ODC
SLC25A21
UniProt:Q9BQT8 SLC25A21
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+
alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]
Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate
Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase
alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
Lysine catabolism