CARDIAK
RICK
RIP2
RIPK2
UniProt:O43353 RIPK2
CD45
PTPRC
UniProt:P08575 PTPRC
INPP5D
SHIP
SHIP1
UniProt:Q92835 INPP5D
Interaction of Csk with PAG
Inactivation of Lck by Csk
Dephosphorylation of Lck-pY505 by CD45
Activation of Lck
Phosphorylation of ITAM motifs in CD3 complexes
Recruitment of ZAP-70 to phosphorylated ITAMs
Phosphorylation of ZAP-70 by Lck
Activation of ZAP-70
Phosphorylation of TBSMs in LAT
Recruitment of Gads to LAT
Recruitment of SLP-76 to Gads
Phosphorylation of SLP-76
Recruitment of ITK to SLP-76
Recruitment of PLC-gamma1 to SLP-76
Recruitment of PLC-gamma1 to LAT
Phosphorylation of PLC-gamma1
Disassociation of PLC-gamma1 from LAT
Disassociation of PLC-gamma1 from SLP-76
Translocation of PLC-gamma1 to PIP2
PLC-gamma1 hydrolyses PIP2
p-SLP-76 binds ADAP
p-SLP-76:ADAP binds Ena/VASP
p-SLP-76 binds NCK
NCK binds PAK
NCK recruits WASP
Recruitment of PI3K to plasmamembrane
PI3K phosphorylates PIP2 to PIP3
Hydrolysis of PIP3 to PI(3,4)P2
Hydrolysis of PIP3 to PIP2
Translocation of PDK1 to Plasma membrane
Translocation of PKC theta to plasma membrane
Change of PKC theta conformation
Phosphorylation of PKC theta
Translocation of CARMA1 to Plasma membrane
Phosphorylation of CARMA1
Oligomerization of CARMA1
Interaction of Bcl10 to CARMA1
Phosphorylation of Bcl10
Oligomerization of Bcl10
Interaction and oligomerization of MALT1 to Bcl10
Translocation of TRAF6 to CBM complex
Auto-ubiquitination of TRAF6
Activation of TAK1-TAB2 complex
Activation of IKK complex
Ubiquitination of NEMO by TRAF6
Activation of NF-kB complex
TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
Downstream TCR signaling