UniProt:P30291 WEE1
label: WEE1

CDC25A
label: UniProt:P30304 CDC25A

MYT1
label: PKMYT1
label: UniProt:Q99640 PKMYT1

Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex
directly activates: Cdt1 is displaced from the pre-replicative complex.
directly activates: CDK and DDK associate with the Mcm10:pre-replicative complex

Cdt1 is displaced from the pre-replicative complex.
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex
directly activates: BiochemicalReaction50

CDK and DDK associate with the Mcm10:pre-replicative complex
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex
directly activates: Mcm2-7 is phosphorylated by DDK
directly activates: Cdc45 associates with the pre-replicative complex at the origin
directly activates: Catalysis4

Mcm2-7 is phosphorylated by DDK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Activation of the pre-replicative complex

Inactivation of Cyclin E:Cdk2 complexes by p27/p21
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004861
BFO_0000050: Cyclin E associated events during G1/S transition
directly activates: Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
directly activates: Catalysis831

Formation of Cyclin E:Cdk2 complexes
type: GO_0003674
BFO_0000050: Cyclin E associated events during G1/S transition
directly activates: Translocation of Cyclin E:Cdk2 complex to the nucleus

Translocation of Cyclin E:Cdk2 complex to the nucleus
type: GO_0003674
BFO_0000050: Cyclin E associated events during G1/S transition
directly activates: Inactivation of Cyclin E:Cdk2 complexes by p27/p21
directly activates: Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1
directly activates: CAK-mediated phosphorylation of Cyclin E:Cdk2
directly activates: Catalysis808
directly activates: Catalysis834
directly activates: Catalysis838

Translocation of p21 to the nucleus
type: GO_0003674
BFO_0000050: Cyclin E associated events during G1/S transition
directly activates: Inactivation of Cyclin E:Cdk2 complexes by p27/p21
directly activates: BiochemicalReaction1917
directly activates: Catalysis808
directly activates: Catalysis845

Translocation of p27 to the nucleoplasm
type: GO_0003674
BFO_0000050: Cyclin E associated events during G1/S transition
directly activates: Inactivation of Cyclin E:Cdk2 complexes by p27/p21
directly activates: BiochemicalReaction1917
directly activates: Catalysis808
directly activates: Catalysis845

Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: SCF(Skp2)-mediated degradation of p27/p21
directly activates: Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex

Association of Cks1 with SCF(Skp2) complex
type: GO_0003674
BFO_0000050: SCF(Skp2)-mediated degradation of p27/p21
directly activates: Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex

Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex
type: GO_0003674
BFO_0000050: SCF(Skp2)-mediated degradation of p27/p21
directly activates: Ubiquitination of phospho-p27/p21
directly activates: Catalysis832

Ubiquitination of phospho-p27/p21
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: SCF(Skp2)-mediated degradation of p27/p21
directly activates: Degradation of ubiquitinated p27/p21 by the 26S proteasome
directly activates: Catalysis833

Degradation of ubiquitinated p27/p21 by the 26S proteasome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004175
BFO_0000050: SCF(Skp2)-mediated degradation of p27/p21
directly activates: CAK-mediated phosphorylation of Cyclin E:Cdk2
directly activates: BiochemicalReaction1915
directly activates: Catalysis838
directly activates: Catalysis843

Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin E associated events during G1/S transition
directly activates: Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
directly activates: Catalysis837

Cdc45 associates with the pre-replicative complex at the origin
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex
directly activates: DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin

Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin E associated events during G1/S transition

Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: GO_0016301
BFO_0000050: Cyclin E associated events during G1/S transition

Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CDC25A
type: Restriction
  on property: enabled by
  some values from: CDC25A
type: GO_0004721
BFO_0000050: Cyclin E associated events during G1/S transition
directly activates: Inactivation of Cyclin E:Cdk2 complexes by p27/p21
directly activates: BiochemicalReaction1841
directly activates: CAK-mediated phosphorylation of Cyclin E:Cdk2
directly activates: Catalysis808
directly activates: Catalysis809
directly activates: Catalysis838
directly activates: Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes

CAK-mediated phosphorylation of Cyclin E:Cdk2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin E associated events during G1/S transition
directly activates: Association of Rb with Cyclin E:Cdk2 complexes
directly activates: Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes

Association of Rb with Cyclin E:Cdk2 complexes
type: GO_0003674
BFO_0000050: Cyclin E associated events during G1/S transition
directly activates: Cyclin E:Cdk2-mediated phosphorylation of Rb
directly activates: Catalysis839

Cyclin E:Cdk2-mediated phosphorylation of Rb
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes

Detection of damage during initiation of DNA synthesis in S-phase
type: GO_0003674
BFO_0000050: Inhibition of replication initiation of damaged DNA by RB1/E2F1
directly activates: PP2A mediated localization of RB1 protein in chromatin
directly activates: Catalysis840

PP2A mediated localization of RB1 protein in chromatin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004721
BFO_0000050: Inhibition of replication initiation of damaged DNA by RB1/E2F1
directly activates: Replication initiation regulation by Rb1/E2F1

Replication initiation regulation by Rb1/E2F1
type: GO_0003674
BFO_0000050: Inhibition of replication initiation of damaged DNA by RB1/E2F1

Activation of Cyclin B/Cdk1 by Cdc25a (string) protein
type: GO_0003674
BFO_0000050: E2F-enabled inhibition of pre-replication complex formation
directly activates: Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation

Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation
type: GO_0003674
BFO_0000050: E2F-enabled inhibition of pre-replication complex formation

DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex
directly activates: DNA polymerase alpha:primase binds at the origin
directly activates: DNA polymerase epsilon binds at the origin
directly activates: Control1
directly activates: Control2

DNA polymerase alpha:primase binds at the origin
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex
directly activates: BiochemicalReaction23
directly activates: Catalysis5

DNA polymerase epsilon binds at the origin
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex

G1/S Transition
type: GO_0008150

Cyclin E associated events during G1/S transition
type: GO_0008150
BFO_0000050: G1/S Transition

SCF(Skp2)-mediated degradation of p27/p21
type: GO_0008150
BFO_0000050: Cyclin E associated events during G1/S transition

Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
type: GO_0008150
BFO_0000050: Cyclin E associated events during G1/S transition

Ubiquitin-Dependent Degradation of Cyclin E
type: GO_0003674
BFO_0000050: Cyclin E associated events during G1/S transition

G1/S-Specific Transcription
type: GO_0008150
BFO_0000050: G1/S Transition

E2F mediated regulation of DNA replication
type: GO_0008150
BFO_0000050: G1/S Transition

Inhibition of replication initiation of damaged DNA by RB1/E2F1
type: GO_0008150
BFO_0000050: E2F mediated regulation of DNA replication

E2F-enabled inhibition of pre-replication complex formation
type: GO_0008150
BFO_0000050: E2F mediated regulation of DNA replication

Activation of the pre-replicative complex
type: GO_0008150
BFO_0000050: G1/S Transition

Activation of Cdc25A by c-myc
type: GO_0003674
BFO_0000050: Cyclin E associated events during G1/S transition
directly activates: Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
directly activates: BiochemicalReaction1914
directly activates: Catalysis837
directly activates: Catalysis842

Activation of E2F target genes at G1/S
type: GO_0003674
BFO_0000050: G1/S-Specific Transcription
BFO_0000050: E2F mediated regulation of DNA replication
directly activates: Formation of Cyclin E:Cdk2 complexes
directly activates: Cdc45 associates with the pre-replicative complex at the origin
directly activates: Activation of Cyclin B/Cdk1 by Cdc25a (string) protein
directly activates: BiochemicalReaction2018
directly activates: DNA polymerase alpha:primase binds at the origin
directly activates: BiochemicalReaction7
directly activates: Control1