UniProt:P30291 WEE1
WEE1
CDC25A
UniProt:P30304 CDC25A
MYT1
PKMYT1
UniProt:Q99640 PKMYT1
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7
Cdt1 is displaced from the pre-replicative complex.
CDK and DDK associate with the Mcm10:pre-replicative complex
Mcm2-7 is phosphorylated by DDK
Inactivation of Cyclin E:Cdk2 complexes by p27/p21
Formation of Cyclin E:Cdk2 complexes
Translocation of Cyclin E:Cdk2 complex to the nucleus
Translocation of p21 to the nucleus
Translocation of p27 to the nucleoplasm
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
Association of Cks1 with SCF(Skp2) complex
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex
Ubiquitination of phospho-p27/p21
Degradation of ubiquitinated p27/p21 by the 26S proteasome
Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1
Cdc45 associates with the pre-replicative complex at the origin
Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1
Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
CAK-mediated phosphorylation of Cyclin E:Cdk2
Association of Rb with Cyclin E:Cdk2 complexes
Cyclin E:Cdk2-mediated phosphorylation of Rb
Detection of damage during initiation of DNA synthesis in S-phase
PP2A mediated localization of RB1 protein in chromatin
Replication initiation regulation by Rb1/E2F1
Activation of Cyclin B/Cdk1 by Cdc25a (string) protein
Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin
DNA polymerase alpha:primase binds at the origin
DNA polymerase epsilon binds at the origin
G1/S Transition
Cyclin E associated events during G1/S transition
SCF(Skp2)-mediated degradation of p27/p21
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Ubiquitin-Dependent Degradation of Cyclin E
G1/S-Specific Transcription
E2F mediated regulation of DNA replication
Inhibition of replication initiation of damaged DNA by RB1/E2F1
E2F-enabled inhibition of pre-replication complex formation
Activation of the pre-replicative complex
Activation of Cdc25A by c-myc
Activation of E2F target genes at G1/S