OTUD7C
label: TNFAIP3
label: UniProt:P21580 TNFAIP3

MAP2K6
label: MEK6
label: MKK6
label: PRKMK6
label: SKK3
label: UniProt:P52564 MAP2K6

CYLD
label: CYLD1
label: HSPC057
label: KIAA0849
label: UniProt:Q9NQC7 CYLD

iE-DAP elicits a NOD1 response
type: GO_0003674
BFO_0000050: NOD1/2 Signaling Pathway
directly activates: Activated NOD1 oligomerizes

MDP elicits a NOD2 response
type: GO_0003674
BFO_0000050: NOD1/2 Signaling Pathway
directly activates: Activated NOD2 oligomerizes

Activated NOD1 oligomerizes
type: GO_0003674
BFO_0000050: NOD1/2 Signaling Pathway
directly activates: Activated NOD oligomer recruites RIP2 (RICK)
directly activates: NOD1 induced apoptosis is mediated by RIP2 and CARD8

Activated NOD2 oligomerizes
type: GO_0003674
BFO_0000050: NOD1/2 Signaling Pathway
directly activates: Activated NOD oligomer recruites RIP2 (RICK)

Activated NOD oligomer recruites RIP2 (RICK)
type: GO_0003674
BFO_0000050: NOD1/2 Signaling Pathway
directly activates: RIP2 binds NEMO
directly activates: RIP2 is K63 polyubiquitinated
directly activates: CARD9 binds RIP2 (and NOD2)
directly activates: Catalysis396

RIP2 binds NEMO
type: GO_0003674
BFO_0000050: NOD1/2 Signaling Pathway
directly activates: RIP2 induces K63-linked ubiquitination of NEMO
directly activates: Catalysis394

RIP2 induces K63-linked ubiquitination of NEMO
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: NOD1/2 Signaling Pathway
directly activates: CYLD deubiquitinates NEMO
directly activates: Catalysis395

CYLD deubiquitinates NEMO
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CYLD
type: GO_0070536
BFO_0000050: NOD1/2 Signaling Pathway

RIP2 is K63 polyubiquitinated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0019787
BFO_0000050: NOD1/2 Signaling Pathway
directly activates: A20 deubiquitinates RIP2
directly activates: K63 polyubiquitinated RIP2 associates with the TAK1 complex
directly activates: Catalysis397

A20 deubiquitinates RIP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: OTUD7C
type: GO_0070536
BFO_0000050: NOD1/2 Signaling Pathway

K63 polyubiquitinated RIP2 associates with the TAK1 complex
type: GO_0003674
BFO_0000050: NOD1/2 Signaling Pathway
directly activates: TAK1 is activated
directly activates: BiochemicalReaction1420

TAK1 is activated
type: GO_0003674
BFO_0000050: NOD1/2 Signaling Pathway
directly activates: TAK1 phosphorylates MKK6
directly activates: Activated TAK1 mediates phosphorylation of the IKK Complex
directly activates: Catalysis336
directly activates: Catalysis398

TAK1 phosphorylates MKK6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004709
BFO_0000050: NOD1/2 Signaling Pathway
directly activates: Activation of p38 MAPK
directly activates: BiochemicalReaction6268
directly activates: Catalysis3211
directly activates: Catalysis399

NOD1 induced apoptosis is mediated by RIP2 and CARD8
type: GO_0003674
BFO_0000050: NOD1/2 Signaling Pathway

CARD9 binds RIP2 (and NOD2)
type: GO_0003674
BFO_0000050: NOD1/2 Signaling Pathway
directly activates: Activation of p38 MAPK
directly activates: Catalysis399

Activation of p38 MAPK
type: Restriction
  on property: enabled by
  some values from: MAP2K6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004708
BFO_0000050: NOD1/2 Signaling Pathway

Activated TAK1 mediates phosphorylation of the IKK Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: NOD1/2 Signaling Pathway
directly activates: BiochemicalReaction1425
directly activates: BiochemicalReaction884
directly activates: Catalysis337
directly activates: Catalysis516

NOD1/2 Signaling Pathway
type: GO_0008150