KIAA0221
RENT1
UPF1
UniProt:Q92900 UPF1
UPF1 Binds an mRNP with a Termination Codon Preceding an Exon Junction Complex
SMG1 Phosphorylates UPF1 (Enhanced by Exon Junction Complex)
Phosphorylated UPF1 Recruits SMG5, SMG7, SMG6, and PP2A
SMG6 Cleaves mRNA with Premature Termination Codon
Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex
Formation of UPF1:eRF3 Complex on mRNA with a Premature Termination Codon and No Exon Junction Complex
Nonsense-Mediated Decay
Nonsense Mediated Decay Enhanced by the Exon Junction Complex
Nonsense Mediated Decay Independent of the Exon Junction Complex