ABCC5
label: MRP5
label: UniProt:O15440 ABCC5

CHST1
label: UniProt:O43916 CHST1

GLCE
label: KIAA0836
label: UniProt:O94923 GLCE

GNS
label: UniProt:P15586 GNS

IDUA
label: UniProt:P35475 IDUA

HSS
label: SGSH
label: UniProt:P51688 SGSH

NAGLU
label: UFHSD1
label: UniProt:P54802 NAGLU

HYAL1
label: LUCA1
label: UniProt:Q12794 HYAL1

HFRC
label: SLC35D2
label: UGTREL8
label: UniProt:Q76EJ3 SLC35D2

BRAG
label: CHST15
label: GALNAC4S6ST
label: KIAA0598
label: UniProt:Q7LFX5 CHST15

HS2ST
label: HS2ST1
label: KIAA0448
label: UniProt:Q7LGA3 HS2ST1

CHST14
label: D4ST1
label: UNQ1925/PRO4400
label: UniProt:Q8NCH0 CHST14

HPA2
label: HPSE2
label: UniProt:Q8WWQ2 HPSE2

B3GALT6
label: UniProt:Q96L58 B3GALT6

B4GALT7
label: UNQ748/PRO1478
label: UniProt:Q9UBV7 B4GALT7
label: XGALT1

DSE
label: SART2
label: UniProt:Q9UL01 DSE

DS2ST
label: UST
label: UniProt:Q9Y2C2 UST

SLC26A1,2 transport extracellular SO4(2-) to cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015116
BFO_0000050: Transport and synthesis of PAPS
directly activates: ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate
directly activates: Catalysis1300

SLC35B2,3 transport cytosolic PAPS to Golgi lumen
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0046964
BFO_0000050: Transport and synthesis of PAPS
directly activates: Sulfation of GlcNAc residues on Keratan-PG forms KSPG
directly activates: Further sulfation on galactose residues produces KSPG
directly activates: NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)
directly activates: HS2ST1 sulfates IdoA at C2 in heparan sulfate
directly activates: HS3STs sulfate GlcN at C3 in heparan sulfate
directly activates: HS3ST1 sulfates GlcN at C3 in heparan sulfate
directly activates: HS6STs sulfate GlcN at C6 in heparan sulfate/heparin
directly activates: Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13
directly activates: Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15
directly activates: Chondroitin can be sulfated on position 6 of GalNAc by CHST3,7
directly activates: Dermatan sulfate can be further sulfated on position 2 of iduronate
directly activates: CHST14 transfers SO4(2-) to DS
directly activates: Catalysis1307
directly activates: Catalysis1308
directly activates: Catalysis1323
directly activates: Catalysis1325
directly activates: Catalysis1326
directly activates: Catalysis1327
directly activates: Catalysis1329
directly activates: Catalysis1346
directly activates: Catalysis1347
directly activates: Catalysis1348
directly activates: Catalysis1350
directly activates: Catalysis1351

SLC35D2 exchanges UDP-sugars for UMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0005338
BFO_0000050: Keratan sulfate biosynthesis
BFO_0000050: HS-GAG biosynthesis
directly activates: B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG
directly activates: The addition of GlcNAc to the terminal glucuronate residue creates heparan
directly activates: Catalysis1303
directly activates: Catalysis1318

HAS1,2,3 mediate the polymerisation of HA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0050501
BFO_0000050: Hyaluronan biosynthesis and export
directly activates: Growing HA is extruded from the cell by ABCC5
directly activates: Catalysis1294

Growing HA is extruded from the cell by ABCC5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: GO_0008514
BFO_0000050: Hyaluronan biosynthesis and export
directly activates: Receptor-mediated uptake of HA

Receptor-mediated uptake of HA
type: GO_0003674
BFO_0000050: Hyaluronan uptake and degradation
directly activates: HYAL2 interacts with NHE1 to create an acidic environment

HYAL2 interacts with NHE1 to create an acidic environment
type: GO_0003674
BFO_0000050: Hyaluronan uptake and degradation
directly activates: Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments
directly activates: Catalysis1295

Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004415
BFO_0000050: Hyaluronan uptake and degradation
directly activates: 20kDa HA fragments are translocated to lysosomes

20kDa HA fragments are translocated to lysosomes
type: GO_0003674
BFO_0000050: Hyaluronan uptake and degradation
directly activates: Hyaluronidase 1 (HYAL1) hydrolyses HA from 20kDa to 800Da fragments
directly activates: Catalysis1296

Hyaluronidase 1 (HYAL1) hydrolyses HA from 20kDa to 800Da fragments
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: GO_0004415
BFO_0000050: Hyaluronan uptake and degradation
directly activates: Beta-glucuronidase (GUSB) hydrolyses glucuronate from HA tetrasaccharides
directly activates: Catalysis1297

Beta-glucuronidase (GUSB) hydrolyses glucuronate from HA tetrasaccharides
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004566
BFO_0000050: Hyaluronan uptake and degradation
directly activates: Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from small HA fragments
directly activates: The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol
directly activates: Catalysis1298

Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from small HA fragments
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004563
BFO_0000050: Hyaluronan uptake and degradation
directly activates: Beta-glucuronidase (GUSB) hydrolyses glucuronate from the HA disaccharides
directly activates: The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol
directly activates: Catalysis1299

Beta-glucuronidase (GUSB) hydrolyses glucuronate from the HA disaccharides
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004566
BFO_0000050: Hyaluronan uptake and degradation
directly activates: The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol

The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol
type: GO_0003674
BFO_0000050: Hyaluronan uptake and degradation

ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004781
BFO_0000050: Transport and synthesis of PAPS
directly activates: BiochemicalReaction296
directly activates: APS reacts with another ATP molecule to form PAPS
directly activates: Catalysis111
directly activates: Catalysis1301
directly activates: Control14
label: Activation of inorganic sulfate forms APS
label: PAPSS1,2 transfer PO4(2-) group from ATP to form APS

APS reacts with another ATP molecule to form PAPS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004020
BFO_0000050: Transport and synthesis of PAPS
directly activates: SLC35B2,3 transport cytosolic PAPS to Golgi lumen
directly activates: BiochemicalReaction5894
directly activates: BiochemicalReaction5895
directly activates: BiochemicalReaction5896
directly activates: BiochemicalReaction5897
directly activates: BiochemicalReaction5898
directly activates: BiochemicalReaction5899
directly activates: BiochemicalReaction5900
directly activates: BiochemicalReaction5901
directly activates: BiochemicalReaction5902
directly activates: BiochemicalReaction5903
directly activates: BiochemicalReaction5904
directly activates: BiochemicalReaction5905
directly activates: BiochemicalReaction5906
directly activates: BiochemicalReaction5907
directly activates: BiochemicalReaction5908
directly activates: BiochemicalReaction5909
directly activates: Catalysis3034
directly activates: Catalysis3035
directly activates: Catalysis3036
directly activates: Catalysis3037
directly activates: Catalysis3038
directly activates: Catalysis3039
directly activates: Catalysis3040
directly activates: Catalysis3041
directly activates: Catalysis3042
directly activates: Catalysis3043
directly activates: Catalysis3044
directly activates: Catalysis3045
directly activates: Catalysis3046
directly activates: Catalysis3047
directly activates: Catalysis3048
directly activates: Catalysis3049
directly activates: Catalysis723
label: PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS
label: adenylyl sulfate (APS) + ATP => PAPS + ADP

B4GALTs add galactose to the N-glycan precursor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003831
BFO_0000050: Keratan sulfate biosynthesis
directly activates: B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG
directly activates: Catalysis1303

B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0008532
BFO_0000050: Keratan sulfate biosynthesis
directly activates: B4GALTs add another galactose to the chain
directly activates: Catalysis1304

B4GALTs add another galactose to the chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003831
BFO_0000050: Keratan sulfate biosynthesis
directly activates: B4GALTs can add galactose to a branch of keratan
directly activates: Catalysis1305

B4GALTs can add galactose to a branch of keratan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003831
BFO_0000050: Keratan sulfate biosynthesis
directly activates: The keratan chain can be capped by N-acetylneuraminic acid
directly activates: Catalysis1306

The keratan chain can be capped by N-acetylneuraminic acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003836
BFO_0000050: Keratan sulfate biosynthesis
directly activates: Sulfation of GlcNAc residues on Keratan-PG forms KSPG
directly activates: Catalysis1307

Sulfation of GlcNAc residues on Keratan-PG forms KSPG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0001517
BFO_0000050: Keratan sulfate biosynthesis
directly activates: Further sulfation on galactose residues produces KSPG
directly activates: Catalysis1308

Further sulfation on galactose residues produces KSPG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: CHST1
type: Restriction
  on property: enabled by
  some values from: CHST1
type: Restriction
  on property: enabled by
  some values from: CHST1
type: Restriction
  on property: enabled by
  some values from: CHST1
type: Restriction
  on property: enabled by
  some values from: CHST1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: CHST1
type: Restriction
  on property: enabled by
  some values from: CHST1
type: Restriction
  on property: enabled by
  some values from: CHST1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0045130
BFO_0000050: Keratan sulfate biosynthesis
directly activates: KSPG is secreted from the cell

KSPG is secreted from the cell
type: GO_0003674
BFO_0000050: Keratan sulfate biosynthesis

Extracellular KSPG translocates to the lysosome for degradation
type: GO_0003674
BFO_0000050: Keratan sulfate degradation
directly activates: Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase
directly activates: Catalysis1309

Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004565
BFO_0000050: Keratan sulfate degradation
directly activates: N-acetylgalactosamine-6-sulfatase (GALNS) hydrolyses the sulfate groups of galactose 6-sulfate units of keratan sulfate
directly activates: Catalysis1310

N-acetylgalactosamine-6-sulfatase (GALNS) hydrolyses the sulfate groups of galactose 6-sulfate units of keratan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0043890
BFO_0000050: Keratan sulfate degradation
directly activates: Beta-galactosidase (GLB1) can cleave galactose from a glycosaminoglycan
directly activates: Catalysis1311

Beta-galactosidase (GLB1) can cleave galactose from a glycosaminoglycan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004565
BFO_0000050: Keratan sulfate degradation
directly activates: N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate
directly activates: Catalysis1312

N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: GNS
type: Restriction
  on property: enabled by
  some values from: GNS
type: Restriction
  on property: enabled by
  some values from: GNS
type: Restriction
  on property: enabled by
  some values from: GNS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: GNS
type: Restriction
  on property: enabled by
  some values from: GNS
type: Restriction
  on property: enabled by
  some values from: GNS
type: Restriction
  on property: enabled by
  some values from: GNS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0008449
BFO_0000050: Keratan sulfate degradation
directly activates: Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from keratan sulfate
directly activates: Catalysis1313

Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from keratan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004563
BFO_0000050: Keratan sulfate degradation

GXYLTs transfer Xyl to core protein
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0030158
BFO_0000050: A tetrasaccharide linker sequence is required for GAG synthesis
directly activates: B4GALT7 transfers Gal group to tetrasaccharide linker
directly activates: Catalysis1315
label: Xylose is transferred to a serine residue on the core protein

B4GALT7 transfers Gal group to tetrasaccharide linker
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: enabled by
  some values from: B4GALT7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0046525
BFO_0000050: A tetrasaccharide linker sequence is required for GAG synthesis
directly activates: A second galactose is added in the tetrasaccharide linker
directly activates: Catalysis1316
label: Galactose is the second sugar added in the tetrasaccharide linker

A second galactose is added in the tetrasaccharide linker
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: enabled by
  some values from: B3GALT6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0047220
BFO_0000050: A tetrasaccharide linker sequence is required for GAG synthesis
directly activates: A glucuronate moiety is the fourth addition to the tetrasaccharide linker
directly activates: Catalysis1317
label: B3GALT6 transfers Gal to the tetrasaccharide linker

A glucuronate moiety is the fourth addition to the tetrasaccharide linker
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0015018
BFO_0000050: A tetrasaccharide linker sequence is required for GAG synthesis
directly activates: The addition of GlcNAc to the terminal glucuronate residue creates heparan
directly activates: The addition of GalNAc to the terminal glucuronate residue forms chondroitin
directly activates: Catalysis1318
directly activates: Catalysis1343
label: B3GATs transfer GlcA to tetrasaccharide linker

The addition of GlcNAc to the terminal glucuronate residue creates heparan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050508
BFO_0000050: HS-GAG biosynthesis
directly activates: Glucuronate is added to the heparan chain
directly activates: Catalysis1319

Glucuronate is added to the heparan chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050509
BFO_0000050: HS-GAG biosynthesis
directly activates: Another GlcNAc addition extends the heparan chain
directly activates: Catalysis1320

Another GlcNAc addition extends the heparan chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050508
BFO_0000050: HS-GAG biosynthesis
directly activates: Another GlcA addition extends the heparan chain
directly activates: Catalysis1321

Another GlcA addition extends the heparan chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050509
BFO_0000050: HS-GAG biosynthesis
directly activates: NDST1-4 N-deacetylates GlcNAc residues in heparan
directly activates: Catalysis1322

NDST1-4 N-deacetylates GlcNAc residues in heparan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050119
BFO_0000050: HS-GAG biosynthesis
directly activates: NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)
directly activates: Catalysis1323

NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0015016
BFO_0000050: HS-GAG biosynthesis
directly activates: GLCE epimerises GlcA to IdoA
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1324

GLCE epimerises GlcA to IdoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: GO_0050379
BFO_0000050: HS-GAG biosynthesis
directly activates: HS2ST1 sulfates IdoA at C2 in heparan sulfate
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1325

HS2ST1 sulfates IdoA at C2 in heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: HS2ST
type: Restriction
  on property: enabled by
  some values from: HS2ST
type: Restriction
  on property: enabled by
  some values from: HS2ST
type: Restriction
  on property: enabled by
  some values from: HS2ST
type: Restriction
  on property: enabled by
  some values from: HS2ST
type: Restriction
  on property: enabled by
  some values from: HS2ST
type: Restriction
  on property: enabled by
  some values from: HS2ST
type: Restriction
  on property: enabled by
  some values from: HS2ST
type: GO_0004394
BFO_0000050: HS-GAG biosynthesis
directly activates: HS3STs sulfate GlcN at C3 in heparan sulfate
directly activates: HS3ST1 sulfates GlcN at C3 in heparan sulfate
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1326
directly activates: Catalysis1327

HS3STs sulfate GlcN at C3 in heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0008467
BFO_0000050: HS-GAG biosynthesis
directly activates: GLCE epimerises more GlcA to IdoA as sulfate content rises
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1328

HS3ST1 sulfates GlcN at C3 in heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005796
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005796
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005796
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005796
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005796
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005796
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005796
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005796
type: GO_0008467
BFO_0000050: HS-GAG biosynthesis
directly activates: GLCE epimerises more GlcA to IdoA as sulfate content rises
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1328

GLCE epimerises more GlcA to IdoA as sulfate content rises
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: enabled by
  some values from: GLCE
type: GO_0050379
BFO_0000050: HS-GAG biosynthesis
directly activates: HS6STs sulfate GlcN at C6 in heparan sulfate/heparin
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1329

HS6STs sulfate GlcN at C6 in heparan sulfate/heparin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0017095
BFO_0000050: HS-GAG biosynthesis
directly activates: Some HSPGs are secreted to the plasma membrane

Some HSPGs are secreted to the plasma membrane
type: GO_0003674
BFO_0000050: HS-GAG biosynthesis
directly activates: HS-GAGs translocate to the lysosome for degradation
directly activates: Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane)
directly activates: Catalysis1331

HS-GAGs translocate to the lysosome for degradation
type: GO_0003674
BFO_0000050: HS-GAG degradation
directly activates: Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)
directly activates: Catalysis1330

Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0030305
BFO_0000050: HS-GAG degradation
directly activates: Alpha-L-iduronidase (IDUA) hydrolyses the unsulfated alpha-L-iduronosidic linkage in heparan sulfate
directly activates: Catalysis1332

Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: HPA2
type: Restriction
  on property: enabled by
  some values from: HPA2
type: Restriction
  on property: enabled by
  some values from: HPA2
type: Restriction
  on property: enabled by
  some values from: HPA2
type: Restriction
  on property: enabled by
  some values from: HPA2
type: Restriction
  on property: enabled by
  some values from: HPA2
type: Restriction
  on property: enabled by
  some values from: HPA2
type: Restriction
  on property: enabled by
  some values from: HPA2
type: GO_0030305
BFO_0000050: HS-GAG degradation

Alpha-L-iduronidase (IDUA) hydrolyses the unsulfated alpha-L-iduronosidic linkage in heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: GO_0003940
BFO_0000050: HS-GAG degradation
directly activates: N-sulphoglucosamine sulphohydrolase (SGSH) hydrolyses sulfate from the N-sulphoglucosamine residue of heparan sulfate
directly activates: Catalysis1333

N-sulphoglucosamine sulphohydrolase (SGSH) hydrolyses sulfate from the N-sulphoglucosamine residue of heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: GO_0016250
BFO_0000050: HS-GAG degradation
directly activates: HGSNAT acetylates the terminal N-glucosamine in heparan sulfate
directly activates: Catalysis1334

HGSNAT acetylates the terminal N-glucosamine in heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: GO_0015019
BFO_0000050: HS-GAG degradation
directly activates: Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses N-acetyl-D-glucosamine residues from heparan sulfate
directly activates: Catalysis1335

Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses N-acetyl-D-glucosamine residues from heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: GO_0004561
BFO_0000050: HS-GAG degradation
directly activates: Iduronate 2-sulfatase (IDS) hydrolyses sulfates from L-iduronate 2-sulfate units of heparan sulfate
directly activates: Catalysis1336

Iduronate 2-sulfatase (IDS) hydrolyses sulfates from L-iduronate 2-sulfate units of heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004423
BFO_0000050: HS-GAG degradation
directly activates: Alpha-L-iduronidase (IDUA) hydrolyses another unsulfated alpha-L-iduronosidic linkage in heparan sulfate
directly activates: Catalysis1337

Alpha-L-iduronidase (IDUA) hydrolyses another unsulfated alpha-L-iduronosidic linkage in heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: GO_0003940
BFO_0000050: HS-GAG degradation
directly activates: N-sulphoglucosamine sulphohydrolase (SGSH) hydrolyses another sulfate from the N-sulphoglucosamine residue of heparan sulfate
directly activates: Catalysis1338

N-sulphoglucosamine sulphohydrolase (SGSH) hydrolyses another sulfate from the N-sulphoglucosamine residue of heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: enabled by
  some values from: HSS
type: GO_0016250
BFO_0000050: HS-GAG degradation
directly activates: HGSNAT acetylates another terminal N-glucosamine in heparan
directly activates: Catalysis1339

HGSNAT acetylates another terminal N-glucosamine in heparan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: GO_0015019
BFO_0000050: HS-GAG degradation
directly activates: Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses another N-acetyl-D-glucosamine residue from heparan
directly activates: Catalysis1340

Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses another N-acetyl-D-glucosamine residue from heparan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: GO_0004561
BFO_0000050: HS-GAG degradation
directly activates: Beta-glucuronidase (GUSB) hydrolyses glucuronate from the linker chain
directly activates: Catalysis1341
directly activates: Control223

Beta-glucuronidase (GUSB) hydrolyses glucuronate from the linker chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004566
BFO_0000050: HS-GAG degradation
directly activates: Beta-galactosidase (GLB1) can cleave galactose from the linker chain
directly activates: Catalysis1342

Beta-galactosidase (GLB1) can cleave galactose from the linker chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004565
BFO_0000050: HS-GAG degradation

The addition of GalNAc to the terminal glucuronate residue forms chondroitin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0047238
BFO_0000050: Chondroitin sulfate biosynthesis
directly activates: A glucuronate moiety is added to chondroitin
directly activates: Catalysis1344

A glucuronate moiety is added to chondroitin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050510
BFO_0000050: Chondroitin sulfate biosynthesis
directly activates: GalNAc is added to chondroitin
directly activates: Catalysis1345

GalNAc is added to chondroitin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0047238
BFO_0000050: Chondroitin sulfate biosynthesis
directly activates: Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13
directly activates: Chondroitin can be sulfated on position 6 of GalNAc by CHST3,7
directly activates: Catalysis1346
directly activates: Catalysis1348

Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0047756
BFO_0000050: Chondroitin sulfate biosynthesis
directly activates: Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15
directly activates: CSPG is secreted
directly activates: Catalysis1347

Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: BRAG
type: Restriction
  on property: enabled by
  some values from: BRAG
type: Restriction
  on property: enabled by
  some values from: BRAG
type: Restriction
  on property: enabled by
  some values from: BRAG
type: Restriction
  on property: enabled by
  some values from: BRAG
type: Restriction
  on property: enabled by
  some values from: BRAG
type: Restriction
  on property: enabled by
  some values from: BRAG
type: Restriction
  on property: enabled by
  some values from: BRAG
type: GO_0050659
BFO_0000050: Chondroitin sulfate biosynthesis
directly activates: CSPG is secreted

Chondroitin can be sulfated on position 6 of GalNAc by CHST3,7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0008459
BFO_0000050: Chondroitin sulfate biosynthesis
directly activates: CSPG is secreted

CSPG is secreted
type: GO_0003674
BFO_0000050: Chondroitin sulfate biosynthesis
directly activates: DSPG and CSPG translocate to the lysosome for degradation

Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: DSE
type: Restriction
  on property: enabled by
  some values from: DSE
type: Restriction
  on property: enabled by
  some values from: DSE
type: Restriction
  on property: enabled by
  some values from: DSE
type: Restriction
  on property: enabled by
  some values from: DSE
type: Restriction
  on property: enabled by
  some values from: DSE
type: Restriction
  on property: enabled by
  some values from: DSE
type: Restriction
  on property: enabled by
  some values from: DSE
type: GO_0047757
BFO_0000050: Dermatan sulfate biosynthesis
directly activates: Dermatan sulfate can be further sulfated on position 2 of iduronate
directly activates: DSPGs are secreted
directly activates: Catalysis1350

Dermatan sulfate can be further sulfated on position 2 of iduronate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: DS2ST
type: Restriction
  on property: enabled by
  some values from: DS2ST
type: Restriction
  on property: enabled by
  some values from: DS2ST
type: Restriction
  on property: enabled by
  some values from: DS2ST
type: Restriction
  on property: enabled by
  some values from: DS2ST
type: Restriction
  on property: enabled by
  some values from: DS2ST
type: Restriction
  on property: enabled by
  some values from: DS2ST
type: Restriction
  on property: enabled by
  some values from: DS2ST
type: GO_0008146
BFO_0000050: Dermatan sulfate biosynthesis
directly activates: CHST14 transfers SO4(2-) to DS
directly activates: DSPGs are secreted
directly activates: Catalysis1351

CHST14 transfers SO4(2-) to DS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: CHST14
type: Restriction
  on property: enabled by
  some values from: CHST14
type: Restriction
  on property: enabled by
  some values from: CHST14
type: Restriction
  on property: enabled by
  some values from: CHST14
type: Restriction
  on property: enabled by
  some values from: CHST14
type: Restriction
  on property: enabled by
  some values from: CHST14
type: Restriction
  on property: enabled by
  some values from: CHST14
type: Restriction
  on property: enabled by
  some values from: CHST14
type: GO_0001537
BFO_0000050: Dermatan sulfate biosynthesis
directly activates: DSPGs are secreted
label: GalNAc is sulfated on position 4 once dermatan sulfate is formed

DSPGs are secreted
type: GO_0003674
BFO_0000050: Dermatan sulfate biosynthesis
directly activates: DSPG and CSPG translocate to the lysosome for degradation

DSPG and CSPG translocate to the lysosome for degradation
type: GO_0003674
BFO_0000050: CS/DS degradation
directly activates: DS is cleaved from its proteoglycan
directly activates: CS is cleaved from its proteoglycan
directly activates: Catalysis1352
directly activates: Catalysis1353

DS is cleaved from its proteoglycan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0016798
BFO_0000050: CS/DS degradation
directly activates: Arylsulfatase B (ARSB) hydrolyses sulfate groups from GalNAc 4-sulfate units of DS
directly activates: Catalysis1354

CS is cleaved from its proteoglycan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0016798
BFO_0000050: CS/DS degradation
directly activates: Arylsulfatase B (ARSB) hydrolyses sulfate groups from GalNAc 4-sulfate units of CS
directly activates: Catalysis1358

Arylsulfatase B (ARSB) hydrolyses sulfate groups from GalNAc 4-sulfate units of DS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0003943
BFO_0000050: CS/DS degradation
directly activates: Iduronate 2-sulfatase (IDS) hydrolyses sulfates from L-iduronate 2-sulfate units of dermatan sulfate
directly activates: Hyaluronidase 1 (HYAL1) hydrolyses 1-4 linkages between GalNAc and D-glucuronate residues in CS.
directly activates: Catalysis1355
directly activates: Catalysis1359

Iduronate 2-sulfatase (IDS) hydrolyses sulfates from L-iduronate 2-sulfate units of dermatan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004423
BFO_0000050: CS/DS degradation
directly activates: Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from DS
directly activates: Catalysis1356

Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from DS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004563
BFO_0000050: CS/DS degradation
directly activates: Alpha-L-iduronidase (IDUA) hydrolyses the unsulfated alpha-L-iduronosidic linkage in DS
directly activates: Catalysis1357

Alpha-L-iduronidase (IDUA) hydrolyses the unsulfated alpha-L-iduronosidic linkage in DS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: enabled by
  some values from: IDUA
type: GO_0003940
BFO_0000050: CS/DS degradation

Arylsulfatase B (ARSB) hydrolyses sulfate groups from GalNAc 4-sulfate units of CS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0003943
BFO_0000050: CS/DS degradation
directly activates: Hyaluronidase 1 (HYAL1) hydrolyses 1-4 linkages between GalNAc and D-glucuronate residues in CS.
directly activates: Catalysis1359

Hyaluronidase 1 (HYAL1) hydrolyses 1-4 linkages between GalNAc and D-glucuronate residues in CS.
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: GO_0004415
BFO_0000050: CS/DS degradation

Defective HYAL1 does not hydrolyse 1-4-linkages between GlcNAc and GlcA
type: GO_0003674
BFO_0000050: MPS IX - Natowicz syndrome

Glycosaminoglycan metabolism
type: GO_0008150
BFO_0000050: MPS IX - Natowicz syndrome

Hyaluronan metabolism
type: GO_0008150
BFO_0000050: Glycosaminoglycan metabolism

Hyaluronan biosynthesis and export
type: GO_0008150
BFO_0000050: Hyaluronan metabolism

Hyaluronan uptake and degradation
type: GO_0008150
BFO_0000050: Hyaluronan metabolism

Transport and synthesis of PAPS
type: GO_0008150
BFO_0000050: Glycosaminoglycan metabolism

Keratan sulfate/keratin metabolism
type: GO_0008150
BFO_0000050: Glycosaminoglycan metabolism

Keratan sulfate biosynthesis
type: GO_0008150
BFO_0000050: Keratan sulfate/keratin metabolism

Keratan sulfate degradation
type: GO_0008150
BFO_0000050: Keratan sulfate/keratin metabolism

Heparan sulfate/heparin (HS-GAG) metabolism
type: GO_0008150
BFO_0000050: Glycosaminoglycan metabolism

A tetrasaccharide linker sequence is required for GAG synthesis
type: GO_0008150
BFO_0000050: Heparan sulfate/heparin (HS-GAG) metabolism
BFO_0000050: Chondroitin sulfate/dermatan sulfate metabolism

HS-GAG biosynthesis
type: GO_0008150
BFO_0000050: Heparan sulfate/heparin (HS-GAG) metabolism

HS-GAG degradation
type: GO_0008150
BFO_0000050: Heparan sulfate/heparin (HS-GAG) metabolism

Chondroitin sulfate/dermatan sulfate metabolism
type: GO_0008150
BFO_0000050: Glycosaminoglycan metabolism

Chondroitin sulfate biosynthesis
type: GO_0008150
BFO_0000050: Chondroitin sulfate/dermatan sulfate metabolism

Dermatan sulfate biosynthesis
type: GO_0008150
BFO_0000050: Chondroitin sulfate/dermatan sulfate metabolism

CS/DS degradation
type: GO_0008150
BFO_0000050: Chondroitin sulfate/dermatan sulfate metabolism

MPS IX - Natowicz syndrome
type: GO_0008150