kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer
type: GO_0003674
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer

prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer
type: GO_0003674
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer
directly activates: Catalysis1046

prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004185
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin
directly activates: Catalysis1047

kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: factor XII -> factor XIIa
directly activates: kallikrein + C1Inh -> kallikrein:C1Inh
directly activates: kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin
directly activates: Catalysis1048
directly activates: Control161

factor XII -> factor XIIa
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)
directly activates: factor XIIa + C1Inh -> factor XIIa:C1Inh
directly activates: Catalysis1049

factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex
type: GO_0003674
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)
directly activates: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)
directly activates: Catalysis1049
directly activates: Catalysis1050

factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: activation of factor IX (factor XIa catalyst)
directly activates: Catalysis1051
directly activates: Control162

factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: activation of factor IX (factor XIa catalyst)
directly activates: Catalysis1051
directly activates: Control162

activation of factor IX (factor XIa catalyst)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: factor VIIIa + factor IXa -> factor VIIIa:factor IXa
directly activates: Control163
label: factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)

factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer
type: GO_0003674
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer
directly activates: Catalysis1052

factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: factor VIIIa + factor IXa -> factor VIIIa:factor IXa
directly activates: Control163

factor VIIIa + factor IXa -> factor VIIIa:factor IXa
type: GO_0003674
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: activation of factor X by VIIIa:IXa
directly activates: Catalysis1053

activation of factor X by VIIIa:IXa
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: BiochemicalReaction2396
label: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)

kallikrein + C1Inh -> kallikrein:C1Inh
type: GO_0003674
BFO_0000050: Generation of intrinsic Factor X activating complex

kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin
type: GO_0003674
BFO_0000050: Generation of intrinsic Factor X activating complex

factor XIIa + C1Inh -> factor XIIa:C1Inh
type: GO_0003674
BFO_0000050: Generation of intrinsic Factor X activating complex

Generation of intrinsic Factor X activating complex
type: GO_0008150
label: Intrinsic Pathway