Constitutive dimerization of FGFR3 cysteine mutants
type: GO_0003674
BFO_0000050: Signaling by activated point mutants of FGFR3
directly activates: Autocatalytic phosphorylation of FGFR3 cysteine mutants
directly activates: Catalysis1278

Autocatalytic phosphorylation of FGFR3 cysteine mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by activated point mutants of FGFR3

Dimerization of FGFR3 point mutants with enhanced kinase activity
type: GO_0003674
BFO_0000050: Signaling by activated point mutants of FGFR3
directly activates: Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity
directly activates: Catalysis1279

Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by activated point mutants of FGFR3
label: Autocatalytic phosphorylation of FGFR3 somatic point mutants with enhanced kinase activity

FGFR3c P250R mutant binds to ligand with enhanced affinity
type: GO_0003674
BFO_0000050: Signaling by activated point mutants of FGFR3
directly activates: Autocatalytic phosphorylation of FGFR3c P250R mutant
directly activates: Catalysis1280

Autocatalytic phosphorylation of FGFR3c P250R mutant
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by activated point mutants of FGFR3

Dimerization of FGFR3 t(4;14) translocation mutants
type: GO_0003674
BFO_0000050: t(4;14) translocations of FGFR3

Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: t(4;14) translocations of FGFR3

FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors
type: GO_0003674
BFO_0000050: Signaling by FGFR3 mutants

Signaling by FGFR3 mutants
type: GO_0008150

Signaling by activated point mutants of FGFR3
type: GO_0008150
BFO_0000050: Signaling by FGFR3 mutants

t(4;14) translocations of FGFR3
type: GO_0008150
BFO_0000050: Signaling by FGFR3 mutants