ABCC4
label: MRP4
label: UniProt:O15439 ABCC4

SRC
label: SRC1
label: UniProt:P12931-1 SRC

UniProt:P15498 VAV1
label: VAV
label: VAV1

PLCG2
label: UniProt:P16885 PLCG2

PTP1B
label: PTPN1
label: UniProt:P18031 PTPN1

UniProt:P52735 VAV2
label: VAV2

CSBP
label: CSBP1
label: CSBP2
label: CSPB1
label: MAPK14
label: MXI2
label: SAPK2A
label: UniProt:Q16539 MAPK14

MGLL
label: UniProt:Q99685 MGLL

UniProt:Q9UKW4 VAV3
label: VAV3

Transport of Ca++ from platelet dense tubular system to cytoplasm
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: GO_0005262
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
directly activates: Activation of conventional Protein Kinase C
directly activates: BiochemicalReaction242
directly activates: Control159

Phosphorylation of cPLA2 by MAPK p38 alpha
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: BiochemicalReaction4402

GP1b-IX-V binds 14-3-3-zeta
type: GO_0003674
BFO_0000050: GP1b-IX-V activation signalling
directly activates: GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress
directly activates: GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K
directly activates: 14-3-3-zeta binds Raf1

GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress
type: GO_0003674
BFO_0000050: GP1b-IX-V activation signalling

GP1b-IX-V binds filamin
type: GO_0003674
BFO_0000050: GP1b-IX-V activation signalling

GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K
type: GO_0003674
BFO_0000050: GP1b-IX-V activation signalling

GP1b signaling involves c-Src
type: GO_0003674
BFO_0000050: GP1b-IX-V activation signalling
directly activates: c-Src binds Raf1

c-Src binds Raf1
type: GO_0003674
BFO_0000050: GP1b-IX-V activation signalling
directly activates: BiochemicalReaction1277
directly activates: Catalysis447

14-3-3-zeta binds Raf1
type: GO_0003674
BFO_0000050: GP1b-IX-V activation signalling

ADP binds to P2Y purinoceptor 12
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 12
directly activates: Activated P2Y purinoceptor 12 binds G-protein Gi

Activated P2Y purinoceptor 12 binds G-protein Gi
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 12
directly activates: Gi activation by P2Y purinoceptor 12
directly activates: Catalysis1010

Gi activation by P2Y purinoceptor 12
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: ADP signalling through P2Y purinoceptor 12
directly activates: Dissociation of the P2Y purinoceptor 12:Gi complex

Dissociation of the P2Y purinoceptor 12:Gi complex
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 12
directly activates: BiochemicalReaction3760
directly activates: BiochemicalReaction4352
directly activates: BiochemicalReaction4384
directly activates: BiochemicalReaction4386
directly activates: Catalysis1883
directly activates: Control343

ADP binds to P2Y purinoceptor 1
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: Activated P2Y purinoceptor 1 binds G-protein Gq

Activated P2Y purinoceptor 1 binds G-protein Gq
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: Gq activation by P2Y purinoceptor 1
directly activates: Catalysis1011

Gq activation by P2Y purinoceptor 1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: Dissociation of the P2Y purinoceptor 1:Gq complex

Dissociation of the P2Y purinoceptor 1:Gq complex
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: Src activation following P2Y purinoceptor activation
directly activates: P2Y purinoceptor 1 activates MAP kinase p38 alpha
directly activates: BiochemicalReaction4364
directly activates: BiochemicalReaction4365
directly activates: BiochemicalReaction4366
directly activates: BiochemicalReaction4367
directly activates: BiochemicalReaction4368
directly activates: BiochemicalReaction4370
directly activates: BiochemicalReaction4384
directly activates: BiochemicalReaction4386
directly activates: Catalysis1012
directly activates: Catalysis1889
directly activates: Control345

Src activation following P2Y purinoceptor activation
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 1

P2Y purinoceptor 1 activates MAP kinase p38 alpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: Phosphorylation of cPLA2 by MAPK p38 alpha
directly activates: Catalysis1009

TP receptor can bind thromboxane
type: GO_0003674
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: Activated TP receptor binds G-proten Gq
directly activates: Activated TP receptor binds G-protein G13
directly activates: BiochemicalReaction4372

Activated TP receptor binds G-proten Gq
type: GO_0003674
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: Gq activation by TP receptor
directly activates: Catalysis1013

Activated TP receptor binds G-protein G13
type: GO_0003674
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: G13 activation by TP receptor
directly activates: Catalysis1014

Gq activation by TP receptor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: Dissociation of the TP:Gq complex

G13 activation by TP receptor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: Dissociation of the TP:G13 complex

Dissociation of the TP:Gq complex
type: GO_0003674
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: BiochemicalReaction4364
directly activates: BiochemicalReaction4365
directly activates: BiochemicalReaction4366
directly activates: BiochemicalReaction4367
directly activates: BiochemicalReaction4368
directly activates: BiochemicalReaction4370
directly activates: Catalysis1889
directly activates: Control345

Dissociation of the TP:G13 complex
type: GO_0003674
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: BiochemicalReaction4375
directly activates: BiochemicalReaction4380
directly activates: BiochemicalReaction4382
directly activates: Catalysis1893

Thrombin-mediated activation of Proteinase-activated receptors
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Thrombin-activated PAR binds G-protein Gq
directly activates: Thrombin-activated PAR binds G-protein G12/13
directly activates: Activated PAR1 binds Beta-arrestin-1
directly activates: Activated PAR1 binds beta-arrestin-2

Thrombin-activated PAR binds G-protein Gq
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Gq activation by PAR
directly activates: Catalysis1016

Gq activation by PAR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004930
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Dissociation of the PAR:Gq complex

Dissociation of the PAR:Gq complex
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: BiochemicalReaction4364
directly activates: BiochemicalReaction4365
directly activates: BiochemicalReaction4366
directly activates: BiochemicalReaction4367
directly activates: BiochemicalReaction4368
directly activates: BiochemicalReaction4370
directly activates: BiochemicalReaction4384
directly activates: BiochemicalReaction4386
directly activates: Catalysis1889
directly activates: Control345

Thrombin-activated PAR binds G-protein G12/13
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: G12/13 activation by PAR
directly activates: Catalysis1017

G12/13 activation by PAR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004930
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Dissociation of the PAR:G12/13 complex

Dissociation of the PAR:G12/13 complex
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: BiochemicalReaction4375
directly activates: BiochemicalReaction4380
directly activates: BiochemicalReaction4382
directly activates: BiochemicalReaction4384
directly activates: BiochemicalReaction4386
directly activates: Catalysis1893

Activated PAR1 binds Beta-arrestin-1
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Beta-arrestin-1 acts as scaffold for a PAR1 signalling complex

Activated PAR1 binds beta-arrestin-2
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Beta-arrestin-2 acts as scaffold for a PAR1 signalling complex

Beta-arrestin-1 acts as scaffold for a PAR1 signalling complex
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Activation of beta-arrestin-1-bound Src kinase

Beta-arrestin-2 acts as scaffold for a PAR1 signalling complex
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Src bound to beta-arrestin-2 is not activated

Activation of beta-arrestin-1-bound Src kinase
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)
directly activates: Activated Src activates ERK
directly activates: Catalysis1018

Src bound to beta-arrestin-2 is not activated
type: GO_0003674
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)

Activated Src activates ERK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004672
BFO_0000050: Thrombin signalling through proteinase activated receptors (PARs)

Fyn/Lyn-mediated phosphorylation of FcR1 gamma
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: GPVI-mediated activation cascade
directly activates: Binding of Syk tyrosine kinase

Binding of Syk tyrosine kinase
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: Syk autophosphorylates
directly activates: Syk/Lck phosphorylate LAT
directly activates: Syk activation leads to SLP-76 activation
directly activates: Catalysis1020
directly activates: Catalysis1025

Syk autophosphorylates
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004715
BFO_0000050: GPVI-mediated activation cascade
directly activates: Syk is released
directly activates: GPVI stimulates PI3K beta, gamma

Syk is released
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: Syk binds Vav

Syk binds Vav
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: Syk phosphorylates Vav
directly activates: Catalysis1021

Syk phosphorylates Vav
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004715
BFO_0000050: GPVI-mediated activation cascade
directly activates: VAV1 is a GEF for Rho/Rac family kinases
directly activates: VAV2 is a GEF for Rho/Rac family kinases
directly activates: VAV3 is a GEF for Rho/Rac family kinases
directly activates: PIP3 stimulates Vav
directly activates: PIP2 inhibits Vav
directly activates: Catalysis1022
directly activates: Catalysis1023
directly activates: Catalysis1024

VAV1 is a GEF for Rho/Rac family kinases
type: Restriction
  on property: enabled by
  some values from: UniProt:P15498 VAV1
type: Restriction
  on property: enabled by
  some values from: UniProt:P15498 VAV1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005085
BFO_0000050: GPVI-mediated activation cascade

VAV2 is a GEF for Rho/Rac family kinases
type: Restriction
  on property: enabled by
  some values from: UniProt:P52735 VAV2
type: Restriction
  on property: enabled by
  some values from: UniProt:P52735 VAV2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005085
BFO_0000050: GPVI-mediated activation cascade
directly activates: BiochemicalReaction4379

VAV3 is a GEF for Rho/Rac family kinases
type: Restriction
  on property: enabled by
  some values from: UniProt:Q9UKW4 VAV3
type: Restriction
  on property: enabled by
  some values from: UniProt:Q9UKW4 VAV3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005085
BFO_0000050: GPVI-mediated activation cascade
directly activates: BiochemicalReaction4379

Syk/Lck phosphorylate LAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: GPVI-mediated activation cascade

Syk activation leads to SLP-76 activation
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: SLP-76 stimulates PLC gamma 2
directly activates: p-SLP-76 binds VAV
directly activates: BiochemicalReaction649

SLP-76 stimulates PLC gamma 2
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: PLC gamma 2-mediated PIP2 hydrolysis
directly activates: Catalysis1026

p-SLP-76 binds VAV
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade

PLC gamma 2-mediated PIP2 hydrolysis
type: Restriction
  on property: enabled by
  some values from: PLCG2
type: Restriction
  on property: enabled by
  some values from: PLCG2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004629
BFO_0000050: GPVI-mediated activation cascade
directly activates: Binding of IP3 to IP3 receptor
directly activates: Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
directly activates: Activation of Protein Kinase C novel isoforms
directly activates: DAG activation of TRPC channels
directly activates: DAG is metabolized by DAGL to 2-AG
directly activates: DAG kinase produces phosphatidic acid from DAG
directly activates: Activation of conventional Protein Kinase C
directly activates: BiochemicalReaction715
directly activates: Catalysis1036
directly activates: Catalysis1038
directly activates: Control159

PIP3 stimulates Vav
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: VAV1 is a GEF for Rho/Rac family kinases
directly activates: VAV2 is a GEF for Rho/Rac family kinases
directly activates: VAV3 is a GEF for Rho/Rac family kinases
directly activates: Catalysis1022
directly activates: Catalysis1023
directly activates: Catalysis1024

PIP2 inhibits Vav
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: VAV1 is a GEF for Rho/Rac family kinases
directly activates: VAV2 is a GEF for Rho/Rac family kinases
directly activates: VAV3 is a GEF for Rho/Rac family kinases
directly activates: Catalysis1022
directly activates: Catalysis1023
directly activates: Catalysis1024

GPVI stimulates PI3K beta, gamma
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: PI3K alpha, beta, gamma convert PIP2 to PIP3
directly activates: Catalysis1027

PI3K alpha, beta, gamma convert PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0046934
BFO_0000050: GPVI-mediated activation cascade
directly activates: PIP3 stimulates Vav
directly activates: PIP2 inhibits Vav
directly activates: PIP3 recruits PDK1 and AKT to the membrane
directly activates: BiochemicalReaction679
directly activates: BiochemicalReaction680
directly activates: Control158

PIP3 recruits PDK1 and AKT to the membrane
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: PDK1 binds PKC zeta

PDK1 binds PKC zeta
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: PDK1 activates PKC zeta
directly activates: Catalysis1028

PDK1 activates PKC zeta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004676
BFO_0000050: GPVI-mediated activation cascade

Translocation of RIAM to plasma membrane
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Activation of Talin

Activation of Talin
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Integrin alphaIIb beta3 activation

Integrin alphaIIb beta3 activation
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Interaction of integrin alphaIIb beta3 with Fibrinogen
directly activates: Activated integrin alphaIIb beta3 binds SHC1

Interaction of integrin alphaIIb beta3 with Fibrinogen
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Clustering of Integrin alphaIIb beta3 complexes

Clustering of Integrin alphaIIb beta3 complexes
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Release of CSK from SRC

Release of CSK from SRC
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Dephosphorylation of inactive SRC by PTPB1
directly activates: Catalysis1029

Dephosphorylation of inactive SRC by PTPB1
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004725
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Autophosphorylation of SRC
directly activates: Catalysis1030

Autophosphorylation of SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Translocation of FADK1 to Focal complexes
directly activates: SYK binds to integrin alphaIIb beta3

Translocation of FADK1 to Focal complexes
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Autophosphorylation of FADK1 at Y397
directly activates: Catalysis1031

Autophosphorylation of FADK1 at Y397
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004672
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Phosphorylation of pFADK1 by SRC
directly activates: Catalysis1032

Phosphorylation of pFADK1 by SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004672
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Recruitment of GRB2 to p-FADK1
directly activates: Recruitment of p130Cas to FADK1

Recruitment of GRB2 to p-FADK1
type: GO_0003674
BFO_0000050: GRB2:SOS provides linkage to MAPK signaling for Intergrins
directly activates: Interaction of SOS with GRB2 bound to FADK1

Interaction of SOS with GRB2 bound to FADK1
type: GO_0003674
BFO_0000050: GRB2:SOS provides linkage to MAPK signaling for Intergrins

Recruitment of p130Cas to FADK1
type: GO_0003674
BFO_0000050: p130Cas linkage to MAPK signaling for integrins
directly activates: Phosphorylation of p130Cas by SRC-FADK1 complex
directly activates: Catalysis1033

Phosphorylation of p130Cas by SRC-FADK1 complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004672
BFO_0000050: p130Cas linkage to MAPK signaling for integrins
directly activates: Crk binding to p130cas

Crk binding to p130cas
type: GO_0003674
BFO_0000050: p130Cas linkage to MAPK signaling for integrins

Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Activated integrin alphaIIb beta3 binds SHC1

Activated integrin alphaIIb beta3 binds SHC1
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow

SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: SHC1 dissociates from integrin alphaIIb beta3

SHC1 dissociates from integrin alphaIIb beta3
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: BiochemicalReaction3816

SYK binds to integrin alphaIIb beta3
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: SYK activation by SRC
directly activates: Catalysis1035

SYK activation by SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Integrin alphaIIb beta3 signaling

Alpha-2 adrenoceptors bind catecholamines
type: GO_0003674
BFO_0000050: Adrenaline signalling through Alpha-2 adrenergic receptor
directly activates: BiochemicalReaction4354

Thrombin binding to GP1b:IX:V
type: GO_0003674
BFO_0000050: Platelet Aggregation (Plug Formation)

Thrombopoietin binds the thrombopoietin receptor
type: GO_0003674
BFO_0000050: Platelet Aggregation (Plug Formation)

Binding of IP3 to IP3 receptor
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: Transport of Ca++ from platelet dense tubular system to cytoplasm
directly activates: Catalysis1004

Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: Activation of Rap1 by membrane-associated GEFs
directly activates: Activation of Rap1 by cytosolic GEFs
directly activates: Catalysis321
directly activates: Catalysis322

Activation of Protein Kinase C novel isoforms
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis

DAG activation of TRPC channels
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: BiochemicalReaction2250
directly activates: Catalysis1006

DAG is metabolized by DAGL to 2-AG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0047372
BFO_0000050: Arachidonate production from DAG
directly activates: 2-AG hydrolysis to arachidonate by MAGL
directly activates: Catalysis1037

2-AG hydrolysis to arachidonate by MAGL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0047372
BFO_0000050: Arachidonate production from DAG

DAG kinase produces phosphatidic acid from DAG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004143
BFO_0000050: Effects of PIP2 hydrolysis

Activation of conventional Protein Kinase C
type: GO_0003674
BFO_0000050: Response to elevated platelet cytosolic Ca2+
directly activates: Phosphorylation of Platelet Sec-1
directly activates: Phosphorylation of Syntaxin-4
directly activates: Catalysis1039
directly activates: Catalysis1040

Phosphorylation of Platelet Sec-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004698
BFO_0000050: Disinhibition of SNARE formation

Phosphorylation of Syntaxin-4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004698
BFO_0000050: Disinhibition of SNARE formation

ABCC4 accumulation of dense granule contents
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031088
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031088
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031088
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031088
type: Restriction
  on property: enabled by
  some values from: ABCC4
type: Restriction
  on property: enabled by
  some values from: ABCC4
type: Restriction
  on property: enabled by
  some values from: ABCC4
type: Restriction
  on property: enabled by
  some values from: ABCC4
type: GO_0015662
BFO_0000050: Platelet degranulation

Exocytosis of platelet dense granule content
type: GO_0003674
BFO_0000050: Platelet degranulation

Surface deployment of platelet dense granule membrane components
type: GO_0003674
BFO_0000050: Platelet degranulation

Exocytosis of platelet alpha granule contents
type: GO_0003674
BFO_0000050: Platelet degranulation

Surface deployment of platelet alpha granule membrane components
type: GO_0003674
BFO_0000050: Platelet degranulation

Release of platelet cytosolic components
type: GO_0003674
BFO_0000050: Platelet degranulation

Release of (inferred) platelet cytosolic components
type: GO_0003674
BFO_0000050: Platelet degranulation

Release of platelet secretory granule components
type: GO_0003674
BFO_0000050: Platelet degranulation

Release of Calumenin
type: GO_0003674
BFO_0000050: Platelet degranulation

Release of 78 kDa glucose-regulated protein
type: GO_0003674
BFO_0000050: Platelet degranulation

Exocytosis of Proactivator polypeptide
type: GO_0003674
BFO_0000050: Platelet degranulation

Activation of Rap1 by membrane-associated GEFs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Translocation of RIAM to plasma membrane
directly activates: BiochemicalReaction852
directly activates: BiochemicalReaction853
directly activates: Catalysis323

Activation of Rap1 by cytosolic GEFs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005085
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Translocation of RIAM to plasma membrane
directly activates: BiochemicalReaction852
directly activates: BiochemicalReaction853
directly activates: Catalysis323

Platelet activation, signaling and aggregation
type: GO_0008150

GP1b-IX-V activation signalling
type: GO_0008150
BFO_0000050: Platelet activation, signaling and aggregation

Signal amplification
type: GO_0008150
BFO_0000050: Platelet activation, signaling and aggregation

ADP signalling through P2Y purinoceptor 12
type: GO_0008150
BFO_0000050: Signal amplification

ADP signalling through P2Y purinoceptor 1
type: GO_0008150
BFO_0000050: Signal amplification

Thromboxane signalling through TP receptor
type: GO_0008150
BFO_0000050: Signal amplification

Thrombin signalling through proteinase activated receptors (PARs)
type: GO_0008150
BFO_0000050: Platelet activation, signaling and aggregation

GPVI-mediated activation cascade
type: GO_0008150
BFO_0000050: Platelet activation, signaling and aggregation

Platelet Aggregation (Plug Formation)
type: GO_0008150
BFO_0000050: Platelet activation, signaling and aggregation

Integrin alphaIIb beta3 signaling
type: GO_0008150
BFO_0000050: Platelet Aggregation (Plug Formation)

GRB2:SOS provides linkage to MAPK signaling for Intergrins
type: GO_0008150
BFO_0000050: Integrin alphaIIb beta3 signaling

p130Cas linkage to MAPK signaling for integrins
type: GO_0008150
BFO_0000050: Integrin alphaIIb beta3 signaling

Adrenaline signalling through Alpha-2 adrenergic receptor
type: GO_0008150
BFO_0000050: Platelet Aggregation (Plug Formation)

Effects of PIP2 hydrolysis
type: GO_0008150
BFO_0000050: Platelet activation, signaling and aggregation

Arachidonate production from DAG
type: GO_0008150
BFO_0000050: Effects of PIP2 hydrolysis

Response to elevated platelet cytosolic Ca2+
type: GO_0008150
BFO_0000050: Platelet activation, signaling and aggregation

Disinhibition of SNARE formation
type: GO_0008150
BFO_0000050: Response to elevated platelet cytosolic Ca2+

Platelet degranulation
type: GO_0008150
BFO_0000050: Response to elevated platelet cytosolic Ca2+