Recruitment of TRAF6/TRAF2 to IPS-1
Recruitment of TANK to TRAF6
Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
Recruitment of IRF7 to TRAF6
Phosphorylation and release of IRF7
p-IRF7 dimer interacts with coactivator CBP/p300
Formation of VAF (virus-activated factor) complex
VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes
Dimerization of p-IRF7
Translocation of p-IRF7:p-IRF7 to nucleus
TRAF6 mediated IRF7 activation
Expression of Interferon-alpha and beta