IDUA
label: UniProt:P35475 IDUA

HYAL1
label: LUCA1
label: UniProt:Q12794 HYAL1

DSPG and CSPG translocate to the lysosome for degradation
type: GO_0003674
BFO_0000050: CS/DS degradation
directly activates: DS is cleaved from its proteoglycan
directly activates: CS is cleaved from its proteoglycan
directly activates: Catalysis1352
directly activates: Catalysis1353

DS is cleaved from its proteoglycan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0016798
BFO_0000050: CS/DS degradation
directly activates: Arylsulfatase B (ARSB) hydrolyses sulfate groups from GalNAc 4-sulfate units of DS
directly activates: Catalysis1354

CS is cleaved from its proteoglycan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0016798
BFO_0000050: CS/DS degradation
directly activates: Arylsulfatase B (ARSB) hydrolyses sulfate groups from GalNAc 4-sulfate units of CS
directly activates: Catalysis1358

Arylsulfatase B (ARSB) hydrolyses sulfate groups from GalNAc 4-sulfate units of DS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0003943
BFO_0000050: CS/DS degradation
directly activates: Iduronate 2-sulfatase (IDS) hydrolyses sulfates from L-iduronate 2-sulfate units of dermatan sulfate
directly activates: Hyaluronidase 1 (HYAL1) hydrolyses 1-4 linkages between GalNAc and D-glucuronate residues in CS.
directly activates: Catalysis1355
directly activates: Catalysis1359

Iduronate 2-sulfatase (IDS) hydrolyses sulfates from L-iduronate 2-sulfate units of dermatan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004423
BFO_0000050: CS/DS degradation
directly activates: Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from DS
directly activates: Catalysis1356

Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from DS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004563
BFO_0000050: CS/DS degradation
directly activates: Alpha-L-iduronidase (IDUA) hydrolyses the unsulfated alpha-L-iduronosidic linkage in DS
directly activates: Catalysis1357

Alpha-L-iduronidase (IDUA) hydrolyses the unsulfated alpha-L-iduronosidic linkage in DS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: IDUA
type: GO_0003940
BFO_0000050: CS/DS degradation

Arylsulfatase B (ARSB) hydrolyses sulfate groups from GalNAc 4-sulfate units of CS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0003943
BFO_0000050: CS/DS degradation
directly activates: Hyaluronidase 1 (HYAL1) hydrolyses 1-4 linkages between GalNAc and D-glucuronate residues in CS.
directly activates: Catalysis1359

Hyaluronidase 1 (HYAL1) hydrolyses 1-4 linkages between GalNAc and D-glucuronate residues in CS.
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004415
BFO_0000050: CS/DS degradation

CS/DS degradation
type: GO_0008150