LIG1
UniProt:P18858 LIG1
FEN1
RAD2
UniProt:P39748 FEN1
Biogenesis And Assembly Of The Telomerase RNP
TERC RNA + 2 TERT + 2 DKC1 (dyskerin) => telomerase RNP
Recruitment of Telomerase RNP to the Telomeric Chromosome End
Alignment Of The RNA Template On The Telomeric Chromosome End
Elongation Of The Telomeric Chromosome End
Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End
Elongation of Extended Telomeric Chromosome End
Disassociation of Telomerase RNP and the Chromosome End
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere
RFC binding displaces Pol Alpha on the C-strand of the telomere
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere
RFC dissociates after sliding clamp formation on the C-strand of the telomere
Formation of Processive Complex on the C-strand of the telomere
Formation of C-strand Okazaki fragments
Formation of the Flap Intermediate on the C-strand
RPA binds to the Flap on the C-strand
Recruitment of Dna2 endonuclease to the C strand
Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand
Removal of remaining Flap from the C-strand
Joining of adjacent Okazaki fragments of the C-strand
Disassociation of Processive Complex and Completed Telomere End
Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure
Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure
Maintenance of Telomeres
Telomere Maintenance
Extension of Telomeres
Telomere Extension By Telomerase
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Removal of the Flap Intermediate from the C-strand
Packaging Of Telomere Ends