@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (24)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

obo:UniProtKB_P52961
	rdfs:label "ART1"@em ,
		   "UniProt:P52961 ART1"@em .

biopax:BiochemicalReaction1147
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway307 ;
	obo:directly_activates biopax:BiochemicalReaction1148 ,
			       biopax:BiochemicalReaction1151 ;
	rdfs:label "Pre-pro-defensins are cleaved to remove the signal peptide"@em .

biopax:BiochemicalReaction1148
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway308 ;
	obo:directly_activates biopax:BiochemicalReaction1149 ;
	rdfs:label "Pro-HNP1-4 are cleaved to biologically active defensin"@em .

biopax:BiochemicalReaction1149
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway308 ;
	obo:directly_activates biopax:BiochemicalReaction1150 ;
	rdfs:label "HNP1-4 are stored in primary neutrophil granules"@em .

biopax:BiochemicalReaction1150
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway308 ;
	obo:directly_activates biopax:BiochemicalReaction1154 ,
			       biopax:BiochemicalReaction1157 ,
			       biopax:BiochemicalReaction1158 ,
			       biopax:BiochemicalReaction1159 ,
			       biopax:Catalysis412 ;
	rdfs:label "HNP1-4 are released into phagocytic vacuoles"@em .

biopax:BiochemicalReaction1151
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway308 ;
	obo:directly_activates biopax:BiochemicalReaction1152 ;
	rdfs:label "pro-defensin alpha 5 is stored in Paneth cell granules"@em .

biopax:BiochemicalReaction1152
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway308 ;
	obo:directly_activates biopax:BiochemicalReaction1153 ,
			       biopax:Catalysis411 ;
	rdfs:label "pro-defensin alpha 5 is secreted"@em .

biopax:BiochemicalReaction1153
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005576
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005576
	  ] ,
	  obo:GO_0008236 ;
	obo:BFO_0000050 biopax:Pathway308 ;
	obo:directly_activates biopax:BiochemicalReaction1154 ;
	rdfs:label "pro-HD5 is cleaved by trypsin"@em .

biopax:BiochemicalReaction1154
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway308 ;
	obo:directly_activates biopax:BiochemicalReaction1155 ;
	rdfs:label "Alpha-defensins form biologically active dimers"@em .

biopax:BiochemicalReaction1155
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway308 ;
	obo:directly_activates biopax:BiochemicalReaction1156 ;
	rdfs:label "Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids"@em .

biopax:BiochemicalReaction1156
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway308 ;
	rdfs:label "Alpha-defensin dimers multimerize to form a pore complex"@em .

biopax:BiochemicalReaction1157
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway308 ;
	rdfs:label "HNP1-3 bind gp120"@em .

biopax:BiochemicalReaction1158
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway308 ;
	rdfs:label "HNP1-3 bind CD4"@em .

biopax:BiochemicalReaction1159
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P52961
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P52961
	  ] ,
	  obo:GO_0006471 ;
	obo:BFO_0000050 biopax:Pathway308 ;
	rdfs:label "ADP-Ribosylation of HNP-1"@em .

biopax:BiochemicalReaction1160
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway309 ;
	obo:directly_activates biopax:BiochemicalReaction1161 ;
	rdfs:label "Beta-defensins are secreted"@em .

biopax:BiochemicalReaction1161
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway309 ;
	rdfs:label "Beta-defensins bind microbial membranes causing disruption"@em .

biopax:BiochemicalReaction1162
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway309 ;
	rdfs:label "Beta-defensins 1, 4A and 103 bind CCR6"@em .

biopax:BiochemicalReaction1163
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway309 ;
	rdfs:label "Beta-defensins 4A and 103 bind CCR2"@em .

biopax:BiochemicalReaction1164
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway309 ;
	rdfs:label "Beta defensin 103 activates TLR1:TLR2"@em .

biopax:BiochemicalReaction1165
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway307 ;
	rdfs:label "Binding of defensins to lipid II"@em .

biopax:Pathway307
	a obo:GO_0008150 ;
	rdfs:label "Defensins"@em .

biopax:Pathway308
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway307 ;
	rdfs:label "Alpha-defensins"@em .

biopax:Pathway309
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway307 ;
	rdfs:label "Beta defensins"@em .