MSK1
label: RPS6KA5
label: UniProt:O75582 RPS6KA5

FARP2
label: KIAA0793
label: PLEKHC3
label: UniProt:O94887 FARP2

FYN
label: UniProt:P06241 FYN

CDC2
label: CDC28A
label: CDK1
label: CDKN1
label: P34CDC2
label: UniProt:P06493 CDK1

SRC
label: SRC1
label: UniProt:P12931-1 SRC

PTPA
label: PTPRA
label: PTPRL2
label: UniProt:P18433 PTPRA

ERK2
label: MAPK1
label: PRKM1
label: PRKM2
label: UniProt:P28482 MAPK1

DRT
label: EPHB2
label: EPHT3
label: EPTH3
label: ERK
label: HEK5
label: TYRO5
label: UniProt:P29323 EPHB2

GSK3B
label: UniProt:P49841 GSK3B

MAP2K6
label: MEK6
label: MKK6
label: PRKMK6
label: SKK3
label: UniProt:P52564 MAP2K6

UniProt:P52735 VAV2
label: VAV2

PRKCQ
label: PRKCT
label: UniProt:Q04759 PRKCQ

FAK
label: FAK1
label: PTK2
label: UniProt:Q05397 PTK2

PAK1
label: UniProt:Q13153 PAK1

Dimerization of LIMK1 by Hsp90
type: GO_0003674
BFO_0000050: Sema3A PAK dependent Axon repulsion
directly activates: Transphosphorylation of pLIMK1
directly activates: Catalysis432

Transphosphorylation of pLIMK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Sema3A PAK dependent Axon repulsion
directly activates: Phosphorylation of cofilin by LIMK-1
directly activates: Catalysis433

Phosphorylation of cofilin by LIMK-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Sema3A PAK dependent Axon repulsion

p-RAF binds 14-3-3 beta/alpha
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Transient dissociation of 14-3-3 upon Ras binding

Transient dissociation of 14-3-3 upon Ras binding
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Stabilisation of RAS:RAF by 14-3-3

Stabilisation of RAS:RAF by 14-3-3
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Stabilisation of RAF by further phosphorylation
directly activates: Catalysis447

Stabilisation of RAF by further phosphorylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: RAF activation
directly activates: Activated RAF1 complex binds MEK

Phosphorylated human RAF1 binds to RAS:GTP complex
type: GO_0003674
BFO_0000050: RAF activation
directly activates: RAF1 phosphorylates MEK1
directly activates: RAF1 phosphorylates MEK2
directly activates: Catalysis448
directly activates: Catalysis449

Activated RAF1 complex binds MEK
type: GO_0003674
BFO_0000050: MEK activation
directly activates: RAF1 phosphorylates MEK1
directly activates: RAF1 phosphorylates MEK2
directly activates: Catalysis448
directly activates: Catalysis449

RAF1 phosphorylates MEK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016301
BFO_0000050: RAF phosphorylates MEK
directly activates: MEK1 binds ERK-1

RAF1 phosphorylates MEK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016301
BFO_0000050: RAF phosphorylates MEK
directly activates: MEK2 binds ERK-2

Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4
type: GO_0003674
BFO_0000050: Signaling by NODAL
directly activates: The SMAD2/3:SMAD4 complex transfers to the nucleus
directly activates: BiochemicalReaction325

The SMAD2/3:SMAD4 complex transfers to the nucleus
type: GO_0003674
BFO_0000050: Signaling by NODAL
directly activates: BiochemicalReaction324
directly activates: BiochemicalReaction331
directly activates: BiochemicalReaction333
directly activates: BiochemicalReaction335
directly activates: BiochemicalReaction336
directly activates: BiochemicalReaction337
directly activates: BiochemicalReaction340
directly activates: BiochemicalReaction349
directly activates: BiochemicalReaction350
directly activates: BiochemicalReaction352
directly activates: Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXH1 Binds Activin Response Element
directly activates: Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 Binds FoxO3a-binding Elements
directly activates: Catalysis115
directly activates: Catalysis123
directly activates: Control22
directly activates: Control356
directly activates: Degradation4

ROCK activation by Rho
type: GO_0003674
BFO_0000050: Sema4D induced cell migration and growth-cone collapse
directly activates: Myosin regulatory light chain phosphorylation by ROCK
directly activates: LIM kinase phosphorylation by ROCK
directly activates: Catalysis3170
directly activates: Catalysis3171

Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXH1 Binds Activin Response Element
type: GO_0003674
BFO_0000050: Signaling by NODAL

SEMA4D interacts with Plexin-B1:Met
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Sema4D mediated inhibition of cell attachment and migration
directly activates: Active Rac1 interacts with Plexin-B1:Sema4A

Active Rac1 interacts with Plexin-B1:Sema4A
type: GO_0003674
BFO_0000050: Sema4D mediated inhibition of cell attachment and migration
directly activates: Rnd1 interacts with Plexin-B1:Sema4D
label: Active Rac1 interacts with Plexin-B1:Sema4D

Rnd1 interacts with Plexin-B1:Sema4D
type: GO_0003674
BFO_0000050: Sema4D mediated inhibition of cell attachment and migration
directly activates: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity
directly activates: p190RhoGAP binds Plexin-B1
directly activates: Catalysis3166

Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005096
BFO_0000050: Sema4D mediated inhibition of cell attachment and migration

p190RhoGAP binds Plexin-B1
type: GO_0003674
BFO_0000050: Sema4D mediated inhibition of cell attachment and migration
directly activates: Inactivation of Rho-GTP by p190RhoGAP
directly activates: Catalysis3167

Inactivation of Rho-GTP by p190RhoGAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005100
BFO_0000050: Sema4D mediated inhibition of cell attachment and migration

SEMA4D interacts with Plexin-B1:ErbB2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Sema4D induced cell migration and growth-cone collapse
directly activates: LARG and PDZ-RhoGEF binds to Plexin-B1

LARG and PDZ-RhoGEF binds to Plexin-B1
type: GO_0003674
BFO_0000050: Sema4D induced cell migration and growth-cone collapse
directly activates: Activation of Rho by LARG and PDZ-RhoGEF
directly activates: Catalysis3169

Activation of Rho by LARG and PDZ-RhoGEF
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005089
BFO_0000050: Sema4D induced cell migration and growth-cone collapse
directly activates: ROCK activation by Rho

Myosin regulatory light chain phosphorylation by ROCK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Sema4D induced cell migration and growth-cone collapse

LIM kinase phosphorylation by ROCK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Sema4D induced cell migration and growth-cone collapse

Plexin-A1-4 binds NRP1
type: GO_0003674
BFO_0000050: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
directly activates: Sema3A binds Nrp-1 bound to PlexinA

Sema3A binds Nrp-1 bound to PlexinA
type: GO_0003674
BFO_0000050: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
directly activates: Phosphorylation of Plexin-A
directly activates: Inhibition of integrin activation by sequestering PIP5KIgamma
directly activates: Catalysis3172

Phosphorylation of Plexin-A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
directly activates: Activation of Rac1 by FARP2
directly activates: Catalysis3173

Activation of Rac1 by FARP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: FARP2
type: Restriction
  on property: enabled by
  some values from: FARP2
type: Restriction
  on property: enabled by
  some values from: FARP2
type: Restriction
  on property: enabled by
  some values from: FARP2
type: Restriction
  on property: enabled by
  some values from: FARP2
type: Restriction
  on property: enabled by
  some values from: FARP2
type: Restriction
  on property: enabled by
  some values from: FARP2
type: Restriction
  on property: enabled by
  some values from: FARP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0030676
BFO_0000050: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
directly activates: Rac1 binds PlexinA

Rac1 binds PlexinA
type: GO_0003674
BFO_0000050: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
directly activates: Recruitment of Rnd1 to Plexin A

Recruitment of Rnd1 to Plexin A
type: GO_0003674
BFO_0000050: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
directly activates: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity
directly activates: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
directly activates: Catalysis3166
directly activates: Catalysis3174

Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005096
BFO_0000050: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

Inhibition of integrin activation by sequestering PIP5KIgamma
type: GO_0003674
BFO_0000050: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

Activation of PAK by Rac1
type: GO_0003674
BFO_0000050: Sema3A PAK dependent Axon repulsion
directly activates: Autophosphorylation of PAK
directly activates: Catalysis3175

Autophosphorylation of PAK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Sema3A PAK dependent Axon repulsion
directly activates: Phosphorylation of LIMK-1 by PAK
directly activates: Catalysis3176

Phosphorylation of LIMK-1 by PAK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Sema3A PAK dependent Axon repulsion
directly activates: Dimerization of LIMK1 by Hsp90

Activation of Fyn
type: GO_0003674
BFO_0000050: CRMPs in Sema3A signaling
directly activates: Recruitment and activation of Cdk5
directly activates: Catalysis3177

Recruitment and activation of Cdk5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: CRMPs in Sema3A signaling
directly activates: Phosphorylation of CRMPs by Cdk5
directly activates: Catalysis3178

Phosphorylation of CRMPs by Cdk5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: CRMPs in Sema3A signaling
directly activates: Phosphorylation of CRMPs by GSK3beta
directly activates: Catalysis3179

Phosphorylation of CRMPs by GSK3beta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GSK3B
type: Restriction
  on property: enabled by
  some values from: GSK3B
type: Restriction
  on property: enabled by
  some values from: GSK3B
type: Restriction
  on property: enabled by
  some values from: GSK3B
type: Restriction
  on property: enabled by
  some values from: GSK3B
type: Restriction
  on property: enabled by
  some values from: GSK3B
type: Restriction
  on property: enabled by
  some values from: GSK3B
type: Restriction
  on property: enabled by
  some values from: GSK3B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: CRMPs in Sema3A signaling

Tyrosine phosphorylation of CRMPs by Fes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: CRMPs in Sema3A signaling

SEMA3E binds to PLXND1
type: GO_0003674
BFO_0000050: Other semaphorin interactions

SEMA4A binds to PLXND1
type: GO_0003674
BFO_0000050: Other semaphorin interactions

SEMA4D interacts with CD45
type: GO_0003674
BFO_0000050: Other semaphorin interactions

SEMA4D interacts with CD72
type: GO_0003674
BFO_0000050: Other semaphorin interactions

SEMA5A binds to PLXNB3
type: GO_0003674
BFO_0000050: Other semaphorin interactions

SEMA6A binds to PLXNA2 and PLXNA4
type: GO_0003674
BFO_0000050: Other semaphorin interactions

SEMA6D binds to PLXNA1:TREM2:DAP12
type: GO_0003674
BFO_0000050: Other semaphorin interactions

SEMA7A binds to PLXNC1
type: GO_0003674
BFO_0000050: Other semaphorin interactions

SEMA7A binds to integrin alpha1beta1
type: GO_0003674
BFO_0000050: Other semaphorin interactions

NCAM1 cis-homophilic interaction
type: GO_0003674
BFO_0000050: NCAM signaling for neurite out-growth
directly activates: NCAM1 binds FGFR-1
directly activates: Control499

NCAM1 trans-homophilic interaction
type: GO_0003674
BFO_0000050: NCAM signaling for neurite out-growth
directly activates: Fyn binds NCAM1

NCAM1 binds FGFR-1
type: GO_0003674
BFO_0000050: NCAM signaling for neurite out-growth

Fyn binds NCAM1
type: GO_0003674
BFO_0000050: NCAM signaling for neurite out-growth
directly activates: Dephosphorylation of NCAM1 bound pFyn
directly activates: Catalysis3181

Dephosphorylation of NCAM1 bound pFyn
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: PTPA
type: Restriction
  on property: enabled by
  some values from: PTPA
type: Restriction
  on property: enabled by
  some values from: PTPA
type: Restriction
  on property: enabled by
  some values from: PTPA
type: GO_0004725
BFO_0000050: NCAM signaling for neurite out-growth
directly activates: Autophosphorylation of NCAM1 bound Fyn
directly activates: Catalysis3182

Autophosphorylation of NCAM1 bound Fyn
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: FYN
type: Restriction
  on property: enabled by
  some values from: FYN
type: Restriction
  on property: enabled by
  some values from: FYN
type: Restriction
  on property: enabled by
  some values from: FYN
type: GO_0004713
BFO_0000050: NCAM signaling for neurite out-growth
directly activates: Recruitment of FAK to NCAM1:Fyn in lipid rafts
directly activates: Catalysis3183

Recruitment of FAK to NCAM1:Fyn in lipid rafts
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: FAK
type: Restriction
  on property: enabled by
  some values from: FAK
type: Restriction
  on property: enabled by
  some values from: FAK
type: Restriction
  on property: enabled by
  some values from: FAK
type: GO_0004713
BFO_0000050: NCAM signaling for neurite out-growth
directly activates: Phosphorylation of FAK by Src kinase
directly activates: Catalysis3184

Phosphorylation of FAK by Src kinase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: GO_0004713
BFO_0000050: NCAM signaling for neurite out-growth
directly activates: Recruitment of Grb2 to pFAK:NCAM1

Recruitment of Grb2 to pFAK:NCAM1
type: GO_0003674
BFO_0000050: NCAM signaling for neurite out-growth
directly activates: SOS binds Grb2 bound to pFAK:NCAM1

SOS binds Grb2 bound to pFAK:NCAM1
type: GO_0003674
BFO_0000050: NCAM signaling for neurite out-growth
directly activates: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
directly activates: Catalysis3185

NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005088
BFO_0000050: NCAM signaling for neurite out-growth

Interaction of NCAM1 with GFRalpha-1
type: GO_0003674
BFO_0000050: NCAM1 interactions
directly activates: Interaction of NCAM1:GFRalpha-1 with GDNF

Interaction of NCAM1:GFRalpha-1 with GDNF
type: GO_0003674
BFO_0000050: NCAM1 interactions

Interaction of NCAM1 with Neurocan
type: GO_0003674
BFO_0000050: NCAM1 interactions

Interaction of NCAM1 with collagens
type: GO_0003674
BFO_0000050: NCAM1 interactions

Interaction of NCAM1 with Major prion protein (PrP)
type: GO_0003674
BFO_0000050: NCAM1 interactions

Interaction of NCAM1 with agrin
type: GO_0003674
BFO_0000050: NCAM1 interactions

Interaction of NCAM1 with contactin-2
type: GO_0003674
BFO_0000050: NCAM1 interactions

NCAM1 binds to ATP
type: GO_0003674
BFO_0000050: NCAM1 interactions

Polysialylation of NCAM1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003828
BFO_0000050: NCAM1 interactions

NCAM1 interacts with T- and L-type VDCC
type: GO_0003674
BFO_0000050: NCAM1 interactions

DCC interaction with Netrin-1
type: GO_0003674
BFO_0000050: DCC mediated attractive signaling
directly activates: Netrin-1 induced DCC clustering

Netrin-1 induced DCC clustering
type: GO_0003674
BFO_0000050: DCC mediated attractive signaling
directly activates: FADK1 interaction with DCC

FADK1 interaction with DCC
type: GO_0003674
BFO_0000050: DCC mediated attractive signaling
directly activates: Phosphorylation of FADK1
directly activates: Catalysis3187

Phosphorylation of FADK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: DCC mediated attractive signaling
directly activates: Recruitment of Src and Fyn to DCC:FADK1

Recruitment of Src and Fyn to DCC:FADK1
type: GO_0003674
BFO_0000050: DCC mediated attractive signaling
directly activates: Phosphorylation of DCC by Fyn
directly activates: Catalysis3188

Phosphorylation of DCC by Fyn
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: DCC mediated attractive signaling
directly activates: DCC interacting NCK-1

DCC interacting NCK-1
type: GO_0003674
BFO_0000050: DCC mediated attractive signaling
directly activates: RhoGTPase GEF's recruited to DCC

RhoGTPase GEF's recruited to DCC
type: GO_0003674
BFO_0000050: DCC mediated attractive signaling
directly activates: Activation of Cdc42
directly activates: Activation of Rac1
directly activates: Catalysis3189
directly activates: Catalysis3190

Activation of Cdc42
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005089
BFO_0000050: DCC mediated attractive signaling
directly activates: Recruitment and activation of N-WASP by Cdc42
directly activates: BiochemicalReaction691

Activation of Rac1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005089
BFO_0000050: DCC mediated attractive signaling
directly activates: Recruitment of ABLIM to the plasma membrane
directly activates: BiochemicalReaction691

Recruitment and activation of N-WASP by Cdc42
type: GO_0003674
BFO_0000050: DCC mediated attractive signaling

Recruitment of ABLIM to the plasma membrane
type: GO_0003674
BFO_0000050: DCC mediated attractive signaling

UNC-5 binds Netrin-1
type: GO_0003674
BFO_0000050: Netrin mediated repulsion signals
directly activates: DCC heterodimerizes with UNC-5:Netrin-1

DCC heterodimerizes with UNC-5:Netrin-1
type: GO_0003674
BFO_0000050: Netrin mediated repulsion signals

Phosphorylation of Unc5C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: GO_0004713
BFO_0000050: Netrin mediated repulsion signals
directly activates: Shp2 binds pUnc5C

Shp2 binds pUnc5C
type: GO_0003674
BFO_0000050: Netrin mediated repulsion signals

DCC interaction with ROBO-1
type: GO_0003674
BFO_0000050: Netrin-1 signaling

DCC interaction with SIAH1
type: GO_0003674
BFO_0000050: Netrin-1 signaling

DCC interaction with SIAH2
type: GO_0003674
BFO_0000050: Netrin-1 signaling

Translocation of Ezrin to plasma membrane
type: GO_0003674
BFO_0000050: Netrin-1 signaling
directly activates: Phosphorylation and activation of Ezrin
directly activates: Catalysis3192

Phosphorylation and activation of Ezrin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: PRKCQ
type: Restriction
  on property: enabled by
  some values from: PRKCQ
type: Restriction
  on property: enabled by
  some values from: PRKCQ
type: Restriction
  on property: enabled by
  some values from: PRKCQ
type: GO_0004672
BFO_0000050: Netrin-1 signaling
directly activates: DCC interaction with Ezrin

DCC interaction with Ezrin
type: GO_0003674
BFO_0000050: Netrin-1 signaling

Netrin-4 binds DCC/UNC5A
type: GO_0003674
BFO_0000050: Netrin-1 signaling

Neogenin binds Netrin-1
type: GO_0003674
BFO_0000050: Netrin-1 signaling

Neogenin binds repulsive guidance molecules (RGDs)
type: GO_0003674
BFO_0000050: Netrin-1 signaling

Myosin-X binds DCC/Neogenin
type: GO_0003674
BFO_0000050: Netrin-1 signaling

PIKE-L interaction with UNC5B
type: GO_0003674
BFO_0000050: Netrin-1 signaling

PITPalpha binds DCC
type: GO_0003674
BFO_0000050: Role of second messengers in netrin-1 signaling

Phosphorylation of PLCgamma by Netrin-1
type: GO_0003674
BFO_0000050: Role of second messengers in netrin-1 signaling

PIP2 hydrolysis
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004435
BFO_0000050: Role of second messengers in netrin-1 signaling

Activation of TRPC channels by Netrin-1
type: GO_0003674
BFO_0000050: Role of second messengers in netrin-1 signaling

Proteolytic processing of Slit
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008233
BFO_0000050: Regulation of Commissural axon pathfinding by Slit and Robo

Robo3 antagonizes Robo1/Robo2 to allow floor plate crossing
type: GO_0003674
BFO_0000050: Regulation of Commissural axon pathfinding by Slit and Robo

Glypican-1 binds Slit2
type: GO_0003674
BFO_0000050: Signaling by Robo receptor
directly activates: Robo1 binds Slit2

Robo1 binds Slit2
type: GO_0003674
BFO_0000050: Signaling by Robo receptor
directly activates: Ena/VASP binds Robo1:Slit2 complex
directly activates: SrGAP binds Robo1:Slit2
directly activates: KIAA1688/Vilse binds Robo1:Slit2
directly activates: Nck binds Robo1:Slit2

Ena/VASP binds Robo1:Slit2 complex
type: GO_0003674
BFO_0000050: Signaling by Robo receptor
directly activates: Recruitment of Profilin by Ena/Vasp proteins

Recruitment of Profilin by Ena/Vasp proteins
type: GO_0003674
BFO_0000050: Signaling by Robo receptor

SrGAP binds Robo1:Slit2
type: GO_0003674
BFO_0000050: Inactivation of Cdc42 and Rac
directly activates: Inactivation of Rac1
directly activates: Catalysis3196

Inactivation of Cdc42
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005096
BFO_0000050: Inactivation of Cdc42 and Rac

KIAA1688/Vilse binds Robo1:Slit2
type: GO_0003674
BFO_0000050: Inactivation of Cdc42 and Rac
directly activates: Inactivation of Cdc42
directly activates: Catalysis3195

Inactivation of Rac1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005096
BFO_0000050: Inactivation of Cdc42 and Rac

Nck binds Robo1:Slit2
type: GO_0003674
BFO_0000050: Activation of Rac
directly activates: Recruitment of PAK to Nck

Recruitment of PAK to Nck
type: GO_0003674
BFO_0000050: Activation of Rac
directly activates: Recruitment of Sos to plasma membrane

Recruitment of Sos to plasma membrane
type: GO_0003674
BFO_0000050: Activation of Rac
directly activates: Activation of Rac by Sos
directly activates: Catalysis3197

Activation of Rac by Sos
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005088
BFO_0000050: Activation of Rac

Interaction of Abl with Robo1:Slit2
type: GO_0003674
BFO_0000050: Role of Abl in Robo-Slit signaling
directly activates: Phosphorylation of Rob1 by Abl kinase
directly activates: Activation of CLASP
directly activates: Recruitment of CAP to Abl
directly activates: Catalysis3198

Phosphorylation of Rob1 by Abl kinase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Role of Abl in Robo-Slit signaling

Activation of CLASP
type: GO_0003674
BFO_0000050: Role of Abl in Robo-Slit signaling

Recruitment of CAP to Abl
type: GO_0003674
BFO_0000050: Role of Abl in Robo-Slit signaling

Phosphorylation of L1 by SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: GO_0004713
BFO_0000050: Recycling pathway of L1
directly activates: L1 binds ERM family members

L1 binds ERM family members
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: L1 trans-homophilic interaction

L1 trans-homophilic interaction
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Linkage of L1 with treadmilling F-actin

Linkage of L1 with treadmilling F-actin
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Dephosphorylation of pL1 (Y1176)
directly activates: Catalysis3200

Shootin-1 links L1 and retrograde actin flow
type: GO_0003674
BFO_0000050: Recycling pathway of L1

Dephosphorylation of pL1 (Y1176)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004725
BFO_0000050: Recycling pathway of L1
directly activates: L1 binds to AP-2 Clathrin complex

L1 binds to AP-2 Clathrin complex
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Formation of clathrin coated vesicle
directly activates: Transport of L1 into endosomes
directly activates: Catalysis3201

Formation of clathrin coated vesicle
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: Recycling pathway of L1

Interaction of NUMB with L1
type: GO_0003674
BFO_0000050: Recycling pathway of L1

Transport of L1 into endosomes
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Phosphorylation of L1 by p90rsk
directly activates: Phosphorylation of L1 by ERK
directly activates: Transport of L1 from C-domain to P-domain
directly activates: Catalysis3202
directly activates: Catalysis3203

Phosphorylation of L1 by p90rsk
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Recycling pathway of L1
BFO_0000050: Signal transduction by L1

Phosphorylation of L1 by ERK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: GO_0016301
BFO_0000050: Recycling pathway of L1
BFO_0000050: Signal transduction by L1

Transport of L1 from C-domain to P-domain
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Reinsertion of L1 into the plasma membrane

Reinsertion of L1 into the plasma membrane
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Phosphorylation of L1 by SRC
directly activates: Catalysis3199

L1 dimer binds Ankyrin
type: GO_0003674
BFO_0000050: Interaction between L1 and Ankyrins

L1 linked to actin cytoskeleton by ankyrin
type: GO_0003674
BFO_0000050: Interaction between L1 and Ankyrins

Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1
type: GO_0003674
BFO_0000050: Interaction between L1 and Ankyrins

Phosphorylation of Y1229 in L1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Interaction between L1 and Ankyrins

L1 and NCAM1 engaged in cis-interaction
type: GO_0003674
BFO_0000050: Signal transduction by L1

L1-FGFR cis-heterodimerization
type: GO_0003674
BFO_0000050: Signal transduction by L1

L1-EGFR trans-heterodimerization
type: GO_0003674
BFO_0000050: Signal transduction by L1

L1 binds NRP1
type: GO_0003674
BFO_0000050: Signal transduction by L1

L1 interaction with Integrins
type: GO_0003674
BFO_0000050: Signal transduction by L1

Phosphorylation of VAV2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Signal transduction by L1
directly activates: Activation of Rac1 by VAV2
directly activates: Catalysis3206

Activation of Rac1 by VAV2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: UniProt:P52735 VAV2
type: Restriction
  on property: enabled by
  some values from: UniProt:P52735 VAV2
type: Restriction
  on property: enabled by
  some values from: UniProt:P52735 VAV2
type: Restriction
  on property: enabled by
  some values from: UniProt:P52735 VAV2
type: Restriction
  on property: enabled by
  some values from: UniProt:P52735 VAV2
type: Restriction
  on property: enabled by
  some values from: UniProt:P52735 VAV2
type: Restriction
  on property: enabled by
  some values from: UniProt:P52735 VAV2
type: Restriction
  on property: enabled by
  some values from: UniProt:P52735 VAV2
type: GO_0005085
BFO_0000050: Signal transduction by L1
directly activates: Interaction of PAK1 with Rac1-GTP
directly activates: Catalysis3207

Interaction of PAK1 with Rac1-GTP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PAK1
type: Restriction
  on property: enabled by
  some values from: PAK1
type: Restriction
  on property: enabled by
  some values from: PAK1
type: Restriction
  on property: enabled by
  some values from: PAK1
type: Restriction
  on property: enabled by
  some values from: PAK1
type: Restriction
  on property: enabled by
  some values from: PAK1
type: Restriction
  on property: enabled by
  some values from: PAK1
type: Restriction
  on property: enabled by
  some values from: PAK1
type: GO_0004674
BFO_0000050: Signal transduction by L1

Phosphorylation of L1 by CK-II
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Signal transduction by L1

Interaction of L1 with Neurocan
type: GO_0003674
BFO_0000050: L1CAM interactions

Interaction of L1 with Laminin-1
type: GO_0003674
BFO_0000050: L1CAM interactions

Cis-heterodimerization of L1 and Axonin-1
type: GO_0003674
BFO_0000050: L1CAM interactions

Cis-heterodimerization of L1 and Contactin-1/F3/F11
type: GO_0003674
BFO_0000050: L1CAM interactions

Cis-heterodimerization of L1 and DM-GRASP/ALCAM/BEN
type: GO_0003674
BFO_0000050: L1CAM interactions

L1 binds RanBPM
type: GO_0003674
BFO_0000050: L1CAM interactions

Heat-Stable Antigen binds L1
type: GO_0003674
BFO_0000050: L1CAM interactions

Phosphorylation of L1 by EPHB2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: DRT
type: Restriction
  on property: enabled by
  some values from: DRT
type: Restriction
  on property: enabled by
  some values from: DRT
type: Restriction
  on property: enabled by
  some values from: DRT
type: GO_0004713
BFO_0000050: L1CAM interactions

CHL1 interacts with Ankyrin-G
type: GO_0003674
BFO_0000050: CHL1 interactions

CHL1 interacts with HSP7C
type: GO_0003674
BFO_0000050: CHL1 interactions

CHL1 interacts with NRP1
type: GO_0003674
BFO_0000050: CHL1 interactions

CHL1 interacts with beta1 integrins
type: GO_0003674
BFO_0000050: CHL1 interactions

CHL1 interacts with contactin-6
type: GO_0003674
BFO_0000050: CHL1 interactions

Neurofascin binds Ankyrin-G
type: GO_0003674
BFO_0000050: Neurofascin interactions
directly activates: Trans-homodimerization of Neurofascin

Trans-homodimerization of Neurofascin
type: GO_0003674
BFO_0000050: Neurofascin interactions

Neurofascin and NrCAM heterodimerization
type: GO_0003674
BFO_0000050: Neurofascin interactions

Phosphorylation of Neurofascin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Neurofascin interactions

Doublecortin binds phosphorylated neurofascin
type: GO_0003674
BFO_0000050: Neurofascin interactions

Neurofascin interacts with syntenin-1
type: GO_0003674
BFO_0000050: Neurofascin interactions

Neurofascin binds contactin-1:CASPR complex
type: GO_0003674
BFO_0000050: Neurofascin interactions

NrCAM binds Ankyrin-G
type: GO_0003674
BFO_0000050: NrCAM interactions

NrCAM binds axonin-1
type: GO_0003674
BFO_0000050: NrCAM interactions

NrCAM binds synapse-associated proteins
type: GO_0003674
BFO_0000050: NrCAM interactions

NrCAM binds Neuropilin-2
type: GO_0003674
BFO_0000050: NrCAM interactions

CDO binds BOC
type: GO_0003674
BFO_0000050: CDO in myogenesis
directly activates: CDO binds promyogenic cadherins
directly activates: Neogenin:Netrin-3 binds CDO complex

CDO binds promyogenic cadherins
type: GO_0003674
BFO_0000050: CDO in myogenesis
directly activates: Bnip2 interacts with CDO complex
directly activates: JLP interacts with CDO complex

Bnip2 interacts with CDO complex
type: GO_0003674
BFO_0000050: CDO in myogenesis
directly activates: Interaction of Bnip-2 with Cdc42

Interaction of Bnip-2 with Cdc42
type: GO_0003674
BFO_0000050: CDO in myogenesis

JLP interacts with CDO complex
type: GO_0003674
BFO_0000050: CDO in myogenesis
directly activates: Interaction of ABL1 with CDO complex

Interaction of ABL1 with CDO complex
type: GO_0003674
BFO_0000050: CDO in myogenesis
directly activates: Interaction of p38 MAPK with JLP

Interaction of p38 MAPK with JLP
type: GO_0003674
BFO_0000050: CDO in myogenesis
directly activates: Activation of p38 alpha/beta MAPK
directly activates: Catalysis3211

Activation of p38 alpha/beta MAPK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MAP2K6
type: Restriction
  on property: enabled by
  some values from: MAP2K6
type: Restriction
  on property: enabled by
  some values from: MAP2K6
type: Restriction
  on property: enabled by
  some values from: MAP2K6
type: GO_0004708
BFO_0000050: CDO in myogenesis
directly activates: Nuclear translocation of p38 MAPK

Nuclear translocation of p38 MAPK
type: GO_0003674
BFO_0000050: CDO in myogenesis
directly activates: Phosphorylation of E proteins by p38 MAPK
directly activates: Phosphorylation of MEF2 proteins by p38
directly activates: Catalysis3212
directly activates: Catalysis3213

Phosphorylation of E proteins by p38 MAPK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: CDO in myogenesis
directly activates: Heterodimerization of E proteins with Myod

Heterodimerization of E proteins with Myod
type: GO_0003674
BFO_0000050: CDO in myogenesis
directly activates: Interaction of MyoD:E protein with MEF2

Phosphorylation of MEF2 proteins by p38
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: CDO in myogenesis
directly activates: Interaction of MyoD:E protein with MEF2

Interaction of MyoD:E protein with MEF2
type: GO_0003674
BFO_0000050: CDO in myogenesis

Neogenin:Netrin-3 binds CDO complex
type: GO_0003674
BFO_0000050: CDO in myogenesis

AKT phosphorylates FOXO1A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT-mediated inactivation of FOXO1A
directly activates: Phosphorylated FOXO1A is excluded from the nucleus

Phosphorylated FOXO1A is excluded from the nucleus
type: GO_0003674
BFO_0000050: AKT-mediated inactivation of FOXO1A

Cleavage of NODAL Proprotein
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Signaling by NODAL
directly activates: The NODAL Receptor Binds NODAL Ligands
directly activates: CERBERUS Binds NODAL
directly activates: LEFTY Binds NODAL
directly activates: Control500
directly activates: Control501
directly activates: Control502

The NODAL Receptor Binds NODAL Ligands
type: GO_0003674
BFO_0000050: Signaling by NODAL
directly activates: Type II Activin Receptor (ActRII/ACVR2) Phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in Response to NODAL
directly activates: Type II Activin Receptor (ActRIIB/ACVR2B) Phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in Response to NODAL
directly activates: Catalysis3216
directly activates: Catalysis3217

Type II Activin Receptor (ActRII/ACVR2) Phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in Response to NODAL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Signaling by NODAL
directly activates: Phosphorylation of R-SMAD2/3 by NODAL Receptor
directly activates: Catalysis3218

Type II Activin Receptor (ActRIIB/ACVR2B) Phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in Response to NODAL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Signaling by NODAL
directly activates: Phosphorylation of R-SMAD2/3 by NODAL Receptor
directly activates: Catalysis3218

Phosphorylation of R-SMAD2/3 by NODAL Receptor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Signaling by NODAL
directly activates: Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4

Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 Binds FoxO3a-binding Elements
type: GO_0003674
BFO_0000050: Signaling by NODAL

CERBERUS Binds NODAL
type: GO_0003674
BFO_0000050: Regulation of Signaling by NODAL

LEFTY Binds NODAL
type: GO_0003674
BFO_0000050: Regulation of Signaling by NODAL

LEFTY Binds the EGF-CFC Coreceptor in the NODAL Receptor
type: GO_0003674
BFO_0000050: Regulation of Signaling by NODAL

Formation of PPARG:RXRA Heterodimer (ARF6 Complex)
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation
directly activates: PPARG:RXRA Heterodimer binds to PPARG corepressors

PPARG:RXRA Heterodimer binds to PPARG corepressors
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation
directly activates: PPARG:RXRA Heterodimer Binds to Fatty Acid-like Ligands

PPARG:RXRA Heterodimer Binds to Fatty Acid-like Ligands
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation
directly activates: Expression of ANGPTL4
directly activates: Expression of CD36 (platelet glycoprotein IV, FAT)
directly activates: Expression of FABP4 (aP2)
directly activates: Expression of Perilipin (PLIN)
directly activates: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C)
directly activates: Expression of Lipoprotein lipase (LPL)
directly activates: Expression of CEBPA
directly activates: Expression of Adiponectin
directly activates: TemplateReactionRegulation138
directly activates: TemplateReactionRegulation139
directly activates: TemplateReactionRegulation144
directly activates: TemplateReactionRegulation145
directly activates: TemplateReactionRegulation226
directly activates: TemplateReactionRegulation227
directly activates: TemplateReactionRegulation228
directly activates: TemplateReactionRegulation229
directly activates: TemplateReactionRegulation230
directly activates: TemplateReactionRegulation231
directly activates: TemplateReactionRegulation232
directly activates: TemplateReactionRegulation233
directly activates: TemplateReactionRegulation234
directly activates: TemplateReactionRegulation235
directly activates: TemplateReactionRegulation236
directly activates: TemplateReactionRegulation240
directly activates: TemplateReactionRegulation241
directly activates: TemplateReactionRegulation242

Inactivation of MEK1 by p34cdc2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: GO_0004674
BFO_0000050: ERK1 activation

MEK1 binds ERK-1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: MEK1 phosphorylates ERK-1
directly activates: Catalysis344
directly activates: Control57

MEK1 phosphorylates ERK-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Signal transduction by L1
BFO_0000050: ERK1 activation
directly activates: Dissociation of phospho-ERK-1:MEK1

Dissociation of phospho-ERK-1:MEK1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: Dimerisation of phospho-ERK-1

Dimerisation of phospho-ERK-1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: Nuclear translocation of phospho-ERK-1 dimer

Nuclear translocation of phospho-ERK-1 dimer
type: GO_0000189
BFO_0000050: ERK1 activation
directly activates: BiochemicalReaction905
directly activates: ERK1/2 phosphorylates MSK1
directly activates: BiochemicalReaction908
directly activates: Catalysis346
directly activates: Catalysis347
directly activates: Catalysis349

MEK2 binds ERK-2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: MEK2 phosphorylates ERK-2
directly activates: Catalysis345

MEK2 phosphorylates ERK-2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Signal transduction by L1
BFO_0000050: ERK2 activation
directly activates: Dissociation of phospho-ERK-2:MEK2

Dissociation of phospho-ERK-2:MEK2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: Dimerisation of phospho-ERK-2

Dimerisation of phospho-ERK-2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: Nuclear translocation of phospho-ERK-2 dimer

Nuclear translocation of phospho-ERK-2 dimer
type: GO_0000189
BFO_0000050: ERK2 activation
directly activates: BiochemicalReaction905
directly activates: ERK1/2 phosphorylates MSK1
directly activates: BiochemicalReaction908
directly activates: Catalysis346
directly activates: Catalysis347
directly activates: Catalysis349

ERK1/2 phosphorylates MSK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: NCAM signaling for neurite out-growth
directly activates: MSK1 activates CREB
directly activates: BiochemicalReaction913
directly activates: Catalysis353
directly activates: Catalysis354

MSK1 activates CREB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: GO_0004674
BFO_0000050: NCAM signaling for neurite out-growth

Developmental Biology
type: GO_0008150

Axon guidance
type: GO_0008150
BFO_0000050: Developmental Biology

Semaphorin interactions
type: GO_0008150
BFO_0000050: Axon guidance

Sema4D in semaphorin signaling
type: GO_0008150
BFO_0000050: Semaphorin interactions

Sema4D mediated inhibition of cell attachment and migration
type: GO_0008150
BFO_0000050: Sema4D in semaphorin signaling

Sema4D induced cell migration and growth-cone collapse
type: GO_0008150
BFO_0000050: Sema4D in semaphorin signaling

SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
type: GO_0008150
BFO_0000050: Semaphorin interactions

Sema3A PAK dependent Axon repulsion
type: GO_0008150
BFO_0000050: Semaphorin interactions

CRMPs in Sema3A signaling
type: GO_0008150
BFO_0000050: Semaphorin interactions

Other semaphorin interactions
type: GO_0008150
BFO_0000050: Semaphorin interactions

NCAM signaling for neurite out-growth
type: GO_0008150
BFO_0000050: Axon guidance

NCAM1 interactions
type: GO_0008150
BFO_0000050: NCAM signaling for neurite out-growth

Netrin-1 signaling
type: GO_0008150
BFO_0000050: Axon guidance

DCC mediated attractive signaling
type: GO_0008150
BFO_0000050: Netrin-1 signaling

Netrin mediated repulsion signals
type: GO_0008150
BFO_0000050: Netrin-1 signaling

Role of second messengers in netrin-1 signaling
type: GO_0008150
BFO_0000050: Netrin-1 signaling

Signaling by Robo receptor
type: GO_0008150
BFO_0000050: Axon guidance

Regulation of Commissural axon pathfinding by Slit and Robo
type: GO_0008150
BFO_0000050: Signaling by Robo receptor

Inactivation of Cdc42 and Rac
type: GO_0008150
BFO_0000050: Signaling by Robo receptor

Activation of Rac
type: GO_0008150
BFO_0000050: Signaling by Robo receptor

Role of Abl in Robo-Slit signaling
type: GO_0008150
BFO_0000050: Signaling by Robo receptor

L1CAM interactions
type: GO_0008150
BFO_0000050: Axon guidance

Recycling pathway of L1
type: GO_0008150
BFO_0000050: L1CAM interactions

Interaction between L1 and Ankyrins
type: GO_0008150
BFO_0000050: L1CAM interactions

Signal transduction by L1
type: GO_0008150
BFO_0000050: L1CAM interactions

CHL1 interactions
type: GO_0008150
BFO_0000050: L1CAM interactions

Neurofascin interactions
type: GO_0008150
BFO_0000050: L1CAM interactions

NrCAM interactions
type: GO_0008150
BFO_0000050: L1CAM interactions

Myogenesis
type: GO_0008150
BFO_0000050: Developmental Biology

CDO in myogenesis
type: GO_0008150
BFO_0000050: Myogenesis

Regulation of beta-cell development
type: GO_0008150
BFO_0000050: Developmental Biology

Regulation of gene expression in early pancreatic precursor cells
type: GO_0008150
BFO_0000050: Regulation of beta-cell development

Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
type: GO_0008150
BFO_0000050: Regulation of beta-cell development

Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
type: GO_0008150
BFO_0000050: Regulation of beta-cell development

Regulation of gene expression in beta cells
type: GO_0008150
BFO_0000050: Regulation of beta-cell development

AKT-mediated inactivation of FOXO1A
type: GO_0008150
BFO_0000050: Regulation of gene expression in beta cells

Signaling by NODAL
type: GO_0008150
BFO_0000050: Developmental Biology

Regulation of Signaling by NODAL
type: GO_0008150
BFO_0000050: Signaling by NODAL

Transcriptional Regulation of White Adipocyte Differentiation
type: GO_0008150
BFO_0000050: Developmental Biology

ERK activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

ERK1 activation
type: GO_0008150
BFO_0000050: ERK activation

ERK2 activation
type: GO_0008150
BFO_0000050: ERK activation

RAF/MAP kinase cascade
type: GO_0008150
BFO_0000050: NCAM signaling for neurite out-growth

RAF activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

MEK activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

RAF phosphorylates MEK
type: GO_0008150
BFO_0000050: MEK activation

Expression of ANGPTL4
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation
label: Induction of Angiopoietin-related protein 4 (ANGPTL4) Expression

Expression of CD36 (platelet glycoprotein IV, FAT)
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation
label: Induction of Platelet glycoprotein IV (PAS IV, CD36, GPIV) Expression During Adipogenesis

HNF1B-dependent synthesis of HNF6 protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in early pancreatic precursor cells
directly activates: HNF6-dependent synthesis of ONECUT3 protein during early pancreas specification
directly activates: HNF6- and FGF10-dependent synthesis of PDX1 protein
directly activates: HNF6-dependent synthesis of HNF1B protein
directly activates: HNF6-dependent synthesis of ONECUT3 protein during morphogenesis
directly activates: HNF6-dependent synthesis of NEUROG3 protein during morphogenesis
directly activates: TemplateReactionRegulation180
directly activates: TemplateReactionRegulation181
directly activates: TemplateReactionRegulation182
directly activates: TemplateReactionRegulation185
directly activates: TemplateReactionRegulation186
directly activates: TemplateReactionRegulation187
directly activates: TemplateReactionRegulation188

HNF1B- and FGF10-dependent synthesis of PTF1A protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in early pancreatic precursor cells

HNF6-dependent synthesis of ONECUT3 protein during early pancreas specification
type: GO_0003674
BFO_0000050: Regulation of gene expression in early pancreatic precursor cells

HNF6- and FGF10-dependent synthesis of PDX1 protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in early pancreatic precursor cells
directly activates: PDX1-dependent synthesis of NR5A2 protein
directly activates: PDX1-dependent synthesis of NKX6-1 protein
directly activates: TemplateReactionRegulation183
directly activates: TemplateReactionRegulation184

PDX1-dependent synthesis of NR5A2 protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in early pancreatic precursor cells

PDX1-dependent synthesis of NKX6-1 protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in early pancreatic precursor cells

HNF6-dependent synthesis of HNF1B protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells

HNF6-dependent synthesis of ONECUT3 protein during morphogenesis
type: GO_0003674
BFO_0000050: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells

HNF6-dependent synthesis of NEUROG3 protein during morphogenesis
type: GO_0003674
BFO_0000050: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
directly activates: NEUROG3-dependent synthesis of PAX4 protein
directly activates: NEUROG3-dependent synthesis of NEUROD1
directly activates: NEUROG3-dependent synthesis of NKX2-2
directly activates: NEUROG3-dependent synthesis of INSM1
directly activates: TemplateReactionRegulation191
directly activates: TemplateReactionRegulation192
directly activates: TemplateReactionRegulation193
directly activates: TemplateReactionRegulation194

RBPJ- and NOTCH1-dependent synthesis of HES1 protein during morphogenesis
type: GO_0003674
BFO_0000050: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells

NEUROG3-dependent synthesis of PAX4 protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

NEUROG3-dependent synthesis of NEUROD1
type: GO_0003674
BFO_0000050: Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

NEUROG3-dependent synthesis of NKX2-2
type: GO_0003674
BFO_0000050: Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

NEUROG3-dependent synthesis of INSM1
type: GO_0003674
BFO_0000050: Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

FOXOA2-, MAFA-, and PAX6-dependent synthesis of PDX1 protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells
directly activates: MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein
directly activates: PDX1-dependent synthesis of IAPP protein
directly activates: PDX1-dependent synthesis of NKX6-1 protein
directly activates: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein
directly activates: TemplateReactionRegulation199
directly activates: TemplateReactionRegulation200
directly activates: TemplateReactionRegulation201
directly activates: TemplateReactionRegulation202
directly activates: TemplateReactionRegulation203
directly activates: TemplateReactionRegulation204
directly activates: TemplateReactionRegulation205
directly activates: TemplateReactionRegulation206

MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells
directly activates: BiochemicalReaction3599
directly activates: Catalysis1573

PDX1-dependent synthesis of IAPP protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells

PDX1-dependent synthesis of NKX6-1 protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells

NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells
directly activates: BiochemicalReaction1659
directly activates: Catalysis645

HNF1A-dependent synthesis of GLUT2 protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells

HNF1A-dependent synthesis of the L isoform of PKLR protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells

HNF1A-dependent synthesis of HNF4A
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells

HNF1A-dependent synthesis of HNF4G protein
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells

HNF1A-dependent synthesis of FOXA3
type: GO_0003674
BFO_0000050: Regulation of gene expression in beta cells

Expression of CEBPB
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation
directly activates: Expression of KLF5
directly activates: Expression of EBF1
directly activates: Expression of PPARG
directly activates: Expression of Adiponectin
directly activates: TemplateReactionRegulation214
directly activates: TemplateReactionRegulation215
directly activates: TemplateReactionRegulation216
directly activates: TemplateReactionRegulation217
directly activates: TemplateReactionRegulation218
directly activates: TemplateReactionRegulation219
directly activates: TemplateReactionRegulation220
directly activates: TemplateReactionRegulation221
directly activates: TemplateReactionRegulation222
directly activates: TemplateReactionRegulation223
directly activates: TemplateReactionRegulation224
directly activates: TemplateReactionRegulation225
directly activates: TemplateReactionRegulation240
directly activates: TemplateReactionRegulation241
directly activates: TemplateReactionRegulation242

Expression of CEBPD
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation
directly activates: Expression of KLF5
directly activates: Expression of EBF1
directly activates: Expression of PPARG
directly activates: TemplateReactionRegulation214
directly activates: TemplateReactionRegulation215
directly activates: TemplateReactionRegulation216
directly activates: TemplateReactionRegulation217
directly activates: TemplateReactionRegulation218
directly activates: TemplateReactionRegulation219
directly activates: TemplateReactionRegulation220
directly activates: TemplateReactionRegulation221
directly activates: TemplateReactionRegulation222
directly activates: TemplateReactionRegulation223
directly activates: TemplateReactionRegulation224
directly activates: TemplateReactionRegulation225

Expression of KLF5
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation
directly activates: Expression of PPARG
directly activates: TemplateReactionRegulation218
directly activates: TemplateReactionRegulation219
directly activates: TemplateReactionRegulation220
directly activates: TemplateReactionRegulation221
directly activates: TemplateReactionRegulation222
directly activates: TemplateReactionRegulation223
directly activates: TemplateReactionRegulation224
directly activates: TemplateReactionRegulation225

Expression of EBF1
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation
directly activates: Expression of PPARG
directly activates: Expression of CEBPA
directly activates: TemplateReactionRegulation218
directly activates: TemplateReactionRegulation219
directly activates: TemplateReactionRegulation220
directly activates: TemplateReactionRegulation221
directly activates: TemplateReactionRegulation222
directly activates: TemplateReactionRegulation223
directly activates: TemplateReactionRegulation224
directly activates: TemplateReactionRegulation225
directly activates: TemplateReactionRegulation232
directly activates: TemplateReactionRegulation233
directly activates: TemplateReactionRegulation234
directly activates: TemplateReactionRegulation235
directly activates: TemplateReactionRegulation236

Expression of PPARG
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation
directly activates: Formation of PPARG:RXRA Heterodimer (ARF6 Complex)

Expression of FABP4 (aP2)
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation

Expression of Perilipin (PLIN)
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation

Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C)
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation

Expression of Lipoprotein lipase (LPL)
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation

Expression of CEBPA
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation
directly activates: Maintenance of PPARG Expression in Differentiated Adipocytes
directly activates: Expression of Leptin
directly activates: Expression of Adiponectin
directly activates: Expression of GLUT4
directly activates: TemplateReactionRegulation237
directly activates: TemplateReactionRegulation238
directly activates: TemplateReactionRegulation239
directly activates: TemplateReactionRegulation240
directly activates: TemplateReactionRegulation241
directly activates: TemplateReactionRegulation242
directly activates: TemplateReactionRegulation243
directly activates: TemplateReactionRegulation244

Maintenance of PPARG Expression in Differentiated Adipocytes
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation

Expression of Leptin
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation

Expression of Adiponectin
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation

Expression of GLUT4
type: GO_0003674
BFO_0000050: Transcriptional Regulation of White Adipocyte Differentiation