CARDIAK
label: RICK
label: RIP2
label: RIPK2
label: UNQ277/PRO314/PRO34092
label: UniProt:O43353 RIPK2

CD45
label: PTPRC
label: UniProt:P08575 PTPRC

INPP5D
label: SHIP
label: SHIP1
label: UniProt:Q92835 INPP5D

Interaction of Csk with PAG
type: GO_0003674
BFO_0000050: Phosphorylation of CD3 and TCR zeta chains
directly activates: Inactivation of Lck by Csk
directly activates: Catalysis226

Inactivation of Lck by Csk
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Phosphorylation of CD3 and TCR zeta chains
directly activates: Dephosphorylation of Lck-pY505 by CD45
directly activates: Catalysis227

Dephosphorylation of Lck-pY505 by CD45
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: CD45
type: Restriction
  on property: enabled by
  some values from: CD45
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004725
BFO_0000050: Phosphorylation of CD3 and TCR zeta chains
directly activates: Activation of Lck
directly activates: Catalysis228

Activation of Lck
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Phosphorylation of CD3 and TCR zeta chains
directly activates: Phosphorylation of ITAM motifs in CD3 complexes
directly activates: Catalysis229

Phosphorylation of ITAM motifs in CD3 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Phosphorylation of CD3 and TCR zeta chains
directly activates: Recruitment of ZAP-70 to phosphorylated ITAMs
directly activates: BiochemicalReaction702
directly activates: Catalysis260

Recruitment of ZAP-70 to phosphorylated ITAMs
type: GO_0003674
BFO_0000050: Translocation of ZAP-70 to Immunological synapse
directly activates: Phosphorylation of ZAP-70 by Lck
directly activates: Catalysis230

Phosphorylation of ZAP-70 by Lck
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Translocation of ZAP-70 to Immunological synapse
directly activates: Activation of ZAP-70
directly activates: Catalysis231

Activation of ZAP-70
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Translocation of ZAP-70 to Immunological synapse
directly activates: Phosphorylation of TBSMs in LAT
directly activates: Catalysis232

Phosphorylation of TBSMs in LAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Generation of second messenger molecules
directly activates: Recruitment of Gads to LAT
directly activates: Recruitment of PLC-gamma1 to LAT

Recruitment of Gads to LAT
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: Recruitment of SLP-76 to Gads

Recruitment of SLP-76 to Gads
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: Phosphorylation of SLP-76
directly activates: Catalysis233

Phosphorylation of SLP-76
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Generation of second messenger molecules
directly activates: Recruitment of ITK to SLP-76
directly activates: Recruitment of PLC-gamma1 to SLP-76
directly activates: p-SLP-76 binds ADAP

Recruitment of ITK to SLP-76
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: Phosphorylation of PLC-gamma1
directly activates: Catalysis234

Recruitment of PLC-gamma1 to SLP-76
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: Phosphorylation of PLC-gamma1
directly activates: Catalysis234

Recruitment of PLC-gamma1 to LAT
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: Phosphorylation of PLC-gamma1
directly activates: Catalysis234

Phosphorylation of PLC-gamma1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Generation of second messenger molecules
directly activates: Disassociation of PLC-gamma1 from LAT
directly activates: Disassociation of PLC-gamma1 from SLP-76
directly activates: Translocation of PLC-gamma1 to PIP2

Disassociation of PLC-gamma1 from LAT
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: Translocation of PLC-gamma1 to PIP2

Disassociation of PLC-gamma1 from SLP-76
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: Translocation of PLC-gamma1 to PIP2

Translocation of PLC-gamma1 to PIP2
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: PLC-gamma1 hydrolyses PIP2
directly activates: Catalysis235

PLC-gamma1 hydrolyses PIP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004435
BFO_0000050: Generation of second messenger molecules
directly activates: Recruitment of PI3K to plasmamembrane

p-SLP-76 binds ADAP
type: GO_0003674
BFO_0000050: Generation of second messenger molecules

p-SLP-76:ADAP binds Ena/VASP
type: GO_0003674
BFO_0000050: Generation of second messenger molecules

p-SLP-76 binds NCK
type: GO_0003674
BFO_0000050: Generation of second messenger molecules

NCK binds PAK
type: GO_0003674
BFO_0000050: Generation of second messenger molecules

NCK recruits WASP
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: BiochemicalReaction1226

Recruitment of PI3K to plasmamembrane
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: PI3K phosphorylates PIP2 to PIP3
directly activates: Catalysis236

PI3K phosphorylates PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0046934
BFO_0000050: Downstream TCR signaling
directly activates: BiochemicalReaction2321
directly activates: Hydrolysis of PIP3 to PI(3,4)P2
directly activates: Hydrolysis of PIP3 to PIP2
directly activates: Translocation of PDK1 to Plasma membrane
directly activates: BiochemicalReaction679
directly activates: BiochemicalReaction680
directly activates: Catalysis237
directly activates: Catalysis238
directly activates: Control158

Hydrolysis of PIP3 to PI(3,4)P2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: INPP5D
type: Restriction
  on property: enabled by
  some values from: INPP5D
type: GO_0016314
BFO_0000050: Downstream TCR signaling
directly activates: Translocation of PDK1 to Plasma membrane

Hydrolysis of PIP3 to PIP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016314
BFO_0000050: Downstream TCR signaling

Translocation of PDK1 to Plasma membrane
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Translocation of PKC theta to plasma membrane

Translocation of PKC theta to plasma membrane
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Change of PKC theta conformation
directly activates: Catalysis239

Change of PKC theta conformation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Downstream TCR signaling
directly activates: Phosphorylation of PKC theta
directly activates: Catalysis240

Phosphorylation of PKC theta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: Translocation of CARMA1 to Plasma membrane

Translocation of CARMA1 to Plasma membrane
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Phosphorylation of CARMA1
directly activates: Catalysis241

Phosphorylation of CARMA1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: Oligomerization of CARMA1

Oligomerization of CARMA1
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Interaction of Bcl10 to CARMA1

Interaction of Bcl10 to CARMA1
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Phosphorylation of Bcl10
directly activates: Catalysis242

Phosphorylation of Bcl10
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CARDIAK
type: Restriction
  on property: enabled by
  some values from: CARDIAK
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: Oligomerization of Bcl10

Oligomerization of Bcl10
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Interaction and oligomerization of MALT1 to Bcl10

Interaction and oligomerization of MALT1 to Bcl10
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Translocation of TRAF6 to CBM complex

Translocation of TRAF6 to CBM complex
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Auto-ubiquitination of TRAF6
directly activates: Catalysis243

Auto-ubiquitination of TRAF6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004842
BFO_0000050: Downstream TCR signaling
directly activates: Activation of TAK1-TAB2 complex
directly activates: Catalysis244

Activation of TAK1-TAB2 complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: Activation of IKK complex
directly activates: Catalysis245

Activation of IKK complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: Ubiquitination of NEMO by TRAF6
directly activates: Catalysis246

Ubiquitination of NEMO by TRAF6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004842
BFO_0000050: Downstream TCR signaling
directly activates: Activation of NF-kB complex
directly activates: Catalysis247

Activation of NF-kB complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: BiochemicalReaction1341
directly activates: BiochemicalReaction3896

TCR signaling
type: GO_0008150

Phosphorylation of CD3 and TCR zeta chains
type: GO_0008150
BFO_0000050: TCR signaling

Translocation of ZAP-70 to Immunological synapse
type: GO_0008150
BFO_0000050: TCR signaling

Generation of second messenger molecules
type: GO_0008150
BFO_0000050: TCR signaling

Downstream TCR signaling
type: GO_0008150
BFO_0000050: TCR signaling