FYN
label: UniProt:P06241 FYN

COT
label: ESTF
label: MAP3K8
label: UniProt:P41279 MAP3K8

CD28 homodimer binds B7-1 homodimer
type: GO_0003674
BFO_0000050: CD28 co-stimulation
directly activates: Phosphorylation of CD28
directly activates: Catalysis248

CD28 homodimer binds B7-2 monomer
type: GO_0003674
BFO_0000050: CD28 co-stimulation
directly activates: Phosphorylation of CD28
directly activates: Catalysis248

Phosphorylation of CD28
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: CD28 co-stimulation
directly activates: Gads binds CD28
directly activates: PI3K binds CD28
directly activates: Grb2 binds CD28

Gads binds CD28
type: GO_0003674
BFO_0000050: CD28 co-stimulation

PI3K binds CD28
type: GO_0003674
BFO_0000050: CD28 dependent PI3K/Akt signaling
directly activates: CD28 bound PI3K phosphorylates PIP2 to PIP3
directly activates: Catalysis249

CD28 bound PI3K phosphorylates PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0046934
BFO_0000050: CD28 dependent PI3K/Akt signaling
directly activates: BiochemicalReaction2321
directly activates: BiochemicalReaction656
directly activates: PIP3 recruits PDPK1 to the membrane
directly activates: PIP3 recruits AKT to the membrane
directly activates: Control158

PIP3 recruits PDPK1 to the membrane
type: GO_0003674
BFO_0000050: CD28 dependent PI3K/Akt signaling

PIP3 recruits AKT to the membrane
type: GO_0003674
BFO_0000050: CD28 dependent PI3K/Akt signaling

TORC2 (mTOR) phosphorylates AKT at S473
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: CD28 dependent PI3K/Akt signaling
directly activates: AKT interacts and phosphorylates Cot
directly activates: BiochemicalReaction735
directly activates: BiochemicalReaction736
directly activates: BiochemicalReaction737
directly activates: BiochemicalReaction738
directly activates: BiochemicalReaction739
directly activates: BiochemicalReaction740
directly activates: BiochemicalReaction741
directly activates: BiochemicalReaction742
directly activates: Catalysis252
directly activates: Catalysis282
directly activates: Catalysis283
directly activates: Catalysis284
directly activates: Catalysis285
directly activates: Catalysis286
directly activates: Catalysis287
directly activates: Catalysis288
directly activates: Catalysis289

AKT binds PDPK1
type: GO_0003674
BFO_0000050: CD28 dependent PI3K/Akt signaling

PDPK1 phosphorylates AKT at T308
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: CD28 dependent PI3K/Akt signaling
directly activates: BiochemicalReaction735
directly activates: BiochemicalReaction736
directly activates: BiochemicalReaction737
directly activates: BiochemicalReaction738
directly activates: BiochemicalReaction739
directly activates: BiochemicalReaction740
directly activates: BiochemicalReaction741
directly activates: BiochemicalReaction742
directly activates: Catalysis282
directly activates: Catalysis283
directly activates: Catalysis284
directly activates: Catalysis285
directly activates: Catalysis286
directly activates: Catalysis287
directly activates: Catalysis288
directly activates: Catalysis289

AKT interacts and phosphorylates Cot
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: CD28 dependent PI3K/Akt signaling
directly activates: p-S400-Cot phosphorylates NIK
directly activates: Catalysis253

p-S400-Cot phosphorylates NIK
type: Restriction
  on property: enabled by
  some values from: COT
type: Restriction
  on property: enabled by
  some values from: COT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004709
BFO_0000050: CD28 dependent PI3K/Akt signaling

Grb2 binds CD28
type: GO_0003674
BFO_0000050: CD28 dependent Vav1 pathway
directly activates: Translocation of Vav1 to CD28

Translocation of Vav1 to CD28
type: GO_0003674
BFO_0000050: CD28 dependent Vav1 pathway
directly activates: Activation of Vav1
directly activates: Catalysis254

Activation of Vav1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: FYN
type: Restriction
  on property: enabled by
  some values from: FYN
type: GO_0004713
BFO_0000050: CD28 dependent Vav1 pathway
directly activates: Activation of Rac1 by pVav1
directly activates: Activation of Cdc42 by pVav1
directly activates: Catalysis255
directly activates: Catalysis256

Activation of Rac1 by pVav1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: CD28 dependent Vav1 pathway
directly activates: Activation of PAK by Rac1 and Cdc42

Activation of Cdc42 by pVav1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: CD28 dependent Vav1 pathway
directly activates: Activation of PAK by Rac1 and Cdc42

Activation of PAK by Rac1 and Cdc42
type: GO_0003674
BFO_0000050: CD28 dependent Vav1 pathway

CD28 co-stimulation
type: GO_0008150

CD28 dependent PI3K/Akt signaling
type: GO_0008150
BFO_0000050: CD28 co-stimulation

CD28 dependent Vav1 pathway
type: GO_0008150
BFO_0000050: CD28 co-stimulation