CYP1A2
label: UniProt:P05177 CYP1A2

COMT
label: UniProt:P21964 COMT

NNMT
label: UniProt:P40261 NNMT

TPMT
label: UniProt:P51580 TPMT

MTR transfers CH3 group from MeCbl to HCYS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008705
BFO_0000050: Methylation
directly activates: BiochemicalReaction5600
directly activates: Catalysis2771
label: Methionine is reformed

SAM is sythesized from methionine's reaction with ATP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004478
BFO_0000050: Methylation
directly activates: BiochemicalReaction5755
directly activates: 6-mercaptopurine can be S-methylated
directly activates: 2-mercaptoethanol can be S-methylated
directly activates: Pyridine can be N-methylated
directly activates: 3,4-dihydroxybenzoate can be O-methylated
directly activates: Catalysis2911
directly activates: Catalysis3054
directly activates: Catalysis3055
directly activates: Catalysis3056
directly activates: Catalysis3057

S-adenoylhomocysteine is hydrolyzed
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004013
BFO_0000050: Methylation
directly activates: MTR transfers CH3 group from MeCbl to HCYS
directly activates: BiochemicalReaction5805
directly activates: BiochemicalReaction5806
directly activates: Catalysis2773
directly activates: Catalysis2953
directly activates: Catalysis2954

S-atom dealkylation of 6-methylmercaptopurine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: GO_0019825
BFO_0000050: Methylation
directly activates: 6-mercaptopurine can be S-methylated
directly activates: Catalysis3054

6-mercaptopurine can be S-methylated
type: Restriction
  on property: enabled by
  some values from: TPMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008119
BFO_0000050: Methylation
directly activates: S-adenoylhomocysteine is hydrolyzed
directly activates: Catalysis2952

2-mercaptoethanol can be S-methylated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0018708
BFO_0000050: Methylation
directly activates: S-adenoylhomocysteine is hydrolyzed
directly activates: Catalysis2952

Pyridine can be N-methylated
type: Restriction
  on property: enabled by
  some values from: NNMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0030760
BFO_0000050: Methylation
directly activates: S-adenoylhomocysteine is hydrolyzed
directly activates: Catalysis2952

3,4-dihydroxybenzoate can be O-methylated
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016206
BFO_0000050: Methylation
directly activates: S-adenoylhomocysteine is hydrolyzed
directly activates: Catalysis2952

Methylation
type: GO_0008150