MSK1
RPS6KA5
UniProt:O75582 RPS6KA5
FARP2
KIAA0793
PLEKHC3
UniProt:O94887 FARP2
FYN
UniProt:P06241 FYN
CDC2
CDC28A
CDK1
CDKN1
P34CDC2
UniProt:P06493 CDK1
SRC
SRC1
UniProt:P12931-1 SRC
PTPA
PTPRA
PTPRL2
UniProt:P18433 PTPRA
ERK2
MAPK1
PRKM1
PRKM2
UniProt:P28482 MAPK1
DRT
EPHB2
EPHT3
EPTH3
ERK
HEK5
TYRO5
UniProt:P29323 EPHB2
GSK3B
UniProt:P49841 GSK3B
MAP2K6
MEK6
MKK6
PRKMK6
SKK3
UniProt:P52564 MAP2K6
UniProt:P52735 VAV2
VAV2
PRKCQ
PRKCT
UniProt:Q04759 PRKCQ
FAK
FAK1
PTK2
UniProt:Q05397 PTK2
PAK1
UniProt:Q13153 PAK1
Dimerization of LIMK1 by Hsp90
Transphosphorylation of pLIMK1
Phosphorylation of cofilin by LIMK-1
p-RAF binds 14-3-3 beta/alpha
Transient dissociation of 14-3-3 upon Ras binding
Stabilisation of RAS:RAF by 14-3-3
Stabilisation of RAF by further phosphorylation
Phosphorylated human RAF1 binds to RAS:GTP complex
Activated RAF1 complex binds MEK
RAF1 phosphorylates MEK1
RAF1 phosphorylates MEK2
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4
The SMAD2/3:SMAD4 complex transfers to the nucleus
ROCK activation by Rho
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXH1 Binds Activin Response Element
SEMA4D interacts with Plexin-B1:Met
Active Rac1 interacts with Plexin-B1:Sema4A
Active Rac1 interacts with Plexin-B1:Sema4D
Rnd1 interacts with Plexin-B1:Sema4D
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity
p190RhoGAP binds Plexin-B1
Inactivation of Rho-GTP by p190RhoGAP
SEMA4D interacts with Plexin-B1:ErbB2
LARG and PDZ-RhoGEF binds to Plexin-B1
Activation of Rho by LARG and PDZ-RhoGEF
Myosin regulatory light chain phosphorylation by ROCK
LIM kinase phosphorylation by ROCK
Plexin-A1-4 binds NRP1
Sema3A binds Nrp-1 bound to PlexinA
Phosphorylation of Plexin-A
Activation of Rac1 by FARP2
Rac1 binds PlexinA
Recruitment of Rnd1 to Plexin A
Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
Inhibition of integrin activation by sequestering PIP5KIgamma
Activation of PAK by Rac1
Autophosphorylation of PAK
Phosphorylation of LIMK-1 by PAK
Activation of Fyn
Recruitment and activation of Cdk5
Phosphorylation of CRMPs by Cdk5
Phosphorylation of CRMPs by GSK3beta
Tyrosine phosphorylation of CRMPs by Fes
SEMA3E binds to PLXND1
SEMA4A binds to PLXND1
SEMA4D interacts with CD45
SEMA4D interacts with CD72
SEMA5A binds to PLXNB3
SEMA6A binds to PLXNA2 and PLXNA4
SEMA6D binds to PLXNA1:TREM2:DAP12
SEMA7A binds to PLXNC1
SEMA7A binds to integrin alpha1beta1
NCAM1 cis-homophilic interaction
NCAM1 trans-homophilic interaction
NCAM1 binds FGFR-1
Fyn binds NCAM1
Dephosphorylation of NCAM1 bound pFyn
Autophosphorylation of NCAM1 bound Fyn
Recruitment of FAK to NCAM1:Fyn in lipid rafts
Phosphorylation of FAK by Src kinase
Recruitment of Grb2 to pFAK:NCAM1
SOS binds Grb2 bound to pFAK:NCAM1
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
Interaction of NCAM1 with GFRalpha-1
Interaction of NCAM1:GFRalpha-1 with GDNF
Interaction of NCAM1 with Neurocan
Interaction of NCAM1 with collagens
Interaction of NCAM1 with Major prion protein (PrP)
Interaction of NCAM1 with agrin
Interaction of NCAM1 with contactin-2
NCAM1 binds to ATP
Polysialylation of NCAM1
NCAM1 interacts with T- and L-type VDCC
DCC interaction with Netrin-1
Netrin-1 induced DCC clustering
FADK1 interaction with DCC
Phosphorylation of FADK1
Recruitment of Src and Fyn to DCC:FADK1
Phosphorylation of DCC by Fyn
DCC interacting NCK-1
RhoGTPase GEF's recruited to DCC
Activation of Cdc42
Activation of Rac1
Recruitment and activation of N-WASP by Cdc42
Recruitment of ABLIM to the plasma membrane
UNC-5 binds Netrin-1
DCC heterodimerizes with UNC-5:Netrin-1
Phosphorylation of Unc5C
Shp2 binds pUnc5C
DCC interaction with ROBO-1
DCC interaction with SIAH1
DCC interaction with SIAH2
Translocation of Ezrin to plasma membrane
Phosphorylation and activation of Ezrin
DCC interaction with Ezrin
Netrin-4 binds DCC/UNC5A
Neogenin binds Netrin-1
Neogenin binds repulsive guidance molecules (RGDs)
Myosin-X binds DCC/Neogenin
PIKE-L interaction with UNC5B
PITPalpha binds DCC
Phosphorylation of PLCgamma by Netrin-1
PIP2 hydrolysis
Activation of TRPC channels by Netrin-1
Proteolytic processing of Slit
Robo3 antagonizes Robo1/Robo2 to allow floor plate crossing
Glypican-1 binds Slit2
Robo1 binds Slit2
Ena/VASP binds Robo1:Slit2 complex
Recruitment of Profilin by Ena/Vasp proteins
SrGAP binds Robo1:Slit2
Inactivation of Cdc42
KIAA1688/Vilse binds Robo1:Slit2
Inactivation of Rac1
Nck binds Robo1:Slit2
Recruitment of PAK to Nck
Recruitment of Sos to plasma membrane
Activation of Rac by Sos
Interaction of Abl with Robo1:Slit2
Phosphorylation of Rob1 by Abl kinase
Activation of CLASP
Recruitment of CAP to Abl
Phosphorylation of L1 by SRC
L1 binds ERM family members
L1 trans-homophilic interaction
Linkage of L1 with treadmilling F-actin
Shootin-1 links L1 and retrograde actin flow
Dephosphorylation of pL1 (Y1176)
L1 binds to AP-2 Clathrin complex
Formation of clathrin coated vesicle
Interaction of NUMB with L1
Transport of L1 into endosomes
Phosphorylation of L1 by p90rsk
Phosphorylation of L1 by ERK
Transport of L1 from C-domain to P-domain
Reinsertion of L1 into the plasma membrane
L1 dimer binds Ankyrin
L1 linked to actin cytoskeleton by ankyrin
Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1
Phosphorylation of Y1229 in L1
L1 and NCAM1 engaged in cis-interaction
L1-FGFR cis-heterodimerization
L1-EGFR trans-heterodimerization
L1 binds NRP1
L1 interaction with Integrins
Phosphorylation of VAV2
Activation of Rac1 by VAV2
Interaction of PAK1 with Rac1-GTP
Phosphorylation of L1 by CK-II
Interaction of L1 with Neurocan
Interaction of L1 with Laminin-1
Cis-heterodimerization of L1 and Axonin-1
Cis-heterodimerization of L1 and Contactin-1/F3/F11
Cis-heterodimerization of L1 and DM-GRASP/ALCAM/BEN
L1 binds RanBPM
Heat-Stable Antigen binds L1
Phosphorylation of L1 by EPHB2
CHL1 interacts with Ankyrin-G
CHL1 interacts with HSP7C
CHL1 interacts with NRP1
CHL1 interacts with beta1 integrins
CHL1 interacts with contactin-6
Neurofascin binds Ankyrin-G
Trans-homodimerization of Neurofascin
Neurofascin and NrCAM heterodimerization
Phosphorylation of Neurofascin
Doublecortin binds phosphorylated neurofascin
Neurofascin interacts with syntenin-1
Neurofascin binds contactin-1:CASPR complex
NrCAM binds Ankyrin-G
NrCAM binds axonin-1
NrCAM binds synapse-associated proteins
NrCAM binds Neuropilin-2
CDO binds BOC
CDO binds promyogenic cadherins
Bnip2 interacts with CDO complex
Interaction of Bnip-2 with Cdc42
JLP interacts with CDO complex
Interaction of ABL1 with CDO complex
Interaction of p38 MAPK with JLP
Activation of p38 alpha/beta MAPK
Nuclear translocation of p38 MAPK
Phosphorylation of E proteins by p38 MAPK
Heterodimerization of E proteins with Myod
Phosphorylation of MEF2 proteins by p38
Interaction of MyoD:E protein with MEF2
Neogenin:Netrin-3 binds CDO complex
AKT phosphorylates FOXO1A
Phosphorylated FOXO1A is excluded from the nucleus
Cleavage of NODAL Proprotein
The NODAL Receptor Binds NODAL Ligands
Type II Activin Receptor (ActRII/ACVR2) Phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in Response to NODAL
Type II Activin Receptor (ActRIIB/ACVR2B) Phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in Response to NODAL
Phosphorylation of R-SMAD2/3 by NODAL Receptor
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 Binds FoxO3a-binding Elements
CERBERUS Binds NODAL
LEFTY Binds NODAL
LEFTY Binds the EGF-CFC Coreceptor in the NODAL Receptor
Formation of PPARG:RXRA Heterodimer (ARF6 Complex)
PPARG:RXRA Heterodimer binds to PPARG corepressors
PPARG:RXRA Heterodimer Binds to Fatty Acid-like Ligands
Inactivation of MEK1 by p34cdc2
MEK1 binds ERK-1
MEK1 phosphorylates ERK-1
Dissociation of phospho-ERK-1:MEK1
Dimerisation of phospho-ERK-1
Nuclear translocation of phospho-ERK-1 dimer
MEK2 binds ERK-2
MEK2 phosphorylates ERK-2
Dissociation of phospho-ERK-2:MEK2
Dimerisation of phospho-ERK-2
Nuclear translocation of phospho-ERK-2 dimer
ERK1/2 phosphorylates MSK1
MSK1 activates CREB
Developmental Biology
Axon guidance
Semaphorin interactions
Sema4D in semaphorin signaling
Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Sema3A PAK dependent Axon repulsion
CRMPs in Sema3A signaling
Other semaphorin interactions
NCAM signaling for neurite out-growth
NCAM1 interactions
Netrin-1 signaling
DCC mediated attractive signaling
Netrin mediated repulsion signals
Role of second messengers in netrin-1 signaling
Signaling by Robo receptor
Regulation of Commissural axon pathfinding by Slit and Robo
Inactivation of Cdc42 and Rac
Activation of Rac
Role of Abl in Robo-Slit signaling
L1CAM interactions
Recycling pathway of L1
Interaction between L1 and Ankyrins
Signal transduction by L1
CHL1 interactions
Neurofascin interactions
NrCAM interactions
Myogenesis
CDO in myogenesis
Regulation of beta-cell development
Regulation of gene expression in early pancreatic precursor cells
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Regulation of gene expression in beta cells
AKT-mediated inactivation of FOXO1A
Signaling by NODAL
Regulation of Signaling by NODAL
Transcriptional Regulation of White Adipocyte Differentiation
ERK activation
ERK1 activation
ERK2 activation
RAF/MAP kinase cascade
RAF activation
MEK activation
RAF phosphorylates MEK
Expression of ANGPTL4
Induction of Angiopoietin-related protein 4 (ANGPTL4) Expression
Expression of CD36 (platelet glycoprotein IV, FAT)
Induction of Platelet glycoprotein IV (PAS IV, CD36, GPIV) Expression During Adipogenesis
HNF1B-dependent synthesis of HNF6 protein
HNF1B- and FGF10-dependent synthesis of PTF1A protein
HNF6-dependent synthesis of ONECUT3 protein during early pancreas specification
HNF6- and FGF10-dependent synthesis of PDX1 protein
PDX1-dependent synthesis of NR5A2 protein
PDX1-dependent synthesis of NKX6-1 protein
HNF6-dependent synthesis of HNF1B protein
HNF6-dependent synthesis of ONECUT3 protein during morphogenesis
HNF6-dependent synthesis of NEUROG3 protein during morphogenesis
RBPJ- and NOTCH1-dependent synthesis of HES1 protein during morphogenesis
NEUROG3-dependent synthesis of PAX4 protein
NEUROG3-dependent synthesis of NEUROD1
NEUROG3-dependent synthesis of NKX2-2
NEUROG3-dependent synthesis of INSM1
FOXOA2-, MAFA-, and PAX6-dependent synthesis of PDX1 protein
MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein
PDX1-dependent synthesis of IAPP protein
NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein
HNF1A-dependent synthesis of GLUT2 protein
HNF1A-dependent synthesis of the L isoform of PKLR protein
HNF1A-dependent synthesis of HNF4A
HNF1A-dependent synthesis of HNF4G protein
HNF1A-dependent synthesis of FOXA3
Expression of CEBPB
Expression of CEBPD
Expression of KLF5
Expression of EBF1
Expression of PPARG
Expression of FABP4 (aP2)
Expression of Perilipin (PLIN)
Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C)
Expression of Lipoprotein lipase (LPL)
Expression of CEBPA
Maintenance of PPARG Expression in Differentiated Adipocytes
Expression of Leptin
Expression of Adiponectin
Expression of GLUT4