KIAA0702
label: NCKX1
label: SLC24A1
label: UniProt:O60721 SLC24A1

GRK1
label: RHOK
label: UniProt:Q15835 GRK1

Photons induce isomerization of 11cRAL to atRAL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0009881
BFO_0000050: Activation of the phototransduction cascade
directly activates: MII catalyses GDP/GTP exchange on Gt
directly activates: GRK1 phosphorylates MII to p-MII
directly activates: Catalysis1391
directly activates: Catalysis1399
directly activates: Control225
directly activates: Control226
directly activates: Control234
directly activates: Control235
directly activates: Control236
directly activates: Control237
directly activates: Control238
label: Rhodopsin activation

MII catalyses GDP/GTP exchange on Gt
type: Restriction
  on property: BFO_0000066
  some values from: GO_0097381
type: Restriction
  on property: BFO_0000066
  some values from: GO_0097381
type: GO_0005085
BFO_0000050: Activation of the phototransduction cascade
directly activates: Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1

Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1
type: GO_0003674
BFO_0000050: Activation of the phototransduction cascade
directly activates: GNAT1-GTP binds PDE6 and activates it
directly activates: Control227

GNAT1-GTP binds PDE6 and activates it
type: GO_0003674
BFO_0000050: Activation of the phototransduction cascade
directly activates: PDE hydrolyses cGMP to GMP
directly activates: Catalysis1392
directly activates: Control228

PDE hydrolyses cGMP to GMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0097381
type: Restriction
  on property: BFO_0000066
  some values from: GO_0097381
type: GO_0047555
BFO_0000050: Activation of the phototransduction cascade
directly activates: Decreased cGMP closes cation channels
directly activates: Control231
directly activates: Control232
directly activates: Control233

cGMP:CNG transports Na+ and Ca2+ into the rod outer segment
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005221
BFO_0000050: Activation of the phototransduction cascade
directly activates: NCKX1 exchanges Na+ for Ca2+/K+
directly activates: Catalysis1394
directly activates: Control230

NCKX1 exchanges Na+ for Ca2+/K+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: KIAA0702
type: Restriction
  on property: enabled by
  some values from: KIAA0702
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008273
BFO_0000050: Activation of the phototransduction cascade
label: NCKX1 removes Ca2+ from the rod outer segment

Decreased cGMP closes cation channels
type: GO_0003674
BFO_0000050: Activation of the phototransduction cascade
label: cGMP dissociates from CNG channels

METAP1/2 demethylates GNAT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004177
BFO_0000050: Inactivation, recovery and regulation of the phototransduction cascade

NMT1/2 transfer MYS to GNAT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004379
BFO_0000050: Inactivation, recovery and regulation of the phototransduction cascade

FNTA:FNTB transfers FARN to GNGT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004660
BFO_0000050: Inactivation, recovery and regulation of the phototransduction cascade
label: Farnesyltransferase complex farnesylates the gamma subunit of transducin

Unknown N-acyltransferase N-acylates glycine residue in GNAT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0047961
BFO_0000050: Inactivation, recovery and regulation of the phototransduction cascade
label: Unknown NAT N-acylates Gly in GNAT1

GRK1 phosphorylates MII to p-MII
type: Restriction
  on property: BFO_0000066
  some values from: GO_0097381
type: Restriction
  on property: BFO_0000066
  some values from: GO_0097381
type: Restriction
  on property: enabled by
  some values from: GRK1
type: Restriction
  on property: enabled by
  some values from: GRK1
type: GO_0050254
BFO_0000050: Inactivation, recovery and regulation of the phototransduction cascade
directly activates: SAG binds p-MII to form p-MII:SAG
label: GRK1 phosphorylates MII to p-S334,S338,S343-MII

Ca2+ and recoverin restrict GRK1 activity
type: GO_0003674
BFO_0000050: Inactivation, recovery and regulation of the phototransduction cascade
label: RCVRN:Ca2+ binds to and inhibits GRK1

SAG binds p-MII to form p-MII:SAG
type: GO_0003674
BFO_0000050: Inactivation, recovery and regulation of the phototransduction cascade
directly activates: atRAL dissociates from p-MII:SAG

atRAL dissociates from p-MII:SAG
type: GO_0003674
BFO_0000050: Inactivation, recovery and regulation of the phototransduction cascade
directly activates: p-MII:SAG dissociates to p-RHO and SAG

p-MII:SAG dissociates to p-RHO and SAG
type: GO_0003674
BFO_0000050: Inactivation, recovery and regulation of the phototransduction cascade
directly activates: BiochemicalReaction1586
directly activates: BiochemicalReaction3197
directly activates: PP2A dephosphorylates p-RHO to RHO
directly activates: Catalysis1400
directly activates: Catalysis574
directly activates: Control241
directly activates: Control242

PP2A dephosphorylates p-RHO to RHO
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004722
BFO_0000050: Inactivation, recovery and regulation of the phototransduction cascade
directly activates: BiochemicalReaction3193

GNAT1-GTP hydrolyses its bound GTP to GDP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0097381
type: Restriction
  on property: BFO_0000066
  some values from: GO_0097381
type: GO_0003924
BFO_0000050: Inactivation, recovery and regulation of the phototransduction cascade
directly activates: GNAT1-GDP binds to GNB1:GNGT1

PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0097381
type: Restriction
  on property: BFO_0000066
  some values from: GO_0097381
type: GO_0004672
BFO_0000050: Inactivation, recovery and regulation of the phototransduction cascade
label: PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP to form p-S478-RGS9-1:GN5B:RGS9BP

GNAT1-GDP binds to GNB1:GNGT1
type: GO_0003674
BFO_0000050: Inactivation, recovery and regulation of the phototransduction cascade
directly activates: MII catalyses GDP/GTP exchange on Gt
directly activates: Catalysis1391
directly activates: Control225
directly activates: Control226

GUCA binds Ca2+ to form GUCA:Ca2+
type: GO_0003674
BFO_0000050: Inactivation, recovery and regulation of the phototransduction cascade

GUCYs converts GTP to cGMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0097381
type: Restriction
  on property: BFO_0000066
  some values from: GO_0097381
type: GO_0004383
BFO_0000050: Inactivation, recovery and regulation of the phototransduction cascade
directly activates: cGMP binds CNG channel to form cGMP:CNG channel
directly activates: Control249
directly activates: Control250
directly activates: Control251
label: cGMP synthesis by guanylyl cyclase

cGMP binds CNG channel to form cGMP:CNG channel
type: GO_0003674
BFO_0000050: Inactivation, recovery and regulation of the phototransduction cascade
directly activates: BiochemicalReaction242

CALM1:Ca2+ binds CNG channel
type: GO_0003674
BFO_0000050: Inactivation, recovery and regulation of the phototransduction cascade
label: Calmodulin:Ca2+ lowers CNG channel sensitivity to cGMP

The phototransduction cascade
type: GO_0008150

Activation of the phototransduction cascade
type: GO_0008150
BFO_0000050: The phototransduction cascade

Inactivation, recovery and regulation of the phototransduction cascade
type: GO_0008150
BFO_0000050: The phototransduction cascade