kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer
prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer
prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer
kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin
factor XII -> factor XIIa
factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)
activation of factor IX (factor XIa catalyst)
factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)
factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer
factor VIIIa + factor IXa -> factor VIIIa:factor IXa
activation of factor X by VIIIa:IXa
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)
kallikrein + C1Inh -> kallikrein:C1Inh
kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin
factor XIIa + C1Inh -> factor XIIa:C1Inh
Generation of intrinsic Factor X activating complex
Intrinsic Pathway