Recruitment of TRAF6/TRAF2 to IPS-1
type: GO_0003674
BFO_0000050: TRAF6 mediated IRF7 activation
directly activates: Recruitment of TANK to TRAF6
directly activates: BiochemicalReaction1132

Recruitment of TANK to TRAF6
type: GO_0003674
BFO_0000050: TRAF6 mediated IRF7 activation
directly activates: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6

Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
type: GO_0003674
BFO_0000050: TRAF6 mediated IRF7 activation
directly activates: Recruitment of IRF7 to TRAF6

Recruitment of IRF7 to TRAF6
type: GO_0003674
BFO_0000050: TRAF6 mediated IRF7 activation
directly activates: Phosphorylation and release of IRF7
directly activates: Catalysis404

Phosphorylation and release of IRF7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0004672
BFO_0000050: TRAF6 mediated IRF7 activation
directly activates: Dimerization of p-IRF7

p-IRF7 dimer interacts with coactivator CBP/p300
type: GO_0003674
BFO_0000050: TRAF6 mediated IRF7 activation
directly activates: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes

Formation of VAF (virus-activated factor) complex
type: GO_0003674
BFO_0000050: TRAF6 mediated IRF7 activation
directly activates: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes

VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes
type: GO_0003674
BFO_0000050: TRAF6 mediated IRF7 activation

Dimerization of p-IRF7
type: GO_0003674
BFO_0000050: TRAF6 mediated IRF7 activation
directly activates: Translocation of p-IRF7:p-IRF7 to nucleus
directly activates: Control66

Translocation of p-IRF7:p-IRF7 to nucleus
type: GO_0003674
BFO_0000050: TRAF6 mediated IRF7 activation
directly activates: p-IRF7 dimer interacts with coactivator CBP/p300

TRAF6 mediated IRF7 activation
type: GO_0008150

Expression of Interferon-alpha and beta
type: GO_0003674
BFO_0000050: TRAF6 mediated IRF7 activation