CDC2
CDC28A
CDK1
CDKN1
P34CDC2
UniProt:P06493 CDK1
RPS6KB1
STK14A
UniProt:P23443 RPS6KB1
ERK1
MAPK3
PRKM3
UniProt:P27361 MAPK3
PPM1A
PPPM1A
UniProt:P35813 PPM1A
PDE3B
UniProt:Q13370 PDE3B
p-RAF binds 14-3-3 beta/alpha
Transient dissociation of 14-3-3 upon Ras binding
Stabilisation of RAS:RAF by 14-3-3
Stabilisation of RAF by further phosphorylation
Phosphorylated human RAF1 binds to RAS:GTP complex
Activated RAF1 complex binds MEK
RAF1 phosphorylates MEK1
RAF1 phosphorylates MEK2
Phosphorylation of PDE3B
Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B
Insulin binding
Autophosphorylation of insulin receptor
Binding of SHC to insulin receptor
Phosphorylation of SHC
Dissociation of SHC-P from insulin receptor
GRB2:SOS binds to SHC-P
SOS mediated nucleotide exchange of RAS (SHC)
Binding of IRS to insulin receptor
Phosphorylation of IRS
Dissociation of IRS-P from insulin receptor
PI3K activation
PIP2 conversion to PIP3
Phosphorylation of TSC2 by PKB
Phosphorylation of complexed TSC2 by PKB
GTP loading by Rheb
Formation of active mTORC1 complex
Activation of S6K1
Phosphorylation of Ribosomal protein S6 by activated S6K1
Phosphorylation and inactivation of eEF2K by activated S6K1
Phosphorylation and activation of eIF4G by activated S6K1
Phosphorylation and activation of eIF4B by activated S6K1
Phosphorylation of 4E-BP1 by activated mTORC1
Dissociation of phosphorylated 4EBP1 from eIF4E
LKB1 forms a trimeric complex with STRAD and MO25
Activation of cytosolic AMPK by phosphorylation
AMPK is dephosphorylated
Phosphorylated AMPK binds AMP
AMPK phosphorylates Raptor
p-AMPK phosphorylates TSC2
TSC2 activates intrinsic GTPase activity of Rheb
PDK1 attachment to plasma membrane
PKB attachment to plasma membrane
Phosphorylation of AKT2 by PDK1
GRB2:SOS binds IRS-P
SOS mediated nucleotide exchange of RAS (IRS)
De-phosphorylation of IRS
De-phosphorylation of SHC
SOS phosphorylation and dissociation (SHC)
SOS phosphorylation and dissociation (IRS)
SOS phosphorylation and dissociation (IRS, Crk)
Binding of Grb10 to the insulin receptor
Internalisation of the insulin receptor
Endosome acidification
Dissociation of insulin from insulin receptor
Insulin receptor de-phosphorylation
Re-integration of insulin receptor into plasma membrane
Inactivation of MEK1 by p34cdc2
MEK1 binds ERK-1
MEK1 phosphorylates ERK-1
Dissociation of phospho-ERK-1:MEK1
Dimerisation of phospho-ERK-1
Nuclear translocation of phospho-ERK-1 dimer
MEK2 binds ERK-2
MEK2 phosphorylates ERK-2
Dissociation of phospho-ERK-2:MEK2
Dimerisation of phospho-ERK-2
Nuclear translocation of phospho-ERK-2 dimer
Insulin degradation
ERK activation
ERK1 activation
ERK2 activation
RAF/MAP kinase cascade
RAF activation
MEK activation
RAF phosphorylates MEK
Insulin receptor mediated signaling
Signaling by Insulin receptor
Insulin receptor signalling cascade
SHC-related events
SHC activation
SHC-mediated signalling
IRS-related events
IRS activation
IRS-mediated signalling
PI3K Cascade
PKB-mediated events
PDE3B signalling
mTOR signalling
Inhibition of TSC complex formation by PKB
mTORC1-mediated signalling
S6K1-mediated signalling
S6K1 signalling
Release of eIF4E
Energy dependent regulation of mTOR by LKB1-AMPK
Regulation of AMPK activity via LKB1
Regulation of Rheb GTPase activity by AMPK
Activation of PKB
SOS-mediated signalling
Signal attenuation
Insulin receptor recycling