NA
label: UniProt:P03468 NA

Binding of the influenza virion to the host cell
type: GO_0046718
BFO_0000050: Influenza Life Cycle
directly activates: Clathrin-Mediated Pit Formation And Endocytosis Of The Influenza Virion
directly activates: Control188
directly activates: Entry of Influenza Virion into Host Cell via Endocytosis

Clathrin-Mediated Pit Formation And Endocytosis Of The Influenza Virion
type: GO_0019065
BFO_0000050: Entry of Influenza Virion into Host Cell via Endocytosis
directly activates: Conformation change in hemagglutinin freeing the fusion peptide of HA2

Conformation change in hemagglutinin freeing the fusion peptide of HA2
type: GO_0003674
BFO_0000050: Fusion of the Influenza Virion to the Host Cell Endosome
directly activates: Fusion of the influenza virion HA2 protein transmembrane domain to the host cell endosome membrane

Fusion of the influenza virion HA2 protein transmembrane domain to the host cell endosome membrane
type: GO_0019064
BFO_0000050: Fusion of the Influenza Virion to the Host Cell Endosome
directly activates: Concerted hemagglutinin pore formation

Concerted hemagglutinin pore formation
type: GO_0019064
BFO_0000050: Fusion of the Influenza Virion to the Host Cell Endosome
directly activates: Virion-associated M2 protein mediated ion infusion
directly activates: Catalysis1160

Virion-associated M2 protein mediated ion infusion
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030666
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030666
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030666
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030666
type: GO_0005215
type: GO_0019061
BFO_0000050: Uncoating of the Influenza Virion
directly activates: Ribonucleoprotein release from M1 proteins

Ribonucleoprotein release from M1 proteins
type: GO_0019061
BFO_0000050: Uncoating of the Influenza Virion
directly activates: Recognition of the Nuclear Localization Signal (NLS) by a Karyopherin Alpha Family Protein

Recognition of the Nuclear Localization Signal (NLS) by a Karyopherin Alpha Family Protein
type: GO_0075733
BFO_0000050: Transport of Ribonucleoproteins into the Host Nucleus
directly activates: Recruitment of Karyopherin Beta to form a Trimeric Complex

Recruitment of Karyopherin Beta to form a Trimeric Complex
type: GO_0075733
BFO_0000050: Transport of Ribonucleoproteins into the Host Nucleus
directly activates: Docking and transport of the RNP:Karyopherin complex through the nuclear pore
directly activates: Control189

Docking and transport of the RNP:Karyopherin complex through the nuclear pore
type: GO_0075733
BFO_0000050: Transport of Ribonucleoproteins into the Host Nucleus
directly activates: Release of the RNP into the host cell nucleus

Release of the RNP into the host cell nucleus
type: GO_0075733
BFO_0000050: Transport of Ribonucleoproteins into the Host Nucleus
directly activates: Viral Polymerase Assembly
directly activates: NP binds vRNA
directly activates: Control190
directly activates: Control191

Viral Polymerase Assembly
type: GO_0003674
BFO_0000050: vRNP Assembly
directly activates: Assembly of an Active Transcription Complex
directly activates: Control192
directly activates: Control193

NP binds vRNA
type: GO_0003674
BFO_0000050: vRNP Assembly
directly activates: Assembly of an Active Transcription Complex
directly activates: Control192
directly activates: Control193

Assembly of an Active Transcription Complex
type: GO_0019083
BFO_0000050: Viral Messenger RNA Synthesis
directly activates: Priming and Initiation of Transcription
directly activates: Catalysis1161

Priming and Initiation of Transcription
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003968
type: GO_0019083
BFO_0000050: Viral Messenger RNA Synthesis
directly activates: Elongation of viral mRNA
directly activates: Catalysis1162

Elongation of viral mRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003968
type: GO_0019083
BFO_0000050: Viral Messenger RNA Synthesis
directly activates: Polyadenylation and Termination
directly activates: Catalysis1163

Polyadenylation and Termination
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003968
type: GO_0019083
BFO_0000050: Viral Messenger RNA Synthesis
directly activates: Viral mRNA Splicing (M, NS segments)
directly activates: Viral mRNA Export
directly activates: Control194

Viral mRNA Splicing (M, NS segments)
type: GO_0003674
BFO_0000050: Viral Messenger RNA Synthesis
directly activates: Export of Spliced Viral mRNA

Export of Spliced Viral mRNA
type: GO_0003674
BFO_0000050: Viral Messenger RNA Synthesis

Viral mRNA Export
type: GO_0003674
BFO_0000050: Viral Messenger RNA Synthesis

Initiation of cRNA Synthesis
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003968
BFO_0000050: cRNA Synthesis
directly activates: cRNA Extension
directly activates: Catalysis1165

cRNA Extension
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003968
BFO_0000050: cRNA Synthesis

Initiation of vRNA Synthesis
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003968
BFO_0000050: vRNA Synthesis
directly activates: vRNA Extension
directly activates: Catalysis1167

vRNA Extension
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003968
BFO_0000050: vRNA Synthesis

Synthesis of PB1-F2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003746
BFO_0000050: Viral mRNA Translation

Viral Protein Synthesis
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003746
BFO_0000050: Viral mRNA Translation

Newly synthesized vRNP for export
type: GO_0003674
BFO_0000050: Viral RNP Complexes in the Host Cell Nucleus
directly activates: Binding of M1 to vRNP
directly activates: Control200

Binding of M1 to vRNP
type: GO_0003674
BFO_0000050: Viral RNP Complexes in the Host Cell Nucleus
directly activates: Binding of NEP/NS2 to vRNP:M1

Binding of NEP/NS2 to vRNP:M1
type: GO_0075733
BFO_0000050: Viral RNP Complexes in the Host Cell Nucleus

Binding of vRNP:M1:NEP complex to CRM1 export receptor
type: GO_0075733
BFO_0000050: NEP/NS2 Interacts with the Cellular Export Machinery
directly activates: vRNP Export through the nuclear pore
directly activates: Control201

vRNP Export through the nuclear pore
type: GO_0075733
BFO_0000050: NEP/NS2 Interacts with the Cellular Export Machinery

Entry of M2 into the endoplasmic reticulum
type: GO_0003674
BFO_0000050: Assembly of Viral Components at the Budding Site
directly activates: Assembly of M2 tetramers

Assembly of M2 tetramers
type: GO_0003674
BFO_0000050: Assembly of Viral Components at the Budding Site
directly activates: Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus

Entry of NA into the endoplasmic reticulum
type: GO_0003674
BFO_0000050: Assembly of Viral Components at the Budding Site
directly activates: Glycosylation of NA

Glycosylation of NA
type: GO_0003674
BFO_0000050: Assembly of Viral Components at the Budding Site
directly activates: Assembly of NA tetramers

Assembly of NA tetramers
type: GO_0003674
BFO_0000050: Assembly of Viral Components at the Budding Site
directly activates: Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus

Entry of HA into the endoplasmic reticulum
type: GO_0019060
BFO_0000050: Assembly of Viral Components at the Budding Site
directly activates: Glycosylation and Folding of HA
directly activates: Control202
directly activates: Control203

Glycosylation and Folding of HA
type: GO_0003674
BFO_0000050: Assembly of Viral Components at the Budding Site
directly activates: Trimerization of HA

Trimerization of HA
type: GO_0019082
BFO_0000050: Assembly of Viral Components at the Budding Site
directly activates: Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus

Budding of vesicle with the HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum into the cytosol
type: GO_0019060
BFO_0000050: Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus
directly activates: Fusion of vesicle containing the HA trimer, NA tetramer and M2 tetramer to the Golgi apparatus

Fusion of vesicle containing the HA trimer, NA tetramer and M2 tetramer to the Golgi apparatus
type: GO_0019060
BFO_0000050: Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus

Palmitoylation of cysteine residues on HA in the cis-Golgi network
type: GO_0019082
BFO_0000050: Assembly of Viral Components at the Budding Site
directly activates: Association of HA into rafts

Palmitoylation of cysteine residues on M2 in the cis-golgi network
type: GO_0003674
BFO_0000050: Assembly of Viral Components at the Budding Site
directly activates: Transport of processed viral proteins to the cell membrane

Association of HA into rafts
type: GO_0019068
BFO_0000050: Assembly of Viral Components at the Budding Site
directly activates: Transport of processed viral proteins to the cell membrane

Association of NP into rafts
type: GO_0019068
BFO_0000050: Assembly of Viral Components at the Budding Site
directly activates: Transport of processed viral proteins to the cell membrane

Association of NA into rafts
type: GO_0003674
BFO_0000050: Assembly of Viral Components at the Budding Site
directly activates: Transport of processed viral proteins to the cell membrane

Transport of processed viral proteins to the cell membrane
type: GO_0003674
BFO_0000050: Assembly of Viral Components at the Budding Site

Accumulation of M1 at the inner leaflet of the lipid bilayer
type: GO_0019068
BFO_0000050: Assembly of Viral Components at the Budding Site

RNP association
type: GO_0019072
BFO_0000050: Packaging of Eight RNA Segments

Association with M1 at cell membrane
type: GO_0003674
BFO_0000050: Packaging of Eight RNA Segments

Membrane fusion
type: GO_0046766
BFO_0000050: Budding

Neuraminidase enzymatic release from sialic acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: NA
type: Restriction
  on property: enabled by
  some values from: NA
type: Restriction
  on property: enabled by
  some values from: NA
type: Restriction
  on property: enabled by
  some values from: NA
type: GO_0004308
type: GO_0019076
BFO_0000050: Release

Influenza Life Cycle
type: GO_0008150

Entry of Influenza Virion into Host Cell via Endocytosis
type: GO_0008150
BFO_0000050: Influenza Life Cycle

Fusion and Uncoating of the Influenza Virion
type: GO_0008150
BFO_0000050: Influenza Life Cycle

Fusion of the Influenza Virion to the Host Cell Endosome
type: GO_0008150
BFO_0000050: Fusion and Uncoating of the Influenza Virion

Uncoating of the Influenza Virion
type: GO_0008150
BFO_0000050: Fusion and Uncoating of the Influenza Virion

Transport of Ribonucleoproteins into the Host Nucleus
type: GO_0008150
BFO_0000050: Influenza Life Cycle

Influenza Viral RNA Transcription and Replication
type: GO_0008150
BFO_0000050: Influenza Life Cycle

vRNP Assembly
type: GO_0008150
BFO_0000050: Influenza Viral RNA Transcription and Replication

Viral Messenger RNA Synthesis
type: GO_0008150
BFO_0000050: Influenza Viral RNA Transcription and Replication

cRNA Synthesis
type: GO_0008150
BFO_0000050: Influenza Viral RNA Transcription and Replication

vRNA Synthesis
type: GO_0008150
BFO_0000050: Influenza Viral RNA Transcription and Replication

Viral mRNA Translation
type: GO_0008150
BFO_0000050: Influenza Viral RNA Transcription and Replication

Export of Viral Ribonucleoproteins from Nucleus
type: GO_0008150
BFO_0000050: Influenza Life Cycle

Viral RNP Complexes in the Host Cell Nucleus
type: GO_0008150
BFO_0000050: Export of Viral Ribonucleoproteins from Nucleus

NEP/NS2 Interacts with the Cellular Export Machinery
type: GO_0008150
BFO_0000050: Export of Viral Ribonucleoproteins from Nucleus

Virus Assembly and Release
type: GO_0008150
BFO_0000050: Influenza Life Cycle

Assembly of Viral Components at the Budding Site
type: GO_0008150
BFO_0000050: Virus Assembly and Release

Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus
type: GO_0008150
BFO_0000050: Assembly of Viral Components at the Budding Site

Packaging of Eight RNA Segments
type: GO_0008150
BFO_0000050: Virus Assembly and Release

Budding
type: GO_0008150
BFO_0000050: Virus Assembly and Release

Release
type: GO_0008150
BFO_0000050: Virus Assembly and Release