ABCC4
label: MRP4
label: UniProt:O15439 ABCC4

PAI1
label: PLANH1
label: SERPINE1
label: UniProt:P05121 SERPINE1

AAP
label: PLI
label: SERPINF2
label: UniProt:P08697 SERPINF2

FGR
label: SRC2
label: UniProt:P09769 FGR

SRC
label: SRC1
label: UniProt:P12931-1 SRC

UniProt:P15498 VAV1
label: VAV
label: VAV1

PLCG2
label: UniProt:P16885 PLCG2

PTP1B
label: PTPN1
label: UniProt:P18031 PTPN1

UniProt:P52735 VAV2
label: VAV2

ITPK1
label: UniProt:Q13572 ITPK1

JHDM2C
label: JMJD1C
label: KIAA1380
label: TRIP8
label: UniProt:Q15652 JMJD1C

CSBP
label: CSBP1
label: CSBP2
label: CSPB1
label: MAPK14
label: MXI2
label: SAPK2A
label: UniProt:Q16539 MAPK14

MGLL
label: UniProt:Q99685 MGLL

AK3
label: AK3L1
label: AK6
label: AKL3L
label: UniProt:Q9UIJ7 AK3

UniProt:Q9UKW4 VAV3
label: VAV3

Na+/Ca2+ exchanger transport
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005432
BFO_0000050: Reduction of cytosolic Ca++ levels

ATP2B1-4 transport cytosolic Ca2+ to extracellular region
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005388
BFO_0000050: Reduction of cytosolic Ca++ levels
label: PMCA extrusion of Ca2+

ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: GO_0005388
BFO_0000050: Reduction of cytosolic Ca++ levels
label: Sequestration of Ca2+ to dense tubular network lumen

Integrin alpha5beta1 binds fibronectin
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall
directly activates: BiochemicalReaction2118

Prostacyclin binds the Prostacyclin receptor PTGIR
type: GO_0003674
BFO_0000050: Prostacyclin signalling through prostacyclin receptor
directly activates: Activated prostacyclin receptor binds G-protein Gs

Activated prostacyclin receptor binds G-protein Gs
type: GO_0003674
BFO_0000050: Prostacyclin signalling through prostacyclin receptor
directly activates: Gs activation by prostacyclin receptor
directly activates: Catalysis998

Gs activation by prostacyclin receptor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: Prostacyclin signalling through prostacyclin receptor
directly activates: Dissociation of the Prostacyclin receptor:Gs complex

Dissociation of the Prostacyclin receptor:Gs complex
type: GO_0003674
BFO_0000050: Prostacyclin signalling through prostacyclin receptor
directly activates: BiochemicalReaction1770
directly activates: BiochemicalReaction4346
directly activates: BiochemicalReaction4384
directly activates: BiochemicalReaction4386
directly activates: Catalysis1880

Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004517
BFO_0000050: Nitric oxide stimulates guanylate cyclase
directly activates: NO binds to Guanylate Cyclase
directly activates: BiochemicalReaction2795
directly activates: BiochemicalReaction2796
directly activates: BiochemicalReaction2802

NO binds to Guanylate Cyclase
type: GO_0003674
BFO_0000050: Nitric oxide stimulates guanylate cyclase

Soluble guanylate cyclase converts GTP to cGMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004383
BFO_0000050: Nitric oxide stimulates guanylate cyclase
directly activates: cGMP stimulates Protein Kinase G
directly activates: cGMP is degraded by PDEs
directly activates: Catalysis1001

cGMP stimulates Protein Kinase G
type: GO_0003674
BFO_0000050: cGMP effects
directly activates: PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release
directly activates: PKG1 phosphorylates BK channels
directly activates: Catalysis1002
directly activates: Catalysis1003

cGMP is degraded by PDEs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0047555
BFO_0000050: cGMP effects

PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004692
BFO_0000050: cGMP effects

PKG1 phosphorylates BK channels
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004692
BFO_0000050: cGMP effects

Binding of ATP to P2X1
type: GO_0003674
BFO_0000050: Platelet homeostasis
directly activates: P2X1-mediated entry of Ca++ from plasma
directly activates: Catalysis1005

Transport of Ca++ from platelet dense tubular system to cytoplasm
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: GO_0005262
BFO_0000050: Elevation of cytosolic Ca2+ levels
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
directly activates: Activation of conventional Protein Kinase C
directly activates: BiochemicalReaction242
directly activates: Control159

P2X1-mediated entry of Ca++ from plasma
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005262
BFO_0000050: Elevation of cytosolic Ca2+ levels
directly activates: Activation of conventional Protein Kinase C
directly activates: Control159

Cation influx mediated by TRPC3/6/7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005261
BFO_0000050: Elevation of cytosolic Ca2+ levels
directly activates: Activation of conventional Protein Kinase C
directly activates: Control159

LDL binds to LRP8
type: GO_0003674
BFO_0000050: Platelet sensitization by LDL
directly activates: FGR binds and phosphorylates LRP8
directly activates: Catalysis1007

FGR binds and phosphorylates LRP8
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: FGR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: FGR
type: Restriction
  on property: enabled by
  some values from: FGR
type: Restriction
  on property: enabled by
  some values from: FGR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Platelet sensitization by LDL
directly activates: Fgr may phosphorylate p38 MAPK
directly activates: Catalysis1008

Fgr may phosphorylate p38 MAPK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: FGR
type: Restriction
  on property: enabled by
  some values from: FGR
type: Restriction
  on property: enabled by
  some values from: FGR
type: Restriction
  on property: enabled by
  some values from: FGR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004715
BFO_0000050: Platelet sensitization by LDL
directly activates: Phosphorylation of cPLA2 by MAPK p38 alpha
directly activates: Catalysis1009

Phosphorylation of cPLA2 by MAPK p38 alpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Platelet sensitization by LDL
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: BiochemicalReaction4402

LDL leads to activation of PECAM1
type: GO_0003674
BFO_0000050: Platelet sensitization by LDL
directly activates: PECAM-1 binds PP2A
directly activates: Interaction of PECAM-1 and SHP-1
directly activates: Interaction of PECAM-1 and SHP-2

PECAM-1 binds PP2A
type: GO_0003674
BFO_0000050: Platelet sensitization by LDL

Interaction of PECAM-1 and SHP-1
type: GO_0003674
BFO_0000050: Platelet sensitization by LDL
BFO_0000050: PECAM1 interactions

Interaction of PECAM-1 and SHP-2
type: GO_0003674
BFO_0000050: Platelet sensitization by LDL
BFO_0000050: PECAM1 interactions

Integrin alpha2beta1 collagen adhesion
type: GO_0003674
BFO_0000050: Platelet Adhesion to exposed collagen

Interaction of GPVI and FceRI gamma
type: GO_0003674
BFO_0000050: Platelet Adhesion to exposed collagen
directly activates: GPVI binds Fyn and Lyn

GPVI binds Fyn and Lyn
type: GO_0003674
BFO_0000050: Platelet Adhesion to exposed collagen
directly activates: Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen

Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen
type: GO_0003674
BFO_0000050: Platelet Adhesion to exposed collagen
BFO_0000050: Cell surface interactions at the vascular wall
directly activates: Fyn/Lyn-mediated phosphorylation of FcR1 gamma
directly activates: Catalysis1019

vWF binds to collagen
type: GO_0003674
BFO_0000050: Platelet Adhesion to exposed collagen
directly activates: GPIb-IX-V binds to vWF:Collagen complex

GPIb-IX-V binds to vWF:Collagen complex
type: GO_0003674
BFO_0000050: Platelet Adhesion to exposed collagen
directly activates: GP1b-IX-V binds 14-3-3-zeta
directly activates: GP1b-IX-V binds filamin
directly activates: GP1b signaling involves c-Src

GP1b-IX-V binds 14-3-3-zeta
type: GO_0003674
BFO_0000050: GP1b-IX-V activation signalling
directly activates: GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress
directly activates: GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K
directly activates: 14-3-3-zeta binds Raf1

GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress
type: GO_0003674
BFO_0000050: GP1b-IX-V activation signalling

GP1b-IX-V binds filamin
type: GO_0003674
BFO_0000050: GP1b-IX-V activation signalling

GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K
type: GO_0003674
BFO_0000050: GP1b-IX-V activation signalling

GP1b signaling involves c-Src
type: GO_0003674
BFO_0000050: GP1b-IX-V activation signalling
directly activates: c-Src binds Raf1

c-Src binds Raf1
type: GO_0003674
BFO_0000050: GP1b-IX-V activation signalling
directly activates: BiochemicalReaction1277
directly activates: Catalysis447

14-3-3-zeta binds Raf1
type: GO_0003674
BFO_0000050: GP1b-IX-V activation signalling

ADP binds to P2Y purinoceptor 12
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 12
directly activates: Activated P2Y purinoceptor 12 binds G-protein Gi

Activated P2Y purinoceptor 12 binds G-protein Gi
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 12
directly activates: Gi activation by P2Y purinoceptor 12
directly activates: Catalysis1010

Gi activation by P2Y purinoceptor 12
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: ADP signalling through P2Y purinoceptor 12
directly activates: Dissociation of the P2Y purinoceptor 12:Gi complex

Dissociation of the P2Y purinoceptor 12:Gi complex
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 12
directly activates: BiochemicalReaction3760
directly activates: BiochemicalReaction4352
directly activates: BiochemicalReaction4384
directly activates: BiochemicalReaction4386
directly activates: Catalysis1883
directly activates: Control343

ADP binds to P2Y purinoceptor 1
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: Activated P2Y purinoceptor 1 binds G-protein Gq

Activated P2Y purinoceptor 1 binds G-protein Gq
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: Gq activation by P2Y purinoceptor 1
directly activates: Catalysis1011

Gq activation by P2Y purinoceptor 1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: Dissociation of the P2Y purinoceptor 1:Gq complex

Dissociation of the P2Y purinoceptor 1:Gq complex
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: Src activation following P2Y purinoceptor activation
directly activates: P2Y purinoceptor 1 activates MAP kinase p38 alpha
directly activates: BiochemicalReaction4364
directly activates: BiochemicalReaction4365
directly activates: BiochemicalReaction4366
directly activates: BiochemicalReaction4367
directly activates: BiochemicalReaction4368
directly activates: BiochemicalReaction4370
directly activates: BiochemicalReaction4384
directly activates: BiochemicalReaction4386
directly activates: Catalysis1012
directly activates: Catalysis1889
directly activates: Control345

Src activation following P2Y purinoceptor activation
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 1

P2Y purinoceptor 1 activates MAP kinase p38 alpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: Phosphorylation of cPLA2 by MAPK p38 alpha
directly activates: Catalysis1009

TP receptor can bind thromboxane
type: GO_0003674
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: Activated TP receptor binds G-proten Gq
directly activates: Activated TP receptor binds G-protein G13
directly activates: BiochemicalReaction4372

Activated TP receptor binds G-proten Gq
type: GO_0003674
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: Gq activation by TP receptor
directly activates: Catalysis1013

Activated TP receptor binds G-protein G13
type: GO_0003674
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: G13 activation by TP receptor
directly activates: Catalysis1014

Gq activation by TP receptor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: Dissociation of the TP:Gq complex

G13 activation by TP receptor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: Dissociation of the TP:G13 complex

Dissociation of the TP:Gq complex
type: GO_0003674
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: BiochemicalReaction4364
directly activates: BiochemicalReaction4365
directly activates: BiochemicalReaction4366
directly activates: BiochemicalReaction4367
directly activates: BiochemicalReaction4368
directly activates: BiochemicalReaction4370
directly activates: Catalysis1889
directly activates: Control345

Dissociation of the TP:G13 complex
type: GO_0003674
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: BiochemicalReaction4375
directly activates: BiochemicalReaction4380
directly activates: BiochemicalReaction4382
directly activates: Catalysis1893

Thrombin-mediated activation of Proteinase-activated receptors
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Thrombin-activated PAR binds G-protein Gq
directly activates: Thrombin-activated PAR binds G-protein G12/13
directly activates: Activated PAR1 binds Beta-arrestin-1
directly activates: Activated PAR1 binds beta-arrestin-2

Thrombin-activated PAR binds G-protein Gq
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Gq activation by PAR
directly activates: Catalysis1016

Gq activation by PAR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004930
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Dissociation of the PAR:Gq complex

Dissociation of the PAR:Gq complex
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: BiochemicalReaction4364
directly activates: BiochemicalReaction4365
directly activates: BiochemicalReaction4366
directly activates: BiochemicalReaction4367
directly activates: BiochemicalReaction4368
directly activates: BiochemicalReaction4370
directly activates: BiochemicalReaction4384
directly activates: BiochemicalReaction4386
directly activates: Catalysis1889
directly activates: Control345

Thrombin-activated PAR binds G-protein G12/13
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: G12/13 activation by PAR
directly activates: Catalysis1017

G12/13 activation by PAR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004930
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Dissociation of the PAR:G12/13 complex

Dissociation of the PAR:G12/13 complex
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: BiochemicalReaction4375
directly activates: BiochemicalReaction4380
directly activates: BiochemicalReaction4382
directly activates: BiochemicalReaction4384
directly activates: BiochemicalReaction4386
directly activates: Catalysis1893

Activated PAR1 binds Beta-arrestin-1
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Beta-arrestin-1 acts as scaffold for a PAR1 signalling complex

Activated PAR1 binds beta-arrestin-2
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Beta-arrestin-2 acts as scaffold for a PAR1 signalling complex

Beta-arrestin-1 acts as scaffold for a PAR1 signalling complex
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Activation of beta-arrestin-1-bound Src kinase

Beta-arrestin-2 acts as scaffold for a PAR1 signalling complex
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Src bound to beta-arrestin-2 is not activated

Activation of beta-arrestin-1-bound Src kinase
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Activated Src activates ERK
directly activates: Catalysis1018

Src bound to beta-arrestin-2 is not activated
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)

Activated Src activates ERK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004672
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)

Fyn/Lyn-mediated phosphorylation of FcR1 gamma
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: GPVI-mediated activation cascade
directly activates: Binding of Syk tyrosine kinase

Binding of Syk tyrosine kinase
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: Syk autophosphorylates
directly activates: Syk/Lck phosphorylate LAT
directly activates: Syk activation leads to SLP-76 activation
directly activates: Catalysis1020
directly activates: Catalysis1025

Syk autophosphorylates
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004715
BFO_0000050: GPVI-mediated activation cascade
directly activates: Syk is released
directly activates: GPVI stimulates PI3K beta, gamma

Syk is released
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: Syk binds Vav

Syk binds Vav
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: Syk phosphorylates Vav
directly activates: Catalysis1021

Syk phosphorylates Vav
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004715
BFO_0000050: GPVI-mediated activation cascade
directly activates: VAV1 is a GEF for Rho/Rac family kinases
directly activates: VAV2 is a GEF for Rho/Rac family kinases
directly activates: VAV3 is a GEF for Rho/Rac family kinases
directly activates: PIP3 stimulates Vav
directly activates: PIP2 inhibits Vav
directly activates: Catalysis1022
directly activates: Catalysis1023
directly activates: Catalysis1024

VAV1 is a GEF for Rho/Rac family kinases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: UniProt:P15498 VAV1
type: Restriction
  on property: enabled by
  some values from: UniProt:P15498 VAV1
type: Restriction
  on property: enabled by
  some values from: UniProt:P15498 VAV1
type: Restriction
  on property: enabled by
  some values from: UniProt:P15498 VAV1
type: GO_0005085
BFO_0000050: GPVI-mediated activation cascade

VAV2 is a GEF for Rho/Rac family kinases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: UniProt:P52735 VAV2
type: Restriction
  on property: enabled by
  some values from: UniProt:P52735 VAV2
type: Restriction
  on property: enabled by
  some values from: UniProt:P52735 VAV2
type: Restriction
  on property: enabled by
  some values from: UniProt:P52735 VAV2
type: GO_0005085
BFO_0000050: GPVI-mediated activation cascade
directly activates: BiochemicalReaction4379

VAV3 is a GEF for Rho/Rac family kinases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: UniProt:Q9UKW4 VAV3
type: Restriction
  on property: enabled by
  some values from: UniProt:Q9UKW4 VAV3
type: Restriction
  on property: enabled by
  some values from: UniProt:Q9UKW4 VAV3
type: Restriction
  on property: enabled by
  some values from: UniProt:Q9UKW4 VAV3
type: GO_0005085
BFO_0000050: GPVI-mediated activation cascade
directly activates: BiochemicalReaction4379

Syk/Lck phosphorylate LAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: GPVI-mediated activation cascade

Syk activation leads to SLP-76 activation
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: SLP-76 stimulates PLC gamma 2
directly activates: p-SLP-76 binds VAV
directly activates: BiochemicalReaction649

SLP-76 stimulates PLC gamma 2
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: PLC gamma 2-mediated PIP2 hydrolysis
directly activates: Catalysis1026

p-SLP-76 binds VAV
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade

PLC gamma 2-mediated PIP2 hydrolysis
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: PLCG2
type: Restriction
  on property: enabled by
  some values from: PLCG2
type: Restriction
  on property: enabled by
  some values from: PLCG2
type: Restriction
  on property: enabled by
  some values from: PLCG2
type: GO_0004629
BFO_0000050: GPVI-mediated activation cascade
directly activates: Binding of IP3 to IP3 receptor
directly activates: Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
directly activates: Activation of Protein Kinase C novel isoforms
directly activates: DAG activation of TRPC channels
directly activates: DAG is metabolized by DAGL to 2-AG
directly activates: DAG kinase produces phosphatidic acid from DAG
directly activates: Activation of conventional Protein Kinase C
directly activates: BiochemicalReaction715
directly activates: Catalysis1036
directly activates: Catalysis1038
directly activates: Control159

PIP3 stimulates Vav
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: VAV1 is a GEF for Rho/Rac family kinases
directly activates: VAV2 is a GEF for Rho/Rac family kinases
directly activates: VAV3 is a GEF for Rho/Rac family kinases
directly activates: Catalysis1022
directly activates: Catalysis1023
directly activates: Catalysis1024

PIP2 inhibits Vav
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: VAV1 is a GEF for Rho/Rac family kinases
directly activates: VAV2 is a GEF for Rho/Rac family kinases
directly activates: VAV3 is a GEF for Rho/Rac family kinases
directly activates: Catalysis1022
directly activates: Catalysis1023
directly activates: Catalysis1024

GPVI stimulates PI3K beta, gamma
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: PI3K alpha, beta, gamma convert PIP2 to PIP3
directly activates: Catalysis1027

PI3K alpha, beta, gamma convert PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0046934
BFO_0000050: GPVI-mediated activation cascade
directly activates: PIP3 stimulates Vav
directly activates: PIP2 inhibits Vav
directly activates: PIP3 recruits PDK1 and AKT to the membrane
directly activates: BiochemicalReaction679
directly activates: BiochemicalReaction680
directly activates: Control158

PIP3 recruits PDK1 and AKT to the membrane
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: PDK1 binds PKC zeta

PDK1 binds PKC zeta
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: PDK1 activates PKC zeta
directly activates: Catalysis1028

PDK1 activates PKC zeta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004676
BFO_0000050: GPVI-mediated activation cascade

Translocation of RIAM to plasma membrane
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Activation of Talin

Activation of Talin
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Integrin alphaIIb beta3 activation

Integrin alphaIIb beta3 activation
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Interaction of integrin alphaIIb beta3 with Fibrinogen
directly activates: Activated integrin alphaIIb beta3 binds SHC1

Interaction of integrin alphaIIb beta3 with Fibrinogen
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Clustering of Integrin alphaIIb beta3 complexes

Clustering of Integrin alphaIIb beta3 complexes
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Release of CSK from SRC

Release of CSK from SRC
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Dephosphorylation of inactive SRC by PTPB1
directly activates: Catalysis1029

Dephosphorylation of inactive SRC by PTPB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: GO_0004725
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Autophosphorylation of SRC
directly activates: Catalysis1030

Autophosphorylation of SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: GO_0004713
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Translocation of FADK1 to Focal complexes
directly activates: SYK binds to integrin alphaIIb beta3

Translocation of FADK1 to Focal complexes
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Autophosphorylation of FADK1 at Y397
directly activates: Catalysis1031

Autophosphorylation of FADK1 at Y397
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004672
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Phosphorylation of pFADK1 by SRC
directly activates: Catalysis1032

Phosphorylation of pFADK1 by SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004672
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Recruitment of GRB2 to p-FADK1
directly activates: Recruitment of p130Cas to FADK1

Recruitment of GRB2 to p-FADK1
type: GO_0003674
BFO_0000050: GRB2:SOS provides linkage to MAPK signaling for Intergrins
directly activates: Interaction of SOS with GRB2 bound to FADK1

Interaction of SOS with GRB2 bound to FADK1
type: GO_0003674
BFO_0000050: GRB2:SOS provides linkage to MAPK signaling for Intergrins

Recruitment of p130Cas to FADK1
type: GO_0003674
BFO_0000050: p130Cas linkage to MAPK signaling for integrins
directly activates: Phosphorylation of p130Cas by SRC-FADK1 complex
directly activates: Catalysis1033

Phosphorylation of p130Cas by SRC-FADK1 complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004672
BFO_0000050: p130Cas linkage to MAPK signaling for integrins
directly activates: Crk binding to p130cas

Crk binding to p130cas
type: GO_0003674
BFO_0000050: p130Cas linkage to MAPK signaling for integrins

Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Activated integrin alphaIIb beta3 binds SHC1

Activated integrin alphaIIb beta3 binds SHC1
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow

SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: SHC1 dissociates from integrin alphaIIb beta3

SHC1 dissociates from integrin alphaIIb beta3
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: BiochemicalReaction3816

SYK binds to integrin alphaIIb beta3
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: SYK activation by SRC
directly activates: Catalysis1035

SYK activation by SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Integrin alphaIIb beta3 signaling

Alpha-2 adrenoceptors bind catecholamines
type: GO_0003674
BFO_0000050: Adrenaline signalling through Alpha-2 adrenergic receptor
directly activates: BiochemicalReaction4354

Thrombin binding to GP1b:IX:V
type: GO_0003674
BFO_0000050: Platelet Aggregation (Plug Formation)

Thrombopoietin binds the thrombopoietin receptor
type: GO_0003674
BFO_0000050: Platelet Aggregation (Plug Formation)

Binding of IP3 to IP3 receptor
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: Transport of Ca++ from platelet dense tubular system to cytoplasm
directly activates: Catalysis1004

Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: Activation of Rap1 by membrane-associated GEFs
directly activates: Activation of Rap1 by cytosolic GEFs
directly activates: Catalysis321
directly activates: Catalysis322

Activation of Protein Kinase C novel isoforms
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis

DAG activation of TRPC channels
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: Cation influx mediated by TRPC3/6/7
directly activates: Catalysis1006

DAG is metabolized by DAGL to 2-AG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0047372
BFO_0000050: Arachidonate production from DAG
directly activates: 2-AG hydrolysis to arachidonate by MAGL
directly activates: Catalysis1037

2-AG hydrolysis to arachidonate by MAGL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: GO_0047372
BFO_0000050: Arachidonate production from DAG

DAG kinase produces phosphatidic acid from DAG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004143
BFO_0000050: Effects of PIP2 hydrolysis

Activation of conventional Protein Kinase C
type: GO_0003674
BFO_0000050: Response to elevated platelet cytosolic Ca2+
directly activates: Phosphorylation of Platelet Sec-1
directly activates: Phosphorylation of Syntaxin-4
directly activates: Catalysis1039
directly activates: Catalysis1040

Phosphorylation of Platelet Sec-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004698
BFO_0000050: Disinhibition of SNARE formation

Phosphorylation of Syntaxin-4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004698
BFO_0000050: Disinhibition of SNARE formation

ABCC4 accumulation of dense granule contents
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031088
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031088
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031088
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031088
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031088
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031088
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031088
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031088
type: Restriction
  on property: enabled by
  some values from: ABCC4
type: Restriction
  on property: enabled by
  some values from: ABCC4
type: Restriction
  on property: enabled by
  some values from: ABCC4
type: Restriction
  on property: enabled by
  some values from: ABCC4
type: Restriction
  on property: enabled by
  some values from: ABCC4
type: Restriction
  on property: enabled by
  some values from: ABCC4
type: Restriction
  on property: enabled by
  some values from: ABCC4
type: Restriction
  on property: enabled by
  some values from: ABCC4
type: GO_0015662
BFO_0000050: Platelet degranulation

Exocytosis of platelet dense granule content
type: GO_0003674
BFO_0000050: Platelet degranulation

Surface deployment of platelet dense granule membrane components
type: GO_0003674
BFO_0000050: Platelet degranulation

Exocytosis of platelet alpha granule contents
type: GO_0003674
BFO_0000050: Platelet degranulation

Surface deployment of platelet alpha granule membrane components
type: GO_0003674
BFO_0000050: Platelet degranulation

Release of platelet cytosolic components
type: GO_0003674
BFO_0000050: Platelet degranulation

Release of (inferred) platelet cytosolic components
type: GO_0003674
BFO_0000050: Platelet degranulation

Release of platelet secretory granule components
type: GO_0003674
BFO_0000050: Platelet degranulation

Release of Calumenin
type: GO_0003674
BFO_0000050: Platelet degranulation

Release of 78 kDa glucose-regulated protein
type: GO_0003674
BFO_0000050: Platelet degranulation

Exocytosis of Proactivator polypeptide
type: GO_0003674
BFO_0000050: Platelet degranulation

sequestered tissue factor -> tissue factor
type: GO_0003674
BFO_0000050: Extrinsic Pathway
directly activates: formation of TF:F7 complex
directly activates: formation of TF:F7a complex

formation of TF:F7 complex
type: GO_0003674
BFO_0000050: Extrinsic Pathway
directly activates: activation of factor X by TF:F7
directly activates: Catalysis1042
label: tissue factor (TF) + factor VII (F7) -> TF:F7 complex

activation of factor X by TF:F7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Extrinsic Pathway
directly activates: activation of factor VII
directly activates: Catalysis1043
label: factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)

activation of factor VII
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Extrinsic Pathway
directly activates: formation of TF:F7a complex
label: factor VII -> factor VIIa

formation of TF:F7a complex
type: GO_0003674
BFO_0000050: Extrinsic Pathway
directly activates: activation of factor X by TF:F7a
directly activates: activation of factor IX (TF:F7a catalyst)
directly activates: Inactivation of factor VIIa by TFPI
directly activates: Catalysis1044
directly activates: Catalysis1045
label: tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex

activation of factor X by TF:F7a
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Extrinsic Pathway
directly activates: activation of factor VII
directly activates: Inactivation of factor VIIa by TFPI
directly activates: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)
directly activates: factor Va + factor Xa -> Va:Xa complex (prothrombinase)
directly activates: Catalysis1043
directly activates: Catalysis1054
label: factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)

activation of factor IX (TF:F7a catalyst)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Extrinsic Pathway
directly activates: factor VIIIa + factor IXa -> factor VIIIa:factor IXa
directly activates: Control163
label: factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)

Inactivation of factor VIIa by TFPI
type: GO_0003674
BFO_0000050: Extrinsic Pathway
label: TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa

kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer
type: GO_0003674
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer

prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer
type: GO_0003674
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer
directly activates: Catalysis1046

prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004185
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin
directly activates: Catalysis1047

kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: factor XII -> factor XIIa
directly activates: kallikrein + C1Inh -> kallikrein:C1Inh
directly activates: kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin
directly activates: Catalysis1048
directly activates: Control161

factor XII -> factor XIIa
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)
directly activates: factor XIIa + C1Inh -> factor XIIa:C1Inh
directly activates: Catalysis1049

factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex
type: GO_0003674
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)
directly activates: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)
directly activates: Catalysis1049
directly activates: Catalysis1050

factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: activation of factor IX (factor XIa catalyst)
directly activates: Catalysis1051
directly activates: Control162

factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: activation of factor IX (factor XIa catalyst)
directly activates: Catalysis1051
directly activates: Control162

activation of factor IX (factor XIa catalyst)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: factor VIIIa + factor IXa -> factor VIIIa:factor IXa
directly activates: Control163
label: factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)

factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer
type: GO_0003674
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer
directly activates: Catalysis1052

factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: factor VIIIa + factor IXa -> factor VIIIa:factor IXa
directly activates: Control163

factor VIIIa + factor IXa -> factor VIIIa:factor IXa
type: GO_0003674
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: activation of factor X by VIIIa:IXa
directly activates: Catalysis1053

activation of factor X by VIIIa:IXa
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Generation of intrinsic Factor X activating complex
directly activates: factor Va + factor Xa -> Va:Xa complex (prothrombinase)
label: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)

kallikrein + C1Inh -> kallikrein:C1Inh
type: GO_0003674
BFO_0000050: Generation of intrinsic Factor X activating complex

kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin
type: GO_0003674
BFO_0000050: Generation of intrinsic Factor X activating complex

factor XIIa + C1Inh -> factor XIIa:C1Inh
type: GO_0003674
BFO_0000050: Generation of intrinsic Factor X activating complex

prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Common Pathway
directly activates: factor V -> factor Va + factor V activation peptide
directly activates: Catalysis1055

factor V -> factor Va + factor V activation peptide
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Common Pathway
directly activates: factor Va + factor Xa -> Va:Xa complex (prothrombinase)
directly activates: factor Va -> factor Vi
directly activates: Catalysis1062
directly activates: Control166

factor Va + factor Xa -> Va:Xa complex (prothrombinase)
type: GO_0003674
BFO_0000050: Common Pathway
directly activates: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)
directly activates: Catalysis1056

prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Common Pathway
directly activates: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)
directly activates: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer
directly activates: factor V -> factor Va + factor V activation peptide
directly activates: fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B
directly activates: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides
directly activates: activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin
directly activates: activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin
directly activates: Catalysis1050
directly activates: Catalysis1052
directly activates: Catalysis1055
directly activates: Catalysis1057
directly activates: Catalysis1058
directly activates: Control164

fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Common Pathway
directly activates: n fibrin monomers -> fibrin multimer

n fibrin monomers -> fibrin multimer
type: GO_0003674
BFO_0000050: Common Pathway
directly activates: fibrin multimer -> fibrin multimer, crosslinked + NH4+
directly activates: Catalysis1059

factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Common Pathway
directly activates: factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain

factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain
type: GO_0003674
BFO_0000050: Common Pathway
directly activates: fibrin multimer -> fibrin multimer, crosslinked + NH4+
directly activates: Catalysis1059

fibrin multimer -> fibrin multimer, crosslinked + NH4+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0003810
BFO_0000050: Common Pathway
directly activates: crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain)

antithrombin III + heparin -> antithrombin III:heparin
type: GO_0003674
BFO_0000050: Common Pathway
directly activates: activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin

activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin
type: GO_0003674
BFO_0000050: Common Pathway
directly activates: thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin
directly activates: Catalysis1060

thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Common Pathway
directly activates: thrombin:cleaved antithrombin III:heparin -> thrombin:cleaved antithrombin III + heparin

thrombin:cleaved antithrombin III:heparin -> thrombin:cleaved antithrombin III + heparin
type: GO_0003674
BFO_0000050: Common Pathway

activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin
type: GO_0003674
BFO_0000050: Common Pathway
directly activates: protein C -> activated protein C + protein C heavy chain activation peptide
directly activates: Catalysis1061
directly activates: Control165

protein C -> activated protein C + protein C heavy chain activation peptide
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Common Pathway
BFO_0000050: Cell surface interactions at the vascular wall
directly activates: factor Va -> factor Vi
directly activates: Catalysis1062
directly activates: Control166

factor Va -> factor Vi
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Common Pathway

histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen
type: GO_0003674
BFO_0000050: Dissolution of Fibrin Clot

histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen
type: GO_0003674
BFO_0000050: Dissolution of Fibrin Clot
directly activates: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen

crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain)
type: GO_0003674
BFO_0000050: Dissolution of Fibrin Clot
directly activates: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen
directly activates: BiochemicalReaction2420
directly activates: Catalysis1068

crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen
type: GO_0003674
BFO_0000050: Dissolution of Fibrin Clot
directly activates: crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin
directly activates: Catalysis1063

crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Dissolution of Fibrin Clot
directly activates: fibrin multimer, crosslinked -> fibrin digestion products (plasmin)
directly activates: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)
directly activates: alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin
directly activates: Catalysis1064
directly activates: Catalysis1065
directly activates: Catalysis1069

fibrin multimer, crosslinked -> fibrin digestion products (plasmin)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Dissolution of Fibrin Clot

crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Dissolution of Fibrin Clot
directly activates: crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen
directly activates: BiochemicalReaction2419
directly activates: Catalysis1067

crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen
type: GO_0003674
BFO_0000050: Dissolution of Fibrin Clot
directly activates: crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin
directly activates: Catalysis1066

crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Dissolution of Fibrin Clot
directly activates: fibrin multimer, crosslinked -> fibrin digestion products (plasmin)
directly activates: alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin
directly activates: Catalysis1064
directly activates: Catalysis1069

BiochemicalReaction2419
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: PAI1
type: Restriction
  on property: enabled by
  some values from: PAI1
type: GO_0004867
BFO_0000050: Dissolution of Fibrin Clot
label: fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1

BiochemicalReaction2420
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: PAI1
type: Restriction
  on property: enabled by
  some values from: PAI1
type: GO_0004867
BFO_0000050: Dissolution of Fibrin Clot
label: fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1

alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: AAP
type: Restriction
  on property: enabled by
  some values from: AAP
type: GO_0004867
BFO_0000050: Dissolution of Fibrin Clot

urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR
type: GO_0003674
BFO_0000050: Dissolution of Fibrin Clot
directly activates: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)
directly activates: Catalysis1070

plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein
type: GO_0003674
BFO_0000050: Dissolution of Fibrin Clot
directly activates: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)
directly activates: Catalysis1070

plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Dissolution of Fibrin Clot
directly activates: fibrin multimer, crosslinked -> fibrin digestion products (plasmin)
directly activates: urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR
directly activates: Catalysis1064
directly activates: Catalysis1071

urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Dissolution of Fibrin Clot
directly activates: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)
directly activates: urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR
directly activates: urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR
directly activates: Catalysis1072
directly activates: Catalysis1073
directly activates: Catalysis1074

plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Dissolution of Fibrin Clot
directly activates: fibrin multimer, crosslinked -> fibrin digestion products (plasmin)
directly activates: Catalysis1064

urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: PAI1
type: Restriction
  on property: enabled by
  some values from: PAI1
type: GO_0004867
BFO_0000050: Dissolution of Fibrin Clot

urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004867
BFO_0000050: Dissolution of Fibrin Clot

MAC1 binds JAM-C
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall

JAM-B binds JAM-C
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall
directly activates: VLA-4 binds JAM-B
directly activates: Control168

VLA-4 binds JAM-B
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall

JAM-A homodimerises
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall

LFA1 binds JAM-A
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall

Integrin alphaXbeta2 binds JAM-C
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall

MERTK receptor binds ligands (Gas6 or Protein S)
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall

CD84 homodimerises
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall

P-selectin binds P-selectin ligand
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall

JAM-B homodimerises
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall

JAM-C homodimerises
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall

CD177 binds PECAM-1
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall

CD47 binds SIRP
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall

CD48 binds CD244
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall

CD58 binds CD2
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall

OLR1 binds to oxidized LDL
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall

Platelet-derived TREM-1 ligand binds to TREM-1
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall

Interaction of Tie2 with Ang1
type: GO_0003674
BFO_0000050: Tie2 Signaling
directly activates: Dimerization of Tie2/Ang1 complex

Dimerization of Tie2/Ang1 complex
type: GO_0003674
BFO_0000050: Tie2 Signaling
directly activates: Trans-phosphorylation of Tie2
directly activates: Catalysis1075

Trans-phosphorylation of Tie2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Tie2 Signaling
directly activates: Interaction of Tie2 and p85 of PI3K
directly activates: Interaction of Tie2 and Grb2
directly activates: Interaction of Tie2 and Shc1
directly activates: Interaction of Tie2 and Dok-2
directly activates: Interaction of Tie2 and Shp2
directly activates: Interaction of Tie2 and Grb7
directly activates: Interaction of Tie2 and Grb14

Interaction of Tie2 and p85 of PI3K
type: GO_0003674
BFO_0000050: Tie2 Signaling

Interaction of Tie2 and Grb2
type: GO_0003674
BFO_0000050: Tie2 Signaling
directly activates: Interaction of SOS-1 to Tie2 bound Grb2

Interaction of SOS-1 to Tie2 bound Grb2
type: GO_0003674
BFO_0000050: Tie2 Signaling
directly activates: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
directly activates: Catalysis1076

Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005088
BFO_0000050: Tie2 Signaling

Interaction of Tie2 and Shc1
type: GO_0003674
BFO_0000050: Tie2 Signaling

Interaction of Tie2 and Dok-2
type: GO_0003674
BFO_0000050: Tie2 Signaling

Interaction of Tie2 with Ang2
type: GO_0003674
BFO_0000050: Tie2 Signaling

Interaction of Tie2 and Ang4
type: GO_0003674
BFO_0000050: Tie2 Signaling

Interaction of Tie2 and Shp2
type: GO_0003674
BFO_0000050: Tie2 Signaling

Interaction of Tie2 and Grb7
type: GO_0003674
BFO_0000050: Tie2 Signaling

Interaction of Tie2 and Grb14
type: GO_0003674
BFO_0000050: Tie2 Signaling

Trans-homophilic interaction of PECAM-1
type: GO_0003674
BFO_0000050: PECAM1 interactions

Interaction of integrin alphaVbeta3 with PECAM-1
type: GO_0003674
BFO_0000050: PECAM1 interactions

Phoshorylation of PECAM-1 by Fyn or Lyn or c-Src
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: PECAM1 interactions
directly activates: Interaction of PECAM-1 and SHP-1
directly activates: Interaction of PECAM-1 and SHP-2
directly activates: Interaction of PECAM-1 and SHIP
directly activates: Interaction of PECAM-1 and PLC gamma1

Interaction of PECAM-1 and SHIP
type: GO_0003674
BFO_0000050: PECAM1 interactions

Interaction of PECAM-1 and PLC gamma1
type: GO_0003674
BFO_0000050: PECAM1 interactions

CyP60 chaperones Basigin
type: GO_0003674
BFO_0000050: Basigin interactions

Basigin homodimerises
type: GO_0003674
BFO_0000050: Basigin interactions

Caveolin-1 binds Basigin
type: GO_0003674
BFO_0000050: Basigin interactions

Basigin binds CyPA
type: GO_0003674
BFO_0000050: Basigin interactions

Basigin interacts with CD43
type: GO_0003674
BFO_0000050: Basigin interactions

Basigin binds Matrix metalloproteinase-1
type: GO_0003674
BFO_0000050: Basigin interactions

Basigin binds Mannose-carrying cell recognition molecules
type: GO_0003674
BFO_0000050: Basigin interactions

Basigin binds to integrins
type: GO_0003674
BFO_0000050: Basigin interactions

Basigin binds MCT1, MCT3 and MCT4
type: GO_0003674
BFO_0000050: Basigin interactions

Basigin binds CD98 complex
type: GO_0003674
BFO_0000050: Basigin interactions

RAD51B binds RAD51C
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production
directly activates: RAD51B:RAD51C binds single-stranded DNA

RAD51B:RAD51C binds single-stranded DNA
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production

Dual-specific AKAPs bind type I and II PKA regulatory subunits
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production

Mitofusins trans-interact linking mitochondria prior to fusion
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production

p53, SIN3A and MYB form a complex
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production

IRF1 binds the promoters of Interferon alpha and beta
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production
directly activates: Expression of Interferon-alpha and beta
directly activates: TemplateReactionRegulation45
directly activates: TemplateReactionRegulation46
directly activates: TemplateReactionRegulation47

IRF2 binds the promoters of Interferon alpha and beta
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production
directly activates: Expression of Interferon-alpha and beta
directly activates: TemplateReactionRegulation45
directly activates: TemplateReactionRegulation46
directly activates: TemplateReactionRegulation47

HP1 alpha binds Histone H3K9(me)3
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production

ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ITPK1
type: Restriction
  on property: enabled by
  some values from: ITPK1
type: GO_0047325
BFO_0000050: Factors involved in megakaryocyte development and platelet production

ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ITPK1
type: Restriction
  on property: enabled by
  some values from: ITPK1
type: GO_0052726
BFO_0000050: Factors involved in megakaryocyte development and platelet production

ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ITPK1
type: Restriction
  on property: enabled by
  some values from: ITPK1
type: GO_0052725
BFO_0000050: Factors involved in megakaryocyte development and platelet production

LRRC16A binds F-actin capping protein
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production
directly activates: F-actin capping protein binds to the barbed end of elongating F-actin

F-actin capping protein is a heterodimer
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production
directly activates: LRRC16A binds F-actin capping protein
directly activates: F-actin capping protein binds to the barbed end of elongating F-actin

F-actin capping protein binds to the barbed end of elongating F-actin
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production

REST recruits the BHC complex
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production

ZFPM proteins bind GATA proteins
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production

JMJD1C demethylates H3K9 mono- and di-methylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: JHDM2C
type: Restriction
  on property: enabled by
  some values from: JHDM2C
type: GO_0032454
BFO_0000050: Factors involved in megakaryocyte development and platelet production

SH2B proteins bind JAK2
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production

Adenylate Kinase 3 is a GTP-AMP phosphotransferase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: AK3
type: Restriction
  on property: enabled by
  some values from: AK3
type: GO_0046899
BFO_0000050: Factors involved in megakaryocyte development and platelet production

NFE2 is a heterodimer
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production
directly activates: NFE2 binds the beta globin locus control region

NFE2 binds the beta globin locus control region
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production
directly activates: Expression of globin genes under control of the beta globin control region
directly activates: Control170

Expression of globin genes under control of the beta globin control region
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production

EHD proteins interact with Rabenosyn-5
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production
directly activates: Rabenosyn-5 connects Rab5 to VPS-45

Rabenosyn-5 connects Rab5 to VPS-45
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production

DOCKs bind to RhoGEFs
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production

Cables link CDK5 and ABL1
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production

Cables1 links CDK2 and WEE1
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production

Kinesin-1 is a heterotetramer
type: GO_0003674
BFO_0000050: Kinesins
directly activates: Kinesins bind microtubules

Kinesin-2 is a heterotrimer
type: GO_0003674
BFO_0000050: Kinesins
directly activates: Kinesins bind microtubules

Kinesin-3 is a dimer
type: GO_0003674
BFO_0000050: Kinesins
directly activates: Kinesins bind microtubules

Chromokinesins form dimers
type: GO_0003674
BFO_0000050: Kinesins
directly activates: Kinesins bind microtubules

Kinesin-5 is a homotetramer
type: GO_0003674
BFO_0000050: Kinesins
directly activates: Kinesins bind microtubules

Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin
type: GO_0003674
BFO_0000050: Kinesins
directly activates: Kinesins bind microtubules

Kinesin-7 is a dimer
type: GO_0003674
BFO_0000050: Kinesins
directly activates: Kinesins bind microtubules

Kinesin-8 is a dimer
type: GO_0003674
BFO_0000050: Kinesins
directly activates: Kinesins bind microtubules

Kinesin-9 is a dimer
type: GO_0003674
BFO_0000050: Kinesins
directly activates: Kinesins bind microtubules

Kinesin-12 is a dimer
type: GO_0003674
BFO_0000050: Kinesins
directly activates: Kinesins bind microtubules

Kinesin-13 is a dimer
type: GO_0003674
BFO_0000050: Kinesins
directly activates: Kinesins bind microtubules

Kinesin-14 is a dimer
type: GO_0003674
BFO_0000050: Kinesins
directly activates: Kinesins bind microtubules

Kinesins bind microtubules
type: GO_0003674
BFO_0000050: Kinesins
directly activates: Kinesins move along microtubules consuming ATP

Kinesins move along microtubules consuming ATP
type: GO_0003674
BFO_0000050: Kinesins

STIM1 activation of CRAC
type: GO_0003674
BFO_0000050: Elevation of cytosolic Ca2+ levels
directly activates: Calcium influx via CRAC
directly activates: Catalysis274

Calcium influx via CRAC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015279
BFO_0000050: Elevation of cytosolic Ca2+ levels
directly activates: BiochemicalReaction242
directly activates: BiochemicalReaction722

CXADR binds to AMICA1
type: GO_0003674
BFO_0000050: Cell surface interactions at the vascular wall

Activation of Rap1 by membrane-associated GEFs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Translocation of RIAM to plasma membrane
directly activates: BiochemicalReaction852
directly activates: BiochemicalReaction853
directly activates: Catalysis323

Activation of Rap1 by cytosolic GEFs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005085
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Translocation of RIAM to plasma membrane
directly activates: BiochemicalReaction852
directly activates: BiochemicalReaction853
directly activates: Catalysis323

Blood coagulation
type: GO_0008150
label: Hemostasis

Platelet homeostasis
type: GO_0008150
BFO_0000050: Blood coagulation

Prostacyclin signalling through prostacyclin receptor
type: GO_0008150
BFO_0000050: Platelet homeostasis

Nitric oxide stimulates guanylate cyclase
type: GO_0008150
BFO_0000050: Platelet homeostasis

cGMP effects
type: GO_0008150
BFO_0000050: Nitric oxide stimulates guanylate cyclase

Platelet calcium homeostasis
type: GO_0008150
BFO_0000050: Platelet homeostasis

Elevation of cytosolic Ca2+ levels
type: GO_0008150
BFO_0000050: Platelet calcium homeostasis

Reduction of cytosolic Ca++ levels
type: GO_0008150
BFO_0000050: Platelet calcium homeostasis

Platelet sensitization by LDL
type: GO_0008150
BFO_0000050: Platelet homeostasis

Platelet Adhesion to exposed collagen
type: GO_0008150
BFO_0000050: Blood coagulation

Platelet activation, signaling and aggregation
type: GO_0008150
BFO_0000050: Blood coagulation

GP1b-IX-V activation signalling
type: GO_0008150
BFO_0000050: Platelet activation, signaling and aggregation

Signal amplification
type: GO_0008150
BFO_0000050: Platelet activation, signaling and aggregation

ADP signalling through P2Y purinoceptor 12
type: GO_0008150
BFO_0000050: Signal amplification

ADP signalling through P2Y purinoceptor 1
type: GO_0008150
BFO_0000050: Signal amplification

Thromboxane signalling through TP receptor
type: GO_0008150
BFO_0000050: Signal amplification

Thrombin signalling through proteinase activated receptors (PARs)
type: GO_0008150
BFO_0000050: Platelet activation, signaling and aggregation

GPVI-mediated activation cascade
type: GO_0008150
BFO_0000050: Platelet activation, signaling and aggregation

Platelet Aggregation (Plug Formation)
type: GO_0008150
BFO_0000050: Platelet activation, signaling and aggregation

Integrin alphaIIb beta3 signaling
type: GO_0008150
BFO_0000050: Platelet Aggregation (Plug Formation)

GRB2:SOS provides linkage to MAPK signaling for Intergrins
type: GO_0008150
BFO_0000050: Integrin alphaIIb beta3 signaling

p130Cas linkage to MAPK signaling for integrins
type: GO_0008150
BFO_0000050: Integrin alphaIIb beta3 signaling

Adrenaline signalling through Alpha-2 adrenergic receptor
type: GO_0008150
BFO_0000050: Platelet Aggregation (Plug Formation)

Effects of PIP2 hydrolysis
type: GO_0008150
BFO_0000050: Platelet activation, signaling and aggregation

Arachidonate production from DAG
type: GO_0008150
BFO_0000050: Effects of PIP2 hydrolysis

Response to elevated platelet cytosolic Ca2+
type: GO_0008150
BFO_0000050: Platelet activation, signaling and aggregation

Disinhibition of SNARE formation
type: GO_0008150
BFO_0000050: Response to elevated platelet cytosolic Ca2+

Platelet degranulation
type: GO_0008150
BFO_0000050: Response to elevated platelet cytosolic Ca2+

Formation of Fibrin Clot (Clotting Cascade)
type: GO_0008150
BFO_0000050: Blood coagulation

Extrinsic Pathway
type: GO_0008150
BFO_0000050: Formation of Fibrin Clot (Clotting Cascade)
label: Generation of extrinsic Factor X activating complex

Generation of intrinsic Factor X activating complex
type: GO_0008150
BFO_0000050: Formation of Fibrin Clot (Clotting Cascade)
label: Intrinsic Pathway

Common Pathway
type: GO_0008150
BFO_0000050: Formation of Fibrin Clot (Clotting Cascade)

Dissolution of Fibrin Clot
type: GO_0008150
BFO_0000050: Blood coagulation

Cell surface interactions at the vascular wall
type: GO_0008150
BFO_0000050: Blood coagulation

Tie2 Signaling
type: GO_0008150
BFO_0000050: Cell surface interactions at the vascular wall

PECAM1 interactions
type: GO_0008150
BFO_0000050: Cell surface interactions at the vascular wall

Basigin interactions
type: GO_0008150
BFO_0000050: Cell surface interactions at the vascular wall

Factors involved in megakaryocyte development and platelet production
type: GO_0008150
BFO_0000050: Blood coagulation

Kinesins
type: GO_0008150
BFO_0000050: Factors involved in megakaryocyte development and platelet production

Expression of Interferon-alpha and beta
type: GO_0003674
BFO_0000050: Factors involved in megakaryocyte development and platelet production