CGL1
CSPB
CTLA1
GRB
GZMB
UniProt:P10144 GZMB
NMT
NMT1
UniProt:P30419 NMT1
JNK1
MAPK8
PRKM8
SAPK1
SAPK1C
UniProt:P45983 MAPK8
PAK2
UniProt:Q13177 PAK2
FASL binds FAS Receptor
Trimerization of the FASL:FAS receptor complex
FasL:Fas binds FADD
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-10
TNF-alpha cleavage by TACE
Soluble TNF-alpha binds TNF-R1
Membrane-anchored TNF-alpha binds TNF-R1
TNF:TNF-R1 binds TRADD, TRAF2 and RIP
TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex.
TRADD:TRAF2:RIP1 complex binds FADD
TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
TRAIL Binds TRAIL-Receptor2
Trimerization of TRAIL: TRAIL receptor-2 complex
TRAIL:TRAIL receptor-2 Trimer Binds FADD
TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-8
TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-10
FAS-mediated dimerization of procaspase-8
TRAIL-mediated dimerization of procaspase-8
TNF-mediated dimerization of procaspase-8
Caspase-8 processing
FLIP(L) and procaspase-8 form heterodimer in TNF signaling
FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling
FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling
Caspase-8 and FLIP(L) processing at DISC
FLIP(S) and procaspase-8 form heterodimer
Caspase-8 activates BID by cleavage
Granzyme-B activates BID by cleavage
Myristoylation of tBID by NMT1
Translocation of tBID to mitochondria
Sequestration of BAD protein by 14-3-3
Activation of BAD by calcineurin
Translocation of activated BAD protein to mitochondria
BAD displaces tBID from BCL-2 sequestration
Translocation of NOXA to mitochondria
Translocation of PUMA protein to mitochondria
MAPK8 phosphorylates BCL2L11
Phosphorylation of BIM by JNK
Translocation of BIM to mitochondria
Phosphorylation of DLC2 by MAPK8
Translocation of BMF to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2
Sequestration of tBID by BCL-2
BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL
tBID binds to inactive BAX protein
tBID activates BAX protein
Translocation of activated BAX to the mitochondria
Oligomerization of BAX at the mitochondrial membrane
tBID binds to inactive BAK protein
tBID activates BAK protein
Oligomerization of BAK at the mitochondrial membrane
Release of Cytochrome c from mitochondria
Release of SMAC from mitochondria
Cytochrome C Binds to Apaf-1
Cytochrome C:Apaf-1 binds Procaspase-9
Cleavage of Procaspase-9 to Caspase-9
Cleavage of Procaspase-3 by the apoptosome
Cleavage of Procaspase-7 by the apoptosome
SMAC binds XIAP:Caspase-3
SMAC binds XIAP:Caspase-7
SMAC binds XIAP:Caspase-9
Dissociation of Caspase-3 from SMAC:XIAP:Caspase-3
Dissociation of Caspase-7 from SMAC:XIAP:Caspase-7
Dissociation of Caspase-9 from SMAC:XIAP:Caspase-9
Caspase-mediated cleavage of alpha adducin
Caspase mediated cleavage of alpha-II-Fodrin
Caspase-mediated cleavage of GAS2
Caspase mediated cleavage of HIP-55
Caspase-mediated cleavage of vimentin at DSVD (85)
Caspase mediated cleavage of vimentin at IDVD (259)
Caspase-mediated cleavage of vimentin at TNLD (429)
Caspase-mediated cleavage of gelsolin
Caspase-mediated cleavage of plectin-1
Caspase-mediated cleavage of Tau
Caspase-mediated cleavage of E-Cadherin
Caspase mediated cleavage of beta-catenin
Caspase-mediated cleavage of Desmoglein 3
Caspase-mediated cleavage of Desmoglein 2
Caspase-mediated cleavage of Desmoglein 1
Caspase-mediated cleavage of Desmoplakin
Caspase-mediated cleavage of plakophilin-1
Caspase-mediated cleavage of TJP1
Caspase-mediated cleavage of Z0-2
Caspase-mediated cleavage of occludin
Caspase-mediated cleavage of Lamin A
Caspase-mediated cleavage of Lamin B1
Caspase mediated cleavage of APC
Caspase mediated cleavage of C-IAP1
Caspase-mediated cleavage of FADK 1
Caspase 3-mediated cleavage of PKC delta
Caspase-mediated cleavage of PKC theta
Caspase-mediated cleavage of Acinus
Caspase-mediated cleavage of Rock-1
Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha
Caspase mediated cleavage of BAP31
Caspase-mediated cleavage of Etk
Caspase-mediated cleavage of MASK
Caspase-mediated cleavage of MST3
Caspase-mediated cleavage of claspin
Cleavage of Satb1
Association of DFF40 with DFF45
Association of DFF with alpha:beta importin
Translocation of DFF to the nucleus
Translocation of caspase-3 to the nucleus
Caspase 3-mediated cleavage of DFF45 (117)
Cleavage of DFF45 (224) by caspase-3
Cleaved fragments of DFF45 dissociate from DFF40
Homodimerization of DFF40
Association of DFF40 with chromatin
Association of HMGB1/HMGB2 with chromatin
Cleavage of DNA by DFF40
Cleavage of PAK-2 at 212
Autophosphorylation of PAK-2p34 in the activation loop
Proteolytic PAK-2p34 fragment translocates to the nucleus
Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197
Translocation of active caspase-8 to the mitochondrial membrane
Mitochondrial recruitment of Drp1
Nuclear translocation of catalytic domain of Mst3
Ubiquitination of PAK-2p34
Proteasome mediated degradation of PAK-2p34
Rho GTPase-activating protein 10 (RHG10) interacts with caspase-activated PAK-2p34
Interaction of PAK-2p34 with RGH10/ PS-GAP results in accumulation of PAK-2p34 in the perinuclear region
Caspase cleavage of DCC
DCC interacts with DIP13alpha
Caspase-9 binds DCC:DIP13alpha complex
Activation of caspase-3
Caspase cleavage of UNC5B
DAPK binds UNC5B
Caspase cleavage of UNC5A
UNC5A binds NRAGE
AKT phosphorylates BAD
Apoptosis
Extrinsic Pathway for Apoptosis
Death Receptor Signalling
FasL/ CD95L signaling
TNF signaling
TRAIL signaling
Caspase-8 activation
Dimerization of procaspase-8
Regulation by c-FLIP
Intrinsic Pathway for Apoptosis
Activation of BID and translocation to mitochondria
Activation, myristolyation of BID and translocation to mitochondria
Activation of BH3-only proteins
Activation of BAD and translocation to mitochondria
Activation of NOXA and translocation to mitochondria
Activation of PUMA and translocation to mitochondria
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Activation, translocation and oligomerization of BAX
Activation and oligomerization of BAK protein
Permeabilization of mitochondria
Release of apoptotic factors from the mitochondria
Apoptotic factor-mediated response
Cytochrome c-mediated apoptotic response
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
SMAC-mediated apoptotic response
SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
Apoptotic execution phase
Apoptotic cleavage of cellular proteins
Caspase-mediated cleavage of cytoskeletal proteins
Apoptotic cleavage of cell adhesion proteins
Breakdown of the nuclear lamina
Apoptosis induced DNA fragmentation
Activation of DNA fragmentation factor
Stimulation of the cell death response by PAK-2p34
Regulation of Apoptosis
Regulation of activated PAK-2p34 by proteasome mediated degradation
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Role of DCC in regulating apoptosis
Transactivation of NOXA by p53
Transactivation of NOXA by E2F1
Transactivation of PUMA by p53
Transactivation of PUMA by E2F1