BPNT1
label: UniProt:O95861 BPNT1

CYP1A2
label: UniProt:P05177 CYP1A2

AAC2
label: NAT2
label: UniProt:P11245 NAT2

AAC1
label: NAT1
label: UniProt:P18440 NAT1

COMT
label: UniProt:P21964 COMT

NNMT
label: UniProt:P40261 NNMT

TPMT
label: UniProt:P51580 TPMT

ACSM2
label: ACSM2B
label: HYST1046
label: UniProt:Q68CK6 ACSM2B

ACGNAT
label: CAT
label: GAT
label: GLYAT
label: UniProt:Q6IB77 GLYAT

SLC26A1,2 transport extracellular SO4(2-) to cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015116
BFO_0000050: Transport and synthesis of PAPS
directly activates: ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate
directly activates: Catalysis1300

SLC35B2,3 transport cytosolic PAPS to Golgi lumen
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0046964
BFO_0000050: Transport and synthesis of PAPS
directly activates: BiochemicalReaction3073
directly activates: BiochemicalReaction3074
directly activates: BiochemicalReaction3091
directly activates: BiochemicalReaction3093
directly activates: BiochemicalReaction3094
directly activates: BiochemicalReaction3095
directly activates: BiochemicalReaction3097
directly activates: BiochemicalReaction3116
directly activates: BiochemicalReaction3117
directly activates: BiochemicalReaction3118
directly activates: BiochemicalReaction3121
directly activates: BiochemicalReaction3122
directly activates: Catalysis1307
directly activates: Catalysis1308
directly activates: Catalysis1323
directly activates: Catalysis1325
directly activates: Catalysis1326
directly activates: Catalysis1327
directly activates: Catalysis1329
directly activates: Catalysis1346
directly activates: Catalysis1347
directly activates: Catalysis1348
directly activates: Catalysis1350
directly activates: Catalysis1351

UDP-glucuronate transport from the cytosol to ER lumen
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0005461
BFO_0000050: Formation of the active cofactor, UDP-glucuronate
directly activates: BiochemicalReaction5840
directly activates: BiochemicalReaction5841
directly activates: Formation of O-glucuronides
directly activates: Formation of N-glucuronides
directly activates: Catalysis2981
directly activates: Catalysis2982
directly activates: Catalysis3032
directly activates: Catalysis3033

ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004781
BFO_0000050: Transport and synthesis of PAPS
directly activates: BiochemicalReaction296
directly activates: APS reacts with another ATP molecule to form PAPS
directly activates: Catalysis111
directly activates: Catalysis1301
directly activates: Control14
label: Activation of inorganic sulfate forms APS
label: PAPSS1,2 transfer PO4(2-) group from ATP to form APS

APS reacts with another ATP molecule to form PAPS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004020
BFO_0000050: Transport and synthesis of PAPS
directly activates: SLC35B2,3 transport cytosolic PAPS to Golgi lumen
directly activates: Acetaminophen can form an O- sulfate conjugate
directly activates: N-hydroxy-4-aminobiphenyl can form a sulfate conjugate
directly activates: Phenol can form a sulfate conjugate
directly activates: Dopamine can form an O-sulfate conjugate
directly activates: 3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP
directly activates: 3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP
directly activates: p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP
directly activates: N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP
directly activates: cholesterol + PAPS => cholesterol sulfate + PAP
directly activates: 27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP
directly activates: SULTs transfer (SO4)2- group to PREG
directly activates: estrone + PAPS => estrone 3-sulfate + PAP
directly activates: dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP
directly activates: beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP
directly activates: lithocholate + PAPS => lithocholate sulfate + PAP
directly activates: taurolithocholate + PAPS => taurolithocholate sulfate + PAP
directly activates: Catalysis3034
directly activates: Catalysis3035
directly activates: Catalysis3036
directly activates: Catalysis3037
directly activates: Catalysis3038
directly activates: Catalysis3039
directly activates: Catalysis3040
directly activates: Catalysis3041
directly activates: Catalysis3042
directly activates: Catalysis3043
directly activates: Catalysis3044
directly activates: Catalysis3045
directly activates: Catalysis3046
directly activates: Catalysis3047
directly activates: Catalysis3048
directly activates: Catalysis3049
directly activates: Catalysis723
label: PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS
label: adenylyl sulfate (APS) + ATP => PAPS + ADP

UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003983
BFO_0000050: Formation of the active cofactor, UDP-glucuronate
directly activates: BiochemicalReaction296
directly activates: BiochemicalReaction4570
directly activates: UDP-glucose is oxidised to UDP-glucuronate
directly activates: Catalysis111
directly activates: Catalysis1987
directly activates: Catalysis3031
directly activates: Control14

MTR transfers CH3 group from MeCbl to HCYS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008705
BFO_0000050: Methylation
directly activates: BiochemicalReaction5600
directly activates: Catalysis2771
label: Methionine is reformed

SAM is sythesized from methionine's reaction with ATP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004478
BFO_0000050: Methylation
directly activates: BiochemicalReaction5755
directly activates: 6-mercaptopurine can be S-methylated
directly activates: 2-mercaptoethanol can be S-methylated
directly activates: Pyridine can be N-methylated
directly activates: 3,4-dihydroxybenzoate can be O-methylated
directly activates: Catalysis2911
directly activates: Catalysis3054
directly activates: Catalysis3055
directly activates: Catalysis3056
directly activates: Catalysis3057

S-adenoylhomocysteine is hydrolyzed
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004013
BFO_0000050: Methylation
directly activates: MTR transfers CH3 group from MeCbl to HCYS
directly activates: BiochemicalReaction5805
directly activates: BiochemicalReaction5806
directly activates: Catalysis2773
directly activates: Catalysis2953
directly activates: Catalysis2954

Glutamate and cysteine combine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004357
BFO_0000050: Glutathione synthesis and recycling
directly activates: Formation of 5-oxoproline from gamma-glutamylcysteine
directly activates: gamma-glutamylcysteine combines with glycine to form glutathione
directly activates: Catalysis3059
directly activates: Catalysis3060
directly activates: Control489

A dipeptidase cleaves cysteinylglycine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004180
BFO_0000050: Glutathione synthesis and recycling
directly activates: Glutamate and cysteine combine
directly activates: gamma-glutamylcysteine combines with glycine to form glutathione
directly activates: Catalysis2956
directly activates: Catalysis3060
directly activates: Control489

UDP-glucose is oxidised to UDP-glucuronate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003979
BFO_0000050: Formation of the active cofactor, UDP-glucuronate
directly activates: UDP-glucuronate transport from the cytosol to ER lumen
directly activates: Catalysis727

Formation of O-glucuronides
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0015020
BFO_0000050: Glucuronidation

Formation of N-glucuronides
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0015020
BFO_0000050: Glucuronidation

Acetaminophen can form an O- sulfate conjugate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004062
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

N-hydroxy-4-aminobiphenyl can form a sulfate conjugate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004062
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

Phenol can form a sulfate conjugate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004062
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

Dopamine can form an O-sulfate conjugate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004062
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004062
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004062
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004062
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008146
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

cholesterol + PAPS => cholesterol sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004027
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004027
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050
label: SULTs transfer (SO4)2- group to 27HCHOL

SULTs transfer (SO4)2- group to PREG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0050294
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050
label: pregnenolone + PAPS => pregnenolone sulfate + PAP

estrone + PAPS => estrone 3-sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004304
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0050294
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0050294
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

lithocholate + PAPS => lithocholate sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008146
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

taurolithocholate + PAPS => taurolithocholate sulfate + PAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008146
BFO_0000050: Cytosolic sulfonation of small molecules
directly activates: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
directly activates: Catalysis3050

Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
type: Restriction
  on property: enabled by
  some values from: BPNT1
type: Restriction
  on property: enabled by
  some values from: BPNT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008441
type: GO_0050427
BFO_0000050: Cytosolic sulfonation of small molecules

The acetyl group from acetyl-CoA is transferred to the NAT1
type: GO_0003674
BFO_0000050: Acetylation
directly activates: NAT1 acetylation
directly activates: Catalysis3051

The acetyl group from acetyl-CoA is transferred to the NAT2
type: GO_0003674
BFO_0000050: Acetylation
directly activates: NAT2 acetylation
directly activates: Catalysis3052

NAT1 acetylation
type: Restriction
  on property: enabled by
  some values from: AAC1
type: Restriction
  on property: enabled by
  some values from: AAC1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004060
BFO_0000050: Acetylation
directly activates: The acetyl group from acetyl-CoA is transferred to the NAT1

NAT2 acetylation
type: Restriction
  on property: enabled by
  some values from: AAC2
type: Restriction
  on property: enabled by
  some values from: AAC2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004060
BFO_0000050: Acetylation
directly activates: The acetyl group from acetyl-CoA is transferred to the NAT2

S-atom dealkylation of 6-methylmercaptopurine
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: enabled by
  some values from: CYP1A2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0019825
BFO_0000050: Methylation
directly activates: 6-mercaptopurine can be S-methylated
directly activates: Catalysis3054

6-mercaptopurine can be S-methylated
type: Restriction
  on property: enabled by
  some values from: TPMT
type: Restriction
  on property: enabled by
  some values from: TPMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008119
BFO_0000050: Methylation
directly activates: S-adenoylhomocysteine is hydrolyzed
directly activates: Catalysis2952

2-mercaptoethanol can be S-methylated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0018708
BFO_0000050: Methylation
directly activates: S-adenoylhomocysteine is hydrolyzed
directly activates: Catalysis2952

Pyridine can be N-methylated
type: Restriction
  on property: enabled by
  some values from: NNMT
type: Restriction
  on property: enabled by
  some values from: NNMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0030760
BFO_0000050: Methylation
directly activates: S-adenoylhomocysteine is hydrolyzed
directly activates: Catalysis2952

3,4-dihydroxybenzoate can be O-methylated
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016206
BFO_0000050: Methylation
directly activates: S-adenoylhomocysteine is hydrolyzed
directly activates: Catalysis2952

Cleavage of 5-oxoproline to form glutamate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0017168
BFO_0000050: Glutathione synthesis and recycling
directly activates: Glutamate and cysteine combine
directly activates: Catalysis2956

Formation of 5-oxoproline from gamma-glutamylcysteine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003839
BFO_0000050: Glutathione synthesis and recycling
directly activates: Cleavage of 5-oxoproline to form glutamate
directly activates: Catalysis3058

gamma-glutamylcysteine combines with glycine to form glutathione
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004363
BFO_0000050: Glutathione synthesis and recycling
directly activates: Export of glutathione to the extracellular space
directly activates: Glutathione conjugation of luminal substrates
directly activates: GST dimers conjugate GSH with cytosolic substrates
directly activates: Catalysis3063
directly activates: Catalysis3064

Export of glutathione to the extracellular space
type: GO_0003674
BFO_0000050: Glutathione synthesis and recycling
directly activates: Glutathione is hydrolyzed
directly activates: Catalysis3061

Glutathione is hydrolyzed
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003840
BFO_0000050: Glutathione synthesis and recycling
directly activates: Cysteinylglycine and gamma-glutamate:AA are imported into the cell

Cysteinylglycine and gamma-glutamate:AA are imported into the cell
type: GO_0003674
BFO_0000050: Glutathione synthesis and recycling
directly activates: A dipeptidase cleaves cysteinylglycine
directly activates: 5-oxoproline can be formed from gamma-glutamyl-AA products
directly activates: Catalysis2957
directly activates: Catalysis3062

5-oxoproline can be formed from gamma-glutamyl-AA products
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003839
BFO_0000050: Glutathione synthesis and recycling
directly activates: Cleavage of 5-oxoproline to form glutamate
directly activates: Catalysis3058

Glutathione conjugation of luminal substrates
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004364
BFO_0000050: Glutathione conjugation
label: MGST trimers conjugate GSH with luminal substrates

GST dimers conjugate GSH with cytosolic substrates
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004364
BFO_0000050: Glutathione conjugation
label: Glutathione conjugation of cytosolic substrates

Benzoate and Coenzyme A react to form benzoyl-CoA thioester
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0016405
BFO_0000050: Conjugation of benzoate with glycine
directly activates: Benzoyl-CoA forms an amide bond with glycine
directly activates: Catalysis3066
label: benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate

Benzoyl-CoA forms an amide bond with glycine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: GO_0047962
BFO_0000050: Conjugation of benzoate with glycine
label: benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A

Synthesis of phenylacetyl CoA from phenylacetate and Coenzyme A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0016405
BFO_0000050: Conjugation of phenylacetate with glutamine
directly activates: Synthesis of phenylacetyl glutamine from phenylacetyl-CoA and glutamine
directly activates: Catalysis3068
label: phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate

Synthesis of phenylacetyl glutamine from phenylacetyl-CoA and glutamine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0016410
BFO_0000050: Conjugation of phenylacetate with glutamine
label: phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A

Salicylic acid and Coenzyme A react to form salicylate-CoA thioester
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: Restriction
  on property: enabled by
  some values from: ACSM2
type: GO_0016405
BFO_0000050: Conjugation of salicylate with glycine
directly activates: Salicylate-CoA forms an amide bond with glycine
directly activates: Catalysis3070
label: salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate

Salicylate-CoA forms an amide bond with glycine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: Restriction
  on property: enabled by
  some values from: ACGNAT
type: GO_0047962
BFO_0000050: Conjugation of salicylate with glycine
label: salicylate-CoA + glycine => salicyluric acid + Coenzyme A

Phase II conjugation
type: GO_0008150

Glucuronidation
type: GO_0008150
BFO_0000050: Phase II conjugation

Formation of the active cofactor, UDP-glucuronate
type: GO_0008150
BFO_0000050: Glucuronidation

Cytosolic sulfonation of small molecules
type: GO_0008150
BFO_0000050: Phase II conjugation

Acetylation
type: GO_0008150
BFO_0000050: Phase II conjugation

Methylation
type: GO_0008150
BFO_0000050: Phase II conjugation

Glutathione conjugation
type: GO_0008150
BFO_0000050: Phase II conjugation

Glutathione synthesis and recycling
type: GO_0008150
BFO_0000050: Glutathione conjugation

Amino Acid conjugation
type: GO_0008150
BFO_0000050: Phase II conjugation

Conjugation of carboxylic acids
type: GO_0008150
BFO_0000050: Amino Acid conjugation

Conjugation of benzoate with glycine
type: GO_0008150
BFO_0000050: Conjugation of carboxylic acids

Conjugation of phenylacetate with glutamine
type: GO_0008150
BFO_0000050: Conjugation of carboxylic acids

Conjugation of salicylate with glycine
type: GO_0008150
BFO_0000050: Conjugation of carboxylic acids

Transport and synthesis of PAPS
type: GO_0008150
BFO_0000050: Cytosolic sulfonation of small molecules