Ligand-independent dimerization of overexpressed FGFR1
Ligand-independent phosphorylation of overexpressed FGFR1
Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers
Dimerization of FGFR1 fusion proteins
Phosphorylation of FGFR1 fusion dimers
Tyrosine kinase inhibitors bind and inhibit FGFR1 fusion dimer phosphorylation
FGFR1 fusions bind PLCgamma
PLCgamma is phosphorylated by FGFR1-fusions
p-PLCgamma dissociates from FGFR1 fusions
FGFR1 fusion proteins recruit PIK3R1
Recruitment of the catalytic subunit of PI3K to activated FGFR1 fusions
FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3
Phosphorylation of BCR moiety of BCR-FGFR1
p-BCR-pFGFR1 recruits GRB2:GAB2
GAB2 is phosphorylated by p-BCR-p-FGFR1
Recruitment of the p85 regulatory subunit of PI3K to the BCR-FGFR1 complex.
The catalytic subunit of PI3K is recruited to the BCR-FGFR1 fusion.
BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3.
Phosphorylation of STAT5 by FGFR1 fusions
FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3
FGFR1 P252X mutants bind ligand with enhanced affinity
Autocatalytic phosphorylation of FGFR1 P252X mutant dimers
Dimerization of FGFR1 point mutants with enhanced kinase activity
Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity
Signaling by FGFR1 mutants
Signaling by FGFR1 amplification mutants
Signaling by FGFR1 fusion mutants
Signaling by activated point mutants of FGFR1