CGL1
label: CSPB
label: CTLA1
label: GRB
label: GZMB
label: UniProt:P10144 GZMB

NMT
label: NMT1
label: UniProt:P30419 NMT1

JNK1
label: MAPK8
label: PRKM8
label: SAPK1
label: SAPK1C
label: UniProt:P45983 MAPK8

PAK2
label: UniProt:Q13177 PAK2

FASL binds FAS Receptor
type: GO_0097190
BFO_0000050: FasL/ CD95L signaling
directly activates: Trimerization of the FASL:FAS receptor complex

Trimerization of the FASL:FAS receptor complex
type: GO_0003674
BFO_0000050: FasL/ CD95L signaling
directly activates: FasL:Fas binds FADD

FasL:Fas binds FADD
type: GO_0003674
BFO_0000050: FasL/ CD95L signaling
directly activates: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
directly activates: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-10
directly activates: Control490

FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
type: GO_0003674
BFO_0000050: FasL/ CD95L signaling
directly activates: FAS-mediated dimerization of procaspase-8
directly activates: TRAIL-mediated dimerization of procaspase-8
directly activates: FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling
directly activates: FLIP(S) and procaspase-8 form heterodimer
directly activates: Control494
directly activates: Control495

FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-10
type: GO_0003674
BFO_0000050: FasL/ CD95L signaling

TNF-alpha cleavage by TACE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004222
BFO_0000050: TNF signaling
directly activates: Soluble TNF-alpha binds TNF-R1

Soluble TNF-alpha binds TNF-R1
type: GO_0003674
BFO_0000050: TNF signaling
directly activates: TNF:TNF-R1 binds TRADD, TRAF2 and RIP
directly activates: Control491

Membrane-anchored TNF-alpha binds TNF-R1
type: GO_0003674
BFO_0000050: TNF signaling
directly activates: TNF:TNF-R1 binds TRADD, TRAF2 and RIP
directly activates: Control491

TNF:TNF-R1 binds TRADD, TRAF2 and RIP
type: GO_0003674
BFO_0000050: TNF signaling
directly activates: TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex.

TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex.
type: GO_0003674
BFO_0000050: TNF signaling
directly activates: TRADD:TRAF2:RIP1 complex binds FADD

TRADD:TRAF2:RIP1 complex binds FADD
type: GO_0003674
BFO_0000050: TNF signaling
directly activates: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8

TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
type: GO_0003674
BFO_0000050: TNF signaling
directly activates: TNF-mediated dimerization of procaspase-8
directly activates: FLIP(L) and procaspase-8 form heterodimer in TNF signaling
directly activates: FLIP(S) and procaspase-8 form heterodimer
directly activates: Control496

TRAIL Binds TRAIL-Receptor2
type: GO_0003674
BFO_0000050: TRAIL signaling
directly activates: Trimerization of TRAIL: TRAIL receptor-2 complex
directly activates: TRAIL:TRAIL receptor-2 Trimer Binds FADD
directly activates: Control492

Trimerization of TRAIL: TRAIL receptor-2 complex
type: GO_0003674
BFO_0000050: TRAIL signaling

TRAIL:TRAIL receptor-2 Trimer Binds FADD
type: GO_0003674
BFO_0000050: TRAIL signaling
directly activates: TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-8
directly activates: TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-10
directly activates: Control493

TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-8
type: GO_0003674
BFO_0000050: TRAIL signaling
directly activates: FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling
directly activates: FLIP(S) and procaspase-8 form heterodimer

TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-10
type: GO_0003674
BFO_0000050: TRAIL signaling

FAS-mediated dimerization of procaspase-8
type: GO_0003674
BFO_0000050: Dimerization of procaspase-8
directly activates: Caspase-8 processing
directly activates: Catalysis3105
directly activates: Control497

TRAIL-mediated dimerization of procaspase-8
type: GO_0003674
BFO_0000050: Dimerization of procaspase-8
directly activates: Caspase-8 processing
directly activates: Catalysis3105
directly activates: Control497

TNF-mediated dimerization of procaspase-8
type: GO_0003674
BFO_0000050: Dimerization of procaspase-8
directly activates: Caspase-8 processing
directly activates: Catalysis3105
directly activates: Control497

Caspase-8 processing
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-8 activation
directly activates: Caspase-8 activates BID by cleavage
directly activates: Caspase mediated cleavage of vimentin at IDVD (259)
directly activates: Caspase-mediated cleavage of plectin-1
directly activates: Translocation of active caspase-8 to the mitochondrial membrane
directly activates: Catalysis3107
directly activates: Catalysis3121
directly activates: Catalysis3124

FLIP(L) and procaspase-8 form heterodimer in TNF signaling
type: GO_0003674
BFO_0000050: Regulation by c-FLIP
directly activates: Caspase-8 and FLIP(L) processing at DISC
directly activates: Catalysis3106

FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling
type: GO_0003674
BFO_0000050: Regulation by c-FLIP
directly activates: Caspase-8 and FLIP(L) processing at DISC
directly activates: Catalysis3106

FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling
type: GO_0003674
BFO_0000050: Regulation by c-FLIP
directly activates: Caspase-8 and FLIP(L) processing at DISC
directly activates: Catalysis3106

Caspase-8 and FLIP(L) processing at DISC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Regulation by c-FLIP

FLIP(S) and procaspase-8 form heterodimer
type: GO_1902042
BFO_0000050: Regulation by c-FLIP

Caspase-8 activates BID by cleavage
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Activation of BID and translocation to mitochondria
directly activates: Myristoylation of tBID by NMT1
directly activates: tBID binds to inactive BAX protein
directly activates: Catalysis3109

Granzyme-B activates BID by cleavage
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CGL1
type: Restriction
  on property: enabled by
  some values from: CGL1
type: Restriction
  on property: enabled by
  some values from: CGL1
type: Restriction
  on property: enabled by
  some values from: CGL1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004252
BFO_0000050: Activation of BID and translocation to mitochondria
directly activates: Myristoylation of tBID by NMT1
directly activates: tBID binds to inactive BAX protein
directly activates: Catalysis3109

Myristoylation of tBID by NMT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: NMT
type: Restriction
  on property: enabled by
  some values from: NMT
type: Restriction
  on property: enabled by
  some values from: NMT
type: Restriction
  on property: enabled by
  some values from: NMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0019107
BFO_0000050: Activation of BID and translocation to mitochondria
directly activates: Translocation of tBID to mitochondria
directly activates: tBID binds to inactive BAK protein

Translocation of tBID to mitochondria
type: GO_0003674
BFO_0000050: Activation of BID and translocation to mitochondria
directly activates: Sequestration of tBID by BCL-2
directly activates: Release of Cytochrome c from mitochondria
directly activates: Release of SMAC from mitochondria
directly activates: Permeabilization of mitochondria

Sequestration of BAD protein by 14-3-3
type: GO_0003674
BFO_0000050: Activation of BAD and translocation to mitochondria
directly activates: Activation of BAD by calcineurin
directly activates: Catalysis3110

Activation of BAD by calcineurin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008597
BFO_0000050: Activation of BAD and translocation to mitochondria
directly activates: Translocation of activated BAD protein to mitochondria

Translocation of activated BAD protein to mitochondria
type: GO_0001844
BFO_0000050: Activation of BAD and translocation to mitochondria
directly activates: BAD displaces tBID from BCL-2 sequestration

BAD displaces tBID from BCL-2 sequestration
type: GO_0003674
BFO_0000050: Activation of BAD and translocation to mitochondria

Translocation of NOXA to mitochondria
type: GO_0001844
BFO_0000050: Activation of NOXA and translocation to mitochondria

Translocation of PUMA protein to mitochondria
type: GO_0001844
BFO_0000050: Activation of PUMA and translocation to mitochondria

MAPK8 phosphorylates BCL2L11
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Activation of BIM and translocation to mitochondria
label: Phosphorylation of BIM by JNK

Translocation of BIM to mitochondria
type: GO_0001844
BFO_0000050: Activation of BIM and translocation to mitochondria

Phosphorylation of DLC2 by MAPK8
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Activation of BMF and translocation to mitochondria

Translocation of BMF to mitochondria
type: GO_0001844
BFO_0000050: Activation of BMF and translocation to mitochondria

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2
type: GO_0003674
BFO_0000050: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

Sequestration of tBID by BCL-2
type: GO_0003674
BFO_0000050: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
directly activates: BAD displaces tBID from BCL-2 sequestration

BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL
type: GO_0003674
BFO_0000050: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

tBID binds to inactive BAX protein
type: GO_0003674
BFO_0000050: Activation, translocation and oligomerization of BAX
directly activates: tBID activates BAX protein

tBID activates BAX protein
type: GO_0003674
BFO_0000050: Activation, translocation and oligomerization of BAX
directly activates: Translocation of activated BAX to the mitochondria

Translocation of activated BAX to the mitochondria
type: GO_0001844
BFO_0000050: Activation, translocation and oligomerization of BAX
directly activates: Oligomerization of BAX at the mitochondrial membrane

Oligomerization of BAX at the mitochondrial membrane
type: GO_0003674
BFO_0000050: Activation, translocation and oligomerization of BAX
directly activates: Release of Cytochrome c from mitochondria
directly activates: Release of SMAC from mitochondria

tBID binds to inactive BAK protein
type: GO_0003674
BFO_0000050: Activation and oligomerization of BAK protein
directly activates: tBID activates BAK protein

tBID activates BAK protein
type: GO_0003674
BFO_0000050: Activation and oligomerization of BAK protein
directly activates: Oligomerization of BAK at the mitochondrial membrane

Oligomerization of BAK at the mitochondrial membrane
type: GO_0003674
BFO_0000050: Activation and oligomerization of BAK protein
directly activates: Release of Cytochrome c from mitochondria
directly activates: Release of SMAC from mitochondria

Release of Cytochrome c from mitochondria
type: GO_0003674
BFO_0000050: Release of apoptotic factors from the mitochondria
directly activates: Cytochrome c-mediated apoptotic response
directly activates: Formation of apoptosome

Release of SMAC from mitochondria
type: GO_0003674
BFO_0000050: Release of apoptotic factors from the mitochondria
directly activates: SMAC binds XIAP:Caspase-3
directly activates: SMAC binds XIAP:Caspase-7
directly activates: SMAC binds XIAP:Caspase-9
directly activates: SMAC-mediated apoptotic response
directly activates: SMAC binds to IAPs

Cytochrome C Binds to Apaf-1
type: GO_0003674
BFO_0000050: Formation of apoptosome

Cytochrome C:Apaf-1 binds Procaspase-9
type: GO_0003674
BFO_0000050: Formation of apoptosome
directly activates: Cleavage of Procaspase-9 to Caspase-9
directly activates: Catalysis3113

Cleavage of Procaspase-9 to Caspase-9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Formation of apoptosome

Cleavage of Procaspase-3 by the apoptosome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Activation of caspases through apoptosome-mediated cleavage
directly activates: Caspase-mediated cleavage of alpha adducin
directly activates: Caspase mediated cleavage of alpha-II-Fodrin
directly activates: Caspase-mediated cleavage of GAS2
directly activates: Caspase mediated cleavage of HIP-55
directly activates: Caspase-mediated cleavage of vimentin at DSVD (85)
directly activates: Caspase-mediated cleavage of gelsolin
directly activates: Caspase-mediated cleavage of Tau
directly activates: Caspase-mediated cleavage of E-Cadherin
directly activates: Caspase mediated cleavage of beta-catenin
directly activates: Caspase-mediated cleavage of Desmoglein 3
directly activates: Caspase-mediated cleavage of Desmoglein 2
directly activates: Caspase-mediated cleavage of Desmoglein 1
directly activates: Caspase mediated cleavage of APC
directly activates: Caspase mediated cleavage of C-IAP1
directly activates: Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha
directly activates: Caspase-mediated cleavage of Etk
directly activates: Caspase-mediated cleavage of MASK
directly activates: Cleavage of PAK-2 at 212
directly activates: Catalysis3116
directly activates: Catalysis3117
directly activates: Catalysis3118
directly activates: Catalysis3119
directly activates: Catalysis3120
directly activates: Catalysis3123
directly activates: Catalysis3125
directly activates: Catalysis3126
directly activates: Catalysis3127
directly activates: Catalysis3128
directly activates: Catalysis3129
directly activates: Catalysis3130
directly activates: Catalysis3138
directly activates: Catalysis3139
directly activates: Catalysis3145
directly activates: Catalysis3147
directly activates: Catalysis3148
directly activates: Catalysis3155

Cleavage of Procaspase-7 by the apoptosome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Activation of caspases through apoptosome-mediated cleavage
directly activates: Caspase-mediated cleavage of GAS2
directly activates: Caspase-mediated cleavage of vimentin at DSVD (85)
directly activates: Caspase-mediated cleavage of FADK 1
directly activates: Caspase-mediated cleavage of claspin
directly activates: Catalysis3118
directly activates: Catalysis3120
directly activates: Catalysis3140
directly activates: Catalysis3150

SMAC binds XIAP:Caspase-3
type: GO_0003674
BFO_0000050: SMAC binds to IAPs
directly activates: Dissociation of Caspase-3 from SMAC:XIAP:Caspase-3
directly activates: Caspase-mediated cleavage of E-Cadherin
directly activates: Catalysis3126

SMAC binds XIAP:Caspase-7
type: GO_0003674
BFO_0000050: SMAC binds to IAPs
directly activates: Dissociation of Caspase-7 from SMAC:XIAP:Caspase-7

SMAC binds XIAP:Caspase-9
type: GO_0003674
BFO_0000050: SMAC binds to IAPs
directly activates: Dissociation of Caspase-9 from SMAC:XIAP:Caspase-9

Dissociation of Caspase-3 from SMAC:XIAP:Caspase-3
type: GO_0003674
BFO_0000050: SMAC-mediated dissociation of IAP:caspase complexes
directly activates: Caspase-mediated cleavage of alpha adducin
directly activates: Caspase mediated cleavage of alpha-II-Fodrin
directly activates: Caspase-mediated cleavage of GAS2
directly activates: Caspase mediated cleavage of HIP-55
directly activates: Caspase mediated cleavage of beta-catenin
directly activates: Caspase-mediated cleavage of Desmoglein 3
directly activates: Caspase-mediated cleavage of Desmoglein 2
directly activates: Caspase-mediated cleavage of Desmoglein 1
directly activates: Caspase mediated cleavage of APC
directly activates: Caspase mediated cleavage of C-IAP1
directly activates: Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha
directly activates: Caspase-mediated cleavage of Etk
directly activates: Caspase-mediated cleavage of MASK
directly activates: Catalysis3116
directly activates: Catalysis3117
directly activates: Catalysis3118
directly activates: Catalysis3119
directly activates: Catalysis3127
directly activates: Catalysis3128
directly activates: Catalysis3129
directly activates: Catalysis3130
directly activates: Catalysis3138
directly activates: Catalysis3139
directly activates: Catalysis3145
directly activates: Catalysis3147
directly activates: Catalysis3148

Dissociation of Caspase-7 from SMAC:XIAP:Caspase-7
type: GO_0003674
BFO_0000050: SMAC-mediated dissociation of IAP:caspase complexes
directly activates: Caspase-mediated cleavage of GAS2
directly activates: Caspase-mediated cleavage of FADK 1
directly activates: Catalysis3118
directly activates: Catalysis3140

Dissociation of Caspase-9 from SMAC:XIAP:Caspase-9
type: GO_0003674
BFO_0000050: SMAC-mediated dissociation of IAP:caspase complexes

Caspase-mediated cleavage of alpha adducin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase mediated cleavage of alpha-II-Fodrin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase-mediated cleavage of GAS2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase mediated cleavage of HIP-55
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase-mediated cleavage of vimentin at DSVD (85)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase mediated cleavage of vimentin at IDVD (259)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase-mediated cleavage of vimentin at TNLD (429)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase-mediated cleavage of gelsolin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase-mediated cleavage of plectin-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase-mediated cleavage of Tau
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase-mediated cleavage of E-Cadherin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase mediated cleavage of beta-catenin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of Desmoglein 3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of Desmoglein 2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of Desmoglein 1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of Desmoplakin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of plakophilin-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of TJP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of Z0-2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of occludin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of Lamin A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004197
BFO_0000050: Breakdown of the nuclear lamina

Caspase-mediated cleavage of Lamin B1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004197
BFO_0000050: Breakdown of the nuclear lamina

Caspase mediated cleavage of APC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase mediated cleavage of C-IAP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase-mediated cleavage of FADK 1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase 3-mediated cleavage of PKC delta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase-mediated cleavage of PKC theta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase-mediated cleavage of Acinus
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase-mediated cleavage of Rock-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase mediated cleavage of BAP31
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins
directly activates: Mitochondrial recruitment of Drp1

Caspase-mediated cleavage of Etk
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase-mediated cleavage of MASK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase-mediated cleavage of MST3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins
directly activates: Nuclear translocation of catalytic domain of Mst3

Caspase-mediated cleavage of claspin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Cleavage of Satb1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Association of DFF40 with DFF45
type: GO_0003674
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Association of DFF with alpha:beta importin

Association of DFF with alpha:beta importin
type: GO_0003674
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Translocation of DFF to the nucleus

Translocation of DFF to the nucleus
type: GO_0003674
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Caspase 3-mediated cleavage of DFF45 (117)
directly activates: Catalysis3152

Translocation of caspase-3 to the nucleus
type: GO_0003674
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Caspase 3-mediated cleavage of DFF45 (117)
directly activates: Catalysis3152

Caspase 3-mediated cleavage of DFF45 (117)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004197
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Cleavage of DFF45 (224) by caspase-3
directly activates: Catalysis3153

Cleavage of DFF45 (224) by caspase-3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004197
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Cleaved fragments of DFF45 dissociate from DFF40

Cleaved fragments of DFF45 dissociate from DFF40
type: GO_0003674
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Homodimerization of DFF40

Homodimerization of DFF40
type: GO_0003674
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Association of DFF40 with chromatin

Association of DFF40 with chromatin
type: GO_0003674
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Cleavage of DNA by DFF40
directly activates: Catalysis3154
directly activates: Control498

Association of HMGB1/HMGB2 with chromatin
type: GO_0003674
BFO_0000050: Activation of DNA fragmentation factor

Cleavage of DNA by DFF40
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004536
BFO_0000050: Activation of DNA fragmentation factor

Cleavage of PAK-2 at 212
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Stimulation of the cell death response by PAK-2p34
directly activates: Autophosphorylation of PAK-2p34 in the activation loop
directly activates: Catalysis3156

Autophosphorylation of PAK-2p34 in the activation loop
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PAK2
type: Restriction
  on property: enabled by
  some values from: PAK2
type: Restriction
  on property: enabled by
  some values from: PAK2
type: Restriction
  on property: enabled by
  some values from: PAK2
type: GO_0016301
BFO_0000050: Stimulation of the cell death response by PAK-2p34
directly activates: Proteolytic PAK-2p34 fragment translocates to the nucleus
directly activates: Ubiquitination of PAK-2p34
directly activates: Rho GTPase-activating protein 10 (RHG10) interacts with caspase-activated PAK-2p34
directly activates: Catalysis3158

Proteolytic PAK-2p34 fragment translocates to the nucleus
type: GO_0003674
BFO_0000050: Stimulation of the cell death response by PAK-2p34

Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PAK2
type: Restriction
  on property: enabled by
  some values from: PAK2
type: Restriction
  on property: enabled by
  some values from: PAK2
type: Restriction
  on property: enabled by
  some values from: PAK2
type: GO_0016301
BFO_0000050: Stimulation of the cell death response by PAK-2p34
directly activates: Cleavage of PAK-2 at 212
directly activates: Catalysis3155

Translocation of active caspase-8 to the mitochondrial membrane
type: GO_0003674
BFO_0000050: Apoptotic execution phase
directly activates: Caspase mediated cleavage of BAP31
directly activates: Catalysis3146

Mitochondrial recruitment of Drp1
type: GO_0003674
BFO_0000050: Apoptotic execution phase

Nuclear translocation of catalytic domain of Mst3
type: GO_0003674
BFO_0000050: Apoptotic execution phase

Ubiquitination of PAK-2p34
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Regulation of activated PAK-2p34 by proteasome mediated degradation
directly activates: Proteasome mediated degradation of PAK-2p34
directly activates: Catalysis3159

Proteasome mediated degradation of PAK-2p34
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Regulation of activated PAK-2p34 by proteasome mediated degradation

Rho GTPase-activating protein 10 (RHG10) interacts with caspase-activated PAK-2p34
type: GO_0003674
BFO_0000050: Regulation of PAK-2p34 activity by PS-GAP/RHG10
directly activates: Interaction of PAK-2p34 with RGH10/ PS-GAP results in accumulation of PAK-2p34 in the perinuclear region

Interaction of PAK-2p34 with RGH10/ PS-GAP results in accumulation of PAK-2p34 in the perinuclear region
type: GO_0003674
BFO_0000050: Regulation of PAK-2p34 activity by PS-GAP/RHG10

Caspase cleavage of DCC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004190
BFO_0000050: Role of DCC in regulating apoptosis
directly activates: DCC interacts with DIP13alpha

DCC interacts with DIP13alpha
type: GO_0003674
BFO_0000050: Role of DCC in regulating apoptosis
directly activates: Caspase-9 binds DCC:DIP13alpha complex

Caspase-9 binds DCC:DIP13alpha complex
type: GO_0003674
BFO_0000050: Role of DCC in regulating apoptosis
directly activates: Activation of caspase-3
directly activates: Catalysis3161

Activation of caspase-3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Role of DCC in regulating apoptosis

Caspase cleavage of UNC5B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Role of DCC in regulating apoptosis
directly activates: DAPK binds UNC5B

DAPK binds UNC5B
type: GO_0003674
BFO_0000050: Role of DCC in regulating apoptosis

Caspase cleavage of UNC5A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Role of DCC in regulating apoptosis

UNC5A binds NRAGE
type: GO_0003674
BFO_0000050: Role of DCC in regulating apoptosis

AKT phosphorylates BAD
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Activation of BAD and translocation to mitochondria
directly activates: Sequestration of BAD protein by 14-3-3

Apoptosis
type: GO_0008150

Extrinsic Pathway for Apoptosis
type: GO_0008150
BFO_0000050: Apoptosis

Death Receptor Signalling
type: GO_0008150
BFO_0000050: Extrinsic Pathway for Apoptosis

FasL/ CD95L signaling
type: GO_0008150
BFO_0000050: Death Receptor Signalling

TNF signaling
type: GO_0008150
BFO_0000050: Death Receptor Signalling

TRAIL signaling
type: GO_0008150
BFO_0000050: Death Receptor Signalling

Caspase-8 activation
type: GO_0008150
BFO_0000050: Extrinsic Pathway for Apoptosis

Dimerization of procaspase-8
type: GO_0008150
BFO_0000050: Caspase-8 activation

Regulation by c-FLIP
type: GO_0008150
BFO_0000050: Extrinsic Pathway for Apoptosis

Intrinsic Pathway for Apoptosis
type: GO_0008150
BFO_0000050: Apoptosis

Activation of BID and translocation to mitochondria
type: GO_0008150
BFO_0000050: Intrinsic Pathway for Apoptosis
label: Activation, myristolyation of BID and translocation to mitochondria

Activation of BH3-only proteins
type: GO_0008150
BFO_0000050: Intrinsic Pathway for Apoptosis

Activation of BAD and translocation to mitochondria
type: GO_0008150
BFO_0000050: Activation of BH3-only proteins

Activation of NOXA and translocation to mitochondria
type: GO_0008150
BFO_0000050: Activation of BH3-only proteins

Activation of PUMA and translocation to mitochondria
type: GO_0008150
BFO_0000050: Activation of BH3-only proteins

Activation of BIM and translocation to mitochondria
type: GO_0008150
BFO_0000050: Activation of BH3-only proteins

Activation of BMF and translocation to mitochondria
type: GO_0008150
BFO_0000050: Activation of BH3-only proteins

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
type: GO_0008150
BFO_0000050: Intrinsic Pathway for Apoptosis

Activation, translocation and oligomerization of BAX
type: GO_0008150
BFO_0000050: Intrinsic Pathway for Apoptosis

Activation and oligomerization of BAK protein
type: GO_0008150
BFO_0000050: Intrinsic Pathway for Apoptosis

Permeabilization of mitochondria
type: GO_0003674
BFO_0000050: Intrinsic Pathway for Apoptosis
directly activates: Release of apoptotic factors from the mitochondria

Release of apoptotic factors from the mitochondria
type: GO_0008150
BFO_0000050: Intrinsic Pathway for Apoptosis

Apoptotic factor-mediated response
type: GO_0008150
BFO_0000050: Intrinsic Pathway for Apoptosis

Cytochrome c-mediated apoptotic response
type: GO_0008150
BFO_0000050: Apoptotic factor-mediated response

Formation of apoptosome
type: GO_0008150
BFO_0000050: Cytochrome c-mediated apoptotic response

Activation of caspases through apoptosome-mediated cleavage
type: GO_0008150
BFO_0000050: Cytochrome c-mediated apoptotic response

SMAC-mediated apoptotic response
type: GO_0008150
BFO_0000050: Apoptotic factor-mediated response

SMAC binds to IAPs
type: GO_0008150
BFO_0000050: SMAC-mediated apoptotic response

SMAC-mediated dissociation of IAP:caspase complexes
type: GO_0008150
BFO_0000050: SMAC-mediated apoptotic response

Apoptotic execution phase
type: GO_0008150
BFO_0000050: Apoptosis

Apoptotic cleavage of cellular proteins
type: GO_0008150
BFO_0000050: Apoptotic execution phase

Caspase-mediated cleavage of cytoskeletal proteins
type: GO_0008150
BFO_0000050: Apoptotic cleavage of cellular proteins

Apoptotic cleavage of cell adhesion proteins
type: GO_0008150
BFO_0000050: Apoptotic cleavage of cellular proteins

Breakdown of the nuclear lamina
type: GO_0008150
BFO_0000050: Apoptotic cleavage of cellular proteins

Apoptosis induced DNA fragmentation
type: GO_0008150
BFO_0000050: Apoptotic execution phase

Activation of DNA fragmentation factor
type: GO_0008150
BFO_0000050: Apoptosis induced DNA fragmentation

Stimulation of the cell death response by PAK-2p34
type: GO_0008150
BFO_0000050: Apoptotic execution phase

Regulation of Apoptosis
type: GO_0008150
BFO_0000050: Apoptosis

Regulation of activated PAK-2p34 by proteasome mediated degradation
type: GO_0008150
BFO_0000050: Regulation of Apoptosis

Regulation of PAK-2p34 activity by PS-GAP/RHG10
type: GO_0008150
BFO_0000050: Regulation of Apoptosis

Role of DCC in regulating apoptosis
type: GO_0008150
BFO_0000050: Regulation of Apoptosis

Transactivation of NOXA by p53
type: GO_0003674
BFO_0000050: Activation of NOXA and translocation to mitochondria
directly activates: Translocation of NOXA to mitochondria

Transactivation of NOXA by E2F1
type: GO_0003674
BFO_0000050: Activation of NOXA and translocation to mitochondria
directly activates: Translocation of NOXA to mitochondria

Transactivation of PUMA by p53
type: GO_0003674
BFO_0000050: Activation of PUMA and translocation to mitochondria
directly activates: Translocation of PUMA protein to mitochondria

Transactivation of PUMA by E2F1
type: GO_0003674
BFO_0000050: Activation of PUMA and translocation to mitochondria
directly activates: Translocation of PUMA protein to mitochondria