Ligand-independent dimerization of overexpressed FGFR1
type: GO_0003674
BFO_0000050: Signaling by FGFR1 amplification mutants
directly activates: Ligand-independent phosphorylation of overexpressed FGFR1
directly activates: Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers
directly activates: Catalysis1262

Ligand-independent phosphorylation of overexpressed FGFR1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by FGFR1 amplification mutants
directly activates: BiochemicalReaction3039

Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers
type: GO_0003674
BFO_0000050: Signaling by FGFR1 amplification mutants

Dimerization of FGFR1 fusion proteins
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: Phosphorylation of FGFR1 fusion dimers
directly activates: Tyrosine kinase inhibitors bind and inhibit FGFR1 fusion dimer phosphorylation
directly activates: Catalysis1263

Phosphorylation of FGFR1 fusion dimers
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: FGFR1 fusions bind PLCgamma
directly activates: FGFR1 fusion proteins recruit PIK3R1
directly activates: Phosphorylation of BCR moiety of BCR-FGFR1
directly activates: Phosphorylation of STAT5 by FGFR1 fusions
directly activates: FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3
directly activates: Catalysis1266
directly activates: Catalysis1269
directly activates: Catalysis1270

Tyrosine kinase inhibitors bind and inhibit FGFR1 fusion dimer phosphorylation
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants

FGFR1 fusions bind PLCgamma
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: PLCgamma is phosphorylated by FGFR1-fusions
directly activates: Catalysis1264

PLCgamma is phosphorylated by FGFR1-fusions
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: p-PLCgamma dissociates from FGFR1 fusions

p-PLCgamma dissociates from FGFR1 fusions
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants

FGFR1 fusion proteins recruit PIK3R1
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: Recruitment of the catalytic subunit of PI3K to activated FGFR1 fusions

Recruitment of the catalytic subunit of PI3K to activated FGFR1 fusions
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3
directly activates: Catalysis1265

FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Signaling by FGFR1 fusion mutants

Phosphorylation of BCR moiety of BCR-FGFR1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: FGFR1 fusion proteins recruit PIK3R1
directly activates: p-BCR-pFGFR1 recruits GRB2:GAB2

p-BCR-pFGFR1 recruits GRB2:GAB2
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: GAB2 is phosphorylated by p-BCR-p-FGFR1
directly activates: The catalytic subunit of PI3K is recruited to the BCR-FGFR1 fusion.
directly activates: Catalysis1267

GAB2 is phosphorylated by p-BCR-p-FGFR1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: Recruitment of the p85 regulatory subunit of PI3K to the BCR-FGFR1 complex.

Recruitment of the p85 regulatory subunit of PI3K to the BCR-FGFR1 complex.
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants

The catalytic subunit of PI3K is recruited to the BCR-FGFR1 fusion.
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3.
directly activates: Catalysis1268

BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3.
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Signaling by FGFR1 fusion mutants

Phosphorylation of STAT5 by FGFR1 fusions
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Signaling by FGFR1 fusion mutants

FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Signaling by FGFR1 fusion mutants

FGFR1 P252X mutants bind ligand with enhanced affinity
type: GO_0003674
BFO_0000050: Signaling by activated point mutants of FGFR1
directly activates: Autocatalytic phosphorylation of FGFR1 P252X mutant dimers
directly activates: Catalysis1271

Autocatalytic phosphorylation of FGFR1 P252X mutant dimers
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by activated point mutants of FGFR1

Dimerization of FGFR1 point mutants with enhanced kinase activity
type: GO_0003674
BFO_0000050: Signaling by activated point mutants of FGFR1
directly activates: Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity
directly activates: Catalysis1272

Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by activated point mutants of FGFR1

Signaling by FGFR1 mutants
type: GO_0008150

Signaling by FGFR1 amplification mutants
type: GO_0008150
BFO_0000050: Signaling by FGFR1 mutants

Signaling by FGFR1 fusion mutants
type: GO_0008150
BFO_0000050: Signaling by FGFR1 mutants

Signaling by activated point mutants of FGFR1
type: GO_0008150
BFO_0000050: Signaling by FGFR1 mutants