CGL1
CSPB
CTLA1
GRB
GZMB
UniProt:P10144 GZMB
NMT
NMT1
UniProt:P30419 NMT1
JNK1
MAPK8
PRKM8
SAPK1
SAPK1C
UniProt:P45983 MAPK8
Caspase-8 activates BID by cleavage
Granzyme-B activates BID by cleavage
Myristoylation of tBID by NMT1
Translocation of tBID to mitochondria
Sequestration of BAD protein by 14-3-3
Activation of BAD by calcineurin
Translocation of activated BAD protein to mitochondria
BAD displaces tBID from BCL-2 sequestration
Translocation of NOXA to mitochondria
Translocation of PUMA protein to mitochondria
MAPK8 phosphorylates BCL2L11
Phosphorylation of BIM by JNK
Translocation of BIM to mitochondria
Phosphorylation of DLC2 by MAPK8
Translocation of BMF to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2
Sequestration of tBID by BCL-2
BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL
tBID binds to inactive BAX protein
tBID activates BAX protein
Translocation of activated BAX to the mitochondria
Oligomerization of BAX at the mitochondrial membrane
tBID binds to inactive BAK protein
tBID activates BAK protein
Oligomerization of BAK at the mitochondrial membrane
Release of Cytochrome c from mitochondria
Release of SMAC from mitochondria
Cytochrome C Binds to Apaf-1
Cytochrome C:Apaf-1 binds Procaspase-9
Cleavage of Procaspase-9 to Caspase-9
Cleavage of Procaspase-3 by the apoptosome
Cleavage of Procaspase-7 by the apoptosome
SMAC binds XIAP:Caspase-3
SMAC binds XIAP:Caspase-7
SMAC binds XIAP:Caspase-9
Dissociation of Caspase-3 from SMAC:XIAP:Caspase-3
Dissociation of Caspase-7 from SMAC:XIAP:Caspase-7
Dissociation of Caspase-9 from SMAC:XIAP:Caspase-9
AKT phosphorylates BAD
Intrinsic Pathway for Apoptosis
Activation of BID and translocation to mitochondria
Activation, myristolyation of BID and translocation to mitochondria
Activation of BH3-only proteins
Activation of BAD and translocation to mitochondria
Activation of NOXA and translocation to mitochondria
Activation of PUMA and translocation to mitochondria
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Activation, translocation and oligomerization of BAX
Activation and oligomerization of BAK protein
Permeabilization of mitochondria
Release of apoptotic factors from the mitochondria
Apoptotic factor-mediated response
Cytochrome c-mediated apoptotic response
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
SMAC-mediated apoptotic response
SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
Transactivation of NOXA by p53
Transactivation of NOXA by E2F1
Transactivation of PUMA by p53
Transactivation of PUMA by E2F1