ABCC5
label: MRP5
label: UniProt:O15440 ABCC5

TREA
label: TREH
label: UniProt:O43280 TREH

G6PT
label: G6PT1
label: PRO0685
label: SLC37A4
label: TRG19
label: UniProt:O43826 SLC37A4

CHST1
label: UniProt:O43916 CHST1

GLCE
label: KIAA0836
label: UniProt:O94923 GLCE

PGLS
label: UniProt:O95336 PGLS

GALT
label: UniProt:P07902 GALT

GNS
label: UniProt:P15586 GNS

GLUT5
label: SLC2A5
label: UniProt:P22732 SLC2A5

IDUA
label: UniProt:P35475 IDUA

PCK1
label: PEPCK1
label: UniProt:P35558 PCK1

AGL
label: GDE
label: UniProt:P35573 AGL

G6PC
label: G6PT
label: UniProt:P35575 G6PC

TAL
label: TALDO
label: TALDO1
label: TALDOR
label: UniProt:P37837 TALDO1

RPI
label: RPIA
label: UniProt:P49247 RPIA

GALK
label: GALK1
label: UniProt:P51570 GALK1

HSS
label: SGSH
label: UniProt:P51688 SGSH

SLC20A3
label: SLC25A1
label: UniProt:P53007 SLC25A1

NAGLU
label: UFHSD1
label: UniProt:P54802 NAGLU

GBE1
label: UniProt:Q04446 GBE1

HYAL1
label: LUCA1
label: UniProt:Q12794 HYAL1

PCK2
label: PEPCK2
label: UniProt:Q16822 PCK2

HFRC
label: SLC35D2
label: UGTREL8
label: UniProt:Q76EJ3 SLC35D2

BRAG
label: CHST15
label: GALNAC4S6ST
label: KIAA0598
label: UniProt:Q7LFX5 CHST15

HS2ST
label: HS2ST1
label: KIAA0448
label: UniProt:Q7LGA3 HS2ST1

CHST14
label: D4ST1
label: UNQ1925/PRO4400
label: UniProt:Q8NCH0 CHST14

HPA2
label: HPSE2
label: UniProt:Q8WWQ2 HPSE2

B3GALT6
label: UniProt:Q96L58 B3GALT6

G6PC3
label: UGRP
label: UniProt:Q9BUM1 G6PC3

G6PC2
label: IGRP
label: UniProt:Q9NQR9 G6PC2

B4GALT7
label: UNQ748/PRO1478
label: UniProt:Q9UBV7 B4GALT7
label: XGALT1

DIC
label: SLC25A10
label: UniProt:Q9UBX3 SLC25A10

DSE
label: SART2
label: UniProt:Q9UL01 DSE

DS2ST
label: UST
label: UniProt:Q9Y2C2 UST

SLC26A1,2 transport extracellular SO4(2-) to cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015116
BFO_0000050: Transport and synthesis of PAPS
directly activates: ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate
directly activates: Catalysis1300

malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]
type: Restriction
  on property: enabled by
  some values from: DIC
type: Restriction
  on property: enabled by
  some values from: DIC
type: Restriction
  on property: enabled by
  some values from: DIC
type: Restriction
  on property: enabled by
  some values from: DIC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0005310
BFO_0000050: Gluconeogenesis
directly activates: (S)-malate + NAD+ <=> oxaloacetate + NADH + H+
directly activates: Catalysis1967

Transport (influx) of fructose by GLUT5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: GLUT5
type: Restriction
  on property: enabled by
  some values from: GLUT5
type: GO_0005353
BFO_0000050: Hexose transport
directly activates: Transport (efflux) of fructose, galactose, and glucose by GLUT2
directly activates: Catalysis642
label: extracellular fructose => cytosolic fructose

Transport (influx) of glucose, galactose, and sodium ions by SGLT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005412
BFO_0000050: Hexose transport
directly activates: Transport (efflux) of fructose, galactose, and glucose by GLUT2
directly activates: Catalysis642

Transport (efflux) of fructose, galactose, and glucose by GLUT2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015149
BFO_0000050: Hexose transport
label: cytosolic fructose, galactose, or glucose => extracellular fructose, galactose, or glucose

Glucose is taken up across the plasma membrane by a glucose transport protein (GLUT)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005355
BFO_0000050: Glucose transport
directly activates: alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP
directly activates: Catalysis645
label: alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol)

Glucose is secreted across the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005355
BFO_0000050: Glucose transport
label: alpha-D-glucose (cytosol) <=> alpha-D-glucose (extracellular)

GLUT1 + ATP <=> GLUT1:ATP
type: GO_0003674
BFO_0000050: Glucose transport

GLUT1:ATP <=> GLUT1 + ATP
type: GO_0003674
BFO_0000050: Glucose transport

alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004340
BFO_0000050: Glucose transport
directly activates: Glucose 6-phosphate is isomerized to form fructose-6-phosphate
directly activates: alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate
directly activates: alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+
directly activates: Catalysis1954
directly activates: Catalysis1985
directly activates: Catalysis2007

glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex
type: GO_0003674
BFO_0000050: Regulation of Glucokinase by Glucokinase Regulatory Protein
directly activates: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP)
directly activates: GCK1:GKRP [cytosol] => GCK1:GKRP [nucleoplasm]
directly activates: Catalysis646
directly activates: Control117
directly activates: Control118
directly activates: Control119

cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP)
type: GO_0003674
BFO_0000050: Regulation of Glucokinase by Glucokinase Regulatory Protein

GCK1:GKRP [cytosol] => GCK1:GKRP [nucleoplasm]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: GO_0005487
BFO_0000050: Regulation of Glucokinase by Glucokinase Regulatory Protein
directly activates: Dissociation of the nucleoplasmic GCK1:GKRP complex
directly activates: Control120
label: Transport of glucokinase (GCK1):GKRP complex to the nucleus

Dissociation of the nucleoplasmic GCK1:GKRP complex
type: GO_0003674
BFO_0000050: Regulation of Glucokinase by Glucokinase Regulatory Protein
directly activates: glucokinase [nucleoplasm] => glucokinase [cytosol]
label: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP)

glucokinase [nucleoplasm] => glucokinase [cytosol]
type: GO_0003674
BFO_0000050: Regulation of Glucokinase by Glucokinase Regulatory Protein
directly activates: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex
directly activates: Control114
directly activates: Control115
directly activates: Control116

Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: G6PT
type: Restriction
  on property: enabled by
  some values from: G6PT
type: Restriction
  on property: enabled by
  some values from: G6PT
type: Restriction
  on property: enabled by
  some values from: G6PT
type: GO_0061513
BFO_0000050: Glucose transport
directly activates: G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver)
directly activates: Catalysis648
label: alpha-D-glucose 6-phosphate (cytosol) + orthophosphate (ER lumen) => alpha-D-glucose 6-phosphate (ER lumen) + orthophosphate (cytosol) (SLC37A4)

G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: G6PC
type: Restriction
  on property: enabled by
  some values from: G6PC
type: Restriction
  on property: enabled by
  some values from: G6PC
type: Restriction
  on property: enabled by
  some values from: G6PC
type: GO_0004346
BFO_0000050: Glucose transport
directly activates: Efflux of glucose from the endoplasmic reticulum
label: alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC - liver)

G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: G6PC2
type: Restriction
  on property: enabled by
  some values from: G6PC2
type: Restriction
  on property: enabled by
  some values from: G6PC2
type: Restriction
  on property: enabled by
  some values from: G6PC2
type: GO_0004346
BFO_0000050: Glucose transport
label: alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC2 - islet)

G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: G6PC3
type: Restriction
  on property: enabled by
  some values from: G6PC3
type: Restriction
  on property: enabled by
  some values from: G6PC3
type: Restriction
  on property: enabled by
  some values from: G6PC3
type: GO_0004346
BFO_0000050: Glucose transport
label: alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC3 - ubiquitous)

Efflux of glucose from the endoplasmic reticulum
type: GO_0003674
BFO_0000050: Glucose transport

SLC35B2,3 transport cytosolic PAPS to Golgi lumen
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0046964
BFO_0000050: Transport and synthesis of PAPS
directly activates: Sulfation of GlcNAc residues on Keratan-PG forms KSPG
directly activates: Further sulfation on galactose residues produces KSPG
directly activates: NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)
directly activates: HS2ST1 sulfates IdoA at C2 in heparan sulfate
directly activates: HS3STs sulfate GlcN at C3 in heparan sulfate
directly activates: HS3ST1 sulfates GlcN at C3 in heparan sulfate
directly activates: HS6STs sulfate GlcN at C6 in heparan sulfate/heparin
directly activates: Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13
directly activates: Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15
directly activates: Chondroitin can be sulfated on position 6 of GalNAc by CHST3,7
directly activates: Dermatan sulfate can be further sulfated on position 2 of iduronate
directly activates: CHST14 transfers SO4(2-) to DS
directly activates: Catalysis1307
directly activates: Catalysis1308
directly activates: Catalysis1323
directly activates: Catalysis1325
directly activates: Catalysis1326
directly activates: Catalysis1327
directly activates: Catalysis1329
directly activates: Catalysis1346
directly activates: Catalysis1347
directly activates: Catalysis1348
directly activates: Catalysis1350
directly activates: Catalysis1351

SLC35D2 exchanges UDP-sugars for UMP
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: GO_0005338
BFO_0000050: Keratan sulfate biosynthesis
BFO_0000050: HS-GAG biosynthesis
directly activates: B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG
directly activates: The addition of GlcNAc to the terminal glucuronate residue creates heparan
directly activates: Catalysis1303
directly activates: Catalysis1318

HAS1,2,3 mediate the polymerisation of HA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0050501
BFO_0000050: Hyaluronan biosynthesis and export
directly activates: Growing HA is extruded from the cell by ABCC5
directly activates: Catalysis1294

Growing HA is extruded from the cell by ABCC5
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: GO_0008514
BFO_0000050: Hyaluronan biosynthesis and export
directly activates: Receptor-mediated uptake of HA

Receptor-mediated uptake of HA
type: GO_0003674
BFO_0000050: Hyaluronan uptake and degradation
directly activates: HYAL2 interacts with NHE1 to create an acidic environment

HYAL2 interacts with NHE1 to create an acidic environment
type: GO_0003674
BFO_0000050: Hyaluronan uptake and degradation
directly activates: Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments
directly activates: Catalysis1295

Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004415
BFO_0000050: Hyaluronan uptake and degradation
directly activates: 20kDa HA fragments are translocated to lysosomes

20kDa HA fragments are translocated to lysosomes
type: GO_0003674
BFO_0000050: Hyaluronan uptake and degradation
directly activates: Hyaluronidase 1 (HYAL1) hydrolyses HA from 20kDa to 800Da fragments
directly activates: Catalysis1296

Hyaluronidase 1 (HYAL1) hydrolyses HA from 20kDa to 800Da fragments
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: GO_0004415
BFO_0000050: Hyaluronan uptake and degradation
directly activates: Beta-glucuronidase (GUSB) hydrolyses glucuronate from HA tetrasaccharides
directly activates: Catalysis1297

Beta-glucuronidase (GUSB) hydrolyses glucuronate from HA tetrasaccharides
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004566
BFO_0000050: Hyaluronan uptake and degradation
directly activates: Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from small HA fragments
directly activates: The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol
directly activates: Catalysis1298

Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from small HA fragments
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004563
BFO_0000050: Hyaluronan uptake and degradation
directly activates: Beta-glucuronidase (GUSB) hydrolyses glucuronate from the HA disaccharides
directly activates: The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol
directly activates: Catalysis1299

Beta-glucuronidase (GUSB) hydrolyses glucuronate from the HA disaccharides
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004566
BFO_0000050: Hyaluronan uptake and degradation
directly activates: The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol

The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol
type: GO_0003674
BFO_0000050: Hyaluronan uptake and degradation

ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004781
BFO_0000050: Transport and synthesis of PAPS
directly activates: BiochemicalReaction296
directly activates: APS reacts with another ATP molecule to form PAPS
directly activates: Catalysis111
directly activates: Catalysis1301
directly activates: Control14
label: Activation of inorganic sulfate forms APS
label: PAPSS1,2 transfer PO4(2-) group from ATP to form APS

APS reacts with another ATP molecule to form PAPS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004020
BFO_0000050: Transport and synthesis of PAPS
directly activates: SLC35B2,3 transport cytosolic PAPS to Golgi lumen
directly activates: BiochemicalReaction5894
directly activates: BiochemicalReaction5895
directly activates: BiochemicalReaction5896
directly activates: BiochemicalReaction5897
directly activates: BiochemicalReaction5898
directly activates: BiochemicalReaction5899
directly activates: BiochemicalReaction5900
directly activates: BiochemicalReaction5901
directly activates: BiochemicalReaction5902
directly activates: BiochemicalReaction5903
directly activates: BiochemicalReaction5904
directly activates: BiochemicalReaction5905
directly activates: BiochemicalReaction5906
directly activates: BiochemicalReaction5907
directly activates: BiochemicalReaction5908
directly activates: BiochemicalReaction5909
directly activates: Catalysis3034
directly activates: Catalysis3035
directly activates: Catalysis3036
directly activates: Catalysis3037
directly activates: Catalysis3038
directly activates: Catalysis3039
directly activates: Catalysis3040
directly activates: Catalysis3041
directly activates: Catalysis3042
directly activates: Catalysis3043
directly activates: Catalysis3044
directly activates: Catalysis3045
directly activates: Catalysis3046
directly activates: Catalysis3047
directly activates: Catalysis3048
directly activates: Catalysis3049
directly activates: Catalysis723
label: PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS
label: adenylyl sulfate (APS) + ATP => PAPS + ADP

B4GALTs add galactose to the N-glycan precursor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003831
BFO_0000050: Keratan sulfate biosynthesis
directly activates: B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG
directly activates: Catalysis1303

B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0008532
BFO_0000050: Keratan sulfate biosynthesis
directly activates: B4GALTs add another galactose to the chain
directly activates: Catalysis1304

B4GALTs add another galactose to the chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003831
BFO_0000050: Keratan sulfate biosynthesis
directly activates: B4GALTs can add galactose to a branch of keratan
directly activates: Catalysis1305

B4GALTs can add galactose to a branch of keratan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003831
BFO_0000050: Keratan sulfate biosynthesis
directly activates: The keratan chain can be capped by N-acetylneuraminic acid
directly activates: Catalysis1306

The keratan chain can be capped by N-acetylneuraminic acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003836
BFO_0000050: Keratan sulfate biosynthesis
directly activates: Sulfation of GlcNAc residues on Keratan-PG forms KSPG
directly activates: Catalysis1307

Sulfation of GlcNAc residues on Keratan-PG forms KSPG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0001517
BFO_0000050: Keratan sulfate biosynthesis
directly activates: Further sulfation on galactose residues produces KSPG
directly activates: Catalysis1308

Further sulfation on galactose residues produces KSPG
type: Restriction
  on property: enabled by
  some values from: CHST1
type: Restriction
  on property: enabled by
  some values from: CHST1
type: Restriction
  on property: enabled by
  some values from: CHST1
type: Restriction
  on property: enabled by
  some values from: CHST1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: CHST1
type: Restriction
  on property: enabled by
  some values from: CHST1
type: Restriction
  on property: enabled by
  some values from: CHST1
type: Restriction
  on property: enabled by
  some values from: CHST1
type: GO_0045130
BFO_0000050: Keratan sulfate biosynthesis
directly activates: KSPG is secreted from the cell

KSPG is secreted from the cell
type: GO_0003674
BFO_0000050: Keratan sulfate biosynthesis

Extracellular KSPG translocates to the lysosome for degradation
type: GO_0003674
BFO_0000050: Keratan sulfate degradation
directly activates: Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase
directly activates: Catalysis1309

Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004565
BFO_0000050: Keratan sulfate degradation
directly activates: N-acetylgalactosamine-6-sulfatase (GALNS) hydrolyses the sulfate groups of galactose 6-sulfate units of keratan sulfate
directly activates: Catalysis1310

N-acetylgalactosamine-6-sulfatase (GALNS) hydrolyses the sulfate groups of galactose 6-sulfate units of keratan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0043890
BFO_0000050: Keratan sulfate degradation
directly activates: Beta-galactosidase (GLB1) can cleave galactose from a glycosaminoglycan
directly activates: Catalysis1311

Beta-galactosidase (GLB1) can cleave galactose from a glycosaminoglycan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004565
BFO_0000050: Keratan sulfate degradation
directly activates: N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate
directly activates: Catalysis1312

N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate
type: Restriction
  on property: enabled by
  some values from: GNS
type: Restriction
  on property: enabled by
  some values from: GNS
type: Restriction
  on property: enabled by
  some values from: GNS
type: Restriction
  on property: enabled by
  some values from: GNS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: GNS
type: Restriction
  on property: enabled by
  some values from: GNS
type: Restriction
  on property: enabled by
  some values from: GNS
type: Restriction
  on property: enabled by
  some values from: GNS
type: GO_0008449
BFO_0000050: Keratan sulfate degradation
directly activates: Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from keratan sulfate
directly activates: Catalysis1313

Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from keratan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004563
BFO_0000050: Keratan sulfate degradation

GXYLTs transfer Xyl to core protein
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0030158
BFO_0000050: A tetrasaccharide linker sequence is required for GAG synthesis
directly activates: B4GALT7 transfers Gal group to tetrasaccharide linker
directly activates: Catalysis1315
label: Xylose is transferred to a serine residue on the core protein

B4GALT7 transfers Gal group to tetrasaccharide linker
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: GO_0046525
BFO_0000050: A tetrasaccharide linker sequence is required for GAG synthesis
directly activates: A second galactose is added in the tetrasaccharide linker
directly activates: Catalysis1316
label: Galactose is the second sugar added in the tetrasaccharide linker

A second galactose is added in the tetrasaccharide linker
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: GO_0047220
BFO_0000050: A tetrasaccharide linker sequence is required for GAG synthesis
directly activates: A glucuronate moiety is the fourth addition to the tetrasaccharide linker
directly activates: Catalysis1317
label: B3GALT6 transfers Gal to the tetrasaccharide linker

A glucuronate moiety is the fourth addition to the tetrasaccharide linker
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0015018
BFO_0000050: A tetrasaccharide linker sequence is required for GAG synthesis
directly activates: The addition of GlcNAc to the terminal glucuronate residue creates heparan
directly activates: The addition of GalNAc to the terminal glucuronate residue forms chondroitin
directly activates: Catalysis1318
directly activates: Catalysis1343
label: B3GATs transfer GlcA to tetrasaccharide linker

The addition of GlcNAc to the terminal glucuronate residue creates heparan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050508
BFO_0000050: HS-GAG biosynthesis
directly activates: Glucuronate is added to the heparan chain
directly activates: Catalysis1319

Glucuronate is added to the heparan chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050509
BFO_0000050: HS-GAG biosynthesis
directly activates: Another GlcNAc addition extends the heparan chain
directly activates: Catalysis1320

Another GlcNAc addition extends the heparan chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050508
BFO_0000050: HS-GAG biosynthesis
directly activates: Another GlcA addition extends the heparan chain
directly activates: Catalysis1321

Another GlcA addition extends the heparan chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050509
BFO_0000050: HS-GAG biosynthesis
directly activates: NDST1-4 N-deacetylates GlcNAc residues in heparan
directly activates: Catalysis1322

NDST1-4 N-deacetylates GlcNAc residues in heparan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050119
BFO_0000050: HS-GAG biosynthesis
directly activates: NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)
directly activates: Catalysis1323

NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0015016
BFO_0000050: HS-GAG biosynthesis
directly activates: GLCE epimerises GlcA to IdoA
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1324

GLCE epimerises GlcA to IdoA
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: GO_0050379
BFO_0000050: HS-GAG biosynthesis
directly activates: HS2ST1 sulfates IdoA at C2 in heparan sulfate
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1325

HS2ST1 sulfates IdoA at C2 in heparan sulfate
type: Restriction
  on property: enabled by
  some values from: HS2ST
type: Restriction
  on property: enabled by
  some values from: HS2ST
type: Restriction
  on property: enabled by
  some values from: HS2ST
type: Restriction
  on property: enabled by
  some values from: HS2ST
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: HS2ST
type: Restriction
  on property: enabled by
  some values from: HS2ST
type: Restriction
  on property: enabled by
  some values from: HS2ST
type: Restriction
  on property: enabled by
  some values from: HS2ST
type: GO_0004394
BFO_0000050: HS-GAG biosynthesis
directly activates: HS3STs sulfate GlcN at C3 in heparan sulfate
directly activates: HS3ST1 sulfates GlcN at C3 in heparan sulfate
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1326
directly activates: Catalysis1327

HS3STs sulfate GlcN at C3 in heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0008467
BFO_0000050: HS-GAG biosynthesis
directly activates: GLCE epimerises more GlcA to IdoA as sulfate content rises
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1328

HS3ST1 sulfates GlcN at C3 in heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005796
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005796
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005796
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005796
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005796
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005796
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005796
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005796
type: GO_0008467
BFO_0000050: HS-GAG biosynthesis
directly activates: GLCE epimerises more GlcA to IdoA as sulfate content rises
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1328

GLCE epimerises more GlcA to IdoA as sulfate content rises
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: GO_0050379
BFO_0000050: HS-GAG biosynthesis
directly activates: HS6STs sulfate GlcN at C6 in heparan sulfate/heparin
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1329

HS6STs sulfate GlcN at C6 in heparan sulfate/heparin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0017095
BFO_0000050: HS-GAG biosynthesis
directly activates: Some HSPGs are secreted to the plasma membrane

Some HSPGs are secreted to the plasma membrane
type: GO_0003674
BFO_0000050: HS-GAG biosynthesis
directly activates: HS-GAGs translocate to the lysosome for degradation
directly activates: Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane)
directly activates: Catalysis1331

HS-GAGs translocate to the lysosome for degradation
type: GO_0003674
BFO_0000050: HS-GAG degradation
directly activates: Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)
directly activates: Catalysis1330

Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0030305
BFO_0000050: HS-GAG degradation
directly activates: Alpha-L-iduronidase (IDUA) hydrolyses the unsulfated alpha-L-iduronosidic linkage in heparan sulfate
directly activates: Catalysis1332

Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane)
type: Restriction
  on property: enabled by
  some values from: HPA2
type: Restriction
  on property: enabled by
  some values from: HPA2
type: Restriction
  on property: enabled by
  some values from: HPA2
type: Restriction
  on property: enabled by
  some values from: HPA2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: HPA2
type: Restriction
  on property: enabled by
  some values from: HPA2
type: Restriction
  on property: enabled by
  some values from: HPA2
type: Restriction
  on property: enabled by
  some values from: HPA2
type: GO_0030305
BFO_0000050: HS-GAG degradation

Alpha-L-iduronidase (IDUA) hydrolyses the unsulfated alpha-L-iduronosidic linkage in heparan sulfate
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: GO_0003940
BFO_0000050: HS-GAG degradation
directly activates: N-sulphoglucosamine sulphohydrolase (SGSH) hydrolyses sulfate from the N-sulphoglucosamine residue of heparan sulfate
directly activates: Catalysis1333

N-sulphoglucosamine sulphohydrolase (SGSH) hydrolyses sulfate from the N-sulphoglucosamine residue of heparan sulfate
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: GO_0016250
BFO_0000050: HS-GAG degradation
directly activates: HGSNAT acetylates the terminal N-glucosamine in heparan sulfate
directly activates: Catalysis1334

HGSNAT acetylates the terminal N-glucosamine in heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: GO_0015019
BFO_0000050: HS-GAG degradation
directly activates: Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses N-acetyl-D-glucosamine residues from heparan sulfate
directly activates: Catalysis1335

Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses N-acetyl-D-glucosamine residues from heparan sulfate
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: GO_0004561
BFO_0000050: HS-GAG degradation
directly activates: Iduronate 2-sulfatase (IDS) hydrolyses sulfates from L-iduronate 2-sulfate units of heparan sulfate
directly activates: Catalysis1336

Iduronate 2-sulfatase (IDS) hydrolyses sulfates from L-iduronate 2-sulfate units of heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004423
BFO_0000050: HS-GAG degradation
directly activates: Alpha-L-iduronidase (IDUA) hydrolyses another unsulfated alpha-L-iduronosidic linkage in heparan sulfate
directly activates: Catalysis1337

Alpha-L-iduronidase (IDUA) hydrolyses another unsulfated alpha-L-iduronosidic linkage in heparan sulfate
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: GO_0003940
BFO_0000050: HS-GAG degradation
directly activates: N-sulphoglucosamine sulphohydrolase (SGSH) hydrolyses another sulfate from the N-sulphoglucosamine residue of heparan sulfate
directly activates: Catalysis1338

N-sulphoglucosamine sulphohydrolase (SGSH) hydrolyses another sulfate from the N-sulphoglucosamine residue of heparan sulfate
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: GO_0016250
BFO_0000050: HS-GAG degradation
directly activates: HGSNAT acetylates another terminal N-glucosamine in heparan
directly activates: Catalysis1339

HGSNAT acetylates another terminal N-glucosamine in heparan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: GO_0015019
BFO_0000050: HS-GAG degradation
directly activates: Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses another N-acetyl-D-glucosamine residue from heparan
directly activates: Catalysis1340

Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses another N-acetyl-D-glucosamine residue from heparan
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: GO_0004561
BFO_0000050: HS-GAG degradation
directly activates: Beta-glucuronidase (GUSB) hydrolyses glucuronate from the linker chain
directly activates: Catalysis1341
directly activates: Control223

Beta-glucuronidase (GUSB) hydrolyses glucuronate from the linker chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004566
BFO_0000050: HS-GAG degradation
directly activates: Beta-galactosidase (GLB1) can cleave galactose from the linker chain
directly activates: Catalysis1342

Beta-galactosidase (GLB1) can cleave galactose from the linker chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004565
BFO_0000050: HS-GAG degradation

The addition of GalNAc to the terminal glucuronate residue forms chondroitin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0047238
BFO_0000050: Chondroitin sulfate biosynthesis
directly activates: A glucuronate moiety is added to chondroitin
directly activates: Catalysis1344

A glucuronate moiety is added to chondroitin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050510
BFO_0000050: Chondroitin sulfate biosynthesis
directly activates: GalNAc is added to chondroitin
directly activates: Catalysis1345

GalNAc is added to chondroitin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0047238
BFO_0000050: Chondroitin sulfate biosynthesis
directly activates: Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13
directly activates: Chondroitin can be sulfated on position 6 of GalNAc by CHST3,7
directly activates: Catalysis1346
directly activates: Catalysis1348

Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0047756
BFO_0000050: Chondroitin sulfate biosynthesis
directly activates: Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15
directly activates: CSPG is secreted
directly activates: Catalysis1347

Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15
type: Restriction
  on property: enabled by
  some values from: BRAG
type: Restriction
  on property: enabled by
  some values from: BRAG
type: Restriction
  on property: enabled by
  some values from: BRAG
type: Restriction
  on property: enabled by
  some values from: BRAG
type: Restriction
  on property: enabled by
  some values from: BRAG
type: Restriction
  on property: enabled by
  some values from: BRAG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: BRAG
type: Restriction
  on property: enabled by
  some values from: BRAG
type: GO_0050659
BFO_0000050: Chondroitin sulfate biosynthesis
directly activates: CSPG is secreted

Chondroitin can be sulfated on position 6 of GalNAc by CHST3,7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0008459
BFO_0000050: Chondroitin sulfate biosynthesis
directly activates: CSPG is secreted

CSPG is secreted
type: GO_0003674
BFO_0000050: Chondroitin sulfate biosynthesis
directly activates: DSPG and CSPG translocate to the lysosome for degradation

Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)
type: Restriction
  on property: enabled by
  some values from: DSE
type: Restriction
  on property: enabled by
  some values from: DSE
type: Restriction
  on property: enabled by
  some values from: DSE
type: Restriction
  on property: enabled by
  some values from: DSE
type: Restriction
  on property: enabled by
  some values from: DSE
type: Restriction
  on property: enabled by
  some values from: DSE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: DSE
type: Restriction
  on property: enabled by
  some values from: DSE
type: GO_0047757
BFO_0000050: Dermatan sulfate biosynthesis
directly activates: Dermatan sulfate can be further sulfated on position 2 of iduronate
directly activates: DSPGs are secreted
directly activates: Catalysis1350

Dermatan sulfate can be further sulfated on position 2 of iduronate
type: Restriction
  on property: enabled by
  some values from: DS2ST
type: Restriction
  on property: enabled by
  some values from: DS2ST
type: Restriction
  on property: enabled by
  some values from: DS2ST
type: Restriction
  on property: enabled by
  some values from: DS2ST
type: Restriction
  on property: enabled by
  some values from: DS2ST
type: Restriction
  on property: enabled by
  some values from: DS2ST
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: DS2ST
type: Restriction
  on property: enabled by
  some values from: DS2ST
type: GO_0008146
BFO_0000050: Dermatan sulfate biosynthesis
directly activates: CHST14 transfers SO4(2-) to DS
directly activates: DSPGs are secreted
directly activates: Catalysis1351

CHST14 transfers SO4(2-) to DS
type: Restriction
  on property: enabled by
  some values from: CHST14
type: Restriction
  on property: enabled by
  some values from: CHST14
type: Restriction
  on property: enabled by
  some values from: CHST14
type: Restriction
  on property: enabled by
  some values from: CHST14
type: Restriction
  on property: enabled by
  some values from: CHST14
type: Restriction
  on property: enabled by
  some values from: CHST14
type: Restriction
  on property: enabled by
  some values from: CHST14
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: CHST14
type: GO_0001537
BFO_0000050: Dermatan sulfate biosynthesis
directly activates: DSPGs are secreted
label: GalNAc is sulfated on position 4 once dermatan sulfate is formed

DSPGs are secreted
type: GO_0003674
BFO_0000050: Dermatan sulfate biosynthesis
directly activates: DSPG and CSPG translocate to the lysosome for degradation

DSPG and CSPG translocate to the lysosome for degradation
type: GO_0003674
BFO_0000050: CS/DS degradation
directly activates: DS is cleaved from its proteoglycan
directly activates: CS is cleaved from its proteoglycan
directly activates: Catalysis1352
directly activates: Catalysis1353

DS is cleaved from its proteoglycan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0016798
BFO_0000050: CS/DS degradation
directly activates: Arylsulfatase B (ARSB) hydrolyses sulfate groups from GalNAc 4-sulfate units of DS
directly activates: Catalysis1354

CS is cleaved from its proteoglycan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0016798
BFO_0000050: CS/DS degradation
directly activates: Arylsulfatase B (ARSB) hydrolyses sulfate groups from GalNAc 4-sulfate units of CS
directly activates: Catalysis1358

Arylsulfatase B (ARSB) hydrolyses sulfate groups from GalNAc 4-sulfate units of DS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0003943
BFO_0000050: CS/DS degradation
directly activates: Iduronate 2-sulfatase (IDS) hydrolyses sulfates from L-iduronate 2-sulfate units of dermatan sulfate
directly activates: Hyaluronidase 1 (HYAL1) hydrolyses 1-4 linkages between GalNAc and D-glucuronate residues in CS.
directly activates: Catalysis1355
directly activates: Catalysis1359

Iduronate 2-sulfatase (IDS) hydrolyses sulfates from L-iduronate 2-sulfate units of dermatan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004423
BFO_0000050: CS/DS degradation
directly activates: Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from DS
directly activates: Catalysis1356

Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from DS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004563
BFO_0000050: CS/DS degradation
directly activates: Alpha-L-iduronidase (IDUA) hydrolyses the unsulfated alpha-L-iduronosidic linkage in DS
directly activates: Catalysis1357

Alpha-L-iduronidase (IDUA) hydrolyses the unsulfated alpha-L-iduronosidic linkage in DS
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0003940
BFO_0000050: CS/DS degradation

Arylsulfatase B (ARSB) hydrolyses sulfate groups from GalNAc 4-sulfate units of CS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0003943
BFO_0000050: CS/DS degradation
directly activates: Hyaluronidase 1 (HYAL1) hydrolyses 1-4 linkages between GalNAc and D-glucuronate residues in CS.
directly activates: Catalysis1359

Hyaluronidase 1 (HYAL1) hydrolyses 1-4 linkages between GalNAc and D-glucuronate residues in CS.
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004415
BFO_0000050: CS/DS degradation

Digestion of linear starch (amylose) by extracellular amylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004556
BFO_0000050: Digestion of dietary carbohydrate
directly activates: Digestion of maltotriose by maltase-glucomylase to yield maltose and glucose
directly activates: Digestion of maltotriose by sucrase-isomaltase to yield maltose and glucose
directly activates: Digestion of maltose by maltase-glucoamylase to yield glucose
directly activates: Digestion of maltose by sucrase-isomaltase to yield glucose
directly activates: Catalysis1947
directly activates: Catalysis1948
directly activates: Catalysis1949
directly activates: Catalysis1950

Digestion of branched starch (amylopectin) by extracellular amylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004556
BFO_0000050: Digestion of dietary carbohydrate
directly activates: Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose
directly activates: Digestion of maltotriose by maltase-glucomylase to yield maltose and glucose
directly activates: Digestion of maltotriose by sucrase-isomaltase to yield maltose and glucose
directly activates: Digestion of maltose by maltase-glucoamylase to yield glucose
directly activates: Digestion of maltose by sucrase-isomaltase to yield glucose
directly activates: Catalysis1946
directly activates: Catalysis1947
directly activates: Catalysis1948
directly activates: Catalysis1949
directly activates: Catalysis1950

Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004558
BFO_0000050: Digestion of dietary carbohydrate
directly activates: Transport (influx) of glucose, galactose, and sodium ions by SGLT1
directly activates: Digestion of maltotriose by maltase-glucomylase to yield maltose and glucose
directly activates: Digestion of maltotriose by sucrase-isomaltase to yield maltose and glucose
directly activates: Digestion of maltose by maltase-glucoamylase to yield glucose
directly activates: Digestion of maltose by sucrase-isomaltase to yield glucose
directly activates: Catalysis1947
directly activates: Catalysis1948
directly activates: Catalysis1949
directly activates: Catalysis1950
directly activates: Catalysis641

Digestion of maltotriose by maltase-glucomylase to yield maltose and glucose
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004558
BFO_0000050: Digestion of dietary carbohydrate
directly activates: Transport (influx) of glucose, galactose, and sodium ions by SGLT1
directly activates: Digestion of maltose by maltase-glucoamylase to yield glucose
directly activates: Digestion of maltose by sucrase-isomaltase to yield glucose
directly activates: Catalysis1949
directly activates: Catalysis1950
directly activates: Catalysis641
label: maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)

Digestion of maltotriose by sucrase-isomaltase to yield maltose and glucose
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004558
BFO_0000050: Digestion of dietary carbohydrate
directly activates: Transport (influx) of glucose, galactose, and sodium ions by SGLT1
directly activates: Digestion of maltose by maltase-glucoamylase to yield glucose
directly activates: Digestion of maltose by sucrase-isomaltase to yield glucose
directly activates: Catalysis1949
directly activates: Catalysis1950
directly activates: Catalysis641
label: maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)

Digestion of maltose by maltase-glucoamylase to yield glucose
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004558
BFO_0000050: Digestion of dietary carbohydrate
directly activates: Transport (influx) of glucose, galactose, and sodium ions by SGLT1
directly activates: Catalysis641
label: maltose + H2O => 2 D-glucose (maltase-glucoamylase)

Digestion of maltose by sucrase-isomaltase to yield glucose
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004558
BFO_0000050: Digestion of dietary carbohydrate
directly activates: Transport (influx) of glucose, galactose, and sodium ions by SGLT1
directly activates: Catalysis641
label: maltose + H2O => 2 D-glucose (sucrase-isomaltase)

Digestion of lactose to yield glucose and galactose
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0000016
BFO_0000050: Digestion of dietary carbohydrate
directly activates: Transport (influx) of glucose, galactose, and sodium ions by SGLT1
directly activates: Catalysis641
label: lactose + H2O => D-glucose + D-galactose

Digestion of sucrose to yield glucose and fructose
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004575
BFO_0000050: Digestion of dietary carbohydrate
directly activates: Transport (influx) of fructose by GLUT5
directly activates: Transport (influx) of glucose, galactose, and sodium ions by SGLT1
directly activates: Catalysis640
directly activates: Catalysis641
label: sucrose + H2O => glucose + fructose

Digestion of trehalose to yield glucose
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: TREA
type: Restriction
  on property: enabled by
  some values from: TREA
type: GO_0004555
BFO_0000050: Digestion of dietary carbohydrate
directly activates: Transport (influx) of glucose, galactose, and sodium ions by SGLT1
directly activates: Catalysis641
label: trehalose + H2O => 2 D-glucose

Glucose 6-phosphate is isomerized to form fructose-6-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004347
BFO_0000050: Glycolysis
directly activates: D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP
directly activates: D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP
directly activates: D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
directly activates: D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate
directly activates: Catalysis1956
directly activates: Catalysis1957
directly activates: Catalysis2015
directly activates: Catalysis2017
directly activates: Control357
directly activates: Control358
directly activates: Control359
directly activates: Control360
directly activates: Control361
directly activates: Control362
label: alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate

Dephosphorylation of phosphoPFKFB1 by PP2A complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008195
BFO_0000050: Glycolysis
directly activates: D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP
directly activates: Catalysis1956
directly activates: Control357

D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003873
BFO_0000050: Glycolysis
label: Fructose 6-phosphate and ATP react to form fructose 2,6-bisphosphate and ADP

D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003872
BFO_0000050: Glycolysis
directly activates: D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate
directly activates: Catalysis1958

D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004332
BFO_0000050: Glycolysis
directly activates: dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate
directly activates: Catalysis1959

dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004807
BFO_0000050: Glycolysis
directly activates: D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+
directly activates: D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate
directly activates: D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate
directly activates: Catalysis1960
directly activates: Catalysis2013
directly activates: Catalysis2017

D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004365
BFO_0000050: Glycolysis
directly activates: 1,3-Bisphosphoglycerate and ADP react to form 3-phosphoglycerate and ATP
directly activates: D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate
directly activates: Catalysis1961
directly activates: Catalysis2000
label: Glyceraldehyde 3 phosphate, NAD+, and orthophosphate react to form 1,3 bisphosphoglycerate and NADH + H+

1,3-Bisphosphoglycerate and ADP react to form 3-phosphoglycerate and ATP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004618
BFO_0000050: Glycolysis
directly activates: 3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate
directly activates: Catalysis1962
label: 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP

3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004619
BFO_0000050: Glycolysis
directly activates: 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O
directly activates: Catalysis1963

2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004634
BFO_0000050: Glycolysis
directly activates: phosphoenolpyruvate + ADP => pyruvate + ATP
directly activates: Catalysis1964
directly activates: Control363
directly activates: Control364
directly activates: Control365
directly activates: Control366

phosphoenolpyruvate + ADP => pyruvate + ATP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004743
BFO_0000050: Glycolysis
directly activates: BiochemicalReaction5399
directly activates: BiochemicalReaction5403
directly activates: Catalysis2595
directly activates: Catalysis2599

Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004736
BFO_0000050: Gluconeogenesis
directly activates: Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+
directly activates: oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]
directly activates: oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]
directly activates: Catalysis1966
directly activates: Catalysis1968
directly activates: Catalysis1973
label: Pyruvate, CO2, and ATP react to form oxaloacetate, ADP, and orthophosphate

Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0030060
BFO_0000050: Gluconeogenesis
directly activates: malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]
directly activates: Exchange of malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane
directly activates: Catalysis1969
directly activates: Catalysis636

(S)-malate + NAD+ <=> oxaloacetate + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0030060
BFO_0000050: Gluconeogenesis
directly activates: Oxaloacetate and GTP react to form phosphoenolpyruvate, CO2, and GDP [cytosol]
directly activates: Catalysis1972
label: malate + NAD+ <=> oxaloacetate + NADH + H+

oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004069
BFO_0000050: Gluconeogenesis
directly activates: Exchange of cytosolic glutamate and mitochondrial aspartate
directly activates: BiochemicalReaction5706
directly activates: Catalysis1970
directly activates: Catalysis2866

Exchange of malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0015367
BFO_0000050: Gluconeogenesis
directly activates: (S)-malate + NAD+ <=> oxaloacetate + NADH + H+
directly activates: Catalysis1967
label: malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]

Exchange of cytosolic glutamate and mitochondrial aspartate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0015172
BFO_0000050: Gluconeogenesis
directly activates: aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1]
directly activates: Catalysis1971
label: aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix]

aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004069
BFO_0000050: Gluconeogenesis
directly activates: Oxaloacetate and GTP react to form phosphoenolpyruvate, CO2, and GDP [cytosol]
directly activates: Catalysis1972

Oxaloacetate and GTP react to form phosphoenolpyruvate, CO2, and GDP [cytosol]
type: Restriction
  on property: enabled by
  some values from: PCK1
type: Restriction
  on property: enabled by
  some values from: PCK1
type: Restriction
  on property: enabled by
  some values from: PCK1
type: Restriction
  on property: enabled by
  some values from: PCK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004613
BFO_0000050: Gluconeogenesis
directly activates: Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate
directly activates: Catalysis1975
label: oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]

oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]
type: Restriction
  on property: enabled by
  some values from: PCK2
type: Restriction
  on property: enabled by
  some values from: PCK2
type: Restriction
  on property: enabled by
  some values from: PCK2
type: Restriction
  on property: enabled by
  some values from: PCK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004613
BFO_0000050: Gluconeogenesis
directly activates: Exchange of cytosolic citrate for mitochondrial phosphoenolpyruvate
directly activates: Catalysis1974

Exchange of cytosolic citrate for mitochondrial phosphoenolpyruvate
type: Restriction
  on property: enabled by
  some values from: SLC20A3
type: Restriction
  on property: enabled by
  some values from: SLC20A3
type: Restriction
  on property: enabled by
  some values from: SLC20A3
type: Restriction
  on property: enabled by
  some values from: SLC20A3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0015142
BFO_0000050: Gluconeogenesis
directly activates: Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate
directly activates: Catalysis1975
label: phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]

Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004634
BFO_0000050: Gluconeogenesis
directly activates: 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate
directly activates: Catalysis1976

2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004619
BFO_0000050: Gluconeogenesis
directly activates: ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate
directly activates: Catalysis1977

ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004618
BFO_0000050: Gluconeogenesis
directly activates: 1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+
directly activates: Catalysis1978

1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004365
BFO_0000050: Gluconeogenesis
directly activates: D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate
directly activates: dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate
directly activates: Catalysis1979
directly activates: Catalysis1980

D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004807
BFO_0000050: Gluconeogenesis
directly activates: dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate
directly activates: Catalysis1980

dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004332
BFO_0000050: Gluconeogenesis
directly activates: D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate
directly activates: Catalysis1981
directly activates: Control368

D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0042132
BFO_0000050: Gluconeogenesis
directly activates: D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate
directly activates: Catalysis1984

Phosphorylation of PF2K-Pase by PKA catalytic subunit
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004691
BFO_0000050: Gluconeogenesis
directly activates: D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP
directly activates: Catalysis1956
directly activates: Control357

Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004331
BFO_0000050: Gluconeogenesis

D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004347
BFO_0000050: Gluconeogenesis
directly activates: Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4
directly activates: alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+
directly activates: Catalysis2007
directly activates: Catalysis647

alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004614
BFO_0000050: Glycogen synthesis
directly activates: UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose
directly activates: Catalysis1986

UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003983
BFO_0000050: Glycogen synthesis
directly activates: BiochemicalReaction296
directly activates: 8 UDP-glucose + glycogenin dimer => 8 UDP + {(1,4)-alpha-D-glucosyl}4 glycogenin dimer
directly activates: BiochemicalReaction5891
directly activates: Catalysis111
directly activates: Catalysis1987
directly activates: Catalysis3031
directly activates: Control14

8 UDP-glucose + glycogenin dimer => 8 UDP + {(1,4)-alpha-D-glucosyl}4 glycogenin dimer
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008466
BFO_0000050: Glycogen synthesis
directly activates: 8 UDP-glucose + ((1,4)-alpha-D-glucosyl}4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS I form]
directly activates: 8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS D form]
directly activates: Catalysis1988
directly activates: Catalysis1989
directly activates: Control370
directly activates: Modulation13

8 UDP-glucose + ((1,4)-alpha-D-glucosyl}4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS I form]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004373
BFO_0000050: Glycogen synthesis
directly activates: poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin
directly activates: Catalysis1990

8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS D form]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004373
BFO_0000050: Glycogen synthesis
directly activates: poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin
directly activates: Catalysis1990

poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin
type: Restriction
  on property: enabled by
  some values from: GBE1
type: Restriction
  on property: enabled by
  some values from: GBE1
type: Restriction
  on property: enabled by
  some values from: GBE1
type: Restriction
  on property: enabled by
  some values from: GBE1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003844
BFO_0000050: Glycogen synthesis

glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004689
BFO_0000050: Glycogen breakdown (glycogenolysis)
directly activates: glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
directly activates: poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
directly activates: Catalysis1994
directly activates: Catalysis1998

glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004689
BFO_0000050: Glycogen breakdown (glycogenolysis)
directly activates: glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
directly activates: poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
directly activates: Catalysis1994
directly activates: Catalysis1998

glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004689
BFO_0000050: Glycogen breakdown (glycogenolysis)
directly activates: glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]
directly activates: poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]
directly activates: Catalysis1995
directly activates: Catalysis1999

PGYB dimer, b form + 2 AMP <=> PGYB b dimer:AMP complex
type: GO_0003674
BFO_0000050: Glycogen breakdown (glycogenolysis)
directly activates: glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
directly activates: poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
directly activates: Catalysis1994
directly activates: Catalysis1998

PGYB b dimer:AMP complex <=> PGYB dimer, b form + 2 AMP
type: GO_0003674
BFO_0000050: Glycogen breakdown (glycogenolysis)

PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex
type: GO_0003674
BFO_0000050: Glycogen breakdown (glycogenolysis)
directly activates: glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
directly activates: poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
directly activates: Catalysis1994
directly activates: Catalysis1998

PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP
type: GO_0003674
BFO_0000050: Glycogen breakdown (glycogenolysis)

glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008184
BFO_0000050: Glycogen breakdown (glycogenolysis)
directly activates: limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin
directly activates: D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate
directly activates: Catalysis1996
directly activates: Catalysis2000

glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008184
BFO_0000050: Glycogen breakdown (glycogenolysis)
directly activates: UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose
directly activates: limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin
directly activates: D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate
directly activates: Catalysis1986
directly activates: Catalysis1996
directly activates: Catalysis2000

limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin
type: Restriction
  on property: enabled by
  some values from: AGL
type: Restriction
  on property: enabled by
  some values from: AGL
type: Restriction
  on property: enabled by
  some values from: AGL
type: Restriction
  on property: enabled by
  some values from: AGL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004134
BFO_0000050: Glycogen breakdown (glycogenolysis)
directly activates: ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose
directly activates: Catalysis1997

((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose
type: Restriction
  on property: enabled by
  some values from: AGL
type: Restriction
  on property: enabled by
  some values from: AGL
type: Restriction
  on property: enabled by
  some values from: AGL
type: Restriction
  on property: enabled by
  some values from: AGL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004135
BFO_0000050: Glycogen breakdown (glycogenolysis)
directly activates: poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
directly activates: poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]
directly activates: Catalysis1998
directly activates: Catalysis1999

poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008184
BFO_0000050: Glycogen breakdown (glycogenolysis)
directly activates: D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate
directly activates: Catalysis2000

poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008184
BFO_0000050: Glycogen breakdown (glycogenolysis)
directly activates: D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate
directly activates: Catalysis2000

D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004614
BFO_0000050: Glycogen breakdown (glycogenolysis)
BFO_0000050: Galactose catabolism
directly activates: alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+
directly activates: Catalysis2007

ATP + beta-D-fructose => ADP + D-fructose 1-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004454
BFO_0000050: Fructose catabolism
directly activates: D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate
directly activates: Catalysis2002

D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004332
BFO_0000050: Fructose catabolism
directly activates: dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate
directly activates: ATP + D-glyceraldehyde => ADP + D-glyceraldehyde 3-phosphate
directly activates: Catalysis1959
directly activates: Catalysis2003

ATP + D-glyceraldehyde => ADP + D-glyceraldehyde 3-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0050354
BFO_0000050: Fructose catabolism
directly activates: D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+
directly activates: Catalysis1960

ATP + D-galactose => ADP + D-galactose 1-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GALK
type: Restriction
  on property: enabled by
  some values from: GALK
type: GO_0004335
BFO_0000050: Galactose catabolism
directly activates: D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose
directly activates: Catalysis2005

D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GALT
type: Restriction
  on property: enabled by
  some values from: GALT
type: GO_0008108
BFO_0000050: Galactose catabolism
directly activates: D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate
directly activates: UDP-galactose <=> UDP-glucose
directly activates: Catalysis2000
directly activates: Catalysis2006

UDP-galactose <=> UDP-glucose
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003978
BFO_0000050: Galactose catabolism
directly activates: D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose
directly activates: Catalysis2005

alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004345
BFO_0000050: Pentose phosphate pathway (hexose monophosphate shunt)
directly activates: D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate
directly activates: BiochemicalReaction5531
directly activates: Catalysis2008
directly activates: Catalysis2717

D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PGLS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PGLS
type: GO_0017057
BFO_0000050: Pentose phosphate pathway (hexose monophosphate shunt)
directly activates: 6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+
directly activates: Catalysis2009

6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004616
BFO_0000050: Pentose phosphate pathway (hexose monophosphate shunt)
directly activates: D-ribulose 5-phosphate <=> xylulose 5-phosphate
directly activates: D-ribulose 5-phosphate <=> ribose 5-phosphate
directly activates: BiochemicalReaction5531
directly activates: Catalysis2010
directly activates: Catalysis2018
directly activates: Catalysis2717

D-ribulose 5-phosphate <=> xylulose 5-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004750
BFO_0000050: Pentose phosphate pathway (hexose monophosphate shunt)
directly activates: ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
directly activates: xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate
directly activates: Catalysis2012
directly activates: Catalysis2016

xylulose 5-phosphate <=> D-ribulose 5-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004750
BFO_0000050: Pentose phosphate pathway (hexose monophosphate shunt)

ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004802
BFO_0000050: Pentose phosphate pathway (hexose monophosphate shunt)
directly activates: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate
directly activates: Catalysis2014

D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004802
BFO_0000050: Pentose phosphate pathway (hexose monophosphate shunt)
directly activates: BiochemicalReaction5356
directly activates: Control434

sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: TAL
type: Restriction
  on property: enabled by
  some values from: TAL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004801
BFO_0000050: Pentose phosphate pathway (hexose monophosphate shunt)
directly activates: xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate
directly activates: Catalysis2016

D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: TAL
type: Restriction
  on property: enabled by
  some values from: TAL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004801
BFO_0000050: Pentose phosphate pathway (hexose monophosphate shunt)
directly activates: D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate
directly activates: Catalysis2013

xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004802
BFO_0000050: Pentose phosphate pathway (hexose monophosphate shunt)

D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004802
BFO_0000050: Pentose phosphate pathway (hexose monophosphate shunt)
directly activates: BiochemicalReaction5356
directly activates: Control434

D-ribulose 5-phosphate <=> ribose 5-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: RPI
type: Restriction
  on property: enabled by
  some values from: RPI
type: GO_0004751
BFO_0000050: Pentose phosphate pathway (hexose monophosphate shunt)
directly activates: ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
directly activates: D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate
directly activates: Catalysis2012
directly activates: Catalysis2021
directly activates: 5-Phosphoribose 1-diphosphate biosynthesis

ribose 5-phosphate <=> D-ribulose 5-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: RPI
type: Restriction
  on property: enabled by
  some values from: RPI
type: GO_0004751
BFO_0000050: Pentose phosphate pathway (hexose monophosphate shunt)

D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004749
BFO_0000050: 5-Phosphoribose 1-diphosphate biosynthesis
directly activates: BiochemicalReaction5442
directly activates: BiochemicalReaction5483
directly activates: Catalysis2630
directly activates: Catalysis2671
directly activates: Control454
directly activates: Control455

D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004749
BFO_0000050: 5-Phosphoribose 1-diphosphate biosynthesis
directly activates: BiochemicalReaction5442
directly activates: BiochemicalReaction5483
directly activates: Catalysis2630
directly activates: Catalysis2671
directly activates: Control454
directly activates: Control455
label: addition of diphosphate (PP) to ribose 5-phosphate to form 5'-Phospho-alpha-D-ribose 1-diphosphate (PRPP)

Carbohydrate metabolism
type: GO_0008150
label: Metabolism of carbohydrates

Digestion of dietary carbohydrate
type: GO_0008150
BFO_0000050: Carbohydrate metabolism

Glucose metabolism
type: GO_0008150
BFO_0000050: Carbohydrate metabolism

Glycolysis
type: GO_0008150
BFO_0000050: Glucose metabolism

Gluconeogenesis
type: GO_0008150
BFO_0000050: Glucose metabolism

Glycogen synthesis
type: GO_0008150
BFO_0000050: Glucose metabolism

Glycogen breakdown (glycogenolysis)
type: GO_0008150
BFO_0000050: Glucose metabolism

Fructose catabolism
type: GO_0008150
BFO_0000050: Carbohydrate metabolism

Galactose catabolism
type: GO_0008150
BFO_0000050: Carbohydrate metabolism

Pentose phosphate pathway (hexose monophosphate shunt)
type: GO_0008150
BFO_0000050: Carbohydrate metabolism

5-Phosphoribose 1-diphosphate biosynthesis
type: GO_0008150
BFO_0000050: Carbohydrate metabolism
label: PRPP biosynthesis
label: Synthesis of cytosolic 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) from D-ribose 5-phosphate

Hexose transport
type: GO_0008150
BFO_0000050: Carbohydrate metabolism
label: Hexose uptake

Glucose transport
type: GO_0008150
BFO_0000050: Hexose transport

Regulation of Glucokinase by Glucokinase Regulatory Protein
type: GO_0008150
BFO_0000050: Glucose transport

Glycosaminoglycan metabolism
type: GO_0008150
BFO_0000050: Carbohydrate metabolism

Hyaluronan metabolism
type: GO_0008150
BFO_0000050: Glycosaminoglycan metabolism

Hyaluronan biosynthesis and export
type: GO_0008150
BFO_0000050: Hyaluronan metabolism

Hyaluronan uptake and degradation
type: GO_0008150
BFO_0000050: Hyaluronan metabolism

Transport and synthesis of PAPS
type: GO_0008150
BFO_0000050: Glycosaminoglycan metabolism

Keratan sulfate/keratin metabolism
type: GO_0008150
BFO_0000050: Glycosaminoglycan metabolism

Keratan sulfate biosynthesis
type: GO_0008150
BFO_0000050: Keratan sulfate/keratin metabolism

Keratan sulfate degradation
type: GO_0008150
BFO_0000050: Keratan sulfate/keratin metabolism

Heparan sulfate/heparin (HS-GAG) metabolism
type: GO_0008150
BFO_0000050: Glycosaminoglycan metabolism

A tetrasaccharide linker sequence is required for GAG synthesis
type: GO_0008150
BFO_0000050: Heparan sulfate/heparin (HS-GAG) metabolism
BFO_0000050: Chondroitin sulfate/dermatan sulfate metabolism

HS-GAG biosynthesis
type: GO_0008150
BFO_0000050: Heparan sulfate/heparin (HS-GAG) metabolism

HS-GAG degradation
type: GO_0008150
BFO_0000050: Heparan sulfate/heparin (HS-GAG) metabolism

Chondroitin sulfate/dermatan sulfate metabolism
type: GO_0008150
BFO_0000050: Glycosaminoglycan metabolism

Chondroitin sulfate biosynthesis
type: GO_0008150
BFO_0000050: Chondroitin sulfate/dermatan sulfate metabolism

Dermatan sulfate biosynthesis
type: GO_0008150
BFO_0000050: Chondroitin sulfate/dermatan sulfate metabolism

CS/DS degradation
type: GO_0008150
BFO_0000050: Chondroitin sulfate/dermatan sulfate metabolism