CGL1
label: CSPB
label: CTLA1
label: GRB
label: GZMB
label: UniProt:P10144 GZMB

NMT
label: NMT1
label: UniProt:P30419 NMT1

JNK1
label: MAPK8
label: PRKM8
label: SAPK1
label: SAPK1C
label: UniProt:P45983 MAPK8

Caspase-8 activates BID by cleavage
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Activation of BID and translocation to mitochondria
directly activates: Myristoylation of tBID by NMT1
directly activates: tBID binds to inactive BAX protein
directly activates: Catalysis3109

Granzyme-B activates BID by cleavage
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CGL1
type: Restriction
  on property: enabled by
  some values from: CGL1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004252
BFO_0000050: Activation of BID and translocation to mitochondria
directly activates: Myristoylation of tBID by NMT1
directly activates: tBID binds to inactive BAX protein
directly activates: Catalysis3109

Myristoylation of tBID by NMT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: NMT
type: Restriction
  on property: enabled by
  some values from: NMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0019107
BFO_0000050: Activation of BID and translocation to mitochondria
directly activates: Translocation of tBID to mitochondria
directly activates: tBID binds to inactive BAK protein

Translocation of tBID to mitochondria
type: GO_0003674
BFO_0000050: Activation of BID and translocation to mitochondria
directly activates: Sequestration of tBID by BCL-2
directly activates: Release of Cytochrome c from mitochondria
directly activates: Release of SMAC from mitochondria
directly activates: Permeabilization of mitochondria

Sequestration of BAD protein by 14-3-3
type: GO_0003674
BFO_0000050: Activation of BAD and translocation to mitochondria
directly activates: Activation of BAD by calcineurin
directly activates: Catalysis3110

Activation of BAD by calcineurin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008597
BFO_0000050: Activation of BAD and translocation to mitochondria
directly activates: Translocation of activated BAD protein to mitochondria

Translocation of activated BAD protein to mitochondria
type: GO_0001844
BFO_0000050: Activation of BAD and translocation to mitochondria
directly activates: BAD displaces tBID from BCL-2 sequestration

BAD displaces tBID from BCL-2 sequestration
type: GO_0003674
BFO_0000050: Activation of BAD and translocation to mitochondria

Translocation of NOXA to mitochondria
type: GO_0001844
BFO_0000050: Activation of NOXA and translocation to mitochondria

Translocation of PUMA protein to mitochondria
type: GO_0001844
BFO_0000050: Activation of PUMA and translocation to mitochondria

MAPK8 phosphorylates BCL2L11
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: GO_0016301
BFO_0000050: Activation of BIM and translocation to mitochondria
label: Phosphorylation of BIM by JNK

Translocation of BIM to mitochondria
type: GO_0001844
BFO_0000050: Activation of BIM and translocation to mitochondria

Phosphorylation of DLC2 by MAPK8
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: GO_0016301
BFO_0000050: Activation of BMF and translocation to mitochondria

Translocation of BMF to mitochondria
type: GO_0001844
BFO_0000050: Activation of BMF and translocation to mitochondria

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2
type: GO_0003674
BFO_0000050: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

Sequestration of tBID by BCL-2
type: GO_0003674
BFO_0000050: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
directly activates: BAD displaces tBID from BCL-2 sequestration

BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL
type: GO_0003674
BFO_0000050: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

tBID binds to inactive BAX protein
type: GO_0003674
BFO_0000050: Activation, translocation and oligomerization of BAX
directly activates: tBID activates BAX protein

tBID activates BAX protein
type: GO_0003674
BFO_0000050: Activation, translocation and oligomerization of BAX
directly activates: Translocation of activated BAX to the mitochondria

Translocation of activated BAX to the mitochondria
type: GO_0001844
BFO_0000050: Activation, translocation and oligomerization of BAX
directly activates: Oligomerization of BAX at the mitochondrial membrane

Oligomerization of BAX at the mitochondrial membrane
type: GO_0003674
BFO_0000050: Activation, translocation and oligomerization of BAX
directly activates: Release of Cytochrome c from mitochondria
directly activates: Release of SMAC from mitochondria

tBID binds to inactive BAK protein
type: GO_0003674
BFO_0000050: Activation and oligomerization of BAK protein
directly activates: tBID activates BAK protein

tBID activates BAK protein
type: GO_0003674
BFO_0000050: Activation and oligomerization of BAK protein
directly activates: Oligomerization of BAK at the mitochondrial membrane

Oligomerization of BAK at the mitochondrial membrane
type: GO_0003674
BFO_0000050: Activation and oligomerization of BAK protein
directly activates: Release of Cytochrome c from mitochondria
directly activates: Release of SMAC from mitochondria

Release of Cytochrome c from mitochondria
type: GO_0003674
BFO_0000050: Release of apoptotic factors from the mitochondria
directly activates: Cytochrome c-mediated apoptotic response
directly activates: Formation of apoptosome

Release of SMAC from mitochondria
type: GO_0003674
BFO_0000050: Release of apoptotic factors from the mitochondria
directly activates: SMAC binds XIAP:Caspase-3
directly activates: SMAC binds XIAP:Caspase-7
directly activates: SMAC binds XIAP:Caspase-9
directly activates: SMAC-mediated apoptotic response
directly activates: SMAC binds to IAPs

Cytochrome C Binds to Apaf-1
type: GO_0003674
BFO_0000050: Formation of apoptosome

Cytochrome C:Apaf-1 binds Procaspase-9
type: GO_0003674
BFO_0000050: Formation of apoptosome
directly activates: Cleavage of Procaspase-9 to Caspase-9
directly activates: Catalysis3113

Cleavage of Procaspase-9 to Caspase-9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Formation of apoptosome

Cleavage of Procaspase-3 by the apoptosome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Activation of caspases through apoptosome-mediated cleavage
directly activates: BiochemicalReaction6037
directly activates: BiochemicalReaction6038
directly activates: BiochemicalReaction6039
directly activates: BiochemicalReaction6040
directly activates: BiochemicalReaction6041
directly activates: BiochemicalReaction6044
directly activates: BiochemicalReaction6046
directly activates: BiochemicalReaction6047
directly activates: BiochemicalReaction6048
directly activates: BiochemicalReaction6049
directly activates: BiochemicalReaction6050
directly activates: BiochemicalReaction6051
directly activates: BiochemicalReaction6059
directly activates: BiochemicalReaction6060
directly activates: BiochemicalReaction6066
directly activates: BiochemicalReaction6068
directly activates: BiochemicalReaction6069
directly activates: BiochemicalReaction6084
directly activates: Catalysis3116
directly activates: Catalysis3117
directly activates: Catalysis3118
directly activates: Catalysis3119
directly activates: Catalysis3120
directly activates: Catalysis3123
directly activates: Catalysis3125
directly activates: Catalysis3126
directly activates: Catalysis3127
directly activates: Catalysis3128
directly activates: Catalysis3129
directly activates: Catalysis3130
directly activates: Catalysis3138
directly activates: Catalysis3139
directly activates: Catalysis3145
directly activates: Catalysis3147
directly activates: Catalysis3148
directly activates: Catalysis3155

Cleavage of Procaspase-7 by the apoptosome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Activation of caspases through apoptosome-mediated cleavage
directly activates: BiochemicalReaction6039
directly activates: BiochemicalReaction6041
directly activates: BiochemicalReaction6061
directly activates: BiochemicalReaction6071
directly activates: Catalysis3118
directly activates: Catalysis3120
directly activates: Catalysis3140
directly activates: Catalysis3150

SMAC binds XIAP:Caspase-3
type: GO_0003674
BFO_0000050: SMAC binds to IAPs
directly activates: Dissociation of Caspase-3 from SMAC:XIAP:Caspase-3
directly activates: BiochemicalReaction6047
directly activates: Catalysis3126

SMAC binds XIAP:Caspase-7
type: GO_0003674
BFO_0000050: SMAC binds to IAPs
directly activates: Dissociation of Caspase-7 from SMAC:XIAP:Caspase-7

SMAC binds XIAP:Caspase-9
type: GO_0003674
BFO_0000050: SMAC binds to IAPs
directly activates: Dissociation of Caspase-9 from SMAC:XIAP:Caspase-9

Dissociation of Caspase-3 from SMAC:XIAP:Caspase-3
type: GO_0003674
BFO_0000050: SMAC-mediated dissociation of IAP:caspase complexes
directly activates: BiochemicalReaction6037
directly activates: BiochemicalReaction6038
directly activates: BiochemicalReaction6039
directly activates: BiochemicalReaction6040
directly activates: BiochemicalReaction6048
directly activates: BiochemicalReaction6049
directly activates: BiochemicalReaction6050
directly activates: BiochemicalReaction6051
directly activates: BiochemicalReaction6059
directly activates: BiochemicalReaction6060
directly activates: BiochemicalReaction6066
directly activates: BiochemicalReaction6068
directly activates: BiochemicalReaction6069
directly activates: Catalysis3116
directly activates: Catalysis3117
directly activates: Catalysis3118
directly activates: Catalysis3119
directly activates: Catalysis3127
directly activates: Catalysis3128
directly activates: Catalysis3129
directly activates: Catalysis3130
directly activates: Catalysis3138
directly activates: Catalysis3139
directly activates: Catalysis3145
directly activates: Catalysis3147
directly activates: Catalysis3148

Dissociation of Caspase-7 from SMAC:XIAP:Caspase-7
type: GO_0003674
BFO_0000050: SMAC-mediated dissociation of IAP:caspase complexes
directly activates: BiochemicalReaction6039
directly activates: BiochemicalReaction6061
directly activates: Catalysis3118
directly activates: Catalysis3140

Dissociation of Caspase-9 from SMAC:XIAP:Caspase-9
type: GO_0003674
BFO_0000050: SMAC-mediated dissociation of IAP:caspase complexes

AKT phosphorylates BAD
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Activation of BAD and translocation to mitochondria
directly activates: Sequestration of BAD protein by 14-3-3

Intrinsic Pathway for Apoptosis
type: GO_0008150

Activation of BID and translocation to mitochondria
type: GO_0008150
BFO_0000050: Intrinsic Pathway for Apoptosis
label: Activation, myristolyation of BID and translocation to mitochondria

Activation of BH3-only proteins
type: GO_0008150
BFO_0000050: Intrinsic Pathway for Apoptosis

Activation of BAD and translocation to mitochondria
type: GO_0008150
BFO_0000050: Activation of BH3-only proteins

Activation of NOXA and translocation to mitochondria
type: GO_0008150
BFO_0000050: Activation of BH3-only proteins

Activation of PUMA and translocation to mitochondria
type: GO_0008150
BFO_0000050: Activation of BH3-only proteins

Activation of BIM and translocation to mitochondria
type: GO_0008150
BFO_0000050: Activation of BH3-only proteins

Activation of BMF and translocation to mitochondria
type: GO_0008150
BFO_0000050: Activation of BH3-only proteins

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
type: GO_0008150
BFO_0000050: Intrinsic Pathway for Apoptosis

Activation, translocation and oligomerization of BAX
type: GO_0008150
BFO_0000050: Intrinsic Pathway for Apoptosis

Activation and oligomerization of BAK protein
type: GO_0008150
BFO_0000050: Intrinsic Pathway for Apoptosis

Permeabilization of mitochondria
type: GO_0003674
BFO_0000050: Intrinsic Pathway for Apoptosis
directly activates: Release of apoptotic factors from the mitochondria

Release of apoptotic factors from the mitochondria
type: GO_0008150
BFO_0000050: Intrinsic Pathway for Apoptosis

Apoptotic factor-mediated response
type: GO_0008150
BFO_0000050: Intrinsic Pathway for Apoptosis

Cytochrome c-mediated apoptotic response
type: GO_0008150
BFO_0000050: Apoptotic factor-mediated response

Formation of apoptosome
type: GO_0008150
BFO_0000050: Cytochrome c-mediated apoptotic response

Activation of caspases through apoptosome-mediated cleavage
type: GO_0008150
BFO_0000050: Cytochrome c-mediated apoptotic response

SMAC-mediated apoptotic response
type: GO_0008150
BFO_0000050: Apoptotic factor-mediated response

SMAC binds to IAPs
type: GO_0008150
BFO_0000050: SMAC-mediated apoptotic response

SMAC-mediated dissociation of IAP:caspase complexes
type: GO_0008150
BFO_0000050: SMAC-mediated apoptotic response

Transactivation of NOXA by p53
type: GO_0003674
BFO_0000050: Activation of NOXA and translocation to mitochondria
directly activates: Translocation of NOXA to mitochondria

Transactivation of NOXA by E2F1
type: GO_0003674
BFO_0000050: Activation of NOXA and translocation to mitochondria
directly activates: Translocation of NOXA to mitochondria

Transactivation of PUMA by p53
type: GO_0003674
BFO_0000050: Activation of PUMA and translocation to mitochondria
directly activates: Translocation of PUMA protein to mitochondria

Transactivation of PUMA by E2F1
type: GO_0003674
BFO_0000050: Activation of PUMA and translocation to mitochondria
directly activates: Translocation of PUMA protein to mitochondria