FYN
UniProt:P06241 FYN
COT
ESTF
MAP3K8
UniProt:P41279 MAP3K8
CD28 homodimer binds B7-1 homodimer
CD28 homodimer binds B7-2 monomer
Phosphorylation of CD28
Gads binds CD28
PI3K binds CD28
CD28 bound PI3K phosphorylates PIP2 to PIP3
PIP3 recruits PDPK1 to the membrane
PIP3 recruits AKT to the membrane
TORC2 (mTOR) phosphorylates AKT at S473
AKT binds PDPK1
PDPK1 phosphorylates AKT at T308
AKT interacts and phosphorylates Cot
p-S400-Cot phosphorylates NIK
Grb2 binds CD28
Translocation of Vav1 to CD28
Activation of Vav1
Activation of Rac1 by pVav1
Activation of Cdc42 by pVav1
Activation of PAK by Rac1 and Cdc42
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway