MBTPS2
S2P
UniProt:O43462 MBTPS2
AGM1
PGM3
UniProt:O95394 PGM3
GCNT3
UniProt:O95395 GCNT3
MCD4
PIGN
UniProt:O95427 PIGN
EPN
MME
UniProt:P08473 MME
IBP1
IGFBP1
UniProt:P08833 IGFBP1
FUR
FURIN
PACE
PCSK3
UniProt:P09958 FURIN
ACE
DCP
DCP1
UniProt:P12821 ACE
SIAT1
ST6GAL1
UniProt:P15907 ST6GAL1
NEC2
PCSK2
UniProt:P16519 PCSK2
IBP3
IGFBP3
UniProt:P17936 IGFBP3
BP2
IBP2
IGFBP2
UniProt:P18065 IGFBP2
IBP4
IGFBP4
UniProt:P22692 IGFBP4
EIF4B
UniProt:P23588 EIF4B
CMA1
CYH
CYM
UniProt:P23946 CMA1
IBP6
IGFBP6
UniProt:P24592 IGFBP6
IBP5
IGFBP5
UniProt:P24593 IGFBP5
GGNT1
GLCT1
GLYT1
MGAT
MGAT1
UniProt:P26572 MGAT1
KIF5B
KNS
KNS1
UniProt:P33176 KIF5B
MPI
PMI1
UniProt:P34949 MPI
GGCX
UniProt:P38435 GGCX
RAB27
RAB27A
UniProt:P51159 RAB27A
EEF1A
EEF1A1
EF1A
LENG7
UniProt:P68104 EEF1A1
GGNT3
MGAT3
UniProt:Q09327 MGAT3
GGNT5
MGAT5
UniProt:Q09328 MGAT5
MGAT2
UniProt:Q10469 MGAT2
CGS23
NANTA3
SIAT4C
ST3GAL4
STZ
UniProt:Q11206 ST3GAL4
PAFAH
PLA2G7
UniProt:Q13093 PLA2G7
PAPPA
UniProt:Q13219 PAPPA
GCS1
MOGS
UniProt:Q13724 MOGS
KIAA0091
MBTPS1
S1P
SKI1
UniProt:Q14703 MBTPS1
EIF4H
KIAA0038
UniProt:Q15056 EIF4H
WBSCR1
WSCR1
ALG11
GT8
UniProt:Q2TAA5 ALG11
MANEA
UniProt:Q5SRI9 MANEA
SLC30A6
UniProt:Q6NXT4 SLC30A6
ZNT6
PGAP1
UniProt:Q75T13 PGAP1
PIGW
UniProt:Q7Z7B1 PIGW
DOLPP1
LSFR2
UniProt:Q86YN1 DOLPP1
FGE
PSEC0152
SUMF1
UniProt:Q8NBK3 SUMF1
SLC30A7
UniProt:Q8NEW0 SLC30A7
ZNT7
ZNTL2
SLC30A5
UniProt:Q8TAD4 SLC30A5
ZNT5
ZNTL1
ZTL1
PIGB
UniProt:Q92521 PIGB
ALG3
NOT
NOT56L
UniProt:Q92685 ALG3
RFT1
UniProt:Q96AA3 RFT1
ERO1L
UniProt:Q96HE7 ERO1L
FKSG89
GOAT
MBOAT4
OACT4
UniProt:Q96T53 MBOAT4
MSTP134
MSTP576
UniProt:Q9BQB6 VKORC1
VKOR
VKORC1
ALG1
HMAT1
HMT1
PSEC0061
UniProt:Q9BT22 ALG1
ALG12
UniProt:Q9BV10 ALG12
ALG8
HUSSY-02
UniProt:Q9BVK2 ALG8
FUT8
UniProt:Q9BYC5 FUT8
ACE2
UniProt:Q9BYF1 ACE2
DPAGT1
DPAGT2
UniProt:Q9H3H5 DPAGT1
ALG2
UniProt:Q9H553 ALG2
ALG9
DIBD1
UniProt:Q9H6U8 ALG9
UniProt:Q9H9G5 cDNA FLJ12769 fis, clone NT2RP2001581
cDNA FLJ12769 fis, clone NT2RP2001581
PREB
SEC12
UniProt:Q9HCU5 PREB
PIGV
UniProt:Q9NUD9 PIGV
CTSZ
UniProt:Q9UBR2 CTSZ
SIAT7B
SIATL1
ST6GALNAC2
STHM
UniProt:Q9UJ37 ST6GALNAC2
MAN1B1
UniProt:Q9UKM7 MAN1B1
DOLK
KIAA1094
TMEM15
UniProt:Q9UPQ8 DOLK
PIGL
UniProt:Q9Y2B2 PIGL
MYH12
MYO5A
UniProt:Q9Y4I1 MYO5A
TEX4
TIM22
TIMM22
UniProt:Q9Y584 TIMM22
ALG6
My046
UniProt:Q9Y672 ALG6
ALG5
HSPC149
UniProt:Q9Y673 ALG5
Dissociation of L13a from the 60s ribosomal subunit
INF-gamma induced phosphorylation of L13a
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA
Sar1p Activation And Membrane Binding
Coat Assembly
Loss of Sar1b GTPase
Cargo, Sec31p:Sec13p, and v-SNARE recruitment
Vesicle Budding
Vesicle Uncoating
unfolded actin/tubulin associates with prefoldin
Actin/tubulin:prefoldin complex associates with CCT/TriC
ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex
Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC
Exchange of ADP for ATP in CCT/TriC:actin complex
Hydrolysis of ATP and release of folded actin from CCT/TriC
Association of CCT/TriC with sphingosine kinase 1
Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone)
Beta-tubulin:GTP + Cofactor A -> Beta-tubulin:GTP: Cofactor A
Beta-tubulin:GTP + Cofactor D -> Beta-tubulin:GTP: Cofactor D
Beta-tubulin:GTP: Cofactor A+ Cofactor D -> Beta-tubulin:GTP:Cofactor D + Cofactor A
alpha-tubulin:GTP + Cofactor B -> alpha-tubulin:GTP: Cofactor B
alpha-tubulin:GTP + Cofactor E -> alpha-tubulin:GTP:Cofactor E
alpha-tubulin:GTP:Cofactor B +Cofactor E -> alpha-tubulin:GTP: Cofactor E +Cofactor B
Beta-tubulin:GTP:Cofactor D+alpha-tubulin:GTP:Cofactor E-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi
vitamin K epoxide -> vitamin K hydroquinone
pro-factor IX, uncarboxylated + 12 CO2 + 12 O2 + 12 vitamin K hydroquinone -> pro-factor IX + 12 H2O + 12 vitamin K epoxide
pro-factor VII, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-factor VII + 10 H2O + 10 vitamin K epoxide
pro-factor X, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-factor X + 11 H2O + 11 vitamin K epoxide
pro-prothrombin, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-prothrombin + 10 H2O + 10 vitamin K epoxide
pro-protein C, uncarboxylated + 8 CO2 + 8 O2 + 8 vitamin K hydroquinone -> pro-protein C + 8 H2O + 8 vitamin K epoxide
pro-protein S, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-protein S + 11 H2O + 11 vitamin K epoxide
pro-protein Z, uncarboxylated + 13 CO2 + 13 O2 + 13 vitamin K hydroquinone -> pro-protein Z + 13 H2O + 13 vitamin K epoxide
pro-GAS6, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-GAS6 + 11 H2O + 11 vitamin K epoxide
Pro-factor IX is transported from the endoplasmic reticulum to the Golgi apparatus
Pro-factor VII is transported from the endoplasmic reticulum to the Golgi apparatus
Pro-factor X is transported from the endoplasmic reticulum to the Golgi apparatus
Pro-prothrombin is transported from the endoplasmic reticulum to the Golgi apparatus
Pro-protein C is transported from the endoplasmic reticulum to the Golgi apparatus
Pro-protein S is transported from the endoplasmic reticulum to the Golgi apparatus
Pro-protein Z is transported from the endoplasmic reticulum to the Golgi apparatus
Pro-GAS6 is transported from the endoplasmic reticulum to the Golgi apparatus
pro-factor IX -> factor IX + factor IX propeptide
pro-factor VII -> factor VII + factor VII propeptide
pro-factor X -> factor X + factor X propeptide
pro-prothrombin -> prothrombin + prothrombin propeptide
pro-protein C -> protein C + protein C propeptide
pro-protein S -> protein S + protein S propeptide
pro-protein Z -> protein Z + protein Z propeptide
pro-GAS6 -> GAS6 + GAS6 propeptide
EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane
EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine
EIF5A(Dhp) + O2 => EIF5A(Hyp)
SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
SUMF2 inhibits SUMF1-mediated activation of arylsulfatases
dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose
Reorientation of dolichyl phosphate D-mannose in the endoplasmic reticulum membrane
phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate
Reorientation of glucosaminyl-acyl-PI in the endoplasmic reticulum membrane
glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH
glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate
mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol
(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate
mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate
mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol
mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI
(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI
uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid
Phosphorylation of dolichol
Dephosphorylation of dolichyl diphosphate
Formation of glucosamine 6-phosphate from fructose 6-phosphate and glutamine
Acetylation of glucosamine 6-phosphate to GlcNAc6P
Isomerization of GlcNAc6P to GlcNAc1P
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine
Fructose 6-phosphate isomerizes to Mannose 6-phosphate
Mannose 6-phosphate isomerizes to Mannose 1-phosphate
Mannose-1-phosphate converted to GDP-Mannose
Synthesis of dolichyl-phosphate-glucose
Flipping of dolichyl-phosphate-glucose into the ER lumen
Addition of N-acetyl-D-glucosamine to Dolichyl phosphate
Addition of the second N-acetyl-glucosamine to the N-glycan precursor
Addition of the first mannose to the N-glycan precursor by ALG13/14
Addition of a second mannose to the N-glycan precursor by ALG2
Addition of a third mannose to the N-glycan precursor by ALG2
Addition of a fourth and fifth mannose to the N-glycan precursor by ALG11
Flipping of the N-glycan precursor to inside the ER
Addition of the sixth mannose to the N-glycan precursor by ALG3.
Addition of the seventh mannose to the N-glycan precursor by ALG9, inside the ER lumen
Addition of the eighth mannose to the N-glycan precursor by ALG12, inside the ER lumen
Addition of the last mannose to the N-glycan precursor by ALG3, inside the ER lumen.
Addition of the first glucose to the N-glycan precursor by ALG6
Addition of a second glucose to the N-glycan precursor by ALG8
Addition of a third glucose to the N-glycan precursor by an ALG10 homologue
Transfer of N-glycan to the protein
Trimming of the first glucose by glucosidase I
Binding of Malectin
Removal of the second glucose by glucosidase II
Binding of calnexin/calreticulin to the unfolded protein
Binding of ERp57
Removal of the third glucose by glucosidase II and release from the chaperone
Incorrectly folded glycoproteins translocate to the ERQC
Trimming of the terminal mannose on the B branch
Trimming of the terminal mannose on the C branch
Trimming of the first mannose on the A branch
Trimming of the second mannose on the A branch
Re-addition of a glucose on the alpha 1,3 branch
Glycoproteins with major folding defects are sent to degradation by EDEMs
Glycoproteins with lesser folding defects get transported back to the ER and the CNX/CRT complex
Correctly folded glycoproteins translocate to the Golgi
Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi
Alternative endo-mannosidase I route
Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2
Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2
Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2
Addition of GlcNAc to the glycan on the A arm
Addition of a bifurcating GlcNAc to the N-glycan by MGAT3
Trimming of mannoses on the alpha1,6 arm by MAN2A1
Addition of a GlcNAc on the alpha 1,4 branch by MGAT2
Addition of alpha 1,6 fucose to the first GlcNAc of the N-glycan
Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV
Addition of GlcNAc to position 5 by MGAT5
Addition of galactose by beta 4-galactosyltransferases
Addition of alpha-2,6-sialic acid to terminal galactose of N-glycans by ST6GAL1
Addition of alpha-2,8-sialic acid to N-glycan over a galactose by ST8SIAs
Addition of alpha-2,3-sialic acid to N-glycan over a galactose by ST3GAL4
Addition of GalNAc to mucins to form the Tn antigen
C1GALT1 transfers galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)
Addition of GlcNAc to the T antigen forms a Core 2 glycoprotein
Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein
Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein
Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein
Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein
Addition of galactose to Core 6 glycoprotein
Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein
Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position
Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position
GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position
ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position
ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen
TOMM40 Complex Transports Proteins Across the Outer Mitochondrial Membrane
MIA40:ERV1 (CHCHD4:GFER) Catalyzes Formation of Disulfide Bonds
TIMM8:TIMM13 Chaperones Hydrophobic Proteins
TIMM9:TIMM10 Binds Hydrophobic Proteins
TIMM9:TIMM10 Delivers Proteins to TIMM22
SAM50 Complex Inserts Proteins into Mitochondrial Outer Membrane
TIMM22 Inserts Proteins into Inner Membrane
Precursor Proteins Enter TIMM23 SORT
MPP Cleaves Presequence of Inner Membrane Precursors
TIMM23 SORT Inserts Proteins into Inner Membrane
Precursor Proteins Enter TIMM23 PAM
MPP Cleaves Presequence of Matrix Precursors
TIMM23 PAM Imports Proteins to Mitochondrial Matrix
Oxidation of Cysteine to Cystine in Proinsulin
Translocation of Cystine-bonded Proinsulin from the Endoplasmic Reticulum to the Golgi
Formation of Proinsulin-Zinc-Calcium Complex
Transport of Proinsulin-Zinc-Calcium Complex to Immature Secretory Granule
Processing of Proinsulin to Insulin
Translocation of Insulin Secretory Granules to Cell Cortex
Traversal of the cortical actin network and docking at plasma membrane
Exocyst complex formation
Cleavage of the Signal Peptide of Preproghrelin
Octanoylation of Proghrelin by Ghrelin O-acyltransferase
Decanoylation of Proghrelin by Ghrelin O-acyltransferase
Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3
Secretion of Acyl Ghrelin and C-Ghrelin
Deacylation of Acyl Ghrelin
Renin Hydrolyzes Angiotensinogen to Yield Angiotensin I
Renin Hydrolyzes Angiotensinogen to Yield Angiotensin-(1-10)
Renin Bound to Renin Receptor Hydrolyzes Angiotensinogen to Yield Angiotensin I
Renin:Prorenin Receptor Hydrolyzes Angiotensinogen to Yield Angiotensin-(1-10)
Prorenin Bound to Renin Receptor Hydrolyzes Angiotensinogen to Yield Angiotensin I
Prorenin:Prorenin Receptor Hydrolyzes Angiotensinogen to Yield Angiotensin-(1-10)
ACE Hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-8)
Angiotensin-converting Enzyme Hydrolyzes Angiotensin I to Yield Angiotensin II
Secreted ACE Hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-8)
Secreted Angiotensin-converting Enzyme Hydrolyzes Angiotensin I to Yield Angiotensin II
Chymase Hydrolyzes Angiotensin I to Yield Angiotensin II
Chymase Hydrolyzes Angiotensin-(1-10) to Yields Angiotensin-(1-8)
Cathepsin G Hydrolyzes Angiotensin I to Yield Angiotensin II
Cathepsin G Hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-8)
Cathepsin Z (Cathepsin X) Hydrolyzes Angiotensin I to Yield Angiotensin II
Cathepsin Z (Cathepsin X) Hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-8)
ACE2 Hydrolyzes Angiotensin I to Yield Angiotensin-(1-9)
ACE2 Hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)
ACE Hydrolyzes Angiotensin-(1-9) to Yield Angiotensin-(1-7)
Neprilysin Hydrolyzes Angiotensin-(1-9) to Yield Angiotensin-(1-7)
Neprilysin Hydrolyzes Angiotensin I to Yield Angiotensin-(1-7)
Neprilysin Hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-7)
ENPEP Hydrolyzes Angiotensin II to Yield Angiotensin III
ENPEP Hydrolyzes Angiotensin-(1-8) to Yield Angiotensin-(2-8)
ANPEP Hydrolyzes Angiotensin III to Yield Angiotensin IV
ANPEP Hydrolyzes Angiotensin-(2-8) to Yield Angiotensin-(3-8)
ACE2 Hydrolyzes Angiotensin II to Yield Angiotensin-(1-7)
ACE2 Hydrolyzes Angiotensin-(1-8) to Yield Angiotensin-(1-7)
Mast Cell Carboxypeptidase Hydrolyzes Angiotensin I to Yield Angiotensin-(1-9)
Mast Cell Carboxypeptidase Hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)
Processing of preproGLP-1 to proGLP-1
Transit of Proglucagon from the ER Lumen to Secretory Granules
Processing of Proglucagon to Glucagon-like Peptide-1
Secretion of Glucagon-like Peptide 1 from Intestinal L Cells
Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1)
Processing of preproGIP to proGIP
Transit of ProGIP from the ER Lumen to Secretory Granules
Processing of proGIP to GIP
Secretion of Glucose-dependent Insulinotropic Polypeptide from Intestinal K Cells
Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP)
Corticotropin cleavage from POMC
Human chorionic gonadotropin (hCG) is a heterodimer
Luteinizing hormone is a heterodimer
Thyrotropin is a heterodimer
Follitropin is a heterodimer
Formation of the IGF:IGFBP-1 Complex
Formation of the IGF:IGFBP-2 Complex
Formation of the IGF:IGFBP-3:ALS Complex
Formation of the IGF:IGFBP-4 Complex
Formation of the IGF:IGFBP-5:ALS Complex
Formation of the IGF:IGFBP-6 Complex
Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G
Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase
Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin
Proteolysis of the IGF:IGFBP-3:ALS Complex by Prostate-specific Antigen
Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin
Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A
Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2
Dissociation of ATF6-alpha:BiP Complex
Translocation of ATF6-alpha to the Golgi
Cleavage of ATF6-alpha by S1P
Cleavage of ATF6-alpha by S2P
Translocation of ATF6-alpha to the Nucleus
Dissociation of IRE1:BiP heterodimer
Dimerization of IRE1
Autophosphorylation of IRE1 dimer
ADP Binding by Phosphorylated IRE1 Homodimer
Cleavage of Xbp1 mRNA by IRE1alpha and Splicing of Cleaved Xbp1 mRNA
Translation and translocation of XBP1(S) to the Nucleus
Dissociation of PERK:BiP Heterodimer
Dimerization of PERK
Phosphorylation of eIF2-alpha by PERK
Release of 40S and 60S subunits from the 80S ribosome
eIF3 and eIF1A bind to the 40S subunit
De novo formation of eIF2:GTP
Met-tRNAi binds to eIF2:GTP to form the ternary complex
Formation of the 43S pre-initiation complex
Release of eIF4E from the inactive eIF4E:4E-BP complex
Formation of the cap-binding eIF4F complex
eIF4F binds to mRNP
Cap-bound mRNA is activated by helicases
Formation of translation initiation complexes containing mRNA that does not circularize
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation
Ribosomal scanning
Start codon recognition
eIF2:GTP is hydrolyzed, eIFs are released
eIF5B:GTP is hydrolyzed and released
The 60S subunit joins the translation initiation complex
Formation of eIF2:GDP:eIF2B intermediate
eIF2 activation
Synthesis of nascent polypeptide containing signal sequence
Association of a nascent polypeptide:mRNA:ribosome complex with a signal recognition particle (SRP)
The SRP receptor binds the SRP:nascent peptide:ribosome complex
Translocation of signal-containing nascent peptide to Endoplasmic Reticulum
Signal peptide cleavage from ribosome-associated nascent protein
eEF1A complexes with GTP
eEF1A:GTP:aminoacyl tRNA ternary complex formation.
Aminoacyl-tRNA binds to the ribosome at the A-site
Hydrolysis of eEF1A:GTP
Peptide transfer from P-site tRNA to the A-site tRNA
Translocation of ribosome by 3 bases in the 3' direction
GTP-binding activates eEF2
Regeneration of eEF1A:GTP by eEF1B activity
Formation of eEF1B complex
GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex
GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex
Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex
Translation
Eukaryotic Translation Initiation
Cap-dependent Translation Initiation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Translation initiation complex formation
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Recycling of eIF2:GDP
Cap-independent Translation Initiation
SRP-dependent cotranslational protein targeting to membrane
Eukaryotic Translation Elongation
Peptide chain elongation
Eukaryotic Translation Termination
ER to Golgi Transport
COPII (Coat Protein 2) Mediated Vesicle Transport
Metabolism of proteins
Protein folding
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Folding of actin by CCT/TriC
Association of TriC/CCT with target proteins during biosynthesis
Post-chaperonin tubulin folding pathway
Post-translational protein modification
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Hypusine synthesis from eIF5A-lysine
Hypusinylation
The activation of arylsulfatases
Post-translational modification: synthesis of GPI-anchored proteins
Synthesis of dolichyl-phosphate mannose
Synthesis of glycosylphosphatidylinositol (GPI)
Attachment of GPI anchor to uPAR
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Synthesis of substrates in N-glycan biosythesis
Synthesis of Dolichyl-phosphate
Synthesis of UDP-N-acetyl-glucosamine
Synthesis of GDP-mannose
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Calnexin/calreticulin cycle
ER Quality Control Compartment (ERQC)
Transport to the Golgi and subsequent modification
N-glycan trimming and elongation in the cis-Golgi
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2
N-glycan antennae elongation in the medial/trans-Golgi
Reactions specific to the hybrid N-glycan synthesis pathway
Reactions specific to the complex N-glycan synthesis pathway
N-Glycan antennae elongation
O-linked glycosylation of mucins
Termination of O-glycan biosynthesis
Mitochondrial Protein Import
Peptide hormone metabolism
Insulin Processing
Synthesis, Secretion, and Deacylation of Ghrelin
Metabolism of Angiotensinogen to Angiotensins
Incretin Synthesis, Secretion, and Inactivation
Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
Peptide hormone biosynthesis
Glycoprotein hormones
Regulation of IGF Activity by IGFBP
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Unfolded Protein Response
Activation of Chaperones by ATF6-alpha
Activation of Chaperone Genes by ATF6-alpha
Activation of Chaperones by IRE1alpha
Activation of Chaperone Genes by XBP1(S)
PERK regulated gene expression
Activation of Genes by ATF4
L13a-mediated translational silencing of Ceruloplasmin expression
Translation and translocation of ATF4
Expression of ATF3
Expression of Asparagine Synthetase
Expression of CCL2
Expression of HERPUD
Expression of IGFBP1
Expression of IL-8
Synthesis of Preproghrelin
Synthesis of Preproglucagon in Intestinal L Cells
Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in Intestinal K Cells
Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5)
Expression of CHOP (DDIT3, GADD153)
Expression of Calreticulin
Expression of HSP90B1 (Endoplasmin)
Expression of Xbp1(S)
Expression of ACADVL
Expression of ADD1 (Adducin alpha)
Expression of ATP6VOD1
Expression of C19orf10
Expression of CTDSP2
Expression of CXXC1
Expression of Cullin-7
Expression of DCTN1
Expression of DDX11
Expression of DNAJB11
Expression of DNAJB9
Expression of EDEM
Expression of EXTL3
Expression of FKBP14
Expression of ARFGAP1 (GAP)
Expression of GFPT1
Expression of GOSR2
Expression of GSK3A
Expression of HDGF
Expression of HYOU1
Expression of KDELR3
Expression of KLHDC3
Expression of LMNA
Expression of PDIA5
Expression of PDIA6 (Protein disulfide-isomerase A6)
Expression of PLA2G4B
Expression of PPP2R5B
Expression of SERP1 (RAMP4)
Expression of SHC1
Expression of SRPR (SRP Receptor subunit alpha)
Expression of SRPRB (SRP Receptor subunit beta)
Expression of SSR1 (Trap alpha)
Expression of SULT1A3
Expression of SYVN1 (HRD1)
Expression of Sec12
Expression of Sec31A
Expression of TATDN2
Expression of TPP1
Expression of TSPYL2
Expression of Talin-1
Expression of WFS1
Expression of WIPI1
Expression of YIF1A
Expression of ZBTB17
Expression of DNAJC3 (p58IPK)