FYN
UniProt:P06241 FYN
JTK8
LYN
UniProt:P07948 LYN
BLK
UniProt:P51451 BLK
AGMX1
ATK
BPK
BTK
UniProt:Q06187 BTK
Calcium binds calmodulin
PIP3 recruits PDPK1 to the membrane
PIP3 recruits AKT to the membrane
TORC2 (mTOR) phosphorylates AKT at S473
AKT binds PDPK1
PDPK1 phosphorylates AKT at T308
The Immunoglobulin of the B Cell Receptor Binds Antigen
The Immunoglobulin of the BCR Binds Antigen
Phosphorylation of ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)
Recruitment of SYK to the Activated B Cell Receptor
Recruitment of SYK to the Activated BCR
Autophosphorylation of SYK at the Activated B Cell Receptor
Autophosphorylation of SYK at the Activated BCR
Activated SYK Phosphorylates BLNK (SLP65)
Assembly of Signalosomes at the Activated B Cell Receptor
Assembly of Signalosomes at the Activated BCR
BCAP Signalosome Generates PIP3
CD19 Signalosome Generates PIP3
BLNK (SLP-65) Signalosome Generates Diacylglycerol and Inositol-1,4,5-trisphosphate
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
Release of calcium from intracellular stores by IP3 receptor activation
Oligomerization of STIM1
STIM1 activation of CRAC
Formation of STIM1:TRPC1 Complex
STIM1 Binds TRPC1
Calcium influx via CRAC
Calcium Influx via TRPC1
Activation of Protein Kinase C beta (PKC-beta)
Phosphorylation of CARMA1 in B Cells
CARMA1 Recruits MALT1 and BCL10 to Form CBM Complex
Formation of CBM Complex
CARMA1:BCL10:MALT1 Complex Recruits TAK1 and IKK
TAK1 Associated with the CBM Complex Phosphorylates IKKbeta
Phosphorylation of I-kappaB by Activated IKK (B cell)
SCF with beta-TrCP1 or beta-TrCP2 Binds NF-kappaB;phospho-IkB
Ubiquitination of IkB by SCF-beta-TrCP
Degradation of Ubiquitinated IkB (B cell)
Translocation of NF-kappaB from the Cytosol to the Nucleus
Activation of RasGRP1 and RasGRP3 by Recruitment to the Membrane and Phosphorylation
Activation of RAS by RasGRP1 and RasGRP3
PI3K phosphorylates PIP2 to PIP3
AKT phosphorylates BAD
AKT phosphorylates GSK3
AKT phosphorylates caspase-9
AKT phosphorylates MDM2
AKT phosphorylates IKKalpha
AKT phosphorylates p21Cip1 and p27Kip1
AKT phosphorylates TSC2, inhibiting it
AKT phosphorylates AKT1S1 (PRAS40)
AKT translocates to the nucleus
AKT phosphorylates CREB1
AKT can phosphorylate forkhead box transcription factors
AKT can phosphorylate RSK
AKT can phosphorylate NR4A1 (NUR77)
PTEN dephosphorylates PIP3
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
PHLPP dephosphorylates S473 in AKT
PDPK1 binds PIP2
MIR26A microRNAs bind PTEN mRNA
PTEN mRNA translation negatively regulated by microRNAs
B Cell Activation
Signaling by the B Cell Receptor (BCR)
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
Downstream Signaling Events Of B Cell Receptor (BCR)
Activation of NF-kappaB in B Cells
Activation of RAS in B Cells
PIP3 activates AKT signaling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network