CTDP1
label: FCP1
label: UniProt:Q9Y5B0 CTDP1

Cleavage of mRNA at the 3'-end
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004519
BFO_0000050: Cleavage of Growing Transcript in the Termination Region
directly activates: BiochemicalReaction299
directly activates: Catalysis114

Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA
type: GO_0003674
BFO_0000050: Cleavage of Growing Transcript in the Termination Region
directly activates: BiochemicalReaction469
directly activates: Control35

Cleavage of the 3'-end of the Histone Pre-mRNA
type: GO_0003674
BFO_0000050: Cleavage of Growing Transcript in the Termination Region
directly activates: BiochemicalReaction472
directly activates: Control38

Cleavage of Intronless Pre-mRNA at 3'-end
type: GO_0003674
BFO_0000050: Cleavage of Growing Transcript in the Termination Region
directly activates: BiochemicalReaction308

Abortive initiation after formation of the first phosphodiester bond
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events

Abortive Initiation After Second Transition
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events

Abortive Initiation Before Second Transition
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events

Formation of DSIF complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: BiochemicalReaction2644
directly activates: DSIF complex binds to RNA Pol II (hypophosphorylated)

Formation of Elongin BC complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: Formation of elongin complex

Formation of FACT complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: BiochemicalReaction2652
directly activates: BiochemicalReaction2662
directly activates: Recruitment of elongation factors to form elongation complex

Formation of NELF complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: BiochemicalReaction2645
directly activates: Formation of DSIF:NELF:early elongation complex

Formation of P-TEFb complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: BiochemicalReaction2661
directly activates: Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
directly activates: Catalysis1150
directly activates: Catalysis137

Formation of elongin complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: BiochemicalReaction2652
directly activates: BiochemicalReaction2662
directly activates: Recruitment of elongation factors to form elongation complex

Resumption of elongation after recovery from pausing
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: Pol II elongation complex moves on the template as transcript elongates

2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: Resumption of elongation after recovery from pausing

7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: TFIIS-mediated recovery of elongation from arrest
directly activates: Abortive termination of elongation after arrest

TFIIS-mediated recovery of elongation from arrest
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: Pol II elongation complex moves on the template as transcript elongates

Abortive termination of early transcription elongation by DSIF:NELF
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events

Abortive termination of elongation after arrest
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events

Elongating transcript encounters a lesion in the template
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: BiochemicalReaction205

Fall Back to Closed Pre-initiation Complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events

Recognition and Binding of Core Promoter Elements by TFIID
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
directly activates: Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex

Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
directly activates: Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex

Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
directly activates: Binding of TFIIE to the growing preinitiation complex

Binding of TFIIE to the growing preinitiation complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
directly activates: Formation of the closed pre-initiation complex

Formation of the closed pre-initiation complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
directly activates: RNA Polymerase II Promoter Opening: First Transition
directly activates: Catalysis127

RNA Polymerase II Promoter Opening: First Transition
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004386
BFO_0000050: RNA Polymerase II Transcription Initiation And Promoter Clearance
directly activates: Fall Back to Closed Pre-initiation Complex
directly activates: NTP Binds Active Site of RNA Polymerase II

NTP Binds Active Site of RNA Polymerase II
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Initiation
directly activates: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP

Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Initiation
directly activates: Newly Formed Phosphodiester Bond Stabilized and PPi Released

Newly Formed Phosphodiester Bond Stabilized and PPi Released
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Initiation
directly activates: Addition of the third nucleotide on the nascent transcript
directly activates: Catalysis128
directly activates: Catalysis129

Addition of the third nucleotide on the nascent transcript
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
type: GO_0004386
BFO_0000050: RNA Polymerase II Promoter Escape
directly activates: Abortive Initiation Before Second Transition
directly activates: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition
directly activates: Catalysis130
directly activates: Catalysis131

Addition of the fourth nucleotide on the Nascent Transcript: Second Transition
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
type: GO_0004386
BFO_0000050: RNA Polymerase II Promoter Escape
directly activates: Abortive Initiation Before Second Transition
directly activates: Addition of Nucleotides 5 through 9 on the growing Transcript
directly activates: Catalysis132

Addition of Nucleotides 5 through 9 on the growing Transcript
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
BFO_0000050: RNA Polymerase II Promoter Escape
directly activates: Abortive Initiation After Second Transition
directly activates: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition
directly activates: Catalysis133

Addition of nucleotides 10 and 11 on the growing transcript: Third Transition
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
BFO_0000050: RNA Polymerase II Promoter Escape
directly activates: Addition of nucleotides between position +11 and +30
directly activates: Catalysis134

Addition of nucleotides between position +11 and +30
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
BFO_0000050: RNA Polymerase II Promoter Escape
directly activates: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex

Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex
type: GO_0003674
BFO_0000050: RNA Pol II CTD phosphorylation and interaction with CE
directly activates: Phosphorylation (Ser5) of RNA pol II CTD
directly activates: Catalysis135

Phosphorylation (Ser5) of RNA pol II CTD
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: RNA Pol II CTD phosphorylation and interaction with CE
directly activates: RNA Polymerase II CTD (phosphorylated) binds to CE

RNA Polymerase II CTD (phosphorylated) binds to CE
type: GO_0003674
BFO_0000050: RNA Pol II CTD phosphorylation and interaction with CE
directly activates: Activation of GT

Activation of GT
type: GO_0003674
BFO_0000050: RNA Pol II CTD phosphorylation and interaction with CE
directly activates: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)

SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
type: GO_0003674
BFO_0000050: RNA Pol II CTD phosphorylation and interaction with CE
directly activates: BiochemicalReaction441

Hypophosphorylation of RNA Pol II CTD by FCP1P protein
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: GO_0004721
BFO_0000050: Formation of the Early Elongation Complex
directly activates: DSIF complex binds to RNA Pol II (hypophosphorylated)

DSIF complex binds to RNA Pol II (hypophosphorylated)
type: GO_0003674
BFO_0000050: Formation of the Early Elongation Complex
directly activates: Formation of DSIF:NELF:early elongation complex

Formation of DSIF:NELF:early elongation complex
type: GO_0003674
BFO_0000050: Formation of the Early Elongation Complex
directly activates: Abortive termination of early transcription elongation by DSIF:NELF
directly activates: Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
directly activates: Catalysis137

Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Formation of RNA Pol II elongation complex
directly activates: Recruitment of elongation factors to form elongation complex

Recruitment of elongation factors to form elongation complex
type: GO_0003674
BFO_0000050: Formation of RNA Pol II elongation complex
directly activates: Addition of nucleotides leads to transcript elongation

Addition of nucleotides leads to transcript elongation
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Elongation
directly activates: 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing
directly activates: 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest
directly activates: Elongating transcript encounters a lesion in the template
directly activates: Pol II elongation complex moves on the template as transcript elongates

Pol II elongation complex moves on the template as transcript elongates
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Elongation
directly activates: Separation of elongating transcript from template

Separation of elongating transcript from template
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Elongation
directly activates: Cleavage of Growing Transcript in the Termination Region

RNA Polymerase II Transcription
type: GO_0008150

RNA Polymerase II Pre-transcription Events
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription

RNA Polymerase II Transcription Initiation And Promoter Clearance
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription

RNA Polymerase II Transcription Initiation
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription Initiation And Promoter Clearance

RNA Polymerase II Promoter Escape
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription Initiation And Promoter Clearance

RNA Pol II CTD phosphorylation and interaction with CE
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription

RNA Polymerase II Transcription Elongation
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription

Formation of the Early Elongation Complex
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription Elongation

Formation of RNA Pol II elongation complex
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription Elongation

RNA Polymerase II Transcription Termination
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription

Cleavage of Growing Transcript in the Termination Region
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription Termination