KIAA0221
label: RENT1
label: UPF1
label: UniProt:Q92900 UPF1

UPF1 Binds an mRNP with a Termination Codon Preceding an Exon Junction Complex
type: GO_0003674
BFO_0000050: Nonsense Mediated Decay Enhanced by the Exon Junction Complex
directly activates: SMG1 Phosphorylates UPF1 (Enhanced by Exon Junction Complex)
directly activates: Catalysis193

SMG1 Phosphorylates UPF1 (Enhanced by Exon Junction Complex)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Nonsense Mediated Decay Enhanced by the Exon Junction Complex
directly activates: Phosphorylated UPF1 Recruits SMG5, SMG7, SMG6, and PP2A

Phosphorylated UPF1 Recruits SMG5, SMG7, SMG6, and PP2A
type: GO_0003674
BFO_0000050: Nonsense Mediated Decay Enhanced by the Exon Junction Complex
directly activates: SMG6 Cleaves mRNA with Premature Termination Codon
directly activates: Catalysis194

SMG6 Cleaves mRNA with Premature Termination Codon
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004521
BFO_0000050: Nonsense Mediated Decay Enhanced by the Exon Junction Complex
directly activates: Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex
directly activates: Catalysis195
directly activates: Catalysis196

Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex
type: Restriction
  on property: enabled by
  some values from: KIAA0221
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: KIAA0221
type: GO_0004004
type: GO_0004722
BFO_0000050: Nonsense Mediated Decay Enhanced by the Exon Junction Complex

Formation of UPF1:eRF3 Complex on mRNA with a Premature Termination Codon and No Exon Junction Complex
type: GO_0003674
BFO_0000050: Nonsense Mediated Decay Independent of the Exon Junction Complex

Nonsense-Mediated Decay
type: GO_0008150

Nonsense Mediated Decay Enhanced by the Exon Junction Complex
type: GO_0008150
BFO_0000050: Nonsense-Mediated Decay

Nonsense Mediated Decay Independent of the Exon Junction Complex
type: GO_0008150
BFO_0000050: Nonsense-Mediated Decay