ODC
label: SLC25A21
label: UniProt:Q9BQT8 SLC25A21

lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0047130
BFO_0000050: Lysine catabolism
directly activates: saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+
directly activates: Catalysis2862

saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0047131
BFO_0000050: Lysine catabolism
directly activates: alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
directly activates: Catalysis2863

alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004043
BFO_0000050: Lysine catabolism
directly activates: alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
directly activates: Catalysis2864

alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0047536
BFO_0000050: Lysine catabolism

alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0047536
BFO_0000050: Lysine catabolism

2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: ODC
type: GO_0015139
BFO_0000050: Lysine catabolism
directly activates: BiochemicalReaction4554
directly activates: alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
directly activates: Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase
directly activates: Catalysis1971
directly activates: Catalysis2865
directly activates: Catalysis2867
label: Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate

Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0034602
BFO_0000050: Lysine catabolism
directly activates: glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
directly activates: Catalysis2868
label: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+

glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004361
BFO_0000050: Lysine catabolism
directly activates: BiochemicalReaction4794
directly activates: Catalysis2150

Lysine catabolism
type: GO_0008150