KIAA0702
NCKX1
SLC24A1
UniProt:O60721 SLC24A1
GRK1
RHOK
UniProt:Q15835 GRK1
Photons induce isomerization of 11cRAL to atRAL
Rhodopsin activation
MII catalyses GDP/GTP exchange on Gt
Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1
GNAT1-GTP binds PDE6 and activates it
PDE hydrolyses cGMP to GMP
cGMP:CNG transports Na+ and Ca2+ into the rod outer segment
NCKX1 exchanges Na+ for Ca2+/K+
NCKX1 removes Ca2+ from the rod outer segment
Decreased cGMP closes cation channels
cGMP dissociates from CNG channels
METAP1/2 demethylates GNAT1
NMT1/2 transfer MYS to GNAT1
FNTA:FNTB transfers FARN to GNGT1
Farnesyltransferase complex farnesylates the gamma subunit of transducin
Unknown N-acyltransferase N-acylates glycine residue in GNAT1
Unknown NAT N-acylates Gly in GNAT1
GRK1 phosphorylates MII to p-MII
GRK1 phosphorylates MII to p-S334,S338,S343-MII
Ca2+ and recoverin restrict GRK1 activity
RCVRN:Ca2+ binds to and inhibits GRK1
SAG binds p-MII to form p-MII:SAG
atRAL dissociates from p-MII:SAG
p-MII:SAG dissociates to p-RHO and SAG
PP2A dephosphorylates p-RHO to RHO
GNAT1-GTP hydrolyses its bound GTP to GDP
PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP
PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP to form p-S478-RGS9-1:GN5B:RGS9BP
GNAT1-GDP binds to GNB1:GNGT1
GUCA binds Ca2+ to form GUCA:Ca2+
GUCYs converts GTP to cGMP
cGMP synthesis by guanylyl cyclase
cGMP binds CNG channel to form cGMP:CNG channel
CALM1:Ca2+ binds CNG channel
Calmodulin:Ca2+ lowers CNG channel sensitivity to cGMP
The phototransduction cascade
Activation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade