SRC
SRC1
UniProt:P12931-1 SRC
PTP1B
PTPN1
UniProt:P18031 PTPN1
Translocation of RIAM to plasma membrane
Activation of Talin
Integrin alphaIIb beta3 activation
Interaction of integrin alphaIIb beta3 with Fibrinogen
Clustering of Integrin alphaIIb beta3 complexes
Release of CSK from SRC
Dephosphorylation of inactive SRC by PTPB1
Autophosphorylation of SRC
Translocation of FADK1 to Focal complexes
Autophosphorylation of FADK1 at Y397
Phosphorylation of pFADK1 by SRC
Recruitment of GRB2 to p-FADK1
Interaction of SOS with GRB2 bound to FADK1
Recruitment of p130Cas to FADK1
Phosphorylation of p130Cas by SRC-FADK1 complex
Crk binding to p130cas
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
Activated integrin alphaIIb beta3 binds SHC1
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
SHC1 dissociates from integrin alphaIIb beta3
SYK binds to integrin alphaIIb beta3
SYK activation by SRC
Activation of Rap1 by membrane-associated GEFs
Activation of Rap1 by cytosolic GEFs
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Intergrins
p130Cas linkage to MAPK signaling for integrins