ABCC4
MRP4
UniProt:O15439 ABCC4
PAI1
PLANH1
SERPINE1
UniProt:P05121 SERPINE1
AAP
PLI
SERPINF2
UniProt:P08697 SERPINF2
FGR
SRC2
UniProt:P09769 FGR
SRC
SRC1
UniProt:P12931-1 SRC
UniProt:P15498 VAV1
VAV
VAV1
PLCG2
UniProt:P16885 PLCG2
PTP1B
PTPN1
UniProt:P18031 PTPN1
UniProt:P52735 VAV2
VAV2
ITPK1
UniProt:Q13572 ITPK1
JHDM2C
JMJD1C
KIAA1380
TRIP8
UniProt:Q15652 JMJD1C
CSBP
CSBP1
CSBP2
CSPB1
MAPK14
MXI2
SAPK2A
UniProt:Q16539 MAPK14
MGLL
UniProt:Q99685 MGLL
AK3
AK3L1
AK6
AKL3L
UniProt:Q9UIJ7 AK3
UniProt:Q9UKW4 VAV3
VAV3
Na+/Ca2+ exchanger transport
ATP2B1-4 transport cytosolic Ca2+ to extracellular region
PMCA extrusion of Ca2+
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen
Sequestration of Ca2+ to dense tubular network lumen
Integrin alpha5beta1 binds fibronectin
Prostacyclin binds the Prostacyclin receptor PTGIR
Activated prostacyclin receptor binds G-protein Gs
Gs activation by prostacyclin receptor
Dissociation of the Prostacyclin receptor:Gs complex
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)
NO binds to Guanylate Cyclase
Soluble guanylate cyclase converts GTP to cGMP
cGMP stimulates Protein Kinase G
cGMP is degraded by PDEs
PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release
PKG1 phosphorylates BK channels
Binding of ATP to P2X1
Transport of Ca++ from platelet dense tubular system to cytoplasm
P2X1-mediated entry of Ca++ from plasma
Cation influx mediated by TRPC3/6/7
LDL binds to LRP8
FGR binds and phosphorylates LRP8
Fgr may phosphorylate p38 MAPK
Phosphorylation of cPLA2 by MAPK p38 alpha
LDL leads to activation of PECAM1
PECAM-1 binds PP2A
Interaction of PECAM-1 and SHP-1
Interaction of PECAM-1 and SHP-2
Integrin alpha2beta1 collagen adhesion
Interaction of GPVI and FceRI gamma
GPVI binds Fyn and Lyn
Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen
vWF binds to collagen
GPIb-IX-V binds to vWF:Collagen complex
GP1b-IX-V binds 14-3-3-zeta
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress
GP1b-IX-V binds filamin
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K
GP1b signaling involves c-Src
c-Src binds Raf1
14-3-3-zeta binds Raf1
ADP binds to P2Y purinoceptor 12
Activated P2Y purinoceptor 12 binds G-protein Gi
Gi activation by P2Y purinoceptor 12
Dissociation of the P2Y purinoceptor 12:Gi complex
ADP binds to P2Y purinoceptor 1
Activated P2Y purinoceptor 1 binds G-protein Gq
Gq activation by P2Y purinoceptor 1
Dissociation of the P2Y purinoceptor 1:Gq complex
Src activation following P2Y purinoceptor activation
P2Y purinoceptor 1 activates MAP kinase p38 alpha
TP receptor can bind thromboxane
Activated TP receptor binds G-proten Gq
Activated TP receptor binds G-protein G13
Gq activation by TP receptor
G13 activation by TP receptor
Dissociation of the TP:Gq complex
Dissociation of the TP:G13 complex
Thrombin-mediated activation of Proteinase-activated receptors
Thrombin-activated PAR binds G-protein Gq
Gq activation by PAR
Dissociation of the PAR:Gq complex
Thrombin-activated PAR binds G-protein G12/13
G12/13 activation by PAR
Dissociation of the PAR:G12/13 complex
Activated PAR1 binds Beta-arrestin-1
Activated PAR1 binds beta-arrestin-2
Beta-arrestin-1 acts as scaffold for a PAR1 signalling complex
Beta-arrestin-2 acts as scaffold for a PAR1 signalling complex
Activation of beta-arrestin-1-bound Src kinase
Src bound to beta-arrestin-2 is not activated
Activated Src activates ERK
Fyn/Lyn-mediated phosphorylation of FcR1 gamma
Binding of Syk tyrosine kinase
Syk autophosphorylates
Syk is released
Syk binds Vav
Syk phosphorylates Vav
VAV1 is a GEF for Rho/Rac family kinases
VAV2 is a GEF for Rho/Rac family kinases
VAV3 is a GEF for Rho/Rac family kinases
Syk/Lck phosphorylate LAT
Syk activation leads to SLP-76 activation
SLP-76 stimulates PLC gamma 2
p-SLP-76 binds VAV
PLC gamma 2-mediated PIP2 hydrolysis
PIP3 stimulates Vav
PIP2 inhibits Vav
GPVI stimulates PI3K beta, gamma
PI3K alpha, beta, gamma convert PIP2 to PIP3
PIP3 recruits PDK1 and AKT to the membrane
PDK1 binds PKC zeta
PDK1 activates PKC zeta
Translocation of RIAM to plasma membrane
Activation of Talin
Integrin alphaIIb beta3 activation
Interaction of integrin alphaIIb beta3 with Fibrinogen
Clustering of Integrin alphaIIb beta3 complexes
Release of CSK from SRC
Dephosphorylation of inactive SRC by PTPB1
Autophosphorylation of SRC
Translocation of FADK1 to Focal complexes
Autophosphorylation of FADK1 at Y397
Phosphorylation of pFADK1 by SRC
Recruitment of GRB2 to p-FADK1
Interaction of SOS with GRB2 bound to FADK1
Recruitment of p130Cas to FADK1
Phosphorylation of p130Cas by SRC-FADK1 complex
Crk binding to p130cas
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
Activated integrin alphaIIb beta3 binds SHC1
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
SHC1 dissociates from integrin alphaIIb beta3
SYK binds to integrin alphaIIb beta3
SYK activation by SRC
Alpha-2 adrenoceptors bind catecholamines
Thrombin binding to GP1b:IX:V
Thrombopoietin binds the thrombopoietin receptor
Binding of IP3 to IP3 receptor
Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
Activation of Protein Kinase C novel isoforms
DAG activation of TRPC channels
DAG is metabolized by DAGL to 2-AG
2-AG hydrolysis to arachidonate by MAGL
DAG kinase produces phosphatidic acid from DAG
Activation of conventional Protein Kinase C
Phosphorylation of Platelet Sec-1
Phosphorylation of Syntaxin-4
ABCC4 accumulation of dense granule contents
Exocytosis of platelet dense granule content
Surface deployment of platelet dense granule membrane components
Exocytosis of platelet alpha granule contents
Surface deployment of platelet alpha granule membrane components
Release of platelet cytosolic components
Release of (inferred) platelet cytosolic components
Release of platelet secretory granule components
Release of Calumenin
Release of 78 kDa glucose-regulated protein
Exocytosis of Proactivator polypeptide
sequestered tissue factor -> tissue factor
formation of TF:F7 complex
tissue factor (TF) + factor VII (F7) -> TF:F7 complex
activation of factor X by TF:F7
factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)
activation of factor VII
factor VII -> factor VIIa
formation of TF:F7a complex
tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex
activation of factor X by TF:F7a
factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)
activation of factor IX (TF:F7a catalyst)
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)
Inactivation of factor VIIa by TFPI
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa
kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer
prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer
prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer
kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin
factor XII -> factor XIIa
factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)
activation of factor IX (factor XIa catalyst)
factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)
factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer
factor VIIIa + factor IXa -> factor VIIIa:factor IXa
activation of factor X by VIIIa:IXa
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)
kallikrein + C1Inh -> kallikrein:C1Inh
kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin
factor XIIa + C1Inh -> factor XIIa:C1Inh
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)
factor V -> factor Va + factor V activation peptide
factor Va + factor Xa -> Va:Xa complex (prothrombinase)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B
n fibrin monomers -> fibrin multimer
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides
factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain
fibrin multimer -> fibrin multimer, crosslinked + NH4+
antithrombin III + heparin -> antithrombin III:heparin
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin
thrombin:cleaved antithrombin III:heparin -> thrombin:cleaved antithrombin III + heparin
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin
protein C -> activated protein C + protein C heavy chain activation peptide
factor Va -> factor Vi
histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen
histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen
crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain)
crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen
crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin
fibrin multimer, crosslinked -> fibrin digestion products (plasmin)
crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)
crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen
crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin
fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1
alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin
urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR
plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein
plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)
urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR
plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)
urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR
urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR
MAC1 binds JAM-C
JAM-B binds JAM-C
VLA-4 binds JAM-B
JAM-A homodimerises
LFA1 binds JAM-A
Integrin alphaXbeta2 binds JAM-C
MERTK receptor binds ligands (Gas6 or Protein S)
CD84 homodimerises
P-selectin binds P-selectin ligand
JAM-B homodimerises
JAM-C homodimerises
CD177 binds PECAM-1
CD47 binds SIRP
CD48 binds CD244
CD58 binds CD2
OLR1 binds to oxidized LDL
Platelet-derived TREM-1 ligand binds to TREM-1
Interaction of Tie2 with Ang1
Dimerization of Tie2/Ang1 complex
Trans-phosphorylation of Tie2
Interaction of Tie2 and p85 of PI3K
Interaction of Tie2 and Grb2
Interaction of SOS-1 to Tie2 bound Grb2
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
Interaction of Tie2 and Shc1
Interaction of Tie2 and Dok-2
Interaction of Tie2 with Ang2
Interaction of Tie2 and Ang4
Interaction of Tie2 and Shp2
Interaction of Tie2 and Grb7
Interaction of Tie2 and Grb14
Trans-homophilic interaction of PECAM-1
Interaction of integrin alphaVbeta3 with PECAM-1
Phoshorylation of PECAM-1 by Fyn or Lyn or c-Src
Interaction of PECAM-1 and SHIP
Interaction of PECAM-1 and PLC gamma1
CyP60 chaperones Basigin
Basigin homodimerises
Caveolin-1 binds Basigin
Basigin binds CyPA
Basigin interacts with CD43
Basigin binds Matrix metalloproteinase-1
Basigin binds Mannose-carrying cell recognition molecules
Basigin binds to integrins
Basigin binds MCT1, MCT3 and MCT4
Basigin binds CD98 complex
RAD51B binds RAD51C
RAD51B:RAD51C binds single-stranded DNA
Dual-specific AKAPs bind type I and II PKA regulatory subunits
Mitofusins trans-interact linking mitochondria prior to fusion
p53, SIN3A and MYB form a complex
IRF1 binds the promoters of Interferon alpha and beta
IRF2 binds the promoters of Interferon alpha and beta
HP1 alpha binds Histone H3K9(me)3
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4
LRRC16A binds F-actin capping protein
F-actin capping protein is a heterodimer
F-actin capping protein binds to the barbed end of elongating F-actin
REST recruits the BHC complex
ZFPM proteins bind GATA proteins
JMJD1C demethylates H3K9 mono- and di-methylation
SH2B proteins bind JAK2
Adenylate Kinase 3 is a GTP-AMP phosphotransferase
NFE2 is a heterodimer
NFE2 binds the beta globin locus control region
Expression of globin genes under control of the beta globin control region
EHD proteins interact with Rabenosyn-5
Rabenosyn-5 connects Rab5 to VPS-45
DOCKs bind to RhoGEFs
Cables link CDK5 and ABL1
Cables1 links CDK2 and WEE1
Kinesin-1 is a heterotetramer
Kinesin-2 is a heterotrimer
Kinesin-3 is a dimer
Chromokinesins form dimers
Kinesin-5 is a homotetramer
Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin
Kinesin-7 is a dimer
Kinesin-8 is a dimer
Kinesin-9 is a dimer
Kinesin-12 is a dimer
Kinesin-13 is a dimer
Kinesin-14 is a dimer
Kinesins bind microtubules
Kinesins move along microtubules consuming ATP
STIM1 activation of CRAC
Calcium influx via CRAC
CXADR binds to AMICA1
Activation of Rap1 by membrane-associated GEFs
Activation of Rap1 by cytosolic GEFs
Blood coagulation
Hemostasis
Platelet homeostasis
Prostacyclin signalling through prostacyclin receptor
Nitric oxide stimulates guanylate cyclase
cGMP effects
Platelet calcium homeostasis
Elevation of cytosolic Ca2+ levels
Reduction of cytosolic Ca++ levels
Platelet sensitization by LDL
Platelet Adhesion to exposed collagen
Platelet activation, signaling and aggregation
GP1b-IX-V activation signalling
Signal amplification
ADP signalling through P2Y purinoceptor 12
ADP signalling through P2Y purinoceptor 1
Thromboxane signalling through TP receptor
Thrombin signalling through proteinase activated receptors (PARs)
GPVI-mediated activation cascade
Platelet Aggregation (Plug Formation)
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Intergrins
p130Cas linkage to MAPK signaling for integrins
Adrenaline signalling through Alpha-2 adrenergic receptor
Effects of PIP2 hydrolysis
Arachidonate production from DAG
Response to elevated platelet cytosolic Ca2+
Disinhibition of SNARE formation
Platelet degranulation
Formation of Fibrin Clot (Clotting Cascade)
Extrinsic Pathway
Generation of extrinsic Factor X activating complex
Generation of intrinsic Factor X activating complex
Intrinsic Pathway
Common Pathway
Dissolution of Fibrin Clot
Cell surface interactions at the vascular wall
Tie2 Signaling
PECAM1 interactions
Basigin interactions
Factors involved in megakaryocyte development and platelet production
Kinesins
Expression of Interferon-alpha and beta