalysis2409
directly activates: Catalysis2411

PI3P is dephosphorylated to PI by SYNJ/MTM[1] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004438
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: BiochemicalReaction5082
directly activates: PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane
directly activates: PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane
directly activates: Catalysis2362
directly activates: Catalysis2410
directly activates: Catalysis2415

PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052810
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2A/B at the plasma membrane
directly activates: Catalysis2414

PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000285
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTM[1] at the plasma membrane
directly activates: Catalysis2412
directly activates: Catalysis2413

PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0043813
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
directly activates: PI3P is dephosphorylated to PI by SYNJ/MTM[1] at the plasma membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane
directly activates: Catalysis2407
directly activates: Catalysis2409
directly activates: Catalysis2411

PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTM[1] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052629
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2A/B at the plasma membrane
directly activates: Catalysis2414

PI5P is phosphorylated to PI(4,5)P2 by PIP4K2A/B at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016309
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: BiochemicalReaction4609
directly activates: BiochemicalReaction4610
directly activates: PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
directly activates: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
directly activates: Catalysis2022
directly activates: Catalysis2023
directly activates: Catalysis2400
directly activates: Catalysis2401

PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004430
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
directly activates: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
directly activates: Catalysis2399
directly activates: Catalysis2405
directly activates: Catalysis2416

PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0034596
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: BiochemicalReaction5082
directly activates: PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane
directly activates: PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane
directly activates: Catalysis2362
directly activates: Catalysis2410
directly activates: Catalysis2415

PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane
type: GO_0003674
BFO_0000050: PIPs transport between plasma and early endosome membranes
directly activates: PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
directly activates: Catalysis2417

PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016316
BFO_0000050: Synthesis of PIPs at the early endosome membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
directly activates: PI3P is dephosphorylated to PI by MTM[2] at the early endosome membrane
directly activates: Catalysis2418
directly activates: Catalysis2422

PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: GO_0000285
BFO_0000050: Synthesis of PIPs at the early endosome membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI5P by MTM[2] at the early endosome membrane
directly activates: PI(3,5)P2 transports from the early endosome membrane to the Golgi membrane
directly activates: Catalysis2419
directly activates: Catalysis2420

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: GO_0043813
BFO_0000050: Synthesis of PIPs at the early endosome membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
directly activates: PI3P is dephosphorylated to PI by MTM[2] at the early endosome membrane
directly activates: Catalysis2418
directly activates: Catalysis2422

PI(3,5)P2 is dephosphorylated to PI5P by MTM[2] at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052629
BFO_0000050: Synthesis of PIPs at the early endosome membrane

PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016303
BFO_0000050: Synthesis of PIPs at the early endosome membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
directly activates: PI3P is dephosphorylated to PI by MTM[2] at the early endosome membrane
directly activates: Catalysis2418
directly activates: Catalysis2422

PI3P is dephosphorylated to PI by MTM[2] at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004438
BFO_0000050: Synthesis of PIPs at the early endosome membrane
directly activates: PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane
directly activates: PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane
directly activates: Catalysis2421
directly activates: Catalysis2423

PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004430
BFO_0000050: Synthesis of PIPs at the early endosome membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane
directly activates: Catalysis2424

PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0035005
BFO_0000050: Synthesis of PIPs at the early endosome membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
directly activates: Catalysis2417

PI(3,5)P2 transports from the early endosome membrane to the Golgi membrane
type: GO_0003674
BFO_0000050: PIPs transport between early endosome and Golgi membranes
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
directly activates: Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome
directly activates: Catalysis2395

Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome
type: GO_0003674
BFO_0000050: PIPs transport between early and late endosome membranes
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI5P by MTM[3] at the late endosome membrane
directly activates: PI(3,5)P2 transports from the late endosome membrane to the Golgi membrane
directly activates: Catalysis2426
directly activates: Catalysis2427

PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: GO_0000285
BFO_0000050: Synthesis of PIPs at the late endosome membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI5P by MTM[3] at the late endosome membrane
directly activates: PI(3,5)P2 transports from the late endosome membrane to the Golgi membrane
directly activates: Catalysis2426
directly activates: Catalysis2427

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: GO_0043813
BFO_0000050: Synthesis of PIPs at the late endosome membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane
directly activates: PI3P is dephosphorylated to PI by MTM[3] at the late endosome membrane
directly activates: Catalysis2425
directly activates: Catalysis2430

PI(3,5)P2 is dephosphorylated to PI5P by MTM[3] at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052629
BFO_0000050: Synthesis of PIPs at the late endosome membrane

PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: GO_0052810
BFO_0000050: Synthesis of PIPs at the late endosome membrane

PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016303
BFO_0000050: Synthesis of PIPs at the late endosome membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane
directly activates: PI3P is dephosphorylated to PI by MTM[3] at the late endosome membrane
directly activates: Catalysis2425
directly activates: Catalysis2430

PI3P is dephosphorylated to PI by MTM[3] at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004438
BFO_0000050: Synthesis of PIPs at the late endosome membrane
directly activates: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane
directly activates: PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane
directly activates: Catalysis2428
directly activates: Catalysis2429

PI(3,5)P2 transports from the late endosome membrane to the Golgi membrane
type: GO_0003674
BFO_0000050: PIPs transport between late endosome and Golgi membranes
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
directly activates: Catalysis2395

PI and PC transport between ER and Golgi membranes
type: GO_0008150
BFO_0000050: PI Metabolism

PI Metabolism
type: GO_0008150

Synthesis of PIPs at the ER membrane
type: GO_0008150
BFO_0000050: PI Metabolism

Synthesis of PIPs at the Golgi membrane
type: GO_0008150
BFO_0000050: PI Metabolism

PIPs transport between Golgi and plasma membranes
type: GO_0008150
BFO_0000050: PI Metabolism

Synthesis of PIPs at the plasma membrane
type: GO_0008150
BFO_0000050: PI Metabolism

PIPs transport between plasma and early endosome membranes
type: GO_0008150
BFO_0000050: PI Metabolism

Synthesis of PIPs at the early endosome membrane
type: GO_0008150
BFO_0000050: PI Metabolism

PIPs transport between early endosome and Golgi membranes
type: GO_0008150
BFO_0000050: PI Metabolism

PIPs transport between early and late endosome membranes
type: GO_0008150
BFO_0000050: PI Metabolism

Synthesis of PIPs at the late endosome membrane
type: GO_0008150
BFO_0000050: PI Metabolism

PIPs transport between late endosome and Golgi membranes
type: GO_0008150
BFO_0000050: PI Metabolism