ABCC4
MRP4
UniProt:O15439 ABCC4
SRC
SRC1
UniProt:P12931-1 SRC
UniProt:P15498 VAV1
VAV
VAV1
PLCG2
UniProt:P16885 PLCG2
PTP1B
PTPN1
UniProt:P18031 PTPN1
UniProt:P52735 VAV2
VAV2
CSBP
CSBP1
CSBP2
CSPB1
MAPK14
MXI2
SAPK2A
UniProt:Q16539 MAPK14
MGLL
UniProt:Q99685 MGLL
UniProt:Q9UKW4 VAV3
VAV3
Transport of Ca++ from platelet dense tubular system to cytoplasm
Phosphorylation of cPLA2 by MAPK p38 alpha
GP1b-IX-V binds 14-3-3-zeta
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress
GP1b-IX-V binds filamin
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K
GP1b signaling involves c-Src
c-Src binds Raf1
14-3-3-zeta binds Raf1
ADP binds to P2Y purinoceptor 12
Activated P2Y purinoceptor 12 binds G-protein Gi
Gi activation by P2Y purinoceptor 12
Dissociation of the P2Y purinoceptor 12:Gi complex
ADP binds to P2Y purinoceptor 1
Activated P2Y purinoceptor 1 binds G-protein Gq
Gq activation by P2Y purinoceptor 1
Dissociation of the P2Y purinoceptor 1:Gq complex
Src activation following P2Y purinoceptor activation
P2Y purinoceptor 1 activates MAP kinase p38 alpha
TP receptor can bind thromboxane
Activated TP receptor binds G-proten Gq
Activated TP receptor binds G-protein G13
Gq activation by TP receptor
G13 activation by TP receptor
Dissociation of the TP:Gq complex
Dissociation of the TP:G13 complex
Thrombin-mediated activation of Proteinase-activated receptors
Thrombin-activated PAR binds G-protein Gq
Gq activation by PAR
Dissociation of the PAR:Gq complex
Thrombin-activated PAR binds G-protein G12/13
G12/13 activation by PAR
Dissociation of the PAR:G12/13 complex
Activated PAR1 binds Beta-arrestin-1
Activated PAR1 binds beta-arrestin-2
Beta-arrestin-1 acts as scaffold for a PAR1 signalling complex
Beta-arrestin-2 acts as scaffold for a PAR1 signalling complex
Activation of beta-arrestin-1-bound Src kinase
Src bound to beta-arrestin-2 is not activated
Activated Src activates ERK
Fyn/Lyn-mediated phosphorylation of FcR1 gamma
Binding of Syk tyrosine kinase
Syk autophosphorylates
Syk is released
Syk binds Vav
Syk phosphorylates Vav
VAV1 is a GEF for Rho/Rac family kinases
VAV2 is a GEF for Rho/Rac family kinases
VAV3 is a GEF for Rho/Rac family kinases
Syk/Lck phosphorylate LAT
Syk activation leads to SLP-76 activation
SLP-76 stimulates PLC gamma 2
p-SLP-76 binds VAV
PLC gamma 2-mediated PIP2 hydrolysis
PIP3 stimulates Vav
PIP2 inhibits Vav
GPVI stimulates PI3K beta, gamma
PI3K alpha, beta, gamma convert PIP2 to PIP3
PIP3 recruits PDK1 and AKT to the membrane
PDK1 binds PKC zeta
PDK1 activates PKC zeta
Translocation of RIAM to plasma membrane
Activation of Talin
Integrin alphaIIb beta3 activation
Interaction of integrin alphaIIb beta3 with Fibrinogen
Clustering of Integrin alphaIIb beta3 complexes
Release of CSK from SRC
Dephosphorylation of inactive SRC by PTPB1
Autophosphorylation of SRC
Translocation of FADK1 to Focal complexes
Autophosphorylation of FADK1 at Y397
Phosphorylation of pFADK1 by SRC
Recruitment of GRB2 to p-FADK1
Interaction of SOS with GRB2 bound to FADK1
Recruitment of p130Cas to FADK1
Phosphorylation of p130Cas by SRC-FADK1 complex
Crk binding to p130cas
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
Activated integrin alphaIIb beta3 binds SHC1
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
SHC1 dissociates from integrin alphaIIb beta3
SYK binds to integrin alphaIIb beta3
SYK activation by SRC
Alpha-2 adrenoceptors bind catecholamines
Thrombin binding to GP1b:IX:V
Thrombopoietin binds the thrombopoietin receptor
Binding of IP3 to IP3 receptor
Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
Activation of Protein Kinase C novel isoforms
DAG activation of TRPC channels
DAG is metabolized by DAGL to 2-AG
2-AG hydrolysis to arachidonate by MAGL
DAG kinase produces phosphatidic acid from DAG
Activation of conventional Protein Kinase C
Phosphorylation of Platelet Sec-1
Phosphorylation of Syntaxin-4
ABCC4 accumulation of dense granule contents
Exocytosis of platelet dense granule content
Surface deployment of platelet dense granule membrane components
Exocytosis of platelet alpha granule contents
Surface deployment of platelet alpha granule membrane components
Release of platelet cytosolic components
Release of (inferred) platelet cytosolic components
Release of platelet secretory granule components
Release of Calumenin
Release of 78 kDa glucose-regulated protein
Exocytosis of Proactivator polypeptide
Activation of Rap1 by membrane-associated GEFs
Activation of Rap1 by cytosolic GEFs
Platelet activation, signaling and aggregation
GP1b-IX-V activation signalling
Signal amplification
ADP signalling through P2Y purinoceptor 12
ADP signalling through P2Y purinoceptor 1
Thromboxane signalling through TP receptor
Thrombin signalling through proteinase activated receptors (PARs)
GPVI-mediated activation cascade
Platelet Aggregation (Plug Formation)
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Intergrins
p130Cas linkage to MAPK signaling for integrins
Adrenaline signalling through Alpha-2 adrenergic receptor
Effects of PIP2 hydrolysis
Arachidonate production from DAG
Response to elevated platelet cytosolic Ca2+
Disinhibition of SNARE formation
Platelet degranulation