OTUD7C
TNFAIP3
UniProt:P21580 TNFAIP3
MAP2K6
MEK6
MKK6
PRKMK6
SKK3
UniProt:P52564 MAP2K6
CYLD
CYLD1
HSPC057
KIAA0849
UniProt:Q9NQC7 CYLD
iE-DAP elicits a NOD1 response
MDP elicits a NOD2 response
Activated NOD1 oligomerizes
Activated NOD2 oligomerizes
Activated NOD oligomer recruites RIP2 (RICK)
RIP2 binds NEMO
RIP2 induces K63-linked ubiquitination of NEMO
CYLD deubiquitinates NEMO
RIP2 is K63 polyubiquitinated
A20 deubiquitinates RIP2
K63 polyubiquitinated RIP2 associates with the TAK1 complex
TAK1 is activated
TAK1 phosphorylates MKK6
NOD1 induced apoptosis is mediated by RIP2 and CARD8
CARD9 binds RIP2 (and NOD2)
Activation of p38 MAPK
Activated TAK1 mediates phosphorylation of the IKK Complex
NOD1/2 Signaling Pathway