GILT
label: IFI30
label: IP30
label: UniProt:P13284 IFI30

LGMN
label: PRSC1
label: UniProt:Q99538 LGMN

Formation of MHC II alpha beta heterodimer
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Interaction of invariant chain trimer and MHC II alpha beta dimer

Interaction of invariant chain trimer and MHC II alpha beta dimer
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Formation of nonameric complex

Formation of nonameric complex
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Formation of COPII vesicle

Formation of COPII vesicle
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Fusion of COPII vesicle with Golgi complex
directly activates: Translocation of MHC II:Ii complex to TGN

Fusion of COPII vesicle with Golgi complex
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Translocation of MHC II:Ii complex to TGN

Translocation of MHC II:Ii complex to TGN
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: TGN-lysosomal vesicle coat assembly
directly activates: Transport of MHC II:Ii complex to plasma membrane
label: Transport of MHC II:Ii complex along Golgi to TGN

TGN-lysosomal vesicle coat assembly
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Translocation of TGN-lysosome vesicle to lysosome
directly activates: Catalysis313

Translocation of TGN-lysosome vesicle to lysosome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003924
BFO_0000050: MHC class II antigen presentation
directly activates: TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome

TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Initial proteolyis of Ii by aspartic proteases to lip22
directly activates: Catalysis315

Transport of MHC II:Ii complex to plasma membrane
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Insertion of MHC II:Ii complex in to the plasma membrane

Insertion of MHC II:Ii complex in to the plasma membrane
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Recruitment of clathrin coated vesicle by Ii

Recruitment of clathrin coated vesicle by Ii
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Internalization of MHC II:Ii clathrin coated vesicle
directly activates: Catalysis314

Internalization of MHC II:Ii clathrin coated vesicle
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: MHC class II antigen presentation
directly activates: Uncoating of clathrin-coated vesicles and fusion with endosomes

Uncoating of clathrin-coated vesicles and fusion with endosomes
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Trafficking of nonameric complex in the endocytic pathway

Trafficking of nonameric complex in the endocytic pathway
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Initial proteolyis of Ii by aspartic proteases to lip22
directly activates: Catalysis315

Initial proteolyis of Ii by aspartic proteases to lip22
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: LGMN
type: GO_0004197
BFO_0000050: MHC class II antigen presentation
directly activates: Cleavage of lip22 to lip10
directly activates: Catalysis316

Cleavage of lip22 to lip10
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004197
BFO_0000050: MHC class II antigen presentation
directly activates: Generation of CLIP from lip10
directly activates: Catalysis317

Generation of CLIP from lip10
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004197
BFO_0000050: MHC class II antigen presentation
directly activates: Disassociation of CLIP from MHC II

Disassociation of CLIP from MHC II
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Loading of antigenic peptides

MHC class II antigen internalization
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Reduction of disulphide bonds in MHC II antigens
directly activates: Catalysis318

Reduction of disulphide bonds in MHC II antigens
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: GILT
type: GO_0016667
BFO_0000050: MHC class II antigen presentation
directly activates: MHC class II antigen processing
directly activates: Catalysis319

MHC class II antigen processing
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004197
BFO_0000050: MHC class II antigen presentation
directly activates: Loading of antigenic peptides

Loading of antigenic peptides
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Transport of antigen loaded MHC II molecules to surface

Transport of antigen loaded MHC II molecules to surface
type: GO_0003674
BFO_0000050: MHC class II antigen presentation

MHC class II antigen presentation
type: GO_0008150